Search clinical trials for: severe dry eye disease

Total 384148 results

Laboratoires Thea

Not yet recruiting

Comparison of the Performance and Safety of T2769 Versus Hylo-Forte® in the Treatment of Moderate to Severe Dry Eye Syndrome.

Dry Eye Syndrome
Invirsa, Inc.

Recruiting

Study of INV-102 Ophthalmic Solution in Adults With Moderate to Severe Dry Eye Disease

Dry Eye Disease

United States
Amgen

Recruiting

A Safety and Efficacy Study of Dazodalibep in Participants With Sjögren's Syndrome (SS) With Moderate-to-Severe Symptom State

Sjögren's Syndrome (SS)

United States
Fidia Farmaceutici s.p.a.

Recruiting

Assessment of Efficacy and Safety of the Use of Two Eye Gel Products Containing 5% Dexpanthenol in Patients With Moderate to Severe Dry Eye Syndrome

Dry Eye Disease

Italy
Amgen

Recruiting

A Study to Evaluate the Efficacy and Safety of Dazodalibep in Participants With Sjögren's Syndrome (SS) With Moderate-to-severe Systemic Disease Activity

Sjogren's Syndrome

United States, Argentina, Japan
Laboratoires Thea

Recruiting

Comparison of the Performance and Safety of T2769 Versus Vismed® Multi in the Treatment of Moderate to Severe Dry Eye Syndrome

Dry Eye

France
Peking Union Medical College Hospital

Not yet recruiting

Tacrolimus Plus Glucocorticoid for Severe Thrombocytopenia in SS

Sjogren Syndrome With Other Organ Involvement
St. Petersburg State Pavlov Medical University

Recruiting

Allogeneic Platelet Lysate Eye Drops for the Treatment of Severe Chronic Ocular Graft-versus-host Disease

Ocular Graft-versus-host Disease

Russian Federation
Taejoon Pharmaceutical Co., Ltd.

Recruiting

Evaluating the Efficacy and Safety of TJO-087 in Moderate to Severe Dry Eye Disease Patients

Dry Eye Syndrome

Korea, Republic of
Yonsei University

Recruiting

A Clinical Trial to Evaluate the Clinical Efficacy of Cyclosporine 0.1% (Ikervis®) for Moderate to Severe Dry Eye Patients. (IKE-03-SWITCHING)

Moderate to Severe Dry Eye

Korea, Republic of
Harbour BioMed (Guangzhou) Co. Ltd.

Recruiting

A Study Evaluating HBM9036 Efficacy and Safety on Moderate to Severe Dry Eye

Dry Eye

China
QuantumLeap Healthcare Collaborative
M.D. Anderson Cancer Center; University of Colorado, Denver; University of Pennsylvania and other collaborators

Recruiting

I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients (I-SPY_COVID)

COVID-19

United States
Fondation Ophtalmologique Adolphe de Rothschild

Recruiting

Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE) (ALTESSE)

Dry Eye Syndromes | Conjunctival Diseases

France
Ocumension Therapeutics (Shanghai) Co., Ltd

Completed

Study of OT202 in Treating Moderate to Severe Dry Eye

Dry Eye

China
Dompé Farmaceutici S.p.A

Completed

A Study to Evaluate Safety and Efficacy of rhNGF Eye Solution vs Vehicle in Patients With Moderate to Severe Dry Eye

Dry Eye Syndrome

United States
Santen SAS

Completed

Effect of IKERVIS® Eye Drops Once Daily on the Quality of Vision in Dry Eye Disease Patients With Severe Keratitis (FAST)

Keratitis

France
Jadran Galenski laboratorij d.d.
Poseidon CRO

Completed

Vizol S Lipid Balance Efficacy and Safety Study in Patients With Dry Eye

Dry Eye Disease

Serbia
Dompé Farmaceutici S.p.A

Completed

Study to Evaluate Safety and Efficacy of Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease (NGF0221)

Dry Eye Syndrome

United States, Italy
Kowa Research Institute, Inc.

Completed

A Study to Confirm the Efficacy and Safety of K-161 Ophthalmic Solution for Treatment of Moderate to Severe Dry Eye Disease

Dry Eye Disease

United States
Centro Oculistico Borroni

Completed

Quantum Molecular Resonance Electrotherapy in Severe Dry Eye Disease (QMR)

Dry Eye

Italy
Santen SAS

Completed

3-year Study in Dry Eye Disease Patients With Severe Keratitis Receiving Ikervis® (1mg/mL Ciclosporin)

Dry Eye Disease With Severe Keratitis

Czechia, France, Italy, Poland, Russian Federation, Spain, Turkey
Eximore Ltd.

Active, not recruiting

Safety, Tolerability, Plug Retention and Preliminary Efficacy of Tacrolimus-loaded Punctal Plug in Patients With Moderate to Severe Dry Eye Disease - Cohort B

Ocular Inflammation | Dry Eye | Keratoconjunctivitis Sicca

Mexico
Dompé Farmaceutici S.p.A

Active, not recruiting

Study to Evaluate Safety and Efficacy of Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease (NGF0121 - PROTEGO-1 Study) (NGF0121)

Dry Eye

United States, Italy
Kowa Research Institute, Inc.

Completed

A Study Assessing the Safety, Efficacy, and Optimum Dosage of K-161 in Subjects With Moderate to Severe Dry Eye Disease

Dry Eye Disease

United States
Novartis Pharmaceuticals

Terminated

A Phase 2 Study to Evaluate the Safety and Efficacy of LOU064 in Patients With Moderate to Severe Sjögren's Syndrome (LOUiSSe)

Sjögren Syndrome

Spain, United States, Belgium, Hungary, Germany, Switzerland, Australia, Denmark, China, Taiwan, United Kingdom, Bulgaria
SIFI SpA

Completed

Safety and Efficacy of Two Different Concentrations (0.5% and 1%) of Progesterone Topical Gel Compared to Placebo in Patients Diagnosed With Moderate to Severe Dry Eye Syndrome (ProGIFT)

Dry Eye Disease

Italy
Zhaoke (Guangzhou) Ophthalmology Pharmaceutical...

Completed

Assess the Safety and Efficacy of CsA Ophthalmic Gel in Subjects With Moderate to Severe Dry Eye Disease

Dry Eye

China
AbbVie

Withdrawn

An Efficacy and Safety Study of Injectable Ravagalimab to Assess Change in EULAR Sjogren's Syndrome Disease Activity Index (ESSDAI) in Adult Participants With Moderately to Severely Active Primary Sjogren's Syndrome (pSS)

Sjogren's Syndrome (SS)

Netherlands
Vienna Institute for Research in Ocular Surgery

Terminated

Efficacy of Different Treatment Regimens With Chitosan-N- Acetylcysteine in Moderate-to-severe Dry Eye Disease

Eye Diseases

Austria
Universidad Nacional de Colombia

Completed

Platelet -Rich Plasma (PRP) Injection for the Treatment of Severe Dry Eye

Dry Eye | Sjogren Syndrome
Harbour BioMed (Guangzhou) Co. Ltd.

Completed

A Study Evaluating the Efficacy and Safety on Moderate to Severe Dry Eye

Dry Eye

China
AbbVie (prior sponsor, Abbott)

Completed

A Pilot Clinical Study Evaluating the Effect of Parathyroid Hormone (PTH) Lowering On Erythropoietin Consumption in Calcitriol-Resistant Patients

Moderate to Severe Secondary Hyperparathyroidism | Stage 5 Chronic Kidney Diseases
Instituto Universitario de Oftalmobiología Aplicada...
Santen Oy

Completed

Efficacy and Safety of Ikervis Under Controlled Environmental Conditions Environment

Dry Eye | Dry Eye Syndromes | Severe Keratitis

Spain
Epitech Mag Ltd.

Terminated

Viveye Ocular Magnetic Neurostimulation System (OMNS) for the Management of Severe Dry Eye Disease (OMNS)

Dry Eye Syndromes | Sjogren's Syndrome | ATD

Israel
Singapore National Eye Centre
Health Science Authority Singapore

Withdrawn

Autologous Plasma Treatment for Severe Dry Eye Patients

Dry Eye

Singapore
National University of Malaysia

Unknown

Umbilical Cord Serum Versus Conventional Eyedrops

Dry Eye Syndromes

Malaysia
Novartis

Completed

Safety and Efficacy of Pimecrolimus Ophthalmic Suspension in Patients With Moderate to Severe Keratoconjunctivitis Sicca

Keratoconjunctivitis Sicca

United States
University of Illinois at Chicago
Johnson & Johnson Vision Care, Inc.

Unknown

Senofilcon A Lenses in Moderate to Severe Dry Eye Disease

Moderate to Severe Dry Eye Disease

United States
Kuopio University Hospital
Business Finland; 4Pharma Ltd.; Finnsusp Ltd.

Completed

Piiloset Trehalose Emulsion Eye Drop Study in Moderate or Severe Dry Eye

Dry Eye Syndrome

Finland
Novaliq GmbH

Completed

CyclASol for the Treatment of Moderate to Severe Dry-eye Disease (DED)

Dry Eye Syndromes

United States
R-Tech Ueno, Ltd.

Completed

A Phase 1/2, RU-101 Ophthalmic Solution in Patients With Severe Dry Eye

Dry Eye

United States
Medical University of Vienna

Completed

Difference in the Frequency of Use of Lachrymal Substitutes in Patients With Moderate to Severe Dry Eye Syndrome

Dry Eye Syndromes

Austria
Medical University of Vienna

Completed

Influence of Three Different Formulations of Lachrymal Substitutes on Tear Film Thickness and Other Signs and Symptoms in Patients With Moderate to Severe Dry Eye Syndrome

Dry Eye Syndromes

Austria
Sylentis, S.A.

Completed

HELIX, a Double-masked Study of SYL1001 in Patients With Moderate to Severe Dry Eye Disease (DED)

Dry Eye Disease

Spain, Portugal, Italy, Estonia, Germany, Slovakia
Seref istek
Usak State Hospital

Completed

The Comparison of 50% AS Versus PFAT+ 0.05 % COE in Severe Dry Eye Syndrome

Dry Eye Syndrome
Pontificia Universidad Catolica de Chile
Hospital Dr Sotero del Rio

Unknown

Efficacy of Two Concentrations of Autologous Serum for the Treatment of Severe Dry Eye

Dry Eye | Keratoconjunctivitis Sicca | Lacrimal Apparatus Diseases | Conjunctival Diseases | Keratitis | Corneal Diseases | Sjogren's Syndrome

Chile
Alcon, a Novartis Company
Novartis Institutes for BioMedical Research

Completed

LME636 in the Relief of Persistent Ocular Discomfort in Subjects With Severe Dry Eye Disease

Dry Eye
Horus Pharma

Completed

Evaluation of the Efficacy and Safety of DM05 Versus Optive™ on the Treatment of Moderate to Severe Ocular Dryness

Dry Eye
Bedford Hospital NHS Trust
Anglia Ruskin University

Unknown

Fingerprick Autologous Blood (FAB) in Severe Dry Eye Disease (DED) (FAB)

Dry Eye Syndromes
Gina Rogers

Withdrawn

Tears Substitutions and Their Effects on Higher Order Aberrometery

Dry Eye Syndrome

United States

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