Search clinical trials for: propofol pharmacodynamics

Total 3834 results

University of British Columbia
BC Children's Hospital Research Institute

Active, not recruiting

Genetic Differences in Propofol Pharmacodynamics in Children

Anesthesia

Canada
Taipei Veterans General Hospital, Taiwan

Completed

Modeling and Application of Triple Drug Response Surface Models

Pharmacodynamics | Drug Interactions

Taiwan
Baylor College of Medicine

Completed

Propofol in Obese Children

Obesity | Pharmacodynamics

United States
Sichuan Haisco Pharmaceutical Group Co., Ltd

Completed

A Study Evaluating the Safety and Pharmacokinetics/Pharmacodynamics of HSK3486

Anesthesia | Sedation

China
Sichuan Haisco Pharmaceutical Group Co., Ltd

Completed

Evaluating the Safety, Pharmacodynamics and Pharmacokinetics of HSK3486 in Healthy Female Subjects.

Anesthesia | Sedation
Sichuan Haisco Pharmaceutical Group Co., Ltd

Completed

A Study Evaluating the Safety, Pharmacodynamics and Pharmacokinetics of HSK3486 in Healthy Subjects.

Anesthesia | Sedation
Centro Hospitalar do Porto

Completed

Propofol Pharmacokinetics and Pharmacodynamics Modelling

Intravenous Anesthetic Agent Overdose

Portugal
Erasmus Medical Center
Amsterdam UMC, location VUmc; ZonMw: The Netherlands Organisation for Health... and other collaborators

Terminated

Optimizing Propofol Dosing for (Preterm) Newborn Infants That Need Endotracheal Intubation (NEOPROP2)

Premature Birth of Newborn | Other Preterm Infants | Anesthesia Intubation Complication | Propofol Overdose

Netherlands
Stanford University

Completed

A High Resolution Pharmacokinetic/Pharmacodynamic Model of Propofol in Morbidly Obese Subjects

Morbid Obesity

United States
Golden Jubilee National Hospital

Completed

Validation Study of Covariates Model (VaSCoM) for Propofol (VaSCoM)

Target Controlled Infusion of Propofol

United Kingdom
Pontificia Universidad Catolica de Chile

Unknown

Pharmacokinetic/Pharmacodynamic Model of Propofol in Children

Anesthesia

Chile
Gangnam Severance Hospital

Unknown

Remifentanil and Midazolam on Propofol for Loss of Consciousness in Elderly Patients

Anesthesia

Korea, Republic of
Severance Hospital

Completed

Remifentanil and Midazolam on Propofol for Loss of Consciousness

Anesthesia

Korea, Republic of
Eisai Inc.

Completed

A Study to Characterize Pharmacokinetics (PK) and Pharmacodynamics (PD) of LUSEDRA® Administered as Continuous Infusion or Bolus Compared With Continuous Infusion of Propofol Injectable Emulsion

Monitored Anesthesia Care

United States
Tianjin Medical University General Hospital

Unknown

Pharmacokinetics and Pharmacodynamics of Rocuronium in Closed-Loop Infusion System

TOF | Sex
Universidad del Desarrollo

Completed

Neuronal Inertia in Propofol Anesthesia (INERTIA)

General Anesthesia | Propofol Pharmacodynamics | Propofol Target Controlled Infusion | Loss of Consciousness and Recovery of Consciousness | Propofol Plasma Concentration

Chile
Ethicon Endo-Surgery

Completed

Exploratory Study of Propofol and Fentanyl Pharmacodynamics

General Anesthesia

United States
Asan Medical Center

Completed

Population Pharmacokinetics/Pharmacodynamics (PK/PD) of Microemulsion Propofol in Healthy Volunteers

Healthy

Korea, Republic of
University of Sao Paulo
Fundação de Amparo à Pesquisa do Estado de São Paulo

Completed

Propofol Pharmacokinetics and Pharmacodynamics During Cardiopulmonary Bypass

Coronary Artery Disease | Cardiopulmonary Bypass | Coronary Artery Bypass Graft

Brazil
Daewoong Pharmaceutical Co. LTD.

Not yet recruiting

to Evaluate the Safety/Tolerability and Pharmacokinetics, and Pharmacodynamics of DWP14012 Injection

Erosive Gastroesophageal Reflux Disease
Ionis Pharmaceuticals, Inc.

Not yet recruiting

ATTUNE: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION440 in Participants With Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome (MDS)

Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome
Beijing Tiantan Hospital

Recruiting

Effects of Esketamine on Recovery of Consciousness After Propofol Anesthesia

Post-anesthesia Recovery

China
Henry M. Jackson Foundation for the Advancement...
Uniformed Services University of the Health Sciences; Brooke Army Medical Center

Not yet recruiting

Ketamine for Sedation in Severe Traumatic Brain Injury (Ketamine)

Intracranial Hypertension | Severe Traumatic Brain Injury | Intracranial Hemorrhage, Hypertensive
Ain Shams University

Not yet recruiting

The Effect of Adding Either Propofol or Ketamine to Magnesium and Lidocaine Infusions in Nasal Surgeries.

Intraoperative Bleeding

Egypt
Gannex Pharma Co., Ltd.

Not yet recruiting

Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASC47 in Healthy Subjects

NASH
Institute of Liver and Biliary Sciences, India
Institute of Liver and Biliary Sciences

Recruiting

Effect of TCI Propofol on Liver Transplant (TCI) Propofol on Intra-operative Usage of Vasopressors in Liver Transplant Recipients.

Liver Transplant Recipients

India
Universidad del Desarrollo
Technical University of Munich

Recruiting

Re-evaluation of the Effect Site Model of the PKPD Propofol Eleveld Model (Eleved PD)

Healthy | Surgery

Chile
Theodor Bilharz Research Institute

Recruiting

The Effects of Different Loading Doses of Dexmedetomidine on The Bispectral Index-Guided Propofol Sedation in Patients Undergoing Advanced Upper Gastrointestinal Endoscopic Procedures: A Randomized Control Study

Procedural Sedation | GIT Endoscopy

Egypt
Baoding First Central Hospital

Not yet recruiting

Ciprofol Versus Propofol in Patients Undergoing Painless Hysteroscopy

Painless Hysteroscopy
Ondokuz Mayıs University

Recruiting

Propofol-ketamine or Propofol-fentanyl for Procedural Sedation in the Short-term Gynecological Case

Sedation | Ketamine | Gynecologic Disease

Turkey
Celgene

Not yet recruiting

A Study to Evaluate the Safety, Tolerability, and Drug Levels of Orally Administered BMS-986368 in Healthy Participants, Healthy Elderly Participants, and Healthy Participants of Japanese Ethnicity

Healthy Participants

United States
AstraZeneca
Parexel

Recruiting

Drug-Drug Interaction and Safety of AZD4041 Study (Part 1) and Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AZD4041 Study in Opioid Use Disorder (Part 2).

Opioid Use Disorder

United States
University of Michigan
National Institute of General Medical Sciences (NIGMS)

Recruiting

Investigating Near-Threshold Perception During Anesthetic Sedation

Anesthesia | Propofol | fMRI

United States
Ruijin Hospital

Recruiting

Analysis of Deep Brain Nuclei LFP and Cortical EEG Signals During the Recovery From General Anesthesia

General Anesthesia | Electrophysiology | Consciousness, Loss of | Deep Brain Stimulation Surgery

China
Benha University

Recruiting

Sevoflurane and Intravenous Anesthesia in Hypospadias Repair

Emergence Delirium | Sevoflurane | Intravenous Anesthesia

Egypt
Korea United Pharm. Inc.

Not yet recruiting

A Study to Compare and Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of UI059 and UIC202201

Gastro-Intestinal Disorder

Korea, Republic of
Haisco Pharmaceutical Group Co., Ltd.

Recruiting

A Multicenter, Open, Controlled, Phase III Clinical Study to Evaluate the Efficacy and Safety of Cipepofol Injection for General Anesthesia in Pediatric Patients Undergoing Elective Surgery

Anesthesia

China
University of Padova

Recruiting

Effects of Sufentanil Target Controlled Infusion on Patient State Index Values and Electroencephalographic Spectrum During Total Intravenous Anesthesia With Propofol

Target Controlled Infusion | Sufentanil | Anesthesia Brain Monitor

Italy
Dr. Lutfi Kirdar Kartal Training and Research Hospital

Not yet recruiting

Sevoflurane Versus Propofol: Effect on Stress Response

Inflammatory Response | Sevoflurane | Propofol

Turkey
Tongji Hospital

Not yet recruiting

Effect of Amobarbital Sodium Combined With Low-dose Propofol on Hemodynamics During Induction and Perioperative Adverse Reactions

Hemodynamics Instability | Amobarbital Sodium
Guangdong Hengrui Pharmaceutical Co., Ltd

Not yet recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SHR-4597 Inhalation in Healthy Subjects and Asthmatic Patients

Healthy Subjects | Asthmatic Patients
Changchun GeneScience Pharmaceutical Co., Ltd.

Recruiting

A Phase I Clinical Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Oral Dose Escalation of GS1-144 Tablets and the Effects of Food on the Pharmacokinetics of GS1-144 in a Chinese Population

Healthy Volunteer | Vasomotor System; Labile

China
Chung-Ang University Gwangmyeong Hospital

Not yet recruiting

Comparison of Remimazolam and Propofol Combination vs. Propofol in IOM

Neurologic Disorder
Al-Balqa Applied University
Luzmila Hospital

Not yet recruiting

Intermittent Boluses Versus Infusion of Propofol During Gastroscopy

Anesthesia
Etienne Xavier Keller

Recruiting

Effect of Propofol vs. Sevoflurane on Erections During Narcosis In Transurethral Surgery (PENIS)

Erection; Incomplete

Switzerland
Alexandria University

Not yet recruiting

Propofol or Benzodiazepine Combined With Ketamine for Procedural Sedation in Emergency Setting

Procedural Sedation
Beni-Suef University

Recruiting

The Sedative Effects of Dexmedetomidine VS Propofol During Peribulbar Anesthesia in Patients Undergoing Vitrectomy Surgery

Satisfaction | Patient

Egypt
Peking Union Medical College Hospital
Xiangya Hospital of Central South University; Ruijin Hospital; China-Japan Friendship...

Recruiting

The Study of Monitoring and Dosing Guidance of Direct Oral Anticoagulants Based on Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics

Pulmonary Embolism

China
Yonsei University

Recruiting

Comparison of Remimazolam and Propofol Effect on Oxygen Reserve During Endoscopic Retrograde Cholangiopancreatography

Hepatobiiliary Diseases Requiring Endoscopic Retrograde Cholangiopancreatography

Korea, Republic of
Changchun BCHT Biotechnology Co.
The First Affiliated Hospital of Yunnan University of Traditional Chinese... and other collaborators

Not yet recruiting

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of the Fully Human Anti-tetanus Toxin Monoclonal Antibody A82 / B86 Injection Combination Formulation

Clostridium Tetanus

3

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