Search clinical trials for: topoisomerase I inhibitor

Total 490902 results

Fundación GECP

Recruiting

Study of Pembrolizumab, Lenvatinib and Chemotherapy Combination in First Line Extensive-stage Small Cell Lung Cancer (PEERS)

Small Cell Lung Cancer Extensive Stage

Spain
Ipsen

Recruiting

A Study to Compare Onivyde Manufactured at Two Different Production Sites in Adult Participants With Advanced Cancer in the Pancreas (SIRACUSA)

Metastatic Pancreatic Adenocarcinoma

Spain, France, Italy, Hungary, Australia, Germany, Portugal
Centre Oscar Lambret

Recruiting

Metronomic Chemotherapy in Wilms Tumor (MetroWilms-1906) (MetroWilms)

Wilms Tumor

France
National University Hospital, Singapore
The N.1 Institute for Health (N.1); Cancer Science Institute of Singapore

Not yet recruiting

Optimizing and Personalising Azacitidine Combination Therapy for Treating Solid Tumours QPOP and CURATE.AI

Breast Cancer | Solid Tumor | Gastrointestinal Cancer

Singapore
Huihan Wang

Recruiting

Dual Growth Factor (rhTPO + G-CSF) and Chemotherapy Combination Regimen in Acute Myeloid Leukemia: Study Protocol for a Randomized Controlled Trial

Acute Myeloid Leukemia

China
Akeso

Recruiting

A Study of AK112 With or Without AK117 in Metastatic Colorectal Cancer

Metastatic Colorectal Cancer

China
Bio-Thera Solutions

Recruiting

Evaluate the Safety, Tolerability and Pharmacokinetic Characteristics of BAT8006 for Injection

Advanced Solid Tumors

China
Janssen Research & Development, LLC

Recruiting

A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer (OrigAMI-1)

Advanced or Metastatic Colorectal Cancer

United States, Korea, Republic of, Taiwan, Malaysia, Germany, Italy, Spain, Belgium, Canada, Puerto Rico, China
Erasmus Medical Center

Recruiting

Concomitant Intraperitoneal and Systemic Chemotherapy in Patients With Extensive Peritoneal Carcinomatosis of Gastric Origin

Gastric Cancer | Peritoneal Metastases

Netherlands
Falo, Louis, MD
National Cancer Institute (NCI)

Recruiting

Microneedle Array Plus Doxorubicin in Cutaneous Squamous Cell Cancer (cSCC) (cSCC)

Cutaneous Squamous Cell Carcinoma | Skin Cancers - Squamous Cell Carcinoma

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brain Metastasis

Anatomic Stage IV Breast Cancer AJCC v8 | Metastatic Malignant Neoplasm in the Brain | Metastatic Breast Carcinoma

United States
National Cancer Institute (NCI)

Recruiting

Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

Malignant Solid Neoplasm

United States
Kite, A Gilead Company

Recruiting

Study of Axicabtagene Ciloleucel Versus Standard of Care Therapy in Participants With Relapsed/Refractory Follicular Lymphoma (ZUMA-22)

Relapsed/Refractory Follicular Lymphoma

United States, Spain, United Kingdom, Italy, France, Japan, Germany
Hoffmann-La Roche

Recruiting

A Study Evaluating the Efficacy, Safety, and Pharmacokinetics of Glofitamab in Combination With Rituximab Plus Ifosfamide, Carboplatin Etoposide Phosphate in Participants With Relapsed/Refractory Transplant or CAR-T Therapy Eligible Diffuse B-Cell Lymphoma

Diffuse Large B-Cell Lymphoma (DLBCL)

United States
National Taiwan University Hospital

Recruiting

Spleen Irradiation With Nanoliposomal Irinotecan Plus 5-FU and Leucovorin in Metastatic Pancreatic Adenocarcinoma (SINAI)

Metastatic Pancreatic Cancer

Taiwan
Institute of Hematology & Blood Diseases Hospital

Recruiting

Efficacy of Venetoclax Based Regimen in Prevention Relapse of Consecutive MRD Positive AML Patients

Acute Myeloid Leukemia | Measurable Disease

China
Amgen

Recruiting

First-Line Tarlatamab in Combination With Carboplatin, Etoposide, and PD-L1 Inhibitor in Subjects With Extensive Stage Small Cell Lung Cancer (ES-SCLC)

Extensive Stage Small Cell Lung Cancer

Korea, Republic of, United States, Netherlands, Taiwan, Switzerland, Spain, Canada, Israel, Germany, France, Belgium, Australia, Japan, Italy, Denmark
Rutgers, The State University of New Jersey

Recruiting

Preoperative ChemoRadiation And FOLFOXIRI for Rectal Cancer (CRAFTER) for Rectal Cancer

Cancer of Rectum

United States
Shanghai Henlius Biotech

Not yet recruiting

A Clinical Study to Evaluate the Efficacy and Safety of HLX07 Combination Therapy in Patients With Extensive Small Cell Lung Cancer

Small-cell Lung Cancer

China
Shanghai Henlius Biotech

Recruiting

A Study to Evaluate the Efficacy and Safety of Serplulimab in Combination With Chemotherapy and Concurrent Radiotherapy in Patients With Limited-Stage Small Cell Lung Cancer

Limited-Stage Small Cell Lung Cancer

United States, China, Greece, Spain, Austria, Czechia, Germany, Hungary, Latvia, Netherlands, Poland
National Cancer Institute (NCI)

Recruiting

Testing of Tazemetostat in Combination With Topotecan and Pembrolizumab in Patients With Recurrent Small Cell Lung Cancer

Extensive Stage Lung Small Cell Carcinoma | Limited Stage Lung Small Cell Carcinoma | Platinum-Resistant Lung Small Cell Carcinoma | Platinum-Sensitive Lung Small Cell Carcinoma | Recurrent Lung Small Cell Carcinoma

United States
Fudan University

Recruiting

Study on the Correlation Between Immunoglobulin and Liposomal Doxorubicin in Vivo

Advanced Malignant Tumors

China
Ruijin Hospital
Shanxi Province Cancer Hospital; The First Affiliated Hospital of Anhui Medical... and other collaborators

Recruiting

Genotype-guided Treatment in DLBCL

Diffuse Large B Cell Lymphoma

China
Xijing Hospital

Recruiting

PLD-cyclophosphamide-Nab-P Continuously Combined With Dual HER2 Blockage for HER2-positive Breast Cancer

Breast Cancer | HER2-positive Breast Cancer

China
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.

Not yet recruiting

A Study of Mitoxantrone Hydrochloride Liposome Injection Combination Therapy in Chinese Patients With Advanced Solid Tumors

Advanced Solid Tumor
Ioannis Mantzaris
AbbVie

Recruiting

Venetoclax Plus Intensive Chemotherapy in AML and Advanced MDS

Acute Myeloid Leukemia | Myelodysplastic Syndromes

United States
Merck Sharp & Dohme LLC

Recruiting

A Study of Combination Therapies With or Without Pembrolizumab (MK-3475) and/or Chemotherapy in Participants With Advanced Esophageal Cancer (MK-3475-06A)

Esophageal Squamous Cell Carcinoma (ESCC)

Japan, Korea, Republic of, Taiwan, Italy, Thailand, France, Turkey, Brazil, Switzerland, Singapore, Germany, Chile, Norway
Yizhuo Zhang

Recruiting

Tucidinostat Plus Etoposide in the Treatment of Neuroblastoma in Childhood. (CSIIT-Q36)

Neuroblastoma in Children

China
National Taiwan University Hospital

Recruiting

Efficacies of Susceptibility-guided vs Empiric Therapy for Rescue Treatment of Helicobacter Pylori Infection

Helicobacter Pylori Infection

Taiwan
Massachusetts Eye and Ear Infirmary

Recruiting

Dropless Pars Plana Vitrectomy Study (DVS)

Rhegmatogenous Retinal Detachment

United States
Zhejiang Cancer Hospital

Not yet recruiting

Phase II Clinical Study of Camrelizumab Combined With Chemotherapy or Anlotinib in Advanced Esophageal Squamous Cell Cancer

Stage IV Esophagus Squamous Cell Carcinoma

China
Fujian Cancer Hospital

Recruiting

Phase I/II Study of the Combination of Irinotecan and POF (POFI) and Tislelizumab

Gastric Cancer Stage IV

China
Imperial College London

Not yet recruiting

Neoadjuvant Systemic and Peritoneal Chemotherapy for Advanced Gastric Cancer (SPECTRA)

Gastric Cancer | Chemotherapy Effect | Peritoneal Metastases

United Kingdom
Merck Sharp & Dohme LLC

Recruiting

A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)

Esophageal Squamous Cell Carcinoma

Japan, Korea, Republic of, China, Taiwan, Italy, Switzerland, Brazil, Germany, Singapore, Turkey, Thailand, Chile, Norway
John Neoptolemos
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest; Deutsches... and other collaborators

Not yet recruiting

Adjuvant Trial in Patients With Resected PDAC Randomized to Allocation of Oxaliplatin- or Gemcitabine-based Chemotherapy by Standard Clinical Criteria or by a Transcriptomic Treatment Specific Stratification Signature

Pancreatic Ductal Adenocarcinoma

Sweden, Germany
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
The First Affiliated Hospital of Nanchang University; Guangzhou First People... and other collaborators

Recruiting

Treateament of Newly Diagnosed Acute Monocytic Leukemia in Children (SCCLG-M5)

Leukemia, Monocytic, Acute | Pediatric AML

China
Sidney Kimmel Comprehensive Cancer Center at Johns...
Genentech, Inc.

Recruiting

Atezolizumab Plus Etoposide and Platinum in Small Cell Bladder Cancer

Bladder Cancer | Small Cell Neuroendocrine Carcinoma of Bladder | Urothelial Carcinoma Bladder

United States
Beijing Chest Hospital

Recruiting

A Study of an Oral Short-course Regimen Including Bedaquiline for the Treatment of Participants With Multidrug-resistant Tuberculosis in China (PROSPECT)

Tuberculosis, Multidrug-Resistant

China
Second Affiliated Hospital, School of Medicine,...

Recruiting

AC vs TC in Patients With HR-positive, HER2-negative Early Breast Cancer

Breast Cancer | Chemotherapeutic Toxicity

China
Central Hospital, Nancy, France
Fresenius Kabi; Société Francophone Nutrition Clinique et Métabolisme; FIlière...

Recruiting

Absorption of Antibiotics With High Oral Bioavailability in Short-bowel Syndrome (GRAAL)

Infection, Bacterial | Short Bowel Syndrome

France
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Not yet recruiting

Allogeneic Hematopoietic Stem Cell Transplantation for 4/M Neuroblastoma

Neuroblastoma

China
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Recruiting

Testing the Combination of Inotuzumab Ozogamicin and Lower Dose Chemotherapy Compared to Usual Chemotherapy for Adults With B-Cell Acute Lymphoblastic Leukemia or B-Cell Lymphoblastic Lymphoma

B Acute Lymphoblastic Leukemia | B Lymphoblastic Lymphoma

United States, Puerto Rico
Merck Sharp & Dohme LLC

Recruiting

Study of Pembrolizumab/Vibostolimab (MK-7684A) in Combination With Concurrent Chemoradiotherapy Followed by Pembrolizumab/Vibostolimab Versus Concurrent Chemoradiotherapy Followed by Durvalumab in Participants With Stage III Non-small Cell Lung Cancer (MK-7684A-006/KEYVIBE-006)

Carcinoma, Non-Small-Cell Lung

United States, Australia, Brazil, Chile, China, Costa Rica, Dominican Republic, Germany, Greece, Guatemala, Israel, Italy, Japan, Korea, Republic of, Malaysia, Mexico, Spain, Turkey, Portugal, Romania, South Africa
Centre Georges Francois Leclerc

Recruiting

Evaluation and Modeling of the Effect of G-CSF on the Evolution of Polynuclear Neutrophils During Dense Dose Epirubicin-Cyclophosphamide Regeneration (EMEG-ECDD)

Localized Breast Cancer

France
Qiu Lugui
Jiangsu Hengrui Pharmaceuticals Co.,Ltd

Recruiting

Mecapegfilgrastim With Chemotherapy for Peripheral Blood Stem Cell Mobilization in MM and Lymphoma

Lymphoma | Multiple Myeloma

China
University of North Carolina, Chapel Hill
National Institute of Allergy and Infectious Diseases (NIAID)

Recruiting

Efficacy of Immunization With 4C-MenB in Preventing Experimental Urethral Infection With Neisseria Gonorrhoeae

Gonorrhea Male

United States
Andrew E. Place, MD
University of Colorado, Denver; AbbVie; Boston Children's Hospital; Gateway for... and other collaborators

Recruiting

Venetoclax Basket Trial for High Risk Hematologic Malignancies

Acute Lymphoblastic Leukemia, in Relapse | Therapy-Related Myelodysplastic Syndrome | Acute Leukemia of Ambiguous Lineage | Acute Leukemia of Ambiguous Lineage in Relapse | Myelodysplastic Syndromes, Previously Treated | Acute Lymphoblastic Leukemia With Failed Remission | Myelodysplastic Syndromes... and other conditions

United States
Cancer Institute and Hospital, Chinese Academy...
CSPC Ouyi Pharmaceutical Co., Ltd.

Not yet recruiting

Adjuvant Albumin-bound Paclitaxel Versus Taxanes in Breast Cancer: a Real-world Study

Breast Cancer

China
Medical University of Vienna

Recruiting

The Effect of Antibiotic Eye Drops on the Nasal Microbiome in Healthy Subjects

Nasal and Pharyngeal Microbiome

Austria
National Cancer Institute (NCI)

Recruiting

M9241 in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer or Intrahepatic Cholangiocarcinoma

Colorectal Neoplasms | Colorectal Cancer | Cholangiocarcinoma | Bile Duct Cancer | Bile Duct Neoplasms | Metastatic Colorectal Cancer (Mcrc) | Intrahepatic Cholangiocarcinoma (Icc) | Intrahepatic Bile Duct Cancer

United States

Search clinical trials for: topoisomerase I inhibitor

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Mozambique

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations