Search clinical trials for: target biomarkers

Total 10158 results

Fondazione IRCCS Ca' Granda, Ospedale Maggiore...

Recruiting

Identification of Biomarkers and Molecular Targets Involved on Intervertebral Disc Degeneration and Discogenic Pain

Intervertebral Disc Degeneration | Discogenic Pain | Discogenic Disease

Italy
Fondazione IRCCS Ca' Granda, Ospedale Maggiore...

Recruiting

Development of Therapeutic Approaches Modulating Molecular Targets Implicated on Cancer Stem Cell-related Aggressiveness

Glioma | Glioblastoma | Glioma Glioblastoma Multiforme

Italy
University Hospital, Basel, Switzerland

Not yet recruiting

Targeted Radionuclide Therapy in Metastatic Prostate Cancer Using a New PSMA Ligand Radiolabelled With Terbium-161 (161Tb-SibuDAB) - Dose Identification/Escalation Phase Ia/b Study (PROGNOSTICS)

Castration-resistant Prostate Cancer

Switzerland
Hospices Civils de Lyon
Centre International de Recherche en Infectiologie (CIRI)

Not yet recruiting

TOward a Better Understanding of the autoPhagy Machinery for the Identification of Potential Novel Biomarkers and Therapeutic Targets in Crohn's Disease - TOPIC Study (TOPIC)

Crohn's Disease

France
Peking University

Recruiting

Targeted Treatment Plus Tislelizumab and HAIC for Advanced CRCLM Failed From Standard Systemic Treatment

Liver Metastasis Colon Cancer | MSS | ctDNA Genotype | Failed From Standard Treatment

China
CerbaXpert

Recruiting

Evaluation of the Physiological Stability Variability and Robustness of NIS4

Evaluate the Physiological Stability of NIS4 Biomarker Between the Fed and Fasting State in Patients With the Target Condition (NAFLD)

France
Helsinki University Central Hospital

Recruiting

Biomarkers for Diagnosis, Prognosis, and Targeted Therapy After Heart Transplantation (EMBIO)

Heart Transplant Rejection

Finland
Assistance Publique - Hôpitaux de Paris
Institut National de la Santé Et de la Recherche Médicale, France

Not yet recruiting

CRACK-TARGET 1: ÉTUDE DESCRIPTIVE DE LA SENSIBILISATION COMPORTEMENTALE OBSERVÉE et ATTENTES (CRACK-TARGET)

Cocaine Use Disorder

France
University College, London
Gustave Roussy, Cancer Campus, Grand Paris

Not yet recruiting

Assessment of Novel Biomarkers in Participants Undergoing Targeted Lung Health Checks (ALPINE)

Lung Cancer

United Kingdom
University Hospital, Basel, Switzerland
University of Zurich

Recruiting

Novel Targetable BIOmarkers in ANorexia NervosA (BIOANNA)

Anorexia Nervosa | Anorexia Nervosa Restricting Type

Switzerland
University of Minnesota

Recruiting

Extracellular Vesicles as Potential Biomarkers and Therapeutic Target in Gaucher Disease

Gaucher Disease

United States
Assistance Publique - Hôpitaux de Paris

Recruiting

Citrate Anticoagulation in Renal Replacement Therapy: Impact of a High Post-filter Calcium Target on Efficacy (Ca-CIBLE)

Renal Replacement Therapy

France
Region Skane

Recruiting

On-treatment Biomarkers in Metastatic Colorectal Cancer for Life (On-CALL)

Metastatic Colorectal Cancer | Lung Metastases | Chemotherapy Effect | Peritoneal Metastases | Liver Metastasis Colon Cancer

Sweden
Central Hospital, Nancy, France

Recruiting

A Study to Evaluate Biomarkers in Moderate to Severe Ulcerative Colitis (UC) Patients Treated With Different Targeted Therapies (ImmUniverse)

Inflammatory Bowel Diseases | Ulcerative Colitis

France
Gitte Moos Knudsen

Recruiting

Precision Medicine in the Treatment of Epilepsy (BDE)

Epilepsy

Denmark
Zhongda Hospital

Recruiting

Assessing the Prognosis of TACE in Combination With PD-1/PD-L1 Inhibitors and Molecular Target Therapies for HCC by Using Clinical and Imaging Biomarkers (CHANCEsub)

Hepatocellular Carcinoma

China
University of Medicine and Pharmacy Craiova
Institutul Clinic Fundeni

Recruiting

"Mechanisms and Biomarkers of Response and Resistance to Current Targeted Therapies in Gastric Cancer" (THERRES) (THERRES)

Gastric Cancer

Romania
University of Maryland, Baltimore

Recruiting

2177GCCC:ID'Ing tx Targets and Biomarkers for Ocular Surface Disease in Pt w/ oGVHD

Dry Eye Disease | oGVHD

United States
Universitaire Ziekenhuizen KU Leuven
KU Leuven

Recruiting

A Single-cell Approach to Identify Biomarkers of Pulmonary Toxicity for Immune Checkpoint Blockade

Immunotherapy | Pneumonitis, Interstitial | Immune-related Adverse Events

Belgium
National Institute on Deafness and Other Communication...

Recruiting

Deep Phenotyping of Hearing Instability Disorders: Cohort Establishment, Biomarker Identification, Development of Novel Phenotyping Measures, and Discovery of Therapeutic Targets

Meniere's Disease | Enlarged Vestibular Aqueduct Syndrome | Autoimmune Inner Ear Disease

United States
TargetCancer Foundation
Foundation Medicine

Recruiting

TCF-001 TRACK (Target Rare Cancer Knowledge) Study (TRACK)

Cholangiocarcinoma | Cancer of Unknown Primary Site | Rare Cancers

United States
National and Kapodistrian University of Athens
University of Oxford; Naval Hospital of Athens; Biomedical Research Foundation...

Recruiting

Serum and Cellular Biomarkers for Aortic Valve Stenosis (AthenaValve)

Aortic Valve Stenosis | Calcific Aortic Valve Disease | Aortic Valve, Calcification of

Greece
King's College London
Guy's and St Thomas' NHS Foundation Trust; Brighton and Sussex University Hospitals...

Recruiting

A Study to Measure the Expression of the HER2-HER3 Dimer in Tumour and Blood (Exosomes) Samples From Patients With HER2 Positive Breast Cancer Receiving HER2 Targeted Therapies (HERdi PREDICT)

HER2-positive Breast Cancer

United Kingdom
University Hospital, Toulouse
European Regional Development Fund

Recruiting

The Inspire Bio-resource Research Platform for Healthy Aging INSPIRE Platform (INSPIRE)

Biological Aging

France
National Institute of Allergy and Infectious Diseases...

Recruiting

Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)

Multiple Sclerosis

United States
Hospital Clinic of Barcelona

Active, not recruiting

Effects of Physical Training on Vascular Function as a Therapeutic Target in Pulmonary Hypertension

Pulmonary Arterial Hypertension

Spain
Centre Hospitalier Régional Metz-Thionville

Suspended

Early DiaGnosis of Anoxic Brain Injury for Resuscitated Patients (EDGAR)

Cardiac Arrest

France
Sumithira Vasu

Completed

Organ-Sparing Marrow-Targeted Irradiation Before Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies

Recurrent Adult Acute Myeloid Leukemia | Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Adult Acute Myeloid Leukemia With Del(5q) | Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) | Adult Acute Myeloid Leukemia With t(8... and other conditions

United States
Fayoum University

Completed

The Long Non Coding MALAT1 as a Potential Salivary Diagnostic Biomarker in Oral Squamous Cell Carcinoma Through Targeting mi RNA 124

Oral Squamous Cell Carcinoma

Egypt
New York State Psychiatric Institute
National Institute on Drug Abuse (NIDA)

Suspended

Transcranial Magnetic Brain Stimulation to Reduce Cannabis Use in Heavy Cannabis Users

Cannabis

United States
Barbara Ann Karmanos Cancer Institute
National Cancer Institute (NCI)

Terminated

Targeted T Cells After Neoadjuvant Chemotherapy in Treating Women With Stage II or III Breast Cancer Undergoing Surgery

Breast Cancer

United States
Prof Gerhard Walzl
London School of Hygiene and Tropical Medicine; Makerere University; Leiden University... and other collaborators

Completed

Evaluation of Host Biomarker-based Point-of-care Tests for Targeted Screening for Active TB (ScreenTB)

Pulmonary Tuberculosis

United Kingdom, Uganda, Ethiopia, Gambia, Germany, Namibia, Netherlands, South Africa
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Colorectal Cancer Umbrella Protocol - Assessment of Targeted Therapies Against Colorectal Cancer (ATTACC Program) Screening Protocol

Colorectal Cancer

United States
Institut Pasteur

Completed

Identification of Biomarkers Related to Liver Fibrosis as New Therapeutic Targets (FIBROTHER)

Fibrosis | Hepatopathy

France
Sentara Norfolk General Hospital
George Mason University; Dorothy G. Hoefer Foundation

Completed

Novel Molecular Targets for Ductal Carcinoma In Situ (DCIS)

Breast Cancer

United States
University Hospital, Montpellier
Assistance Publique - Hôpitaux de Paris; University Hospital, Clermont-Ferrand and other collaborators

Terminated

In Vivo Alzheimer Proteomics (PROMARA)

Parkinson Disease | Brain Trauma | Probable Alzheimer Disease | Neurological Disease Without Cognitive Degradation | Acute Hydrocephaly

France
Institut de Recherches Internationales Servier
ADIR, a Servier Group company

Completed

Vascular Function and Biomarker Assessments in Healthy Volunteers and in Patients With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

Germany
OmicsWay Corp.
Oncobox Ltd., Russia; Vitamed LLC, Russia; Republican Oncological Dispensary...

Active, not recruiting

Molecular Pathway Activation Markers Predicting Efficacy of Trastuzumab Therapy for HER2-positive Breast Cancer

HER2-positive Breast Cancer

United States, Russian Federation
OmicsWay Corp.
Oncobox Ltd; Vitamed LLC; N.N. Blokhin National Medical Research Center of Oncology and other collaborators

Active, not recruiting

Identification of Molecular Biomarkers for Cancer Target Therapy Efficacy

Cancer

Russian Federation, United States
Case Comprehensive Cancer Center

Completed

Targeted Marrow Irradiation, Fludarabine Phosphate, and Busulfan Before Donor Progenitor Cell Transplant in Treating Patients With Hematologic Malignancies

Acute Myeloid Leukemia | Multiple Myeloma | Hodgkin Lymphoma | Myelofibrosis | Chronic Lymphocytic Leukemia | Non Hodgkin Lymphoma | Chronic Myeloid Leukemia | Myelodysplastic Syndrome | Acute Lymphocytic Leukemia | Hematologic Malignancies | Myeloproliferative Syndrome

United States
Aarhus University Hospital
Karolinska University Hospital; Karolinska Institutet; University of Aarhus; Central... and other collaborators

Unknown

Early and Accurate Detection of Prostate Cancer in General Practice

Prostate Cancer | Prostate Adenocarcinoma | Prostate Neoplasm

Denmark
Genervon Biopharmaceuticals, LLC
Massachusetts General Hospital; Columbia University

Completed

GM604 Phase 2A Randomized Double-blind Placebo Controlled Pilot Trial in Amyotrophic Lateral Disease (ALS) (GALS)

Amyotrophic Lateral Sclerosis

United States
Fox Chase Cancer Center
National Cancer Institute (NCI)

Completed

Next Generation Sequence Target-Directed Therapy in Treating Patients With Cancer

Malignant Neoplasm

United States
ArQule, Inc. (a wholly owned subsidiary of Merck...

Terminated

Open-label Phase 1b Study of ARQ 092 in Combination With Anastrozole

Ovarian Cancer | Endometrial Cancer | Solid Tumors

United States
Yale University
National Cancer Institute (NCI)

Completed

Molecularly Targeted Therapy in Treating Patients With BRAF Wild-type Melanoma That is Metastatic

Recurrent Melanoma | Stage IV Melanoma | Stage IIIA Melanoma | Stage IIIB Melanoma | Stage IIIC Melanoma

United States
Fox Chase Cancer Center
National Cancer Institute (NCI)

Terminated

Genetic Sequencing-Informed Targeted Therapy in Treating Patients With Stage IIIB-IV Non-small Cell Lung Cancer

Stage IIIB Non-small Cell Lung Cancer | Recurrent Non-small Cell Lung Cancer | Stage IV Non-small Cell Lung Cancer | Malignant Pleural Effusion | Malignant Pericardial Effusion

United States
University Hospital, Bordeaux

Completed

Level of Expression and Prognostic Value of CXCL4, CXCL4L1 and CXCR3 in Renal Cell Carcinoma (ChemoRenCan)

Kidney Neoplasms | Kidney Diseases | Carcinoma | Carcinoma Renal Cell | Chemokines

France
University Hospital, Lille

Unknown

Prediction of Cognitive Properties of Memantine for Neurodegenerative Diseases (WP3_P002)

Alzheimer Disease | Battery

France
Institut Curie

Terminated

Innovation for Standard Identification of Insertional HPV Mutations and of Target Therapeutic Genes in Cervical Cancer: Towards Development of Personalized Biomarkers in Clinical Oncology (PAIR HPV)

Cervical Cancer

France
Nova Scotia Health Authority

Unknown

Microvascular Injury and Blood-brain Barrier Dysfunction as Novel Biomarkers and Targets for Treatment in Traumatic Brain Injury

Traumatic Brain Injury | Blood Brain Barrier Defect

Canada

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