Docétaxel ou Paclitaxel dans la réduction de la neuropathie périphérique induite par la chimiothérapie chez les patientes afro-américaines atteintes d'un cancer du sein de stade I-III
14 septembre 2026 mis à jour par: ECOG-ACRIN Cancer Research Group
Essai de validation prospectif de la thérapie au taxane (docétaxel ou paclitaxel hebdomadaire) et risque de neuropathie périphérique induite par la chimiothérapie chez les femmes afro-américaines
This phase II trial studies how well docetaxel or paclitaxel work in reducing chemotherapy-induced peripheral neuropathy in African American patients with stages I-III breast cancer. Drugs used in chemotherapy, such as docetaxel and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving docetaxel or paclitaxel may work better than other methods in reducing chemotherapy-induced peripheral neuropathy in patients with breast cancer.
Aperçu de l'étude
Statut
Actif, ne recrute pas
Les conditions
- Cancer du sein anatomique de stade I AJCC v8
- Cancer du sein de stade IA anatomique AJCC v8
- Cancer du sein de stade anatomique IB AJCC v8
- Cancer du sein anatomique de stade II AJCC v8
- Cancer du sein anatomique de stade IIA AJCC v8
- Cancer du sein anatomique de stade IIB AJCC v8
- Cancer du sein anatomique de stade III AJCC v8
- Cancer du sein anatomique de stade IIIA AJCC v8
- Cancer du sein anatomique de stade IIIB AJCC v8
- Cancer du sein anatomique de stade IIIC AJCC v8
- Cancer du sein pronostique de stade I AJCC v8
- Cancer du sein de stade IA pronostique AJCC v8
- Cancer du sein de stade IB pronostique AJCC v8
- Cancer du sein pronostique de stade II AJCC v8
- Cancer du sein de stade IIA pronostique AJCC v8
- Cancer du sein pronostique de stade IIB AJCC v8
- Cancer du sein pronostique de stade III AJCC v8
- Cancer du sein pronostique de stade IIIA AJCC v8
- Cancer du sein pronostique de stade IIIB AJCC v8
- Cancer du sein pronostique de stade IIIC AJCC v8
- Carcinome du sein invasif
Intervention / Traitement
Description détaillée
PRIMARY OBJECTIVE:
I. Prospectively validate a prior germline predictor of paclitaxel-induced peripheral neuropathy (TIPN) using the Common Terminology Criteria for Adverse Events (CTCAE). Specifically, this study will demonstrate that patients with a high-risk TIPN genotype have significantly more grade 2-4 TIPN than patients with a low risk genotype.
SECONDARY OBJECTIVES:
I. Validate a prior germline predictor of TIPN using the Functional Assessment of Cancer Therapy (FACT)/Gynecologic Oncology Group (GOG)-Neurotoxicity (NTX) neurotoxicity subscale in Arm A.
II. Compare grade 2-4 TIPN based on CTCAE between weekly paclitaxel (Arm A) versus (vs.) every three-week docetaxel (Arm B).
III. Prospectively confirm dose reductions due to TIPN are lower for every three-week docetaxel compared with weekly paclitaxel in a prospective cohort of patients of African ancestry.
IV. Prospectively confirm dose reductions due to any cause are lower for every three-week docetaxel compared with weekly paclitaxel in a prospective cohort of patients of African ancestry.
V. Assess the ability of the high-risk genotype to predict TIPN risk for docetaxel.
CORRELATIVE STUDY OBJECTIVES:
I. Identify novel markers of TIPN and elucidate the mechanism. II. Whole genome sequencing of germline blood to evaluate for additional predictors of TIPN.
III. Create induced pluripotent stem cell (iPSC) derived neurons from patient samples.
IIIa. Evaluate whether clinical findings can be mimicked in vitro. IIIb. Evaluate gene expression (ribonucleic acid [RNA] sequencing [seq]) and the epigenome at baseline versus after exposure in those prone to TIPN versus those not.
IV. Create a biorepository of patient derived samples for future translational research.
PATIENT REPORTED OUTCOME OBJECTIVES:
I. Compare grade 2-4 TIPN (moderate to life threatening) based on Patient Reported Outcomes (PRO)-CTCAE items between weekly paclitaxel (Arm A) vs. every three-week docetaxel (Arm B).
II. Prospectively compare FACT/GOG-NTX Health-Related Quality of Life (HRQoL) scores (from the FACT-General [G] portion and Patient-Reported Outcomes Measurement Information System [PROMIS] Physical Function version [v.]2 Short Form [SF] 10a, scores between every three-week docetaxel and weekly paclitaxel and between high risk and low risk genotypes (Arm A) in a cohort of African ancestry.
III. Compare Chemotherapy-Induced Peripheral Neuropathy (CIPN)-20 sensory neuropathy score between weekly paclitaxel (Arm A) vs. every three-week docetaxel (Arm B).
IV. Compare the impact on financial toxicity (Comprehensive Score for Financial Toxicity [COST] scores) for every three-week docetaxel compared with weekly paclitaxel.
V. Examine associations between social determinants of health (zip code, marital status, education, income & insurance status) and dose reductions and treatment discontinuation.
OUTLINE: Patients are assigned to 1 of 2 arms.
ARM A: Patients receive paclitaxel intravenously (IV) over 3 hours once weekly. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. Patients may also receive trastuzumab and/or pertuzumab per institution routine care per treating physician's discretion.
ARM B: Patients receive docetaxel IV over 1 hour once every 3 weeks. Treatment repeats every 21 days for 4-6 cycles in the absence of disease progression or unacceptable toxicity. Patients may also receive cyclophosphamide, doxorubicin, trastuzumab, and/or pertuzumab per institution routine care per treating physician's discretion.
After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.
Type d'étude
Interventionnel
Inscription (Réel)
249
Phase
- Phase 2
Contacts et emplacements
Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.
Lieux d'étude
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Alabama
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Birmingham, Alabama, États-Unis, 35233
- University of Alabama at Birmingham Cancer Center
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Alaska
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Anchorage, Alaska, États-Unis, 98508
- Anchorage Associates in Radiation Medicine
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Anchorage, Alaska, États-Unis, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, États-Unis, 99508
- Alaska Oncology and Hematology LLC
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Anchorage, Alaska, États-Unis, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, États-Unis, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, États-Unis, 99508
- Katmai Oncology Group
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Anchorage, Alaska, États-Unis, 99508
- Providence Alaska Medical Center
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Anchorage, Alaska, États-Unis, 99504
- Anchorage Radiation Therapy Center
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Fairbanks, Alaska, États-Unis, 99701
- Fairbanks Memorial Hospital
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Arizona
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Kingman, Arizona, États-Unis, 86401
- Kingman Regional Medical Center
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Arkansas
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Fort Smith, Arkansas, États-Unis, 72903
- Mercy Hospital Fort Smith
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Jonesboro, Arkansas, États-Unis, 72401
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
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California
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Arroyo Grande, California, États-Unis, 93420
- PCR Oncology
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Burbank, California, États-Unis, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Dublin, California, États-Unis, 94568
- Epic Care-Dublin
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Emeryville, California, États-Unis, 94608
- Bay Area Breast Surgeons Inc
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Emeryville, California, États-Unis, 94608
- Epic Care Partners in Cancer Care
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Martinez, California, États-Unis, 94553-3156
- Contra Costa Regional Medical Center
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Oakland, California, États-Unis, 94609
- Alta Bates Summit Medical Center - Summit Campus
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Oakland, California, États-Unis, 94609
- Bay Area Tumor Institute
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Walnut Creek, California, États-Unis, 94597
- Epic Care Cyberknife Center
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Colorado
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Aurora, Colorado, États-Unis, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, États-Unis, 80012
- The Medical Center of Aurora
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Boulder, Colorado, États-Unis, 80303
- Boulder Community Foothills Hospital
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Boulder, Colorado, États-Unis, 80304
- Rocky Mountain Cancer Centers-Boulder
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Centennial, Colorado, États-Unis, 80112
- Rocky Mountain Cancer Centers - Centennial
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Denver, Colorado, États-Unis, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, États-Unis, 80220
- Rose Medical Center
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Denver, Colorado, États-Unis, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, États-Unis, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, États-Unis, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, États-Unis, 80204
- Cancer Center of Colorado at Sloan's Lake
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Denver, Colorado, États-Unis, 80209
- The Women's Imaging Center
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Denver, Colorado, États-Unis, 80206
- National Jewish Health-Main Campus
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Denver, Colorado, États-Unis, 80220
- Western Surgical Care
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Denver, Colorado, États-Unis, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
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Englewood, Colorado, États-Unis, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, États-Unis, 80113
- Swedish Medical Center
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Englewood, Colorado, États-Unis, 80113
- Rocky Mountain Cancer Centers - Swedish
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Englewood, Colorado, États-Unis, 80113
- The Melanoma and Skin Cancer Institute
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Golden, Colorado, États-Unis, 80401
- National Jewish Health-Western Hematology Oncology
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Grand Junction, Colorado, États-Unis, 81501
- Saint Mary's Hospital and Regional Medical Center
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Greeley, Colorado, États-Unis, 80631
- Banner North Colorado Medical Center
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Lafayette, Colorado, États-Unis, 80026
- Good Samaritan Hospital - Cancer Centers of Colorado
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Lakewood, Colorado, États-Unis, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Littleton, Colorado, États-Unis, 80120
- Rocky Mountain Cancer Centers-Littleton
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Lone Tree, Colorado, États-Unis, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, États-Unis, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Loveland, Colorado, États-Unis, 80539
- Banner North Colorado Medical Center - Loveland Campus
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Thornton, Colorado, États-Unis, 80260
- Rocky Mountain Cancer Centers-Thornton
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Thornton, Colorado, États-Unis, 80260
- National Jewish Health-Northern Hematology Oncology
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Wheat Ridge, Colorado, États-Unis, 80401
- Intermountain Health Lutheran Hospital
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Delaware
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Lewes, Delaware, États-Unis, 19958
- Beebe Medical Center
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Millville, Delaware, États-Unis, 19967
- Beebe South Coastal Health Campus
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Newark, Delaware, États-Unis, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, États-Unis, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, États-Unis, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, États-Unis, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, États-Unis, 19971
- Beebe Health Campus
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Seaford, Delaware, États-Unis, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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Wilmington, Delaware, États-Unis, 19801
- Christiana Care Health System-Wilmington Hospital
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District of Columbia
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Washington D.C., District of Columbia, États-Unis, 20010
- MedStar Washington Hospital Center
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Washington D.C., District of Columbia, États-Unis, 20016
- Sibley Memorial Hospital
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Florida
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Fort Lauderdale, Florida, États-Unis, 33308
- Holy Cross Hospital
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Gainesville, Florida, États-Unis, 32610
- UF Health Cancer Institute - Gainesville
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Georgia
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Atlanta, Georgia, États-Unis, 30308
- Emory University Hospital Midtown
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Atlanta, Georgia, États-Unis, 30322
- Emory University Hospital/Winship Cancer Institute
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Atlanta, Georgia, États-Unis, 30342
- Emory Saint Joseph's Hospital
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Atlanta, Georgia, États-Unis, 30303
- Grady Health System
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Atlanta, Georgia, États-Unis, 30342
- Northside Hospital
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Columbus, Georgia, États-Unis, 31904
- John B Amos Cancer Center
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Duluth, Georgia, États-Unis, 30096
- Northside Hospital - Duluth
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Lawrenceville, Georgia, États-Unis, 30046
- Northside Hospital - Gwinnett
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Savannah, Georgia, États-Unis, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Snellville, Georgia, États-Unis, 30078
- Suburban Hematology Oncology Associates - Snellville
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Idaho
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Boise, Idaho, États-Unis, 83712
- Saint Luke's Cancer Institute - Boise
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Fruitland, Idaho, États-Unis, 83619
- Saint Luke's Cancer Institute - Fruitland
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Meridian, Idaho, États-Unis, 83642
- Saint Luke's Cancer Institute - Meridian
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Nampa, Idaho, États-Unis, 83687
- Saint Luke's Cancer Institute - Nampa
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Twin Falls, Idaho, États-Unis, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Alton, Illinois, États-Unis, 62002
- OSF Saint Anthony's Health Center
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Aurora, Illinois, États-Unis, 60504
- Rush-Copley Medical Center
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Bloomington, Illinois, États-Unis, 61704
- Illinois CancerCare-Bloomington
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Canton, Illinois, États-Unis, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, États-Unis, 62902
- Memorial Hospital of Carbondale
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Carterville, Illinois, États-Unis, 62918
- SIH Cancer Institute
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Carthage, Illinois, États-Unis, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, États-Unis, 62801
- Centralia Oncology Clinic
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Chicago, Illinois, États-Unis, 60611
- Northwestern University
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Chicago, Illinois, États-Unis, 60612
- John H Stroger Jr Hospital of Cook County
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Danville, Illinois, États-Unis, 61832
- Carle at The Riverfront
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Decatur, Illinois, États-Unis, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, États-Unis, 62526
- Cancer Care Specialists of Illinois - Decatur
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Dixon, Illinois, États-Unis, 61021
- Illinois CancerCare-Dixon
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Effingham, Illinois, États-Unis, 62401
- Crossroads Cancer Center
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Effingham, Illinois, États-Unis, 62401
- Carle Physician Group-Effingham
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Eureka, Illinois, États-Unis, 61530
- Illinois CancerCare-Eureka
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Galesburg, Illinois, États-Unis, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, États-Unis, 61401
- Illinois CancerCare-Galesburg
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Kewanee, Illinois, États-Unis, 61443
- Illinois CancerCare-Kewanee Clinic
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Macomb, Illinois, États-Unis, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, États-Unis, 61938
- Carle Physician Group-Mattoon/Charleston
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Mount Vernon, Illinois, États-Unis, 62864
- SSM Health Good Samaritan
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O'Fallon, Illinois, États-Unis, 62269
- Cancer Care Center of O'Fallon
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Ottawa, Illinois, États-Unis, 61350
- Illinois CancerCare-Ottawa Clinic
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Pekin, Illinois, États-Unis, 61554
- Illinois CancerCare-Pekin
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Peoria, Illinois, États-Unis, 61636
- Methodist Medical Center of Illinois
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Peoria, Illinois, États-Unis, 61615
- Illinois CancerCare-Peoria
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Peru, Illinois, États-Unis, 61354
- Illinois CancerCare-Peru
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Peru, Illinois, États-Unis, 61354
- Valley Radiation Oncology
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Princeton, Illinois, États-Unis, 61356
- Illinois CancerCare-Princeton
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Springfield, Illinois, États-Unis, 62702
- Southern Illinois University School of Medicine
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Springfield, Illinois, États-Unis, 62702
- Springfield Clinic
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Springfield, Illinois, États-Unis, 62781
- Springfield Memorial Hospital
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Swansea, Illinois, États-Unis, 62226
- Southwest Illinois Health Services LLP
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Urbana, Illinois, États-Unis, 61801
- Carle Cancer Center
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Urbana, Illinois, États-Unis, 61801
- The Carle Foundation Hospital
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Washington, Illinois, États-Unis, 61571
- Illinois CancerCare - Washington
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Yorkville, Illinois, États-Unis, 60560
- Rush-Copley Healthcare Center
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Indiana
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Avon, Indiana, États-Unis, 46123
- IU Health West Hospital
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Carmel, Indiana, États-Unis, 46032
- IU Health North Hospital
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Crown Point, Indiana, États-Unis, 46307
- Northwest Cancer Center - Crown Point
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Dyer, Indiana, États-Unis, 46311
- Northwest Oncology LLC
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Hobart, Indiana, États-Unis, 46342
- Northwest Cancer Center - Hobart
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Hobart, Indiana, États-Unis, 46342
- Saint Mary Medical Center
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Indianapolis, Indiana, États-Unis, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
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Indianapolis, Indiana, États-Unis, 46202
- Sidney and Lois Eskenazi Hospital
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Indianapolis, Indiana, États-Unis, 46290
- Springmill Medical Center
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Indianapolis, Indiana, États-Unis, 46202
- IU Health Methodist Hospital
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Indianapolis, Indiana, États-Unis, 46312
- Saint Catherine Hospital
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Munster, Indiana, États-Unis, 46321
- The Community Hospital
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Munster, Indiana, États-Unis, 46321
- Women's Diagnostic Center - Munster
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Valparaiso, Indiana, États-Unis, 46383
- Northwest Cancer Center - Valparaiso
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Kansas
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Garden City, Kansas, États-Unis, 67846
- Central Care Cancer Center - Garden City
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Great Bend, Kansas, États-Unis, 67530
- Central Care Cancer Center - Great Bend
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Louisiana
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Baton Rouge, Louisiana, États-Unis, 70805
- LSU Health Baton Rouge-North Clinic
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Baton Rouge, Louisiana, États-Unis, 70809
- Louisiana Hematology Oncology Associates LLC
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Baton Rouge, Louisiana, États-Unis, 70809
- Mary Bird Perkins Cancer Center
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Baton Rouge, Louisiana, États-Unis, 70808
- Our Lady of The Lake
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Baton Rouge, Louisiana, États-Unis, 70817
- Woman's Hospital
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Baton Rouge, Louisiana, États-Unis, 70817
- Our Lady of the Lake Medical Oncology
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Baton Rouge, Louisiana, États-Unis, 70817
- Louisiana Hematology Oncology Associates
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Baton Rouge, Louisiana, États-Unis, 70808
- Our Lady of the Lake Physician Group
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Covington, Louisiana, États-Unis, 70433
- Northshore Oncology Associates-Covington
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Houma, Louisiana, États-Unis, 70360
- Terrebonne General Medical Center
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New Orleans, Louisiana, États-Unis, 70112
- University Medical Center New Orleans
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New Orleans, Louisiana, États-Unis, 70112
- Louisiana State University Health Science Center
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Maryland
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Baltimore, Maryland, États-Unis, 21287
- Johns Hopkins University/Sidney Kimmel Cancer Center
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Baltimore, Maryland, États-Unis, 21215
- Sinai Hospital of Baltimore
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Baltimore, Maryland, États-Unis, 21229
- Saint Agnes Hospital
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Baltimore, Maryland, États-Unis, 21239
- MedStar Good Samaritan Hospital
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Easton, Maryland, États-Unis, 21601
- University of Maryland Shore Medical Center at Easton
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Randallstown, Maryland, États-Unis, 21133
- Northwest Hospital Center
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Westminster, Maryland, États-Unis, 21157
- William E Kahlert Regional Cancer Center/Sinai Hospital
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Massachusetts
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Springfield, Massachusetts, États-Unis, 01199
- Baystate Medical Center
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Springfield, Massachusetts, États-Unis, 01104
- Mercy Medical Center
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Michigan
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Ann Arbor, Michigan, États-Unis, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
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Battle Creek, Michigan, États-Unis, 49017
- Bronson Battle Creek
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Brighton, Michigan, États-Unis, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
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Brighton, Michigan, États-Unis, 48114
- Trinity Health Medical Center - Brighton
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Canton, Michigan, États-Unis, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
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Canton, Michigan, États-Unis, 48188
- Trinity Health Medical Center - Canton
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Caro, Michigan, États-Unis, 48723
- Caro Cancer Center
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Chelsea, Michigan, États-Unis, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
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Chelsea, Michigan, États-Unis, 48118
- Chelsea Hospital
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Clarkston, Michigan, États-Unis, 48346
- Hematology Oncology Consultants-Clarkston
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Clarkston, Michigan, États-Unis, 48346
- Newland Medical Associates-Clarkston
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Detroit, Michigan, États-Unis, 48236
- Henry Ford Health Saint John Hospital
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East China, Michigan, États-Unis, 48054
- Henry Ford River District Hospital
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Flint, Michigan, États-Unis, 48503
- Hurley Medical Center
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Flint, Michigan, États-Unis, 48503
- Genesee Hematology Oncology PC
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Flint, Michigan, États-Unis, 48503
- Genesys Hurley Cancer Institute
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Flint, Michigan, États-Unis, 48503
- Cancer Hematology Centers - Flint
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Grand Rapids, Michigan, États-Unis, 49503
- Trinity Health Grand Rapids Hospital
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Grand Rapids, Michigan, États-Unis, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
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Grand Rapids, Michigan, États-Unis, 49503
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
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Grosse Pointe Woods, Michigan, États-Unis, 48236
- Henry Ford Saint John Hospital - Academic
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Grosse Pointe Woods, Michigan, États-Unis, 48236
- Henry Ford Saint John Hospital - Breast
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Grosse Pointe Woods, Michigan, États-Unis, 48236
- Henry Ford Saint John Hospital - Van Elslander
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Kalamazoo, Michigan, États-Unis, 49007
- West Michigan Cancer Center
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Kalamazoo, Michigan, États-Unis, 49007
- Bronson Methodist Hospital
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Kalamazoo, Michigan, États-Unis, 49009
- Beacon Kalamazoo Cancer Center
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Kalamazoo, Michigan, États-Unis, 49048
- Beacon Kalamazoo
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Lansing, Michigan, États-Unis, 48912
- University of Michigan Health - Sparrow Lansing
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Livonia, Michigan, États-Unis, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
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Livonia, Michigan, États-Unis, 48154
- Hope Cancer Clinic
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Macomb, Michigan, États-Unis, 48044
- Henry Ford Warren Hospital - Breast Macomb
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Macomb, Michigan, États-Unis, 48044
- Henry Ford Saint John Hospital - Macomb Medical
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Marlette, Michigan, États-Unis, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
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Muskegon, Michigan, États-Unis, 49444
- Trinity Health Muskegon Hospital
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Niles, Michigan, États-Unis, 49120
- Corewell Health Lakeland Hospitals - Niles Hospital
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Norton Shores, Michigan, États-Unis, 49444
- Cancer and Hematology Centers of Western Michigan - Norton Shores
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Pontiac, Michigan, États-Unis, 48341
- Hope Cancer Center
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Pontiac, Michigan, États-Unis, 48341
- Newland Medical Associates-Pontiac
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Pontiac, Michigan, États-Unis, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
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Pontiac, Michigan, États-Unis, 48341
- Michigan Healthcare Professionals Pontiac
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Reed City, Michigan, États-Unis, 49677
- Corewell Health Reed City Hospital
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Rochester Hills, Michigan, États-Unis, 48309
- Henry Ford Rochester Hospital
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Saginaw, Michigan, États-Unis, 48604
- Oncology Hematology Associates of Saginaw Valley PC
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Saginaw, Michigan, États-Unis, 48601
- MyMichigan Medical Center Saginaw
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Saint Joseph, Michigan, États-Unis, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
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Saint Joseph, Michigan, États-Unis, 49085
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital
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Sterling Heights, Michigan, États-Unis, 48312
- Bhadresh Nayak MD PC-Sterling Heights
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Tawas City, Michigan, États-Unis, 48764
- MyMichigan Medical Center Tawas
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Traverse City, Michigan, États-Unis, 49684
- Munson Medical Center
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Warren, Michigan, États-Unis, 48088
- Advanced Breast Care Center PLLC
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Warren, Michigan, États-Unis, 48093
- Macomb Hematology Oncology PC
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Warren, Michigan, États-Unis, 48093
- Henry Ford Madison Heights Hospital - Breast
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Warren, Michigan, États-Unis, 48093
- Henry Ford Health Warren Hospital
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Warren, Michigan, États-Unis, 48093
- Henry Ford Warren Hospital - GLCMS
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West Branch, Michigan, États-Unis, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
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Wyoming, Michigan, États-Unis, 49519
- University of Michigan Health - West
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Ypsilanti, Michigan, États-Unis, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
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Ypsilanti, Michigan, États-Unis, 48106
- Huron Gastroenterology PC
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Minnesota
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Burnsville, Minnesota, États-Unis, 55337
- Fairview Ridges Hospital
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Burnsville, Minnesota, États-Unis, 55337
- Minnesota Oncology - Burnsville
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Cambridge, Minnesota, États-Unis, 55008
- Cambridge Medical Center
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Coon Rapids, Minnesota, États-Unis, 55433
- Mercy Hospital
-
Edina, Minnesota, États-Unis, 55435
- Fairview Southdale Hospital
-
Fridley, Minnesota, États-Unis, 55432
- Unity Hospital
-
Maple Grove, Minnesota, États-Unis, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, États-Unis, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, États-Unis, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, États-Unis, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, États-Unis, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, États-Unis, 55454
- Health Partners Inc
-
Monticello, Minnesota, États-Unis, 55362
- Monticello Cancer Center
-
New Ulm, Minnesota, États-Unis, 56073
- New Ulm Medical Center
-
Princeton, Minnesota, États-Unis, 55371
- Fairview Northland Medical Center
-
Robbinsdale, Minnesota, États-Unis, 55422
- North Memorial Medical Health Center
-
Saint Louis Park, Minnesota, États-Unis, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, États-Unis, 55101
- Regions Hospital
-
Saint Paul, Minnesota, États-Unis, 55102
- United Hospital
-
Shakopee, Minnesota, États-Unis, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, États-Unis, 55082
- Lakeview Hospital
-
Waconia, Minnesota, États-Unis, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, États-Unis, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, États-Unis, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Wyoming, Minnesota, États-Unis, 55092
- Fairview Lakes Medical Center
-
-
Mississippi
-
Columbus, Mississippi, États-Unis, 39705
- Baptist Memorial Hospital and Cancer Center-Golden Triangle
-
Grenada, Mississippi, États-Unis, 38901
- Baptist Cancer Center-Grenada
-
New Albany, Mississippi, États-Unis, 38652
- Baptist Memorial Hospital and Cancer Center-Union County
-
Oxford, Mississippi, États-Unis, 38655
- Baptist Memorial Hospital and Cancer Center-Oxford
-
Southhaven, Mississippi, États-Unis, 38671
- Baptist Memorial Hospital and Cancer Center-Desoto
-
-
Missouri
-
Ballwin, Missouri, États-Unis, 63011
- Mercy Oncology and Hematology - Clayton-Clarkson
-
Bolivar, Missouri, États-Unis, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, États-Unis, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, États-Unis, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, États-Unis, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, États-Unis, 63703
- Mercy Cancer Center - Cape Girardeau
-
City of Saint Peters, Missouri, États-Unis, 63376
- Siteman Cancer Center at Saint Peters Hospital
-
Creve Coeur, Missouri, États-Unis, 63141
- Siteman Cancer Center at West County Hospital
-
Farmington, Missouri, États-Unis, 63640
- Parkland Health Center - Farmington
-
Jefferson City, Missouri, États-Unis, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, États-Unis, 64804
- Freeman Health System
-
Joplin, Missouri, États-Unis, 64804
- Mercy Hospital Joplin
-
Rolla, Missouri, États-Unis, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, États-Unis, 65401
- Phelps Health Delbert Day Cancer Institute
-
Saint Joseph, Missouri, États-Unis, 64506
- Heartland Regional Medical Center
-
Sainte Genevieve, Missouri, États-Unis, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, États-Unis, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, États-Unis, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, États-Unis, 63110
- Washington University School of Medicine
-
St Louis, Missouri, États-Unis, 63129
- Siteman Cancer Center-South County
-
St Louis, Missouri, États-Unis, 63136
- Siteman Cancer Center at Christian Hospital
-
St Louis, Missouri, États-Unis, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, États-Unis, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, États-Unis, 63141
- Mercy Hospital Saint Louis
-
St Louis, Missouri, États-Unis, 63128
- Mercy Hospital South
-
Sullivan, Missouri, États-Unis, 63080
- Missouri Baptist Sullivan Hospital
-
Washington, Missouri, États-Unis, 63090
- Mercy Hospital Washington
-
-
Montana
-
Billings, Montana, États-Unis, 59101
- Saint Vincent Healthcare
-
Billings, Montana, États-Unis, 59102
- Saint Vincent Frontier Cancer Center
-
Butte, Montana, États-Unis, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Missoula, Montana, États-Unis, 59802
- Saint Patrick Hospital - Community Hospital
-
-
Nebraska
-
Bellevue, Nebraska, États-Unis, 68123
- Nebraska Medicine-Bellevue
-
Omaha, Nebraska, États-Unis, 68198
- University of Nebraska Medical Center
-
Omaha, Nebraska, États-Unis, 68118
- Nebraska Medicine-Village Pointe
-
-
Nevada
-
Carson City, Nevada, États-Unis, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, États-Unis, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, États-Unis, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, États-Unis, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, États-Unis, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, États-Unis, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, États-Unis, 89074
- Las Vegas Urology - Green Valley
-
Henderson, Nevada, États-Unis, 89074
- Las Vegas Urology - Pebble
-
Henderson, Nevada, États-Unis, 89074
- Urology Specialists of Nevada - Green Valley
-
Henderson, Nevada, États-Unis, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, États-Unis, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, États-Unis, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, États-Unis, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, États-Unis, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, États-Unis, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, États-Unis, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, États-Unis, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, États-Unis, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, États-Unis, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, États-Unis, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, États-Unis, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, États-Unis, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, États-Unis, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, États-Unis, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, États-Unis, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, États-Unis, 89074
- Las Vegas Urology - Pecos
-
Las Vegas, Nevada, États-Unis, 89102
- Desert West Surgery
-
Las Vegas, Nevada, États-Unis, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, États-Unis, 89106
- Urology Specialists of Nevada - Central
-
Las Vegas, Nevada, États-Unis, 89113
- Las Vegas Prostate Cancer Center
-
Las Vegas, Nevada, États-Unis, 89113
- Las Vegas Urology - Sunset
-
Las Vegas, Nevada, États-Unis, 89128
- Las Vegas Urology - Cathedral Rock
-
Las Vegas, Nevada, États-Unis, 89128
- Las Vegas Urology - Smoke Ranch
-
Las Vegas, Nevada, États-Unis, 89128
- Urology Specialists of Nevada - Northwest
-
Las Vegas, Nevada, États-Unis, 89169
- University Cancer Center
-
Las Vegas, Nevada, États-Unis, 89113
- Urology Specialists of Nevada - Southwest
-
Las Vegas, Nevada, États-Unis, 89128
- Oncology Las Vegas - Tenaya
-
Las Vegas, Nevada, États-Unis, 89183
- OptumCare Cancer Care at Fort Apache
-
Pahrump, Nevada, États-Unis, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, États-Unis, 89502
- Renown Regional Medical Center
-
Reno, Nevada, États-Unis, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, États-Unis, 89509
- Radiation Oncology Associates
-
-
New Jersey
-
Englewood, New Jersey, États-Unis, 07631
- Englewood Hospital and Medical Center
-
Hamilton, New Jersey, États-Unis, 08690
- The Cancer Institute of New Jersey Hamilton
-
Morristown, New Jersey, États-Unis, 07960
- Morristown Medical Center
-
Mullica Hill, New Jersey, États-Unis, 08062
- Inspira Medical Center Mullica Hill
-
New Brunswick, New Jersey, États-Unis, 08903
- Rutgers Cancer Institute of New Jersey
-
Sewell, New Jersey, États-Unis, 08080
- Sidney Kimmel Cancer Center Washington Township
-
Somerville, New Jersey, États-Unis, 08876
- Robert Wood Johnson University Hospital Somerset
-
Summit, New Jersey, États-Unis, 07902
- Overlook Hospital
-
Teaneck, New Jersey, États-Unis, 07666
- Holy Name Hospital
-
Vineland, New Jersey, États-Unis, 08360
- Inspira Medical Center Vineland
-
-
New York
-
Rochester, New York, États-Unis, 14642
- University of Rochester
-
The Bronx, New York, États-Unis, 10461
- Montefiore Medical Center-Einstein Campus
-
The Bronx, New York, États-Unis, 10467
- Montefiore Medical Center - Moses Campus
-
The Bronx, New York, États-Unis, 10461
- Montefiore Medical Center-Weiler Hospital
-
-
Ohio
-
Akron, Ohio, États-Unis, 44307
- Cleveland Clinic Akron General
-
Beachwood, Ohio, États-Unis, 44122
- UHHS-Chagrin Highlands Medical Center
-
Belpre, Ohio, États-Unis, 45714
- Strecker Cancer Center-Belpre
-
Chardon, Ohio, États-Unis, 44024
- Geauga Hospital
-
Chillicothe, Ohio, États-Unis, 45601
- Adena Regional Medical Center
-
Cleveland, Ohio, États-Unis, 44106
- Case Western Reserve University
-
Cleveland, Ohio, États-Unis, 44109
- MetroHealth Medical Center
-
Columbus, Ohio, États-Unis, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, États-Unis, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, États-Unis, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, États-Unis, 43228
- Doctors Hospital
-
Columbus, Ohio, États-Unis, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, États-Unis, 43215
- Grant Medical Center
-
Columbus, Ohio, États-Unis, 43222
- Mount Carmel Health Center West
-
Delaware, Ohio, États-Unis, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, États-Unis, 43015
- Grady Memorial Hospital
-
Dublin, Ohio, États-Unis, 43016
- Dublin Methodist Hospital
-
Dublin, Ohio, États-Unis, 43016
- Columbus Oncology and Hematology Associates
-
Gahanna, Ohio, États-Unis, 43230
- Central Ohio Breast and Endocrine Surgery
-
Grove City, Ohio, États-Unis, 43123
- Mount Carmel Grove City Hospital
-
Lancaster, Ohio, États-Unis, 43130
- Fairfield Medical Center
-
Lima, Ohio, États-Unis, 45801
- Saint Rita's Medical Center
-
Mansfield, Ohio, États-Unis, 44903
- OhioHealth Mansfield Hospital
-
Marietta, Ohio, États-Unis, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, États-Unis, 43302
- OhioHealth Marion General Hospital
-
Mentor, Ohio, États-Unis, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Middleburg Heights, Ohio, États-Unis, 44130
- UH Seidman Cancer Center at Southwest General Hospital
-
Mount Vernon, Ohio, États-Unis, 43050
- Knox Community Hospital
-
Newark, Ohio, États-Unis, 43055
- Licking Memorial Hospital
-
Newark, Ohio, États-Unis, 43055
- Newark Radiation Oncology
-
Parma, Ohio, États-Unis, 44129
- University Hospitals Parma Medical Center
-
Perrysburg, Ohio, États-Unis, 43551
- Mercy Health - Perrysburg Hospital
-
Portsmouth, Ohio, États-Unis, 45662
- Southern Ohio Medical Center
-
Ravenna, Ohio, États-Unis, 44266
- University Hospitals Portage Medical Center
-
Sandusky, Ohio, États-Unis, 44870
- UH Seidman Cancer Center at Firelands Regional Medical Center
-
Toledo, Ohio, États-Unis, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, États-Unis, 43608
- Mercy Health - Saint Vincent Hospital
-
Toledo, Ohio, États-Unis, 43623
- Mercy Health Sylvania Radiation Oncology Center
-
Wadsworth, Ohio, États-Unis, 44281
- University Hospitals Sharon Health Center
-
Westerville, Ohio, États-Unis, 43081
- Saint Ann's Hospital
-
Westlake, Ohio, États-Unis, 44145
- UH Seidman Cancer Center at Saint John Medical Center
-
Zanesville, Ohio, États-Unis, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Oklahoma City, Oklahoma, États-Unis, 73120
- Mercy Hospital Oklahoma City
-
-
Oregon
-
Bend, Oregon, États-Unis, 97701
- Saint Charles Health System
-
Clackamas, Oregon, États-Unis, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, États-Unis, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, États-Unis, 97420
- Bay Area Hospital
-
Newberg, Oregon, États-Unis, 97132
- Providence Newberg Medical Center
-
Portland, Oregon, États-Unis, 97213
- Providence Portland Medical Center
-
Portland, Oregon, États-Unis, 97225
- Providence Saint Vincent Medical Center
-
Redmond, Oregon, États-Unis, 97756
- Saint Charles Health System-Redmond
-
-
Pennsylvania
-
Allentown, Pennsylvania, États-Unis, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, États-Unis, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bryn Mawr, Pennsylvania, États-Unis, 19010
- Bryn Mawr Hospital
-
Chadds Ford, Pennsylvania, États-Unis, 19317
- Christiana Care Health System-Concord Health Center
-
Collegeville, Pennsylvania, États-Unis, 19426
- Main Line Health Center-Collegeville
-
East Norriton, Pennsylvania, États-Unis, 19401
- Fox Chase Cancer Center - East Norriton Hospital Outpatient Center
-
East Stroudsburg, Pennsylvania, États-Unis, 18301
- Pocono Medical Center
-
Exton, Pennsylvania, États-Unis, 19341
- Main Line Health Center-Exton
-
Hazleton, Pennsylvania, États-Unis, 18201
- Lehigh Valley Hospital-Hazleton
-
Media, Pennsylvania, États-Unis, 19063
- Riddle Memorial Hospital
-
Paoli, Pennsylvania, États-Unis, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, États-Unis, 19111
- Fox Chase Cancer Center
-
Philadelphia, Pennsylvania, États-Unis, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, États-Unis, 19114
- Jefferson Torresdale Hospital
-
Philadelphia, Pennsylvania, États-Unis, 19140
- Temple University Hospital
-
Wynnewood, Pennsylvania, États-Unis, 19096
- Lankenau Medical Center
-
-
South Carolina
-
Bluffton, South Carolina, États-Unis, 29910
- Saint Joseph's/Candler - Bluffton Campus
-
Charleston, South Carolina, États-Unis, 29425
- Medical University of South Carolina
-
Georgetown, South Carolina, États-Unis, 29440
- Tidelands Georgetown Memorial Hospital
-
Greenwood, South Carolina, États-Unis, 29646
- Self Regional Healthcare
-
Hilton Head Island, South Carolina, États-Unis, 29926-3827
- South Carolina Cancer Specialists PC
-
West Columbia, South Carolina, États-Unis, 29169
- Lexington Medical Center
-
-
Tennessee
-
Collierville, Tennessee, États-Unis, 38017
- Baptist Memorial Hospital and Cancer Center-Collierville
-
Memphis, Tennessee, États-Unis, 38120
- Baptist Memorial Hospital and Cancer Center-Memphis
-
Memphis, Tennessee, États-Unis, 38120
- Baptist Memorial Hospital for Women
-
-
Texas
-
Beaumont, Texas, États-Unis, 77701
- Baptist Hospitals of Southeast Texas Cancer Center
-
Port Arthur, Texas, États-Unis, 77642
- Baptist Regional Cancer Network-Cancer Center of Southeast Texas
-
-
Utah
-
American Fork, Utah, États-Unis, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, États-Unis, 84720
- Sandra L Maxwell Cancer Center
-
Logan, Utah, États-Unis, 84321
- Logan Regional Hospital
-
Murray, Utah, États-Unis, 84107
- Intermountain Medical Center
-
Ogden, Utah, États-Unis, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, États-Unis, 84604
- Utah Valley Regional Medical Center
-
Riverton, Utah, États-Unis, 84065
- Riverton Hospital
-
Salt Lake City, Utah, États-Unis, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, États-Unis, 84143
- LDS Hospital
-
St. George, Utah, États-Unis, 84770
- Saint George Regional Medical Center
-
-
Virginia
-
Fishersville, Virginia, États-Unis, 22939
- Augusta Health Center for Cancer and Blood Disorders
-
Mechanicsville, Virginia, États-Unis, 23116
- Bon Secours Memorial Regional Medical Center
-
Midlothian, Virginia, États-Unis, 23114
- Bon Secours Saint Francis Medical Center
-
Midlothian, Virginia, États-Unis, 23113
- Bon Secours Westchester Emergency Center
-
Norfolk, Virginia, États-Unis, 23505
- Bon Secours DePaul Medical Center
-
Portsmouth, Virginia, États-Unis, 23707
- Bon Secours Maryview Medical Center
-
Richmond, Virginia, États-Unis, 23226
- Bon Secours Saint Mary's Hospital
-
Richmond, Virginia, États-Unis, 23230
- Bon Secours Cancer Institute at Reynolds Crossing
-
Suffolk, Virginia, États-Unis, 23435
- Bon Secours Health Center at Harbour View
-
-
Washington
-
Aberdeen, Washington, États-Unis, 98520
- Providence Regional Cancer System-Aberdeen
-
Auburn, Washington, États-Unis, 98001
- MultiCare Auburn Medical Center
-
Bellevue, Washington, États-Unis, 98004
- Overlake Medical Center
-
Bellingham, Washington, États-Unis, 98225
- PeaceHealth Saint Joseph Medical Center
-
Centralia, Washington, États-Unis, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, États-Unis, 98026
- Swedish Cancer Institute-Edmonds
-
Everett, Washington, États-Unis, 98201
- Providence Regional Cancer Partnership
-
Gig Harbor, Washington, États-Unis, 98335
- MultiCare Gig Harbor Medical Park
-
Issaquah, Washington, États-Unis, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, États-Unis, 99336
- Kadlec Clinic Hematology and Oncology
-
Lacey, Washington, États-Unis, 98503
- Providence Regional Cancer System-Lacey
-
Longview, Washington, États-Unis, 98632
- PeaceHealth Saint John Medical Center
-
Port Townsend, Washington, États-Unis, 98368
- Jefferson Healthcare
-
Puyallup, Washington, États-Unis, 98372
- MultiCare Good Samaritan Hospital
-
Renton, Washington, États-Unis, 98055
- Valley Medical Center
-
Seattle, Washington, États-Unis, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, États-Unis, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, États-Unis, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, États-Unis, 98122-5711
- Swedish Medical Center-Cherry Hill
-
Sedro-Woolley, Washington, États-Unis, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, États-Unis, 98584
- Providence Regional Cancer System-Shelton
-
Spokane, Washington, États-Unis, 99204
- MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
-
Spokane, Washington, États-Unis, 99218
- MultiCare Deaconess Cancer and Blood Specialty Center - North
-
Spokane Valley, Washington, États-Unis, 99216
- MultiCare Deaconess Cancer and Blood Specialty Center - Valley
-
Tacoma, Washington, États-Unis, 98405
- Mary Bridge Children's Hospital and Health Center
-
Tacoma, Washington, États-Unis, 98405
- MultiCare Tacoma General Hospital
-
Vancouver, Washington, États-Unis, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, États-Unis, 99362
- Providence Saint Mary Regional Cancer Center
-
Yakima, Washington, États-Unis, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
Yelm, Washington, États-Unis, 98597
- Providence Regional Cancer System-Yelm
-
-
Wisconsin
-
Burlington, Wisconsin, États-Unis, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Cudahy, Wisconsin, États-Unis, 53110
- Aurora Saint Luke's South Shore
-
Fond du Lac, Wisconsin, États-Unis, 54937
- Aurora Health Center-Fond du Lac
-
Germantown, Wisconsin, États-Unis, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, États-Unis, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, États-Unis, 54311
- Aurora BayCare Medical Center
-
Kenosha, Wisconsin, États-Unis, 53142
- Aurora Cancer Care-Kenosha South
-
Marinette, Wisconsin, États-Unis, 54143
- Aurora Bay Area Medical Group-Marinette
-
Milwaukee, Wisconsin, États-Unis, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, États-Unis, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, États-Unis, 53233
- Aurora Sinai Medical Center
-
New Richmond, Wisconsin, États-Unis, 54017
- Cancer Center of Western Wisconsin
-
Oshkosh, Wisconsin, États-Unis, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, États-Unis, 53406
- Aurora Cancer Care-Racine
-
Sheboygan, Wisconsin, États-Unis, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Summit, Wisconsin, États-Unis, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, États-Unis, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Wauwatosa, Wisconsin, États-Unis, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, États-Unis, 53227
- Aurora West Allis Medical Center
-
-
Wyoming
-
Cheyenne, Wyoming, États-Unis, 82001
- Cheyenne Regional Medical Center-West
-
-
Critères de participation
Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.
Critère d'éligibilité
Âges éligibles pour étudier
18 ans et plus (Adulte, Adulte plus âgé)
Accepte les volontaires sains
Non
Sexes éligibles pour l'étude
Femelle
La description
Inclusion Criteria:
-
Patients must be women with a known stage I-III invasive breast cancer diagnosis
-
Patients must be capable and willing to provide informed consent
-
Patients must have plans to receive either neoadjuvant or adjuvant:
- Every 3-week docetaxel x 4-6 cycles OR
- Weekly paclitaxel x 4 cycles
- NOTE: Recommended therapies for various therapy regimens are outlined based on estrogen receptor (ER)/progesterone receptor (PR)/HER2 and nodal status. Where there are options, the treating physician will choose a regimen best fitted for that patient. If the physician does not feel any of the regimens are the best fit for the patient, the patient should not be enrolled. Physicians will also document why a regimen was felt to be inappropriate when an option. Patients who have already started the anthracycline portion of their therapy are eligible assuming they have not yet begun the taxane portion and assuming they will be receiving one of the regimens deemed appropriate for her disease setting
-
Patients must self-identify their race as black, African American, or of African descent; patients may be of any ethnicity
-
Patients with a history of other cancers are eligible if they have not received prior taxane or platinum or vinca alkaloid therapy
-
Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1
-
Patients of childbearing potential must be strongly advised to use an accepted and effective method of contraception or to abstain from sexual intercourse for the duration of their participation in the study
Exclusion Criteria:
-
Patients must not have received prior taxane or prior/concurrent platinum therapy
-
Patients must not have received neoadjuvant anti-HER2 therapy
-
Patients must not have pre-existing peripheral neuropathy
-
Patients must not have a total bilirubin > upper limit of normal (ULN) (must be obtained within 3 weeks prior to registration)
-
Patients must not have aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) above 1.5 times the ULN concomitant with alkaline phosphatase above 2.5 times the ULN (must be obtained within 3 weeks prior to registration)
-
Patients must not be pregnant or lactating
- All patients of childbearing potential must have a blood test or urine study within 2 weeks prior to registration to rule out pregnancy
- A patient of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy, or 3) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
Plan d'étude
Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: Soins de soutien
- Répartition: Non randomisé
- Modèle interventionnel: Affectation parallèle
- Masquage: Aucun (étiquette ouverte)
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
|---|---|
|
Expérimental: Arm A (paclitaxel)
Patients receive paclitaxel IV over 3 hours once weekly. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. Patients may also receive trastuzumab and/or pertuzumab per institution routine care per treating physician's discretion. |
Given IV
Autres noms:
Ancillary studies
Autres noms:
Ancillary studies |
|
Expérimental: Arm B (docetaxel)
Patients receive docetaxel IV over 1 hour once every 3 weeks. Treatment repeats every 21 days for 4-6 cycles in the absence of disease progression or unacceptable toxicity. Patients may also receive cyclophosphamide, doxorubicin, trastuzumab, and/or pertuzumab per institution routine care per treating physician's discretion. |
Ancillary studies
Autres noms:
Given IV
Autres noms:
Ancillary studies |
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
Percentage of Participants With Grade 2-4 Taxane-Induced Peripheral Neuropathy (TIPN) by Genotype Risk Group in Arm A
Délai: assessed at baseline, an end of each cycle, at 6 months and 1 year post registration
|
Grade 2-4 TIPN was assessed by treating physician using National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. All patients who started protocol therapy on arm A (paclitaxel) were included in the analysis. The percentage of participants with grade 2-4 TIPN was calculated based on binomial distribution and was compared between high-risk vs low-risk genotype groups using Fisher exact test. Genotype risk group (high vs. low) was determined by genotyping. High-risk genotype was defined by FCAMR GG genotype (homozygous wild type) or SBF2 mutated. Low-risk genotype was defined by carriage of at least one variant allele in FCAMR (AG or AA) and SBF2 wild-type status. |
assessed at baseline, an end of each cycle, at 6 months and 1 year post registration
|
Mesures de résultats secondaires
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
Patient-Reported Neuropathy Score Change Between Baseline and End of Treatment by Genotype Risk Group in Patients on Arm A
Délai: assessed at baseline and at end of treatment, an average of 3 months
|
The patient-reported neurotoxicity was assessed using the 11 items about neurotoxicity in the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group - Neurotoxicity (FACT/GOG-Ntx) questionnaire (i.e., FACT/GOG-Ntx additional concerns subscale). The neurotoxicity total score was the sum of the scores for the 11 items, ranging from 0 to 44. Higher values of the FACT/GOG-Ntx neurotoxicity total score indicate less neurotoxicity. The FACT/GOG-Ntx neurotoxicity total score change between the baseline and at end of treatment (negative value indicates worsening symptom, positive value indicates improving symptom) was calculated and compared using two-sample t test. Genotype risk group (high vs. low) was determined by genotyping. High-risk genotype was defined by FCAMR GG genotype (homozygous wild type) or SBF2 mutated. Low-risk genotype was defined by carriage of at least one variant allele in FCAMR (AG or AA) and SBF2 wild-type status. |
assessed at baseline and at end of treatment, an average of 3 months
|
|
Percentage of Participants With Grade 2-4 TIPN Based on CTCAE Between Arm A and Arm B
Délai: assessed at baseline, an end of each cycle, at 6 months and 1 year post registration
|
Grade 2-4 TIPN was assessed by treating physician using CTCAE version 4.0. All patients who started protocol therapy were included in the analysis. The percentage of participants with grade 2-4 TIPN was calculated based on binomial distribution and was compared between treatment arms using Fisher exact test. |
assessed at baseline, an end of each cycle, at 6 months and 1 year post registration
|
|
Percentage of Participants With Dose Reduction Due to TIPN Between Arm A and Arm B
Délai: Dose reduction due to TIPN was assessed at end of each cycle, up to 4 cycles in arm A and 6 cycles in arm B
|
The percentage of patients with dose reduction due to TIPN was calculated as number of patients with dose reduction due to peripheral neuropathy for any dose of any cycle divided by total number of patients who started protocol therapy. The percentages were calculated along with exact 95% CI based on binomial distribution and were compared between arms using Fisher exact test. |
Dose reduction due to TIPN was assessed at end of each cycle, up to 4 cycles in arm A and 6 cycles in arm B
|
|
Percentage of Participants With Dose Reduction Due to Any Reason Between Arm A and Arm B
Délai: Dose reduction due to any reason was assessed at end of each cycle, up to 4 cycles in arm A and 6 cycles in arm B
|
The percentage of patients with dose reduction due to any reason was calculated as number of patients with any dose reduction for any dose of any cycle, regardless of the reason, divided by total number of patients who started protocol therapy. The percentages were calculated along with exact 95% CI based on binomial distribution and were compared between arms using Fisher exact test. |
Dose reduction due to any reason was assessed at end of each cycle, up to 4 cycles in arm A and 6 cycles in arm B
|
|
Percentage of Participants With Grade 2-4 TIPN by Genotype Risk Group in Arm B
Délai: assessed at baseline, at end of each cycle, at 6 months and 1 year post registration
|
Grade 2-4 TIPN was assessed by treating physician using CTCAE version 4.0. All patients who started protocol therapy on arm B were included in the analysis. The percentage of participants with grade 2-4 TIPN was calculated based on binomial distribution and was compared between high-risk vs low-risk genotype groups using Fisher exact test. Genotype risk group (high vs. low) was determined by genotyping. High-risk genotype was defined by FCAMR GG genotype (homozygous wild type) or SBF2 mutated. Low-risk genotype was defined by carriage of at least one variant allele in FCAMR (AG or AA) and SBF2 wild-type status. |
assessed at baseline, at end of each cycle, at 6 months and 1 year post registration
|
Collaborateurs et enquêteurs
C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.
Parrainer
Collaborateurs
Les enquêteurs
- Chercheur principal: Bryan P Schneider, ECOG-ACRIN Cancer Research Group
Publications et liens utiles
La personne responsable de la saisie des informations sur l'étude fournit volontairement ces publications. Il peut s'agir de tout ce qui concerne l'étude.
Dates d'enregistrement des études
Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.
Dates principales de l'étude
Début de l'étude (Réel)
9 août 2019
Achèvement primaire (Réel)
19 septembre 2023
Achèvement de l'étude (Estimé)
5 avril 2027
Dates d'inscription aux études
Première soumission
19 juin 2019
Première soumission répondant aux critères de contrôle qualité
27 juin 2019
Première publication (Réel)
28 juin 2019
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
6 octobre 2026
Dernière mise à jour soumise répondant aux critères de contrôle qualité
14 septembre 2026
Dernière vérification
1 septembre 2026
Plus d'information
Termes liés à cette étude
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- EAZ171
- UG1CA189828 (Subvention/contrat des NIH des États-Unis)
- EAZ171 (Autre identifiant: CTEP)
- NCI-2019-00266 (Identificateur de registre: CTRP (Clinical Trial Reporting Program))
- ECOG-ACRIN-EAZ171 (Autre identifiant: DCP)
- EAZ171 (Autre identifiant: ECOG-ACRIN Cancer Research Group)
Informations sur les médicaments et les dispositifs, documents d'étude
Étudie un produit pharmaceutique réglementé par la FDA américaine
Non
Étudie un produit d'appareil réglementé par la FDA américaine
Non
Ces informations ont été extraites directement du site Web clinicaltrials.gov sans aucune modification. Si vous avez des demandes de modification, de suppression ou de mise à jour des détails de votre étude, veuillez contacter register@clinicaltrials.gov. Dès qu'un changement est mis en œuvre sur clinicaltrials.gov, il sera également mis à jour automatiquement sur notre site Web .