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Docetaxel nebo paklitaxel při snižování chemoterapie indukované periferní neuropatie u afroamerických pacientů s rakovinou prsu stadia I-III

14. září 2026 aktualizováno: ECOG-ACRIN Cancer Research Group

Prospektivní validační studie taxanové terapie (docetaxel nebo týdenní paklitaxel) a riziko chemoterapie indukované periferní neuropatie u afroamerických žen

This phase II trial studies how well docetaxel or paclitaxel work in reducing chemotherapy-induced peripheral neuropathy in African American patients with stages I-III breast cancer. Drugs used in chemotherapy, such as docetaxel and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving docetaxel or paclitaxel may work better than other methods in reducing chemotherapy-induced peripheral neuropathy in patients with breast cancer.

Přehled studie

Postavení

Aktivní, ne nábor

Podmínky

Intervence / Léčba

Detailní popis

PRIMARY OBJECTIVE:

I. Prospectively validate a prior germline predictor of paclitaxel-induced peripheral neuropathy (TIPN) using the Common Terminology Criteria for Adverse Events (CTCAE). Specifically, this study will demonstrate that patients with a high-risk TIPN genotype have significantly more grade 2-4 TIPN than patients with a low risk genotype.

SECONDARY OBJECTIVES:

I. Validate a prior germline predictor of TIPN using the Functional Assessment of Cancer Therapy (FACT)/Gynecologic Oncology Group (GOG)-Neurotoxicity (NTX) neurotoxicity subscale in Arm A.

II. Compare grade 2-4 TIPN based on CTCAE between weekly paclitaxel (Arm A) versus (vs.) every three-week docetaxel (Arm B).

III. Prospectively confirm dose reductions due to TIPN are lower for every three-week docetaxel compared with weekly paclitaxel in a prospective cohort of patients of African ancestry.

IV. Prospectively confirm dose reductions due to any cause are lower for every three-week docetaxel compared with weekly paclitaxel in a prospective cohort of patients of African ancestry.

V. Assess the ability of the high-risk genotype to predict TIPN risk for docetaxel.

CORRELATIVE STUDY OBJECTIVES:

I. Identify novel markers of TIPN and elucidate the mechanism. II. Whole genome sequencing of germline blood to evaluate for additional predictors of TIPN.

III. Create induced pluripotent stem cell (iPSC) derived neurons from patient samples.

IIIa. Evaluate whether clinical findings can be mimicked in vitro. IIIb. Evaluate gene expression (ribonucleic acid [RNA] sequencing [seq]) and the epigenome at baseline versus after exposure in those prone to TIPN versus those not.

IV. Create a biorepository of patient derived samples for future translational research.

PATIENT REPORTED OUTCOME OBJECTIVES:

I. Compare grade 2-4 TIPN (moderate to life threatening) based on Patient Reported Outcomes (PRO)-CTCAE items between weekly paclitaxel (Arm A) vs. every three-week docetaxel (Arm B).

II. Prospectively compare FACT/GOG-NTX Health-Related Quality of Life (HRQoL) scores (from the FACT-General [G] portion and Patient-Reported Outcomes Measurement Information System [PROMIS] Physical Function version [v.]2 Short Form [SF] 10a, scores between every three-week docetaxel and weekly paclitaxel and between high risk and low risk genotypes (Arm A) in a cohort of African ancestry.

III. Compare Chemotherapy-Induced Peripheral Neuropathy (CIPN)-20 sensory neuropathy score between weekly paclitaxel (Arm A) vs. every three-week docetaxel (Arm B).

IV. Compare the impact on financial toxicity (Comprehensive Score for Financial Toxicity [COST] scores) for every three-week docetaxel compared with weekly paclitaxel.

V. Examine associations between social determinants of health (zip code, marital status, education, income & insurance status) and dose reductions and treatment discontinuation.

OUTLINE: Patients are assigned to 1 of 2 arms.

ARM A: Patients receive paclitaxel intravenously (IV) over 3 hours once weekly. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. Patients may also receive trastuzumab and/or pertuzumab per institution routine care per treating physician's discretion.

ARM B: Patients receive docetaxel IV over 1 hour once every 3 weeks. Treatment repeats every 21 days for 4-6 cycles in the absence of disease progression or unacceptable toxicity. Patients may also receive cyclophosphamide, doxorubicin, trastuzumab, and/or pertuzumab per institution routine care per treating physician's discretion.

After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.

Typ studie

Intervenční

Zápis (Aktuální)

249

Fáze

Fáze 2

Kontakty a umístění

Tato část poskytuje kontaktní údaje pro ty, kteří studii provádějí, a informace o tom, kde se tato studie provádí.

Studijní místa

Spojené státy
- Alabama
  - Birmingham, Alabama, Spojené státy, 35233
    - University of Alabama at Birmingham Cancer Center
- Alaska
  - Anchorage, Alaska, Spojené státy, 98508
    - Anchorage Associates in Radiation Medicine
  - Anchorage, Alaska, Spojené státy, 99508
    - Alaska Breast Care and Surgery LLC
  - Anchorage, Alaska, Spojené státy, 99508
    - Alaska Oncology and Hematology LLC
  - Anchorage, Alaska, Spojené státy, 99508
    - Alaska Women's Cancer Care
  - Anchorage, Alaska, Spojené státy, 99508
    - Anchorage Oncology Centre
  - Anchorage, Alaska, Spojené státy, 99508
    - Katmai Oncology Group
  - Anchorage, Alaska, Spojené státy, 99508
    - Providence Alaska Medical Center
  - Anchorage, Alaska, Spojené státy, 99504
    - Anchorage Radiation Therapy Center
  - Fairbanks, Alaska, Spojené státy, 99701
    - Fairbanks Memorial Hospital
- Arizona
  - Kingman, Arizona, Spojené státy, 86401
    - Kingman Regional Medical Center
- Arkansas
  - Fort Smith, Arkansas, Spojené státy, 72903
    - Mercy Hospital Fort Smith
  - Jonesboro, Arkansas, Spojené státy, 72401
    - NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
- California
  - Arroyo Grande, California, Spojené státy, 93420
    - PCR Oncology
  - Burbank, California, Spojené státy, 91505
    - Providence Saint Joseph Medical Center/Disney Family Cancer Center
  - Dublin, California, Spojené státy, 94568
    - Epic Care-Dublin
  - Emeryville, California, Spojené státy, 94608
    - Bay Area Breast Surgeons Inc
  - Emeryville, California, Spojené státy, 94608
    - Epic Care Partners in Cancer Care
  - Martinez, California, Spojené státy, 94553-3156
    - Contra Costa Regional Medical Center
  - Oakland, California, Spojené státy, 94609
    - Alta Bates Summit Medical Center - Summit Campus
  - Oakland, California, Spojené státy, 94609
    - Bay Area Tumor Institute
  - Walnut Creek, California, Spojené státy, 94597
    - Epic Care Cyberknife Center
- Colorado
  - Aurora, Colorado, Spojené státy, 80012
    - Rocky Mountain Cancer Centers-Aurora
  - Aurora, Colorado, Spojené státy, 80012
    - The Medical Center of Aurora
  - Boulder, Colorado, Spojené státy, 80303
    - Boulder Community Foothills Hospital
  - Boulder, Colorado, Spojené státy, 80304
    - Rocky Mountain Cancer Centers-Boulder
  - Centennial, Colorado, Spojené státy, 80112
    - Rocky Mountain Cancer Centers - Centennial
  - Denver, Colorado, Spojené státy, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Spojené státy, 80220
    - Rose Medical Center
  - Denver, Colorado, Spojené státy, 80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver, Colorado, Spojené státy, 80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver, Colorado, Spojené státy, 80218
    - Colorado Blood Cancer Institute
  - Denver, Colorado, Spojené státy, 80204
    - Cancer Center of Colorado at Sloan's Lake
  - Denver, Colorado, Spojené státy, 80209
    - The Women's Imaging Center
  - Denver, Colorado, Spojené státy, 80206
    - National Jewish Health-Main Campus
  - Denver, Colorado, Spojené státy, 80220
    - Western Surgical Care
  - Denver, Colorado, Spojené státy, 80218
    - Saint Joseph Hospital - Cancer Centers of Colorado
  - Englewood, Colorado, Spojené státy, 80113
    - Mountain Blue Cancer Care Center - Swedish
  - Englewood, Colorado, Spojené státy, 80113
    - Swedish Medical Center
  - Englewood, Colorado, Spojené státy, 80113
    - Rocky Mountain Cancer Centers - Swedish
  - Englewood, Colorado, Spojené státy, 80113
    - The Melanoma and Skin Cancer Institute
  - Golden, Colorado, Spojené státy, 80401
    - National Jewish Health-Western Hematology Oncology
  - Grand Junction, Colorado, Spojené státy, 81501
    - Saint Mary's Hospital and Regional Medical Center
  - Greeley, Colorado, Spojené státy, 80631
    - Banner North Colorado Medical Center
  - Lafayette, Colorado, Spojené státy, 80026
    - Good Samaritan Hospital - Cancer Centers of Colorado
  - Lakewood, Colorado, Spojené státy, 80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Littleton, Colorado, Spojené státy, 80120
    - Rocky Mountain Cancer Centers-Littleton
  - Lone Tree, Colorado, Spojené státy, 80124
    - Sky Ridge Medical Center
  - Lone Tree, Colorado, Spojené státy, 80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Loveland, Colorado, Spojené státy, 80539
    - Banner North Colorado Medical Center - Loveland Campus
  - Thornton, Colorado, Spojené státy, 80260
    - Rocky Mountain Cancer Centers-Thornton
  - Thornton, Colorado, Spojené státy, 80260
    - National Jewish Health-Northern Hematology Oncology
  - Wheat Ridge, Colorado, Spojené státy, 80401
    - Intermountain Health Lutheran Hospital
- Delaware
  - Lewes, Delaware, Spojené státy, 19958
    - Beebe Medical Center
  - Millville, Delaware, Spojené státy, 19967
    - Beebe South Coastal Health Campus
  - Newark, Delaware, Spojené státy, 19713
    - Helen F Graham Cancer Center
  - Newark, Delaware, Spojené státy, 19713
    - Delaware Clinical and Laboratory Physicians PA
  - Newark, Delaware, Spojené státy, 19713
    - Medical Oncology Hematology Consultants PA
  - Newark, Delaware, Spojené státy, 19718
    - Christiana Care Health System-Christiana Hospital
  - Rehoboth Beach, Delaware, Spojené státy, 19971
    - Beebe Health Campus
  - Seaford, Delaware, Spojené státy, 19973
    - TidalHealth Nanticoke / Allen Cancer Center
  - Wilmington, Delaware, Spojené státy, 19801
    - Christiana Care Health System-Wilmington Hospital
- District of Columbia
  - Washington D.C., District of Columbia, Spojené státy, 20010
    - MedStar Washington Hospital Center
  - Washington D.C., District of Columbia, Spojené státy, 20016
    - Sibley Memorial Hospital
- Florida
  - Fort Lauderdale, Florida, Spojené státy, 33308
    - Holy Cross Hospital
  - Gainesville, Florida, Spojené státy, 32610
    - UF Health Cancer Institute - Gainesville
- Georgia
  - Atlanta, Georgia, Spojené státy, 30308
    - Emory University Hospital Midtown
  - Atlanta, Georgia, Spojené státy, 30322
    - Emory University Hospital/Winship Cancer Institute
  - Atlanta, Georgia, Spojené státy, 30342
    - Emory Saint Joseph's Hospital
  - Atlanta, Georgia, Spojené státy, 30303
    - Grady Health System
  - Atlanta, Georgia, Spojené státy, 30342
    - Northside Hospital
  - Columbus, Georgia, Spojené státy, 31904
    - John B Amos Cancer Center
  - Duluth, Georgia, Spojené státy, 30096
    - Northside Hospital - Duluth
  - Lawrenceville, Georgia, Spojené státy, 30046
    - Northside Hospital - Gwinnett
  - Savannah, Georgia, Spojené státy, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
  - Snellville, Georgia, Spojené státy, 30078
    - Suburban Hematology Oncology Associates - Snellville
- Idaho
  - Boise, Idaho, Spojené státy, 83712
    - Saint Luke's Cancer Institute - Boise
  - Fruitland, Idaho, Spojené státy, 83619
    - Saint Luke's Cancer Institute - Fruitland
  - Meridian, Idaho, Spojené státy, 83642
    - Saint Luke's Cancer Institute - Meridian
  - Nampa, Idaho, Spojené státy, 83687
    - Saint Luke's Cancer Institute - Nampa
  - Twin Falls, Idaho, Spojené státy, 83301
    - Saint Luke's Cancer Institute - Twin Falls
- Illinois
  - Alton, Illinois, Spojené státy, 62002
    - OSF Saint Anthony's Health Center
  - Aurora, Illinois, Spojené státy, 60504
    - Rush-Copley Medical Center
  - Bloomington, Illinois, Spojené státy, 61704
    - Illinois CancerCare-Bloomington
  - Canton, Illinois, Spojené státy, 61520
    - Illinois CancerCare-Canton
  - Carbondale, Illinois, Spojené státy, 62902
    - Memorial Hospital of Carbondale
  - Carterville, Illinois, Spojené státy, 62918
    - SIH Cancer Institute
  - Carthage, Illinois, Spojené státy, 62321
    - Illinois CancerCare-Carthage
  - Centralia, Illinois, Spojené státy, 62801
    - Centralia Oncology Clinic
  - Chicago, Illinois, Spojené státy, 60611
    - Northwestern University
  - Chicago, Illinois, Spojené státy, 60612
    - John H Stroger Jr Hospital of Cook County
  - Danville, Illinois, Spojené státy, 61832
    - Carle at The Riverfront
  - Decatur, Illinois, Spojené státy, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Spojené státy, 62526
    - Cancer Care Specialists of Illinois - Decatur
  - Dixon, Illinois, Spojené státy, 61021
    - Illinois CancerCare-Dixon
  - Effingham, Illinois, Spojené státy, 62401
    - Crossroads Cancer Center
  - Effingham, Illinois, Spojené státy, 62401
    - Carle Physician Group-Effingham
  - Eureka, Illinois, Spojené státy, 61530
    - Illinois CancerCare-Eureka
  - Galesburg, Illinois, Spojené státy, 61401
    - Western Illinois Cancer Treatment Center
  - Galesburg, Illinois, Spojené státy, 61401
    - Illinois CancerCare-Galesburg
  - Kewanee, Illinois, Spojené státy, 61443
    - Illinois CancerCare-Kewanee Clinic
  - Macomb, Illinois, Spojené státy, 61455
    - Illinois CancerCare-Macomb
  - Mattoon, Illinois, Spojené státy, 61938
    - Carle Physician Group-Mattoon/Charleston
  - Mount Vernon, Illinois, Spojené státy, 62864
    - SSM Health Good Samaritan
  - O'Fallon, Illinois, Spojené státy, 62269
    - Cancer Care Center of O'Fallon
  - Ottawa, Illinois, Spojené státy, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Pekin, Illinois, Spojené státy, 61554
    - Illinois CancerCare-Pekin
  - Peoria, Illinois, Spojené státy, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Spojené státy, 61615
    - Illinois CancerCare-Peoria
  - Peru, Illinois, Spojené státy, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Spojené státy, 61354
    - Valley Radiation Oncology
  - Princeton, Illinois, Spojené státy, 61356
    - Illinois CancerCare-Princeton
  - Springfield, Illinois, Spojené státy, 62702
    - Southern Illinois University School of Medicine
  - Springfield, Illinois, Spojené státy, 62702
    - Springfield Clinic
  - Springfield, Illinois, Spojené státy, 62781
    - Springfield Memorial Hospital
  - Swansea, Illinois, Spojené státy, 62226
    - Southwest Illinois Health Services LLP
  - Urbana, Illinois, Spojené státy, 61801
    - Carle Cancer Center
  - Urbana, Illinois, Spojené státy, 61801
    - The Carle Foundation Hospital
  - Washington, Illinois, Spojené státy, 61571
    - Illinois CancerCare - Washington
  - Yorkville, Illinois, Spojené státy, 60560
    - Rush-Copley Healthcare Center
- Indiana
  - Avon, Indiana, Spojené státy, 46123
    - IU Health West Hospital
  - Carmel, Indiana, Spojené státy, 46032
    - IU Health North Hospital
  - Crown Point, Indiana, Spojené státy, 46307
    - Northwest Cancer Center - Crown Point
  - Dyer, Indiana, Spojené státy, 46311
    - Northwest Oncology LLC
  - Hobart, Indiana, Spojené státy, 46342
    - Northwest Cancer Center - Hobart
  - Hobart, Indiana, Spojené státy, 46342
    - Saint Mary Medical Center
  - Indianapolis, Indiana, Spojené státy, 46202
    - Indiana University/Melvin and Bren Simon Cancer Center
  - Indianapolis, Indiana, Spojené státy, 46202
    - Sidney and Lois Eskenazi Hospital
  - Indianapolis, Indiana, Spojené státy, 46290
    - Springmill Medical Center
  - Indianapolis, Indiana, Spojené státy, 46202
    - IU Health Methodist Hospital
  - Indianapolis, Indiana, Spojené státy, 46312
    - Saint Catherine Hospital
  - Munster, Indiana, Spojené státy, 46321
    - The Community Hospital
  - Munster, Indiana, Spojené státy, 46321
    - Women's Diagnostic Center - Munster
  - Valparaiso, Indiana, Spojené státy, 46383
    - Northwest Cancer Center - Valparaiso
- Kansas
  - Garden City, Kansas, Spojené státy, 67846
    - Central Care Cancer Center - Garden City
  - Great Bend, Kansas, Spojené státy, 67530
    - Central Care Cancer Center - Great Bend
- Louisiana
  - Baton Rouge, Louisiana, Spojené státy, 70805
    - LSU Health Baton Rouge-North Clinic
  - Baton Rouge, Louisiana, Spojené státy, 70809
    - Louisiana Hematology Oncology Associates LLC
  - Baton Rouge, Louisiana, Spojené státy, 70809
    - Mary Bird Perkins Cancer Center
  - Baton Rouge, Louisiana, Spojené státy, 70808
    - Our Lady of The Lake
  - Baton Rouge, Louisiana, Spojené státy, 70817
    - Woman's Hospital
  - Baton Rouge, Louisiana, Spojené státy, 70817
    - Our Lady of the Lake Medical Oncology
  - Baton Rouge, Louisiana, Spojené státy, 70817
    - Louisiana Hematology Oncology Associates
  - Baton Rouge, Louisiana, Spojené státy, 70808
    - Our Lady of the Lake Physician Group
  - Covington, Louisiana, Spojené státy, 70433
    - Northshore Oncology Associates-Covington
  - Houma, Louisiana, Spojené státy, 70360
    - Terrebonne General Medical Center
  - New Orleans, Louisiana, Spojené státy, 70112
    - University Medical Center New Orleans
  - New Orleans, Louisiana, Spojené státy, 70112
    - Louisiana State University Health Science Center
- Maryland
  - Baltimore, Maryland, Spojené státy, 21287
    - Johns Hopkins University/Sidney Kimmel Cancer Center
  - Baltimore, Maryland, Spojené státy, 21215
    - Sinai Hospital of Baltimore
  - Baltimore, Maryland, Spojené státy, 21229
    - Saint Agnes Hospital
  - Baltimore, Maryland, Spojené státy, 21239
    - MedStar Good Samaritan Hospital
  - Easton, Maryland, Spojené státy, 21601
    - University of Maryland Shore Medical Center at Easton
  - Randallstown, Maryland, Spojené státy, 21133
    - Northwest Hospital Center
  - Westminster, Maryland, Spojené státy, 21157
    - William E Kahlert Regional Cancer Center/Sinai Hospital
- Massachusetts
  - Springfield, Massachusetts, Spojené státy, 01199
    - Baystate Medical Center
  - Springfield, Massachusetts, Spojené státy, 01104
    - Mercy Medical Center
- Michigan
  - Ann Arbor, Michigan, Spojené státy, 48106
    - Trinity Health Saint Joseph Mercy Hospital Ann Arbor
  - Battle Creek, Michigan, Spojené státy, 49017
    - Bronson Battle Creek
  - Brighton, Michigan, Spojené státy, 48114
    - Trinity Health IHA Medical Group Hematology Oncology - Brighton
  - Brighton, Michigan, Spojené státy, 48114
    - Trinity Health Medical Center - Brighton
  - Canton, Michigan, Spojené státy, 48188
    - Trinity Health IHA Medical Group Hematology Oncology - Canton
  - Canton, Michigan, Spojené státy, 48188
    - Trinity Health Medical Center - Canton
  - Caro, Michigan, Spojené státy, 48723
    - Caro Cancer Center
  - Chelsea, Michigan, Spojené státy, 48118
    - Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
  - Chelsea, Michigan, Spojené státy, 48118
    - Chelsea Hospital
  - Clarkston, Michigan, Spojené státy, 48346
    - Hematology Oncology Consultants-Clarkston
  - Clarkston, Michigan, Spojené státy, 48346
    - Newland Medical Associates-Clarkston
  - Detroit, Michigan, Spojené státy, 48236
    - Henry Ford Health Saint John Hospital
  - East China, Michigan, Spojené státy, 48054
    - Henry Ford River District Hospital
  - Flint, Michigan, Spojené státy, 48503
    - Hurley Medical Center
  - Flint, Michigan, Spojené státy, 48503
    - Genesee Hematology Oncology PC
  - Flint, Michigan, Spojené státy, 48503
    - Genesys Hurley Cancer Institute
  - Flint, Michigan, Spojené státy, 48503
    - Cancer Hematology Centers - Flint
  - Grand Rapids, Michigan, Spojené státy, 49503
    - Trinity Health Grand Rapids Hospital
  - Grand Rapids, Michigan, Spojené státy, 49503
    - Corewell Health Grand Rapids Hospitals - Butterworth Hospital
  - Grand Rapids, Michigan, Spojené státy, 49503
    - Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
  - Grosse Pointe Woods, Michigan, Spojené státy, 48236
    - Henry Ford Saint John Hospital - Academic
  - Grosse Pointe Woods, Michigan, Spojené státy, 48236
    - Henry Ford Saint John Hospital - Breast
  - Grosse Pointe Woods, Michigan, Spojené státy, 48236
    - Henry Ford Saint John Hospital - Van Elslander
  - Kalamazoo, Michigan, Spojené státy, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Spojené státy, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Spojené státy, 49009
    - Beacon Kalamazoo Cancer Center
  - Kalamazoo, Michigan, Spojené státy, 49048
    - Beacon Kalamazoo
  - Lansing, Michigan, Spojené státy, 48912
    - University of Michigan Health - Sparrow Lansing
  - Livonia, Michigan, Spojené státy, 48154
    - Trinity Health Saint Mary Mercy Livonia Hospital
  - Livonia, Michigan, Spojené státy, 48154
    - Hope Cancer Clinic
  - Macomb, Michigan, Spojené státy, 48044
    - Henry Ford Warren Hospital - Breast Macomb
  - Macomb, Michigan, Spojené státy, 48044
    - Henry Ford Saint John Hospital - Macomb Medical
  - Marlette, Michigan, Spojené státy, 48453
    - Saint Mary's Oncology/Hematology Associates of Marlette
  - Muskegon, Michigan, Spojené státy, 49444
    - Trinity Health Muskegon Hospital
  - Niles, Michigan, Spojené státy, 49120
    - Corewell Health Lakeland Hospitals - Niles Hospital
  - Norton Shores, Michigan, Spojené státy, 49444
    - Cancer and Hematology Centers of Western Michigan - Norton Shores
  - Pontiac, Michigan, Spojené státy, 48341
    - Hope Cancer Center
  - Pontiac, Michigan, Spojené státy, 48341
    - Newland Medical Associates-Pontiac
  - Pontiac, Michigan, Spojené státy, 48341
    - Trinity Health Saint Joseph Mercy Oakland Hospital
  - Pontiac, Michigan, Spojené státy, 48341
    - Michigan Healthcare Professionals Pontiac
  - Reed City, Michigan, Spojené státy, 49677
    - Corewell Health Reed City Hospital
  - Rochester Hills, Michigan, Spojené státy, 48309
    - Henry Ford Rochester Hospital
  - Saginaw, Michigan, Spojené státy, 48604
    - Oncology Hematology Associates of Saginaw Valley PC
  - Saginaw, Michigan, Spojené státy, 48601
    - MyMichigan Medical Center Saginaw
  - Saint Joseph, Michigan, Spojené státy, 49085
    - Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
  - Saint Joseph, Michigan, Spojené státy, 49085
    - Corewell Health Lakeland Hospitals - Saint Joseph Hospital
  - Sterling Heights, Michigan, Spojené státy, 48312
    - Bhadresh Nayak MD PC-Sterling Heights
  - Tawas City, Michigan, Spojené státy, 48764
    - MyMichigan Medical Center Tawas
  - Traverse City, Michigan, Spojené státy, 49684
    - Munson Medical Center
  - Warren, Michigan, Spojené státy, 48088
    - Advanced Breast Care Center PLLC
  - Warren, Michigan, Spojené státy, 48093
    - Macomb Hematology Oncology PC
  - Warren, Michigan, Spojené státy, 48093
    - Henry Ford Madison Heights Hospital - Breast
  - Warren, Michigan, Spojené státy, 48093
    - Henry Ford Health Warren Hospital
  - Warren, Michigan, Spojené státy, 48093
    - Henry Ford Warren Hospital - GLCMS
  - West Branch, Michigan, Spojené státy, 48661
    - Saint Mary's Oncology/Hematology Associates of West Branch
  - Wyoming, Michigan, Spojené státy, 49519
    - University of Michigan Health - West
  - Ypsilanti, Michigan, Spojené státy, 48197
    - Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
  - Ypsilanti, Michigan, Spojené státy, 48106
    - Huron Gastroenterology PC
- Minnesota
  - Burnsville, Minnesota, Spojené státy, 55337
    - Fairview Ridges Hospital
  - Burnsville, Minnesota, Spojené státy, 55337
    - Minnesota Oncology - Burnsville
  - Cambridge, Minnesota, Spojené státy, 55008
    - Cambridge Medical Center
  - Coon Rapids, Minnesota, Spojené státy, 55433
    - Mercy Hospital
  - Edina, Minnesota, Spojené státy, 55435
    - Fairview Southdale Hospital
  - Fridley, Minnesota, Spojené státy, 55432
    - Unity Hospital
  - Maple Grove, Minnesota, Spojené státy, 55369
    - Fairview Clinics and Surgery Center Maple Grove
  - Maplewood, Minnesota, Spojené státy, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Spojené státy, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Spojené státy, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Spojené státy, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Spojené státy, 55454
    - Health Partners Inc
  - Monticello, Minnesota, Spojené státy, 55362
    - Monticello Cancer Center
  - New Ulm, Minnesota, Spojené státy, 56073
    - New Ulm Medical Center
  - Princeton, Minnesota, Spojené státy, 55371
    - Fairview Northland Medical Center
  - Robbinsdale, Minnesota, Spojené státy, 55422
    - North Memorial Medical Health Center
  - Saint Louis Park, Minnesota, Spojené státy, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Paul, Minnesota, Spojené státy, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Spojené státy, 55102
    - United Hospital
  - Shakopee, Minnesota, Spojené státy, 55379
    - Saint Francis Regional Medical Center
  - Stillwater, Minnesota, Spojené státy, 55082
    - Lakeview Hospital
  - Waconia, Minnesota, Spojené státy, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Spojené státy, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Spojené státy, 55125
    - Minnesota Oncology Hematology PA-Woodbury
  - Wyoming, Minnesota, Spojené státy, 55092
    - Fairview Lakes Medical Center
- Mississippi
  - Columbus, Mississippi, Spojené státy, 39705
    - Baptist Memorial Hospital and Cancer Center-Golden Triangle
  - Grenada, Mississippi, Spojené státy, 38901
    - Baptist Cancer Center-Grenada
  - New Albany, Mississippi, Spojené státy, 38652
    - Baptist Memorial Hospital and Cancer Center-Union County
  - Oxford, Mississippi, Spojené státy, 38655
    - Baptist Memorial Hospital and Cancer Center-Oxford
  - Southhaven, Mississippi, Spojené státy, 38671
    - Baptist Memorial Hospital and Cancer Center-Desoto
- Missouri
  - Ballwin, Missouri, Spojené státy, 63011
    - Mercy Oncology and Hematology - Clayton-Clarkson
  - Bolivar, Missouri, Spojené státy, 65613
    - Central Care Cancer Center - Bolivar
  - Bonne Terre, Missouri, Spojené státy, 63628
    - Parkland Health Center-Bonne Terre
  - Branson, Missouri, Spojené státy, 65616
    - Cox Cancer Center Branson
  - Cape Girardeau, Missouri, Spojené státy, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Spojené státy, 63703
    - Mercy Cancer Center - Cape Girardeau
  - City of Saint Peters, Missouri, Spojené státy, 63376
    - Siteman Cancer Center at Saint Peters Hospital
  - Creve Coeur, Missouri, Spojené státy, 63141
    - Siteman Cancer Center at West County Hospital
  - Farmington, Missouri, Spojené státy, 63640
    - Parkland Health Center - Farmington
  - Jefferson City, Missouri, Spojené státy, 65109
    - MU Health Care Goldschmidt Cancer Center
  - Joplin, Missouri, Spojené státy, 64804
    - Freeman Health System
  - Joplin, Missouri, Spojené státy, 64804
    - Mercy Hospital Joplin
  - Rolla, Missouri, Spojené státy, 65401
    - Mercy Clinic-Rolla-Cancer and Hematology
  - Rolla, Missouri, Spojené státy, 65401
    - Phelps Health Delbert Day Cancer Institute
  - Saint Joseph, Missouri, Spojené státy, 64506
    - Heartland Regional Medical Center
  - Sainte Genevieve, Missouri, Spojené státy, 63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield, Missouri, Spojené státy, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Spojené státy, 65804
    - Mercy Hospital Springfield
  - St Louis, Missouri, Spojené státy, 63110
    - Washington University School of Medicine
  - St Louis, Missouri, Spojené státy, 63129
    - Siteman Cancer Center-South County
  - St Louis, Missouri, Spojené státy, 63136
    - Siteman Cancer Center at Christian Hospital
  - St Louis, Missouri, Spojené státy, 63131
    - Missouri Baptist Medical Center
  - St Louis, Missouri, Spojené státy, 63109
    - Mercy Infusion Center - Chippewa
  - St Louis, Missouri, Spojené státy, 63141
    - Mercy Hospital Saint Louis
  - St Louis, Missouri, Spojené státy, 63128
    - Mercy Hospital South
  - Sullivan, Missouri, Spojené státy, 63080
    - Missouri Baptist Sullivan Hospital
  - Washington, Missouri, Spojené státy, 63090
    - Mercy Hospital Washington
- Montana
  - Billings, Montana, Spojené státy, 59101
    - Saint Vincent Healthcare
  - Billings, Montana, Spojené státy, 59102
    - Saint Vincent Frontier Cancer Center
  - Butte, Montana, Spojené státy, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Missoula, Montana, Spojené státy, 59802
    - Saint Patrick Hospital - Community Hospital
- Nebraska
  - Bellevue, Nebraska, Spojené státy, 68123
    - Nebraska Medicine-Bellevue
  - Omaha, Nebraska, Spojené státy, 68198
    - University of Nebraska Medical Center
  - Omaha, Nebraska, Spojené státy, 68118
    - Nebraska Medicine-Village Pointe
- Nevada
  - Carson City, Nevada, Spojené státy, 89703
    - Carson Tahoe Regional Medical Center
  - Henderson, Nevada, Spojené státy, 89052
    - Comprehensive Cancer Centers of Nevada - Henderson
  - Henderson, Nevada, Spojené státy, 89052
    - Cancer and Blood Specialists-Henderson
  - Henderson, Nevada, Spojené státy, 89052
    - Las Vegas Cancer Center-Henderson
  - Henderson, Nevada, Spojené státy, 89074
    - Comprehensive Cancer Centers of Nevada-Southeast Henderson
  - Henderson, Nevada, Spojené státy, 89052
    - Comprehensive Cancer Centers of Nevada-Horizon Ridge
  - Henderson, Nevada, Spojené státy, 89074
    - Las Vegas Urology - Green Valley
  - Henderson, Nevada, Spojené státy, 89074
    - Las Vegas Urology - Pebble
  - Henderson, Nevada, Spojené státy, 89074
    - Urology Specialists of Nevada - Green Valley
  - Henderson, Nevada, Spojené státy, 89074
    - Oncology Las Vegas - Henderson
  - Las Vegas, Nevada, Spojené státy, 89144
    - Summerlin Hospital Medical Center
  - Las Vegas, Nevada, Spojené státy, 89109
    - Sunrise Hospital and Medical Center
  - Las Vegas, Nevada, Spojené státy, 89102
    - OptumCare Cancer Care at Charleston
  - Las Vegas, Nevada, Spojené státy, 89106
    - Radiation Oncology Centers of Nevada Central
  - Las Vegas, Nevada, Spojené státy, 89119
    - Radiation Oncology Centers of Nevada Southeast
  - Las Vegas, Nevada, Spojené státy, 89128
    - Comprehensive Cancer Centers of Nevada - Northwest
  - Las Vegas, Nevada, Spojené státy, 89128
    - OptumCare Cancer Care at MountainView
  - Las Vegas, Nevada, Spojené státy, 89135
    - Alliance for Childhood Diseases/Cure 4 the Kids Foundation
  - Las Vegas, Nevada, Spojené státy, 89144
    - Comprehensive Cancer Centers of Nevada - Town Center
  - Las Vegas, Nevada, Spojené státy, 89144
    - Comprehensive Cancer Centers of Nevada-Summerlin
  - Las Vegas, Nevada, Spojené státy, 89148
    - Comprehensive Cancer Centers of Nevada
  - Las Vegas, Nevada, Spojené státy, 89169
    - Comprehensive Cancer Centers of Nevada - Central Valley
  - Las Vegas, Nevada, Spojené státy, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Spojené státy, 89148-2405
    - Las Vegas Cancer Center-Medical Center
  - Las Vegas, Nevada, Spojené státy, 89128
    - Ann M Wierman MD LTD
  - Las Vegas, Nevada, Spojené státy, 89074
    - Las Vegas Urology - Pecos
  - Las Vegas, Nevada, Spojené státy, 89102
    - Desert West Surgery
  - Las Vegas, Nevada, Spojené státy, 89103
    - Hope Cancer Care of Nevada
  - Las Vegas, Nevada, Spojené státy, 89106
    - Urology Specialists of Nevada - Central
  - Las Vegas, Nevada, Spojené státy, 89113
    - Las Vegas Prostate Cancer Center
  - Las Vegas, Nevada, Spojené státy, 89113
    - Las Vegas Urology - Sunset
  - Las Vegas, Nevada, Spojené státy, 89128
    - Las Vegas Urology - Cathedral Rock
  - Las Vegas, Nevada, Spojené státy, 89128
    - Las Vegas Urology - Smoke Ranch
  - Las Vegas, Nevada, Spojené státy, 89128
    - Urology Specialists of Nevada - Northwest
  - Las Vegas, Nevada, Spojené státy, 89169
    - University Cancer Center
  - Las Vegas, Nevada, Spojené státy, 89113
    - Urology Specialists of Nevada - Southwest
  - Las Vegas, Nevada, Spojené státy, 89128
    - Oncology Las Vegas - Tenaya
  - Las Vegas, Nevada, Spojené státy, 89183
    - OptumCare Cancer Care at Fort Apache
  - Pahrump, Nevada, Spojené státy, 89048
    - Hope Cancer Care of Nevada-Pahrump
  - Reno, Nevada, Spojené státy, 89502
    - Renown Regional Medical Center
  - Reno, Nevada, Spojené státy, 89503
    - Saint Mary's Regional Medical Center
  - Reno, Nevada, Spojené státy, 89509
    - Radiation Oncology Associates
- New Jersey
  - Englewood, New Jersey, Spojené státy, 07631
    - Englewood Hospital and Medical Center
  - Hamilton, New Jersey, Spojené státy, 08690
    - The Cancer Institute of New Jersey Hamilton
  - Morristown, New Jersey, Spojené státy, 07960
    - Morristown Medical Center
  - Mullica Hill, New Jersey, Spojené státy, 08062
    - Inspira Medical Center Mullica Hill
  - New Brunswick, New Jersey, Spojené státy, 08903
    - Rutgers Cancer Institute of New Jersey
  - Sewell, New Jersey, Spojené státy, 08080
    - Sidney Kimmel Cancer Center Washington Township
  - Somerville, New Jersey, Spojené státy, 08876
    - Robert Wood Johnson University Hospital Somerset
  - Summit, New Jersey, Spojené státy, 07902
    - Overlook Hospital
  - Teaneck, New Jersey, Spojené státy, 07666
    - Holy Name Hospital
  - Vineland, New Jersey, Spojené státy, 08360
    - Inspira Medical Center Vineland
- New York
  - Rochester, New York, Spojené státy, 14642
    - University of Rochester
  - The Bronx, New York, Spojené státy, 10461
    - Montefiore Medical Center-Einstein Campus
  - The Bronx, New York, Spojené státy, 10467
    - Montefiore Medical Center - Moses Campus
  - The Bronx, New York, Spojené státy, 10461
    - Montefiore Medical Center-Weiler Hospital
- Ohio
  - Akron, Ohio, Spojené státy, 44307
    - Cleveland Clinic Akron General
  - Beachwood, Ohio, Spojené státy, 44122
    - UHHS-Chagrin Highlands Medical Center
  - Belpre, Ohio, Spojené státy, 45714
    - Strecker Cancer Center-Belpre
  - Chardon, Ohio, Spojené státy, 44024
    - Geauga Hospital
  - Chillicothe, Ohio, Spojené státy, 45601
    - Adena Regional Medical Center
  - Cleveland, Ohio, Spojené státy, 44106
    - Case Western Reserve University
  - Cleveland, Ohio, Spojené státy, 44109
    - MetroHealth Medical Center
  - Columbus, Ohio, Spojené státy, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Spojené státy, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, Spojené státy, 43214
    - Columbus Oncology and Hematology Associates Inc
  - Columbus, Ohio, Spojené státy, 43228
    - Doctors Hospital
  - Columbus, Ohio, Spojené státy, 43213
    - Mount Carmel East Hospital
  - Columbus, Ohio, Spojené státy, 43215
    - Grant Medical Center
  - Columbus, Ohio, Spojené státy, 43222
    - Mount Carmel Health Center West
  - Delaware, Ohio, Spojené státy, 43015
    - Delaware Health Center-Grady Cancer Center
  - Delaware, Ohio, Spojené státy, 43015
    - Grady Memorial Hospital
  - Dublin, Ohio, Spojené státy, 43016
    - Dublin Methodist Hospital
  - Dublin, Ohio, Spojené státy, 43016
    - Columbus Oncology and Hematology Associates
  - Gahanna, Ohio, Spojené státy, 43230
    - Central Ohio Breast and Endocrine Surgery
  - Grove City, Ohio, Spojené státy, 43123
    - Mount Carmel Grove City Hospital
  - Lancaster, Ohio, Spojené státy, 43130
    - Fairfield Medical Center
  - Lima, Ohio, Spojené státy, 45801
    - Saint Rita's Medical Center
  - Mansfield, Ohio, Spojené státy, 44903
    - OhioHealth Mansfield Hospital
  - Marietta, Ohio, Spojené státy, 45750
    - Marietta Memorial Hospital
  - Marion, Ohio, Spojené státy, 43302
    - OhioHealth Marion General Hospital
  - Mentor, Ohio, Spojené státy, 44060
    - UH Seidman Cancer Center at Lake Health Mentor Campus
  - Middleburg Heights, Ohio, Spojené státy, 44130
    - UH Seidman Cancer Center at Southwest General Hospital
  - Mount Vernon, Ohio, Spojené státy, 43050
    - Knox Community Hospital
  - Newark, Ohio, Spojené státy, 43055
    - Licking Memorial Hospital
  - Newark, Ohio, Spojené státy, 43055
    - Newark Radiation Oncology
  - Parma, Ohio, Spojené státy, 44129
    - University Hospitals Parma Medical Center
  - Perrysburg, Ohio, Spojené státy, 43551
    - Mercy Health - Perrysburg Hospital
  - Portsmouth, Ohio, Spojené státy, 45662
    - Southern Ohio Medical Center
  - Ravenna, Ohio, Spojené státy, 44266
    - University Hospitals Portage Medical Center
  - Sandusky, Ohio, Spojené státy, 44870
    - UH Seidman Cancer Center at Firelands Regional Medical Center
  - Toledo, Ohio, Spojené státy, 43623
    - Mercy Health - Saint Anne Hospital
  - Toledo, Ohio, Spojené státy, 43608
    - Mercy Health - Saint Vincent Hospital
  - Toledo, Ohio, Spojené státy, 43623
    - Mercy Health Sylvania Radiation Oncology Center
  - Wadsworth, Ohio, Spojené státy, 44281
    - University Hospitals Sharon Health Center
  - Westerville, Ohio, Spojené státy, 43081
    - Saint Ann's Hospital
  - Westlake, Ohio, Spojené státy, 44145
    - UH Seidman Cancer Center at Saint John Medical Center
  - Zanesville, Ohio, Spojené státy, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Oklahoma City, Oklahoma, Spojené státy, 73120
    - Mercy Hospital Oklahoma City
- Oregon
  - Bend, Oregon, Spojené státy, 97701
    - Saint Charles Health System
  - Clackamas, Oregon, Spojené státy, 97015
    - Clackamas Radiation Oncology Center
  - Clackamas, Oregon, Spojené státy, 97015
    - Providence Cancer Institute Clackamas Clinic
  - Coos Bay, Oregon, Spojené státy, 97420
    - Bay Area Hospital
  - Newberg, Oregon, Spojené státy, 97132
    - Providence Newberg Medical Center
  - Portland, Oregon, Spojené státy, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Spojené státy, 97225
    - Providence Saint Vincent Medical Center
  - Redmond, Oregon, Spojené státy, 97756
    - Saint Charles Health System-Redmond
- Pennsylvania
  - Allentown, Pennsylvania, Spojené státy, 18103
    - Lehigh Valley Hospital-Cedar Crest
  - Bethlehem, Pennsylvania, Spojené státy, 18017
    - Lehigh Valley Hospital - Muhlenberg
  - Bryn Mawr, Pennsylvania, Spojené státy, 19010
    - Bryn Mawr Hospital
  - Chadds Ford, Pennsylvania, Spojené státy, 19317
    - Christiana Care Health System-Concord Health Center
  - Collegeville, Pennsylvania, Spojené státy, 19426
    - Main Line Health Center-Collegeville
  - East Norriton, Pennsylvania, Spojené státy, 19401
    - Fox Chase Cancer Center - East Norriton Hospital Outpatient Center
  - East Stroudsburg, Pennsylvania, Spojené státy, 18301
    - Pocono Medical Center
  - Exton, Pennsylvania, Spojené státy, 19341
    - Main Line Health Center-Exton
  - Hazleton, Pennsylvania, Spojené státy, 18201
    - Lehigh Valley Hospital-Hazleton
  - Media, Pennsylvania, Spojené státy, 19063
    - Riddle Memorial Hospital
  - Paoli, Pennsylvania, Spojené státy, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Spojené státy, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Spojené státy, 19107
    - Thomas Jefferson University Hospital
  - Philadelphia, Pennsylvania, Spojené státy, 19114
    - Jefferson Torresdale Hospital
  - Philadelphia, Pennsylvania, Spojené státy, 19140
    - Temple University Hospital
  - Wynnewood, Pennsylvania, Spojené státy, 19096
    - Lankenau Medical Center
- South Carolina
  - Bluffton, South Carolina, Spojené státy, 29910
    - Saint Joseph's/Candler - Bluffton Campus
  - Charleston, South Carolina, Spojené státy, 29425
    - Medical University of South Carolina
  - Georgetown, South Carolina, Spojené státy, 29440
    - Tidelands Georgetown Memorial Hospital
  - Greenwood, South Carolina, Spojené státy, 29646
    - Self Regional Healthcare
  - Hilton Head Island, South Carolina, Spojené státy, 29926-3827
    - South Carolina Cancer Specialists PC
  - West Columbia, South Carolina, Spojené státy, 29169
    - Lexington Medical Center
- Tennessee
  - Collierville, Tennessee, Spojené státy, 38017
    - Baptist Memorial Hospital and Cancer Center-Collierville
  - Memphis, Tennessee, Spojené státy, 38120
    - Baptist Memorial Hospital and Cancer Center-Memphis
  - Memphis, Tennessee, Spojené státy, 38120
    - Baptist Memorial Hospital for Women
- Texas
  - Beaumont, Texas, Spojené státy, 77701
    - Baptist Hospitals of Southeast Texas Cancer Center
  - Port Arthur, Texas, Spojené státy, 77642
    - Baptist Regional Cancer Network-Cancer Center of Southeast Texas
- Utah
  - American Fork, Utah, Spojené státy, 84003
    - American Fork Hospital / Huntsman Intermountain Cancer Center
  - Cedar City, Utah, Spojené státy, 84720
    - Sandra L Maxwell Cancer Center
  - Logan, Utah, Spojené státy, 84321
    - Logan Regional Hospital
  - Murray, Utah, Spojené státy, 84107
    - Intermountain Medical Center
  - Ogden, Utah, Spojené státy, 84403
    - McKay-Dee Hospital Center
  - Provo, Utah, Spojené státy, 84604
    - Utah Valley Regional Medical Center
  - Riverton, Utah, Spojené státy, 84065
    - Riverton Hospital
  - Salt Lake City, Utah, Spojené státy, 84106
    - Utah Cancer Specialists-Salt Lake City
  - Salt Lake City, Utah, Spojené státy, 84143
    - LDS Hospital
  - St. George, Utah, Spojené státy, 84770
    - Saint George Regional Medical Center
- Virginia
  - Fishersville, Virginia, Spojené státy, 22939
    - Augusta Health Center for Cancer and Blood Disorders
  - Mechanicsville, Virginia, Spojené státy, 23116
    - Bon Secours Memorial Regional Medical Center
  - Midlothian, Virginia, Spojené státy, 23114
    - Bon Secours Saint Francis Medical Center
  - Midlothian, Virginia, Spojené státy, 23113
    - Bon Secours Westchester Emergency Center
  - Norfolk, Virginia, Spojené státy, 23505
    - Bon Secours DePaul Medical Center
  - Portsmouth, Virginia, Spojené státy, 23707
    - Bon Secours Maryview Medical Center
  - Richmond, Virginia, Spojené státy, 23226
    - Bon Secours Saint Mary's Hospital
  - Richmond, Virginia, Spojené státy, 23230
    - Bon Secours Cancer Institute at Reynolds Crossing
  - Suffolk, Virginia, Spojené státy, 23435
    - Bon Secours Health Center at Harbour View
- Washington
  - Aberdeen, Washington, Spojené státy, 98520
    - Providence Regional Cancer System-Aberdeen
  - Auburn, Washington, Spojené státy, 98001
    - MultiCare Auburn Medical Center
  - Bellevue, Washington, Spojené státy, 98004
    - Overlake Medical Center
  - Bellingham, Washington, Spojené státy, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Centralia, Washington, Spojené státy, 98531
    - Providence Regional Cancer System-Centralia
  - Edmonds, Washington, Spojené státy, 98026
    - Swedish Cancer Institute-Edmonds
  - Everett, Washington, Spojené státy, 98201
    - Providence Regional Cancer Partnership
  - Gig Harbor, Washington, Spojené státy, 98335
    - MultiCare Gig Harbor Medical Park
  - Issaquah, Washington, Spojené státy, 98029
    - Swedish Cancer Institute-Issaquah
  - Kennewick, Washington, Spojené státy, 99336
    - Kadlec Clinic Hematology and Oncology
  - Lacey, Washington, Spojené státy, 98503
    - Providence Regional Cancer System-Lacey
  - Longview, Washington, Spojené státy, 98632
    - PeaceHealth Saint John Medical Center
  - Port Townsend, Washington, Spojené státy, 98368
    - Jefferson Healthcare
  - Puyallup, Washington, Spojené státy, 98372
    - MultiCare Good Samaritan Hospital
  - Renton, Washington, Spojené státy, 98055
    - Valley Medical Center
  - Seattle, Washington, Spojené státy, 98107
    - Swedish Medical Center-Ballard Campus
  - Seattle, Washington, Spojené státy, 98122
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Spojené státy, 98104
    - Pacific Gynecology Specialists
  - Seattle, Washington, Spojené státy, 98122-5711
    - Swedish Medical Center-Cherry Hill
  - Sedro-Woolley, Washington, Spojené státy, 98284
    - PeaceHealth United General Medical Center
  - Shelton, Washington, Spojené státy, 98584
    - Providence Regional Cancer System-Shelton
  - Spokane, Washington, Spojené státy, 99204
    - MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
  - Spokane, Washington, Spojené státy, 99218
    - MultiCare Deaconess Cancer and Blood Specialty Center - North
  - Spokane Valley, Washington, Spojené státy, 99216
    - MultiCare Deaconess Cancer and Blood Specialty Center - Valley
  - Tacoma, Washington, Spojené státy, 98405
    - Mary Bridge Children's Hospital and Health Center
  - Tacoma, Washington, Spojené státy, 98405
    - MultiCare Tacoma General Hospital
  - Vancouver, Washington, Spojené státy, 98664
    - PeaceHealth Southwest Medical Center
  - Walla Walla, Washington, Spojené státy, 99362
    - Providence Saint Mary Regional Cancer Center
  - Yakima, Washington, Spojené státy, 98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
  - Yelm, Washington, Spojené státy, 98597
    - Providence Regional Cancer System-Yelm
- Wisconsin
  - Burlington, Wisconsin, Spojené státy, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Cudahy, Wisconsin, Spojené státy, 53110
    - Aurora Saint Luke's South Shore
  - Fond du Lac, Wisconsin, Spojené státy, 54937
    - Aurora Health Center-Fond du Lac
  - Germantown, Wisconsin, Spojené státy, 53022
    - Aurora Health Care Germantown Health Center
  - Grafton, Wisconsin, Spojené státy, 53024
    - Aurora Cancer Care-Grafton
  - Green Bay, Wisconsin, Spojené státy, 54311
    - Aurora BayCare Medical Center
  - Kenosha, Wisconsin, Spojené státy, 53142
    - Aurora Cancer Care-Kenosha South
  - Marinette, Wisconsin, Spojené státy, 54143
    - Aurora Bay Area Medical Group-Marinette
  - Milwaukee, Wisconsin, Spojené státy, 53209
    - Aurora Cancer Care-Milwaukee
  - Milwaukee, Wisconsin, Spojené státy, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Spojené státy, 53233
    - Aurora Sinai Medical Center
  - New Richmond, Wisconsin, Spojené státy, 54017
    - Cancer Center of Western Wisconsin
  - Oshkosh, Wisconsin, Spojené státy, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Spojené státy, 53406
    - Aurora Cancer Care-Racine
  - Sheboygan, Wisconsin, Spojené státy, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Summit, Wisconsin, Spojené státy, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Spojené státy, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Wauwatosa, Wisconsin, Spojené státy, 53226
    - Aurora Cancer Care-Milwaukee West
  - West Allis, Wisconsin, Spojené státy, 53227
    - Aurora West Allis Medical Center
- Wyoming
  - Cheyenne, Wyoming, Spojené státy, 82001
    - Cheyenne Regional Medical Center-West

Kritéria účasti

Výzkumníci hledají lidi, kteří odpovídají určitému popisu, kterému se říká kritéria způsobilosti. Některé příklady těchto kritérií jsou celkový zdravotní stav osoby nebo předchozí léčba.

Kritéria způsobilosti

Věk způsobilý ke studiu

18 let a starší (Dospělý, Starší dospělý)

Přijímá zdravé dobrovolníky

Pohlaví způsobilá ke studiu

Ženský

Popis

Inclusion Criteria:

Patients must be women with a known stage I-III invasive breast cancer diagnosis
Patients must be capable and willing to provide informed consent
Patients must have plans to receive either neoadjuvant or adjuvant:
- Every 3-week docetaxel x 4-6 cycles OR
- Weekly paclitaxel x 4 cycles
- NOTE: Recommended therapies for various therapy regimens are outlined based on estrogen receptor (ER)/progesterone receptor (PR)/HER2 and nodal status. Where there are options, the treating physician will choose a regimen best fitted for that patient. If the physician does not feel any of the regimens are the best fit for the patient, the patient should not be enrolled. Physicians will also document why a regimen was felt to be inappropriate when an option. Patients who have already started the anthracycline portion of their therapy are eligible assuming they have not yet begun the taxane portion and assuming they will be receiving one of the regimens deemed appropriate for her disease setting
Patients must self-identify their race as black, African American, or of African descent; patients may be of any ethnicity
Patients with a history of other cancers are eligible if they have not received prior taxane or platinum or vinca alkaloid therapy
Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1
Patients of childbearing potential must be strongly advised to use an accepted and effective method of contraception or to abstain from sexual intercourse for the duration of their participation in the study

Exclusion Criteria:

Patients must not have received prior taxane or prior/concurrent platinum therapy
Patients must not have received neoadjuvant anti-HER2 therapy
Patients must not have pre-existing peripheral neuropathy
Patients must not have a total bilirubin > upper limit of normal (ULN) (must be obtained within 3 weeks prior to registration)
Patients must not have aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) above 1.5 times the ULN concomitant with alkaline phosphatase above 2.5 times the ULN (must be obtained within 3 weeks prior to registration)
Patients must not be pregnant or lactating
- All patients of childbearing potential must have a blood test or urine study within 2 weeks prior to registration to rule out pregnancy
- A patient of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy, or 3) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)

Studijní plán

Tato část poskytuje podrobnosti o studijním plánu, včetně toho, jak je studie navržena a co studie měří.

Jak je studie koncipována?

Detaily designu

Primární účel: Podpůrná péče
Přidělení: Nerandomizované
Intervenční model: Paralelní přiřazení
Maskování: Žádné (otevřený štítek)

Počet zbraní

Zbraně a zásahy

Skupina účastníků / Arm	Intervence / Léčba
Experimentální: Arm A (paclitaxel) Patients receive paclitaxel IV over 3 hours once weekly. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. Patients may also receive trastuzumab and/or pertuzumab per institution routine care per treating physician's discretion.	Lék: Paclitaxel Given IV Ostatní jména: Taxol Anzatax Asotax Bristaxol Praxel Taxol Konzentrat Jiný: Quality-of-Life Assessment Ancillary studies Ostatní jména: Hodnocení kvality života Jiný: Questionnaire Administration Ancillary studies
Experimentální: Arm B (docetaxel) Patients receive docetaxel IV over 1 hour once every 3 weeks. Treatment repeats every 21 days for 4-6 cycles in the absence of disease progression or unacceptable toxicity. Patients may also receive cyclophosphamide, doxorubicin, trastuzumab, and/or pertuzumab per institution routine care per treating physician's discretion.	Jiný: Quality-of-Life Assessment Ancillary studies Ostatní jména: Hodnocení kvality života Lék: Docetaxel Given IV Ostatní jména: Taxotere Docecad RP56976 Injekční koncentrát Taxotere RP 56976 RP-56976 Jiný: Questionnaire Administration Ancillary studies

Co je měření studie?

Primární výstupní opatření

Měření výsledku	Popis opatření	Časové okno
Percentage of Participants With Grade 2-4 Taxane-Induced Peripheral Neuropathy (TIPN) by Genotype Risk Group in Arm A Časové okno: assessed at baseline, an end of each cycle, at 6 months and 1 year post registration	Grade 2-4 TIPN was assessed by treating physician using National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. All patients who started protocol therapy on arm A (paclitaxel) were included in the analysis. The percentage of participants with grade 2-4 TIPN was calculated based on binomial distribution and was compared between high-risk vs low-risk genotype groups using Fisher exact test. Genotype risk group (high vs. low) was determined by genotyping. High-risk genotype was defined by FCAMR GG genotype (homozygous wild type) or SBF2 mutated. Low-risk genotype was defined by carriage of at least one variant allele in FCAMR (AG or AA) and SBF2 wild-type status.	assessed at baseline, an end of each cycle, at 6 months and 1 year post registration

Sekundární výstupní opatření

Měření výsledku	Popis opatření	Časové okno
Patient-Reported Neuropathy Score Change Between Baseline and End of Treatment by Genotype Risk Group in Patients on Arm A Časové okno: assessed at baseline and at end of treatment, an average of 3 months	The patient-reported neurotoxicity was assessed using the 11 items about neurotoxicity in the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group - Neurotoxicity (FACT/GOG-Ntx) questionnaire (i.e., FACT/GOG-Ntx additional concerns subscale). The neurotoxicity total score was the sum of the scores for the 11 items, ranging from 0 to 44. Higher values of the FACT/GOG-Ntx neurotoxicity total score indicate less neurotoxicity. The FACT/GOG-Ntx neurotoxicity total score change between the baseline and at end of treatment (negative value indicates worsening symptom, positive value indicates improving symptom) was calculated and compared using two-sample t test. Genotype risk group (high vs. low) was determined by genotyping. High-risk genotype was defined by FCAMR GG genotype (homozygous wild type) or SBF2 mutated. Low-risk genotype was defined by carriage of at least one variant allele in FCAMR (AG or AA) and SBF2 wild-type status.	assessed at baseline and at end of treatment, an average of 3 months
Percentage of Participants With Grade 2-4 TIPN Based on CTCAE Between Arm A and Arm B Časové okno: assessed at baseline, an end of each cycle, at 6 months and 1 year post registration	Grade 2-4 TIPN was assessed by treating physician using CTCAE version 4.0. All patients who started protocol therapy were included in the analysis. The percentage of participants with grade 2-4 TIPN was calculated based on binomial distribution and was compared between treatment arms using Fisher exact test.	assessed at baseline, an end of each cycle, at 6 months and 1 year post registration
Percentage of Participants With Dose Reduction Due to TIPN Between Arm A and Arm B Časové okno: Dose reduction due to TIPN was assessed at end of each cycle, up to 4 cycles in arm A and 6 cycles in arm B	The percentage of patients with dose reduction due to TIPN was calculated as number of patients with dose reduction due to peripheral neuropathy for any dose of any cycle divided by total number of patients who started protocol therapy. The percentages were calculated along with exact 95% CI based on binomial distribution and were compared between arms using Fisher exact test.	Dose reduction due to TIPN was assessed at end of each cycle, up to 4 cycles in arm A and 6 cycles in arm B
Percentage of Participants With Dose Reduction Due to Any Reason Between Arm A and Arm B Časové okno: Dose reduction due to any reason was assessed at end of each cycle, up to 4 cycles in arm A and 6 cycles in arm B	The percentage of patients with dose reduction due to any reason was calculated as number of patients with any dose reduction for any dose of any cycle, regardless of the reason, divided by total number of patients who started protocol therapy. The percentages were calculated along with exact 95% CI based on binomial distribution and were compared between arms using Fisher exact test.	Dose reduction due to any reason was assessed at end of each cycle, up to 4 cycles in arm A and 6 cycles in arm B
Percentage of Participants With Grade 2-4 TIPN by Genotype Risk Group in Arm B Časové okno: assessed at baseline, at end of each cycle, at 6 months and 1 year post registration	Grade 2-4 TIPN was assessed by treating physician using CTCAE version 4.0. All patients who started protocol therapy on arm B were included in the analysis. The percentage of participants with grade 2-4 TIPN was calculated based on binomial distribution and was compared between high-risk vs low-risk genotype groups using Fisher exact test. Genotype risk group (high vs. low) was determined by genotyping. High-risk genotype was defined by FCAMR GG genotype (homozygous wild type) or SBF2 mutated. Low-risk genotype was defined by carriage of at least one variant allele in FCAMR (AG or AA) and SBF2 wild-type status.	assessed at baseline, at end of each cycle, at 6 months and 1 year post registration

Spolupracovníci a vyšetřovatelé

Zde najdete lidi a organizace zapojené do této studie.

Sponzor

ECOG-ACRIN Cancer Research Group

Spolupracovníci

National Cancer Institute (NCI)

Vyšetřovatelé

Vrchní vyšetřovatel: Bryan P Schneider, ECOG-ACRIN Cancer Research Group

Publikace a užitečné odkazy

Osoba odpovědná za zadávání informací o studiu tyto publikace poskytuje dobrovolně. Mohou se týkat čehokoli, co souvisí se studiem.

Obecné publikace

Schneider BP, Zhao F, Ballinger TJ, Garcia SF, Shen F, Virani S, Cella D, Bales C, Jiang G, Hayes L, Miller N, Srinivasiah J, Stringer-Reasor EM, Chitalia A, Davis AA, Makower DF, Incorvati J, Simon MA, Mitchell EP, DeMichele A, Miller KD, Sparano JA, Wagner LI, Wolff AC. ECOG-ACRIN EAZ171: Prospective Validation Trial of Germline Predictors of Taxane-Induced Peripheral Neuropathy in Black Women With Early-Stage Breast Cancer. J Clin Oncol. 2024 Aug 20;42(24):2899-2907. doi: 10.1200/JCO.24.00526. Epub 2024 Jun 3.

Termíny studijních záznamů

Tato data sledují průběh záznamů studie a předkládání souhrnných výsledků na ClinicalTrials.gov. Záznamy ze studií a hlášené výsledky jsou před zveřejněním na veřejné webové stránce přezkoumány Národní lékařskou knihovnou (NLM), aby se ujistily, že splňují specifické standardy kontroly kvality.

Hlavní termíny studia

Začátek studia (Aktuální)

9. srpna 2019

Primární dokončení (Aktuální)

19. září 2023

Dokončení studie (Odhadovaný)

5. dubna 2027

Termíny zápisu do studia

První předloženo

19. června 2019

První předloženo, které splnilo kritéria kontroly kvality

27. června 2019

První zveřejněno (Aktuální)

28. června 2019

Aktualizace studijních záznamů

Poslední zveřejněná aktualizace (Aktuální)

6. října 2026

Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality

14. září 2026

Naposledy ověřeno

1. září 2026

Více informací

Termíny související s touto studií

Další relevantní podmínky MeSH

Další identifikační čísla studie

EAZ171
UG1CA189828 (Grant/smlouva NIH USA)
EAZ171 (Jiný identifikátor: CTEP)
NCI-2019-00266 (Identifikátor registru: CTRP (Clinical Trial Reporting Program))
ECOG-ACRIN-EAZ171 (Jiný identifikátor: DCP)
EAZ171 (Jiný identifikátor: ECOG-ACRIN Cancer Research Group)

Informace o lécích a zařízeních, studijní dokumenty

Studuje lékový produkt regulovaný americkým FDA

Studuje produkt zařízení regulovaný americkým úřadem FDA

Tyto informace byly beze změn načteny přímo z webu clinicaltrials.gov. Máte-li jakékoli požadavky na změnu, odstranění nebo aktualizaci podrobností studie, kontaktujte prosím register@clinicaltrials.gov. Jakmile bude změna implementována na clinicaltrials.gov, bude automaticky aktualizována i na našem webu .

Docetaxel nebo paklitaxel při snižování chemoterapie indukované periferní neuropatie u afroamerických pacientů s rakovinou prsu stadia I-III

Prospektivní validační studie taxanové terapie (docetaxel nebo týdenní paklitaxel) a riziko chemoterapie indukované periferní neuropatie u afroamerických žen

Přehled studie

Postavení

Podmínky

Intervence / Léčba

Detailní popis

Typ studie

Zápis (Aktuální)

Fáze

Kontakty a umístění

Studijní místa

Kritéria účasti

Kritéria způsobilosti

Věk způsobilý ke studiu

Přijímá zdravé dobrovolníky

Pohlaví způsobilá ke studiu

Popis

Studijní plán

Jak je studie koncipována?

Detaily designu

Počet zbraní

Zbraně a zásahy

Skupina účastníků / Arm

Intervence / Léčba

Co je měření studie?

Primární výstupní opatření

Měření výsledku

Popis opatření

Časové okno

Sekundární výstupní opatření

Měření výsledku

Popis opatření

Časové okno

Spolupracovníci a vyšetřovatelé

Sponzor

Spolupracovníci

Vyšetřovatelé

Publikace a užitečné odkazy

Obecné publikace

Termíny studijních záznamů

Hlavní termíny studia

Začátek studia (Aktuální)

Primární dokončení (Aktuální)

Dokončení studie (Odhadovaný)

Termíny zápisu do studia

První předloženo

První předloženo, které splnilo kritéria kontroly kvality

První zveřejněno (Aktuální)

Aktualizace studijních záznamů

Poslední zveřejněná aktualizace (Aktuální)

Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality

Naposledy ověřeno

Více informací

Termíny související s touto studií

Další relevantní podmínky MeSH

Další identifikační čísla studie

Informace o lécích a zařízeních, studijní dokumenty

Studuje lékový produkt regulovaný americkým FDA

Studuje produkt zařízení regulovaný americkým úřadem FDA