- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT04001829
Docetaxel eller Paclitaxel til at reducere kemoterapi-induceret perifer neuropati hos afroamerikanske patienter med stadium I-III brystkræft
Prospektiv valideringsforsøg med taxanterapi (docetaxel eller ugentlig paclitaxel) og risiko for kemoterapi-induceret perifer neuropati hos afroamerikanske kvinder
Studieoversigt
Status
Betingelser
- Anatomisk fase I brystkræft AJCC v8
- Anatomisk fase IA brystkræft AJCC v8
- Anatomisk fase IB brystkræft AJCC v8
- Anatomisk fase II brystkræft AJCC v8
- Anatomisk fase IIA brystkræft AJCC v8
- Anatomisk fase IIB brystkræft AJCC v8
- Anatomisk fase III brystkræft AJCC v8
- Anatomisk fase IIIA brystkræft AJCC v8
- Anatomisk fase IIIB brystkræft AJCC v8
- Anatomisk fase IIIC brystkræft AJCC v8
- Prognostisk fase I brystkræft AJCC v8
- Prognostisk stadium IA brystkræft AJCC v8
- Prognostisk stadium IB brystkræft AJCC v8
- Prognostisk fase II brystkræft AJCC v8
- Prognostisk fase IIA brystkræft AJCC v8
- Prognostisk fase IIB brystkræft AJCC v8
- Prognostisk fase III brystkræft AJCC v8
- Prognostisk fase IIIA brystkræft AJCC v8
- Prognostisk stadium IIIB brystkræft AJCC v8
- Prognostisk fase IIIC brystkræft AJCC v8
- Invasivt brystkarcinom
Intervention / Behandling
Detaljeret beskrivelse
PRIMÆRE MÅL:
I. Prospektivt valider en tidligere kimlinjeprædiktor for paclitaxel-induceret perifer neuropati (TIPN) ved brug af Common Terminology Criteria for Adverse Events (CTCAE). Specifikt vil denne undersøgelse demonstrere, at patienter med en højrisiko TIPN-genotype har signifikant mere grad 2-4 TIPN end patienter med en lavrisiko-genotype.
SEKUNDÆRE MÅL:
I. Valider en tidligere kimlinjeprædiktor for TIPN ved hjælp af funktionel vurdering af cancerterapi (FACT)/Gynækologisk onkologigruppe (GOG)-neurotoksicitet (NTX) neurotoksicitetssubskalaen i arm A.
II. Sammenlign grad 2-4 TIPN baseret på CTCAE mellem ugentlig paclitaxel (arm A) versus (vs.) hver tredje uge docetaxel (arm B).
III. Prospektivt bekræftede dosisreduktioner på grund af TIPN er lavere for hver tre-ugers docetaxel sammenlignet med ugentlig paclitaxel i en prospektiv gruppe af patienter af afrikansk oprindelse.
IV. Prospektive bekræftede dosisreduktioner på grund af en hvilken som helst årsag er lavere for hver tre-ugers docetaxel sammenlignet med ugentlig paclitaxel i en prospektiv gruppe af patienter af afrikansk oprindelse.
V. Vurder højrisiko-genotypens evne til at forudsige TIPN-risiko for docetaxel.
SAMMENLIGNENDE UNDERSØGELSESMÅL:
I. Identificer nye markører for TIPN og belys mekanismen. II. Helgenomsekventering af kimlinjeblod for at evaluere for yderligere prædiktorer for TIPN.
III. Skab inducerede pluripotente stamceller (iPSC) afledte neuroner fra patientprøver.
IIIa. Vurder, om kliniske fund kan efterlignes in vitro. IIIb. Evaluer genekspression (ribonukleinsyre [RNA] sekventering [seq]) og epigenomet ved baseline versus efter eksponering hos dem, der er tilbøjelige til TIPN versus dem, der ikke er.
IV. Opret et biodepot af patientafledte prøver til fremtidig translationel forskning.
MÅL FOR RESULTAT RAPPORTEREDE PATIENT:
I. Sammenlign grad 2-4 TIPN (moderat til livstruende) baseret på patientrapporterede resultater (PRO)-CTCAE-punkter mellem ugentlig paclitaxel (arm A) vs. hver tredje uges docetaxel (arm B).
II. Sammenlign prospektivt FACT/GOG-NTX Sundhedsrelateret Livskvalitet (HRQoL) subskala, Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function version (v.)2 Short Form (SF) 10a, score mellem hver tredje uge docetaxel og ugentlig paclitaxel og mellem højrisiko- og lavrisiko-genotyper (arm A) i en kohorte af afrikanske aner.
III. Sammenlign indvirkningen på finansiel toksicitet (Comprehensive Score for Financial Toxicity [COST]-score) for hver tre-ugers docetaxel sammenlignet med ugentlig paclitaxel.
IV. Undersøg sammenhænge mellem sociale determinanter for sundhed (postnummer, civilstand, uddannelse, indkomst og forsikringsstatus) og dosisreduktioner og behandlingsophør.
OVERSIGT: Patienterne tildeles 1 af 2 arme.
ARM A: Patienter får paclitaxel intravenøst (IV) over 3 timer en gang om ugen. Behandlingen gentages hver 21. dag i 4 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienter kan også modtage trastuzumab og/eller pertuzumab pr. institution rutinemæssig behandling pr. behandlende læge. skøn.
ARM B: Patienterne får docetaxel IV over 1 time en gang hver 3. uge. Behandlingen gentages hver 21. dag i 4-6 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienter kan også modtage cyclophosphamid, doxorubicin, trastuzumab og/eller pertuzumab pr. institution rutinemæssig behandling pr. behandlende læge. skøn.
Efter afsluttet undersøgelsesbehandling følges patienterne hver 3. måned i 2 år og derefter hver 6. måned i 3 år.
Undersøgelsestype
Tilmelding (Faktiske)
Fase
- Fase 2
Kontakter og lokationer
Studiesteder
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Alabama
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Birmingham, Alabama, Forenede Stater, 35233
- University of Alabama at Birmingham Cancer Center
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Alaska
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Anchorage, Alaska, Forenede Stater, 98508
- Anchorage Associates in Radiation Medicine
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Oncology and Hematology LLC
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, Forenede Stater, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, Forenede Stater, 99508
- Katmai Oncology Group
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Anchorage, Alaska, Forenede Stater, 99508
- Providence Alaska Medical Center
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Anchorage, Alaska, Forenede Stater, 99504
- Anchorage Radiation Therapy Center
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Fairbanks, Alaska, Forenede Stater, 99701
- Fairbanks Memorial Hospital
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Arizona
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Kingman, Arizona, Forenede Stater, 86401
- Kingman Regional Medical Center
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Arkansas
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Fort Smith, Arkansas, Forenede Stater, 72903
- Mercy Hospital Fort Smith
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Jonesboro, Arkansas, Forenede Stater, 72401
- Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
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California
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Arroyo Grande, California, Forenede Stater, 93420
- PCR Oncology
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Burbank, California, Forenede Stater, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Dublin, California, Forenede Stater, 94568
- Epic Care-Dublin
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Emeryville, California, Forenede Stater, 94608
- Bay Area Breast Surgeons Inc
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Emeryville, California, Forenede Stater, 94608
- Epic Care Partners in Cancer Care
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Martinez, California, Forenede Stater, 94553-3156
- Contra Costa Regional Medical Center
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Oakland, California, Forenede Stater, 94609
- Alta Bates Summit Medical Center - Summit Campus
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Oakland, California, Forenede Stater, 94609
- Bay Area Tumor Institute
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Walnut Creek, California, Forenede Stater, 94597
- Epic Care Cyberknife Center
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Colorado
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Aurora, Colorado, Forenede Stater, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, Forenede Stater, 80012
- The Medical Center of Aurora
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Boulder, Colorado, Forenede Stater, 80301
- Boulder Community Hospital
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Boulder, Colorado, Forenede Stater, 80303
- Boulder Community Foothills Hospital
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Boulder, Colorado, Forenede Stater, 80304
- Rocky Mountain Cancer Centers-Boulder
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Centennial, Colorado, Forenede Stater, 80112
- Rocky Mountain Cancer Centers - Centennial
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Denver, Colorado, Forenede Stater, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, Forenede Stater, 80218
- SCL Health Saint Joseph Hospital
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Denver, Colorado, Forenede Stater, 80220
- Rose Medical Center
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Denver, Colorado, Forenede Stater, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, Forenede Stater, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, Forenede Stater, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, Forenede Stater, 80204
- Cancer Center of Colorado at Sloan's Lake
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Denver, Colorado, Forenede Stater, 80209
- The Women's Imaging Center
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Denver, Colorado, Forenede Stater, 80206
- National Jewish Health-Main Campus
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Denver, Colorado, Forenede Stater, 80220
- Western Surgical Care
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Englewood, Colorado, Forenede Stater, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, Forenede Stater, 80113
- Swedish Medical Center
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Englewood, Colorado, Forenede Stater, 80113
- Rocky Mountain Cancer Centers - Swedish
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Englewood, Colorado, Forenede Stater, 80113
- The Melanoma and Skin Cancer Institute
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Golden, Colorado, Forenede Stater, 80401
- National Jewish Health-Western Hematology Oncology
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Grand Junction, Colorado, Forenede Stater, 81501
- Saint Mary's Hospital and Regional Medical Center
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Greeley, Colorado, Forenede Stater, 80631
- North Colorado Medical Center
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Lafayette, Colorado, Forenede Stater, 80026
- Good Samaritan Medical Center
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Lakewood, Colorado, Forenede Stater, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Littleton, Colorado, Forenede Stater, 80120
- Rocky Mountain Cancer Centers-Littleton
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Lone Tree, Colorado, Forenede Stater, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, Forenede Stater, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Loveland, Colorado, Forenede Stater, 80539
- McKee Medical Center
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Thornton, Colorado, Forenede Stater, 80260
- Rocky Mountain Cancer Centers-Thornton
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Thornton, Colorado, Forenede Stater, 80260
- National Jewish Health-Northern Hematology Oncology
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Wheat Ridge, Colorado, Forenede Stater, 80033
- SCL Health Lutheran Medical Center
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Delaware
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Frankford, Delaware, Forenede Stater, 19945
- Beebe South Coastal Health Campus
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Lewes, Delaware, Forenede Stater, 19958
- Beebe Medical Center
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Newark, Delaware, Forenede Stater, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, Forenede Stater, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, Forenede Stater, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, Forenede Stater, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, Forenede Stater, 19971
- Beebe Health Campus
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Seaford, Delaware, Forenede Stater, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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Wilmington, Delaware, Forenede Stater, 19801
- Christiana Care Health System-Wilmington Hospital
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District of Columbia
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Washington, District of Columbia, Forenede Stater, 20010
- MedStar Washington Hospital Center
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Washington, District of Columbia, Forenede Stater, 20016
- Sibley Memorial Hospital
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Florida
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Fort Lauderdale, Florida, Forenede Stater, 33308
- Holy Cross Hospital
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Gainesville, Florida, Forenede Stater, 32610
- University of Florida Health Science Center - Gainesville
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Georgia
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Atlanta, Georgia, Forenede Stater, 30308
- Emory University Hospital Midtown
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Atlanta, Georgia, Forenede Stater, 30322
- Emory University Hospital/Winship Cancer Institute
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Atlanta, Georgia, Forenede Stater, 30342
- Emory Saint Joseph's Hospital
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Atlanta, Georgia, Forenede Stater, 30303
- Grady Health System
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Atlanta, Georgia, Forenede Stater, 30342
- Northside Hospital
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Columbus, Georgia, Forenede Stater, 31904
- John B Amos Cancer Center
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Duluth, Georgia, Forenede Stater, 30096
- Northside Hospital - Duluth
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Lawrenceville, Georgia, Forenede Stater, 30046
- Northside Hospital - Gwinnett
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Savannah, Georgia, Forenede Stater, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Snellville, Georgia, Forenede Stater, 30078
- Suburban Hematology Oncology Associates - Snellville
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Idaho
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Boise, Idaho, Forenede Stater, 83712
- Saint Luke's Cancer Institute - Boise
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Fruitland, Idaho, Forenede Stater, 83619
- Saint Luke's Cancer Institute - Fruitland
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Meridian, Idaho, Forenede Stater, 83642
- Saint Luke's Cancer Institute - Meridian
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Nampa, Idaho, Forenede Stater, 83686
- Saint Luke's Cancer Institute - Nampa
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Twin Falls, Idaho, Forenede Stater, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Alton, Illinois, Forenede Stater, 62002
- Saint Anthony's Health
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Aurora, Illinois, Forenede Stater, 60504
- Rush - Copley Medical Center
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Bloomington, Illinois, Forenede Stater, 61704
- Illinois CancerCare-Bloomington
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Canton, Illinois, Forenede Stater, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, Forenede Stater, 62902
- Memorial Hospital of Carbondale
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Carterville, Illinois, Forenede Stater, 62918
- SIH Cancer Institute
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Carthage, Illinois, Forenede Stater, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, Forenede Stater, 62801
- Centralia Oncology Clinic
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Chicago, Illinois, Forenede Stater, 60611
- Northwestern University
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Chicago, Illinois, Forenede Stater, 60612
- John H Stroger Jr Hospital of Cook County
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Danville, Illinois, Forenede Stater, 61832
- Carle on Vermilion
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Decatur, Illinois, Forenede Stater, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Forenede Stater, 62526
- Cancer Care Specialists of Illinois - Decatur
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Dixon, Illinois, Forenede Stater, 61021
- Illinois CancerCare-Dixon
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Effingham, Illinois, Forenede Stater, 62401
- Crossroads Cancer Center
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Effingham, Illinois, Forenede Stater, 62401
- Carle Physician Group-Effingham
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Eureka, Illinois, Forenede Stater, 61530
- Illinois CancerCare-Eureka
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Galesburg, Illinois, Forenede Stater, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, Forenede Stater, 61401
- Illinois CancerCare-Galesburg
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Kewanee, Illinois, Forenede Stater, 61443
- Illinois CancerCare-Kewanee Clinic
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Macomb, Illinois, Forenede Stater, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, Forenede Stater, 61938
- Carle Physician Group-Mattoon/Charleston
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Mount Vernon, Illinois, Forenede Stater, 62864
- Good Samaritan Regional Health Center
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O'Fallon, Illinois, Forenede Stater, 62269
- Cancer Care Center of O'Fallon
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Ottawa, Illinois, Forenede Stater, 61350
- Illinois CancerCare-Ottawa Clinic
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Pekin, Illinois, Forenede Stater, 61554
- Illinois CancerCare-Pekin
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Peoria, Illinois, Forenede Stater, 61636
- Methodist Medical Center of Illinois
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Peoria, Illinois, Forenede Stater, 61615
- Illinois CancerCare-Peoria
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Peru, Illinois, Forenede Stater, 61354
- Illinois CancerCare-Peru
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Peru, Illinois, Forenede Stater, 61354
- Valley Radiation Oncology
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Princeton, Illinois, Forenede Stater, 61356
- Illinois CancerCare-Princeton
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Springfield, Illinois, Forenede Stater, 62781
- Memorial Medical Center
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Springfield, Illinois, Forenede Stater, 62702
- Southern Illinois University School of Medicine
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Springfield, Illinois, Forenede Stater, 62702
- Springfield Clinic
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Swansea, Illinois, Forenede Stater, 62226
- Southwest Illinois Health Services LLP
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Urbana, Illinois, Forenede Stater, 61801
- Carle Cancer Center
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Urbana, Illinois, Forenede Stater, 61801
- The Carle Foundation Hospital
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Washington, Illinois, Forenede Stater, 61571
- Illinois CancerCare - Washington
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Yorkville, Illinois, Forenede Stater, 60560
- Rush-Copley Healthcare Center
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Indiana
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Avon, Indiana, Forenede Stater, 46123
- IU Health West Hospital
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Carmel, Indiana, Forenede Stater, 46032
- IU Health North Hospital
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Crown Point, Indiana, Forenede Stater, 46307
- Northwest Cancer Center - Main Campus
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Dyer, Indiana, Forenede Stater, 46311
- Northwest Oncology LLC
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Hobart, Indiana, Forenede Stater, 46342
- Northwest Cancer Center - Hobart
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Hobart, Indiana, Forenede Stater, 46342
- Saint Mary Medical Center
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Indianapolis, Indiana, Forenede Stater, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
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Indianapolis, Indiana, Forenede Stater, 46202
- Sidney and Lois Eskenazi Hospital
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Indianapolis, Indiana, Forenede Stater, 46290
- Springmill Medical Center
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Indianapolis, Indiana, Forenede Stater, 46202
- IU Health Methodist Hospital
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Indianapolis, Indiana, Forenede Stater, 46312
- Saint Catherine Hospital
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Munster, Indiana, Forenede Stater, 46321
- The Community Hospital
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Munster, Indiana, Forenede Stater, 46321
- Women's Diagnostic Center - Munster
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Valparaiso, Indiana, Forenede Stater, 46383
- Northwest Cancer Center - Valparaiso
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Kansas
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Garden City, Kansas, Forenede Stater, 67846
- Central Care Cancer Center - Garden City
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Great Bend, Kansas, Forenede Stater, 67530
- Central Care Cancer Center - Great Bend
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Louisiana
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Baton Rouge, Louisiana, Forenede Stater, 70805
- LSU Health Baton Rouge-North Clinic
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Baton Rouge, Louisiana, Forenede Stater, 70809
- Louisiana Hematology Oncology Associates LLC
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Baton Rouge, Louisiana, Forenede Stater, 70809
- Mary Bird Perkins Cancer Center
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Baton Rouge, Louisiana, Forenede Stater, 70809
- Our Lady of the Lake Physicians Group - Medical Oncology
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Baton Rouge, Louisiana, Forenede Stater, 70808
- Our Lady of The Lake
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Baton Rouge, Louisiana, Forenede Stater, 70817
- Woman's Hospital
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Baton Rouge, Louisiana, Forenede Stater, 70817
- Our Lady of the Lake Medical Oncology
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Baton Rouge, Louisiana, Forenede Stater, 70817
- Louisiana Hematology Oncology Associates
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Covington, Louisiana, Forenede Stater, 70433
- Northshore Oncology Associates-Covington
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Houma, Louisiana, Forenede Stater, 70360
- Terrebonne General Medical Center
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New Orleans, Louisiana, Forenede Stater, 70112
- University Medical Center New Orleans
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New Orleans, Louisiana, Forenede Stater, 70112
- Louisiana State University Health Science Center
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Maryland
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Baltimore, Maryland, Forenede Stater, 21287
- Johns Hopkins University/Sidney Kimmel Cancer Center
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Baltimore, Maryland, Forenede Stater, 21215
- Sinai Hospital of Baltimore
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Baltimore, Maryland, Forenede Stater, 21229
- Saint Agnes Hospital
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Baltimore, Maryland, Forenede Stater, 21239
- MedStar Good Samaritan Hospital
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Easton, Maryland, Forenede Stater, 21601
- University of Maryland Shore Medical Center at Easton
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Randallstown, Maryland, Forenede Stater, 21133
- Northwest Hospital Center
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Westminster, Maryland, Forenede Stater, 21157
- William E Kahlert Regional Cancer Center/Sinai Hospital
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Massachusetts
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Springfield, Massachusetts, Forenede Stater, 01199
- Baystate Medical Center
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Springfield, Massachusetts, Forenede Stater, 01104
- Mercy Medical Center
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Michigan
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Ann Arbor, Michigan, Forenede Stater, 48106
- Saint Joseph Mercy Hospital
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Battle Creek, Michigan, Forenede Stater, 49017
- Bronson Battle Creek
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Brighton, Michigan, Forenede Stater, 48114
- Saint Joseph Mercy Brighton
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Brighton, Michigan, Forenede Stater, 48114
- IHA Hematology Oncology Consultants-Brighton
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Canton, Michigan, Forenede Stater, 48188
- Saint Joseph Mercy Canton
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Canton, Michigan, Forenede Stater, 48188
- IHA Hematology Oncology Consultants-Canton
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Caro, Michigan, Forenede Stater, 48723
- Caro Cancer Center
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Chelsea, Michigan, Forenede Stater, 48118
- Saint Joseph Mercy Chelsea
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Chelsea, Michigan, Forenede Stater, 48118
- IHA Hematology Oncology Consultants-Chelsea
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Clarkston, Michigan, Forenede Stater, 48346
- Hematology Oncology Consultants-Clarkston
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Clarkston, Michigan, Forenede Stater, 48346
- Newland Medical Associates-Clarkston
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Detroit, Michigan, Forenede Stater, 48236
- Ascension Saint John Hospital
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East China Township, Michigan, Forenede Stater, 48054
- Great Lakes Cancer Management Specialists-Doctors Park
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Flint, Michigan, Forenede Stater, 48503
- Hurley Medical Center
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Flint, Michigan, Forenede Stater, 48503
- Genesee Cancer and Blood Disease Treatment Center
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Flint, Michigan, Forenede Stater, 48503
- Genesee Hematology Oncology PC
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Flint, Michigan, Forenede Stater, 48503
- Genesys Hurley Cancer Institute
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Grand Rapids, Michigan, Forenede Stater, 49503
- Spectrum Health at Butterworth Campus
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Grand Rapids, Michigan, Forenede Stater, 49503
- Helen DeVos Children's Hospital at Spectrum Health
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Grand Rapids, Michigan, Forenede Stater, 49503
- Mercy Health Saint Mary's
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Grosse Pointe Woods, Michigan, Forenede Stater, 48236
- Academic Hematology Oncology Specialists
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Grosse Pointe Woods, Michigan, Forenede Stater, 48236
- Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
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Grosse Pointe Woods, Michigan, Forenede Stater, 48236
- Michigan Breast Specialists-Grosse Pointe Woods
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Kalamazoo, Michigan, Forenede Stater, 49007
- West Michigan Cancer Center
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Kalamazoo, Michigan, Forenede Stater, 49007
- Bronson Methodist Hospital
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Kalamazoo, Michigan, Forenede Stater, 49048
- Borgess Medical Center
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Kalamazoo, Michigan, Forenede Stater, 49009
- Ascension Borgess Cancer Center
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Lansing, Michigan, Forenede Stater, 48912
- Sparrow Hospital
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Livonia, Michigan, Forenede Stater, 48154
- Saint Mary Mercy Hospital
-
Livonia, Michigan, Forenede Stater, 48154
- Hope Cancer Clinic
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Macomb, Michigan, Forenede Stater, 48044
- Great Lakes Cancer Management Specialists-Macomb Medical Campus
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Macomb, Michigan, Forenede Stater, 48044
- Michigan Breast Specialists-Macomb Township
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Marlette, Michigan, Forenede Stater, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
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Muskegon, Michigan, Forenede Stater, 49444
- Mercy Health Mercy Campus
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Niles, Michigan, Forenede Stater, 49120
- Lakeland Hospital Niles
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Norton Shores, Michigan, Forenede Stater, 49444
- Cancer and Hematology Centers of Western Michigan - Norton Shores
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Pontiac, Michigan, Forenede Stater, 48341
- Saint Joseph Mercy Oakland
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Pontiac, Michigan, Forenede Stater, 48341
- 21st Century Oncology-Pontiac
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Pontiac, Michigan, Forenede Stater, 48341
- Hope Cancer Center
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Pontiac, Michigan, Forenede Stater, 48341
- Newland Medical Associates-Pontiac
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Reed City, Michigan, Forenede Stater, 49677
- Spectrum Health Reed City Hospital
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Rochester Hills, Michigan, Forenede Stater, 48309
- Great Lakes Cancer Management Specialists-Rochester Hills
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Saginaw, Michigan, Forenede Stater, 48601
- Ascension Saint Mary's Hospital
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Saginaw, Michigan, Forenede Stater, 48604
- Oncology Hematology Associates of Saginaw Valley PC
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Saint Joseph, Michigan, Forenede Stater, 49085
- Lakeland Medical Center Saint Joseph
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Saint Joseph, Michigan, Forenede Stater, 49085
- Marie Yeager Cancer Center
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Sterling Heights, Michigan, Forenede Stater, 48312
- Bhadresh Nayak MD PC-Sterling Heights
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Tawas City, Michigan, Forenede Stater, 48764
- Ascension Saint Joseph Hospital
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Traverse City, Michigan, Forenede Stater, 49684
- Munson Medical Center
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Warren, Michigan, Forenede Stater, 48093
- Saint John Macomb-Oakland Hospital
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Warren, Michigan, Forenede Stater, 48088
- Advanced Breast Care Center PLLC
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Warren, Michigan, Forenede Stater, 48093
- Great Lakes Cancer Management Specialists-Macomb Professional Building
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Warren, Michigan, Forenede Stater, 48093
- Macomb Hematology Oncology PC
-
Warren, Michigan, Forenede Stater, 48093
- Michigan Breast Specialists-Warren
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West Branch, Michigan, Forenede Stater, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
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Wyoming, Michigan, Forenede Stater, 49519
- Metro Health Hospital
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Ypsilanti, Michigan, Forenede Stater, 48106
- Huron Gastroenterology PC
-
Ypsilanti, Michigan, Forenede Stater, 48197
- IHA Hematology Oncology Consultants-Ann Arbor
-
-
Minnesota
-
Burnsville, Minnesota, Forenede Stater, 55337
- Fairview Ridges Hospital
-
Burnsville, Minnesota, Forenede Stater, 55337
- Minnesota Oncology - Burnsville
-
Cambridge, Minnesota, Forenede Stater, 55008
- Cambridge Medical Center
-
Coon Rapids, Minnesota, Forenede Stater, 55433
- Mercy Hospital
-
Edina, Minnesota, Forenede Stater, 55435
- Fairview Southdale Hospital
-
Fridley, Minnesota, Forenede Stater, 55432
- Unity Hospital
-
Maple Grove, Minnesota, Forenede Stater, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, Forenede Stater, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Forenede Stater, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Forenede Stater, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Forenede Stater, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Forenede Stater, 55454
- Health Partners Inc
-
Monticello, Minnesota, Forenede Stater, 55362
- Monticello Cancer Center
-
New Ulm, Minnesota, Forenede Stater, 56073
- New Ulm Medical Center
-
Princeton, Minnesota, Forenede Stater, 55371
- Fairview Northland Medical Center
-
Robbinsdale, Minnesota, Forenede Stater, 55422
- North Memorial Medical Health Center
-
Saint Louis Park, Minnesota, Forenede Stater, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Forenede Stater, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Forenede Stater, 55102
- United Hospital
-
Shakopee, Minnesota, Forenede Stater, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Forenede Stater, 55082
- Lakeview Hospital
-
Waconia, Minnesota, Forenede Stater, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Forenede Stater, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Forenede Stater, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Wyoming, Minnesota, Forenede Stater, 55092
- Fairview Lakes Medical Center
-
-
Mississippi
-
Columbus, Mississippi, Forenede Stater, 39705
- Baptist Memorial Hospital and Cancer Center-Golden Triangle
-
Grenada, Mississippi, Forenede Stater, 38901
- Baptist Cancer Center-Grenada
-
New Albany, Mississippi, Forenede Stater, 38652
- Baptist Memorial Hospital and Cancer Center-Union County
-
Oxford, Mississippi, Forenede Stater, 38655
- Baptist Memorial Hospital and Cancer Center-Oxford
-
Southhaven, Mississippi, Forenede Stater, 38671
- Baptist Memorial Hospital and Cancer Center-Desoto
-
-
Missouri
-
Ballwin, Missouri, Forenede Stater, 63011
- Saint Louis Cancer and Breast Institute-Ballwin
-
Bolivar, Missouri, Forenede Stater, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, Forenede Stater, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, Forenede Stater, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Southeast Cancer Center
-
Creve Coeur, Missouri, Forenede Stater, 63141
- Siteman Cancer Center at West County Hospital
-
Farmington, Missouri, Forenede Stater, 63640
- Parkland Health Center - Farmington
-
Jefferson City, Missouri, Forenede Stater, 65109
- Capital Region Southwest Campus
-
Joplin, Missouri, Forenede Stater, 64804
- Freeman Health System
-
Joplin, Missouri, Forenede Stater, 64804
- Mercy Hospital Joplin
-
Rolla, Missouri, Forenede Stater, 65401
- Delbert Day Cancer Institute at PCRMC
-
Rolla, Missouri, Forenede Stater, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Saint Joseph, Missouri, Forenede Stater, 64506
- Heartland Regional Medical Center
-
Saint Louis, Missouri, Forenede Stater, 63110
- Washington University School of Medicine
-
Saint Louis, Missouri, Forenede Stater, 63131
- Missouri Baptist Medical Center
-
Saint Louis, Missouri, Forenede Stater, 63141
- Mercy Hospital Saint Louis
-
Saint Louis, Missouri, Forenede Stater, 63128
- Mercy Hospital South
-
Saint Louis, Missouri, Forenede Stater, 63129
- Siteman Cancer Center-South County
-
Saint Louis, Missouri, Forenede Stater, 63136
- Siteman Cancer Center at Christian Hospital
-
Saint Louis, Missouri, Forenede Stater, 63109
- Saint Louis Cancer and Breast Institute-South City
-
Saint Peters, Missouri, Forenede Stater, 63376
- Siteman Cancer Center at Saint Peters Hospital
-
Sainte Genevieve, Missouri, Forenede Stater, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Forenede Stater, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Forenede Stater, 65804
- Mercy Hospital Springfield
-
Sullivan, Missouri, Forenede Stater, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, Forenede Stater, 63127
- Missouri Baptist Outpatient Center-Sunset Hills
-
Washington, Missouri, Forenede Stater, 63090
- Mercy Hospital Washington
-
-
Montana
-
Billings, Montana, Forenede Stater, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Forenede Stater, 59102
- Saint Vincent Frontier Cancer Center
-
Butte, Montana, Forenede Stater, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Missoula, Montana, Forenede Stater, 59802
- Saint Patrick Hospital - Community Hospital
-
-
Nebraska
-
Bellevue, Nebraska, Forenede Stater, 68123
- Nebraska Medicine-Bellevue
-
Omaha, Nebraska, Forenede Stater, 68198
- University of Nebraska Medical Center
-
Omaha, Nebraska, Forenede Stater, 68118
- Nebraska Medicine-Village Pointe
-
-
Nevada
-
Carson City, Nevada, Forenede Stater, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, Forenede Stater, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Forenede Stater, 89052
- OptumCare Cancer Care at Seven Hills
-
Henderson, Nevada, Forenede Stater, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Forenede Stater, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Forenede Stater, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Forenede Stater, 89074
- 21st Century Oncology-Henderson
-
Henderson, Nevada, Forenede Stater, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, Forenede Stater, 89074
- Las Vegas Urology - Green Valley
-
Henderson, Nevada, Forenede Stater, 89074
- Las Vegas Urology - Pebble
-
Henderson, Nevada, Forenede Stater, 89074
- Urology Specialists of Nevada - Green Valley
-
Las Vegas, Nevada, Forenede Stater, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Forenede Stater, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, Forenede Stater, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, Forenede Stater, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Forenede Stater, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Forenede Stater, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Forenede Stater, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, Forenede Stater, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, Forenede Stater, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, Forenede Stater, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Forenede Stater, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Forenede Stater, 89148
- OptumCare Cancer Care at Fort Apache
-
Las Vegas, Nevada, Forenede Stater, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Forenede Stater, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Forenede Stater, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Forenede Stater, 89109
- 21st Century Oncology
-
Las Vegas, Nevada, Forenede Stater, 89128
- 21st Century Oncology-Vegas Tenaya
-
Las Vegas, Nevada, Forenede Stater, 89148
- 21st Century Oncology-Fort Apache
-
Las Vegas, Nevada, Forenede Stater, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, Forenede Stater, 89074
- Las Vegas Urology - Pecos
-
Las Vegas, Nevada, Forenede Stater, 89102
- Desert West Surgery
-
Las Vegas, Nevada, Forenede Stater, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, Forenede Stater, 89106
- Urology Specialists of Nevada - Central
-
Las Vegas, Nevada, Forenede Stater, 89113
- Las Vegas Prostate Cancer Center
-
Las Vegas, Nevada, Forenede Stater, 89113
- Las Vegas Urology - Sunset
-
Las Vegas, Nevada, Forenede Stater, 89128
- Las Vegas Urology - Cathedral Rock
-
Las Vegas, Nevada, Forenede Stater, 89128
- Las Vegas Urology - Smoke Ranch
-
Las Vegas, Nevada, Forenede Stater, 89128
- Urology Specialists of Nevada - Northwest
-
Las Vegas, Nevada, Forenede Stater, 89169
- University Cancer Center
-
Las Vegas, Nevada, Forenede Stater, 89113
- Urology Specialists of Nevada - Southwest
-
Pahrump, Nevada, Forenede Stater, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, Forenede Stater, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Forenede Stater, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, Forenede Stater, 89509
- Radiation Oncology Associates
-
-
New Jersey
-
Englewood, New Jersey, Forenede Stater, 07631
- Englewood Hospital and Medical Center
-
Hamilton, New Jersey, Forenede Stater, 08690
- The Cancer Institute of New Jersey Hamilton
-
Morristown, New Jersey, Forenede Stater, 07960
- Morristown Medical Center
-
Mullica Hill, New Jersey, Forenede Stater, 08062
- Inspira Medical Center Mullica Hill
-
New Brunswick, New Jersey, Forenede Stater, 08903
- Rutgers Cancer Institute of New Jersey
-
Sewell, New Jersey, Forenede Stater, 08080
- Sidney Kimmel Cancer Center Washington Township
-
Somerville, New Jersey, Forenede Stater, 08876
- Robert Wood Johnson University Hospital Somerset
-
Summit, New Jersey, Forenede Stater, 07902
- Overlook Hospital
-
Teaneck, New Jersey, Forenede Stater, 07666
- Holy Name Hospital
-
Vineland, New Jersey, Forenede Stater, 08360
- Inspira Medical Center Vineland
-
-
New York
-
Bronx, New York, Forenede Stater, 10461
- Montefiore Medical Center-Einstein Campus
-
Bronx, New York, Forenede Stater, 10467
- Montefiore Medical Center - Moses Campus
-
Bronx, New York, Forenede Stater, 10461
- Montefiore Medical Center-Weiler Hospital
-
Rochester, New York, Forenede Stater, 14642
- University of Rochester
-
-
Ohio
-
Akron, Ohio, Forenede Stater, 44307
- Cleveland Clinic Akron General
-
Beachwood, Ohio, Forenede Stater, 44122
- UHHS-Chagrin Highlands Medical Center
-
Belpre, Ohio, Forenede Stater, 45714
- Strecker Cancer Center-Belpre
-
Chardon, Ohio, Forenede Stater, 44024
- Geauga Hospital
-
Chillicothe, Ohio, Forenede Stater, 45601
- Adena Regional Medical Center
-
Cleveland, Ohio, Forenede Stater, 44106
- Case Western Reserve University
-
Cleveland, Ohio, Forenede Stater, 44109
- MetroHealth Medical Center
-
Columbus, Ohio, Forenede Stater, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Forenede Stater, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Forenede Stater, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Forenede Stater, 43228
- Doctors Hospital
-
Columbus, Ohio, Forenede Stater, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, Forenede Stater, 43215
- Grant Medical Center
-
Columbus, Ohio, Forenede Stater, 43222
- Mount Carmel Health Center West
-
Delaware, Ohio, Forenede Stater, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, Forenede Stater, 43015
- Grady Memorial Hospital
-
Dublin, Ohio, Forenede Stater, 43016
- Dublin Methodist Hospital
-
Gahanna, Ohio, Forenede Stater, 43230
- Central Ohio Breast and Endocrine Surgery
-
Grove City, Ohio, Forenede Stater, 43123
- Mount Carmel Grove City Hospital
-
Lancaster, Ohio, Forenede Stater, 43130
- Fairfield Medical Center
-
Lima, Ohio, Forenede Stater, 45801
- Saint Rita's Medical Center
-
Mansfield, Ohio, Forenede Stater, 44903
- OhioHealth Mansfield Hospital
-
Marietta, Ohio, Forenede Stater, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, Forenede Stater, 43302
- OhioHealth Marion General Hospital
-
Mentor, Ohio, Forenede Stater, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Middleburg Heights, Ohio, Forenede Stater, 44130
- UH Seidman Cancer Center at Southwest General Hospital
-
Mount Vernon, Ohio, Forenede Stater, 43050
- Knox Community Hospital
-
Newark, Ohio, Forenede Stater, 43055
- Licking Memorial Hospital
-
Newark, Ohio, Forenede Stater, 43055
- Newark Radiation Oncology
-
Parma, Ohio, Forenede Stater, 44129
- University Hospitals Parma Medical Center
-
Perrysburg, Ohio, Forenede Stater, 43551
- Mercy Health Perrysburg Cancer Center
-
Portsmouth, Ohio, Forenede Stater, 45662
- Southern Ohio Medical Center
-
Ravenna, Ohio, Forenede Stater, 44266
- University Hospitals Portage Medical Center
-
Sandusky, Ohio, Forenede Stater, 44870
- UH Seidman Cancer Center at Firelands Regional Medical Center
-
Toledo, Ohio, Forenede Stater, 43608
- Saint Vincent Mercy Medical Center
-
Toledo, Ohio, Forenede Stater, 43623
- Mercy Health - Saint Anne Hospital
-
Wadsworth, Ohio, Forenede Stater, 44281
- University Hospitals Sharon Health Center
-
Westerville, Ohio, Forenede Stater, 43081
- Saint Ann's Hospital
-
Westlake, Ohio, Forenede Stater, 44145
- UH Seidman Cancer Center at Saint John Medical Center
-
Zanesville, Ohio, Forenede Stater, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Oklahoma City, Oklahoma, Forenede Stater, 73120
- Mercy Hospital Oklahoma City
-
-
Oregon
-
Bend, Oregon, Forenede Stater, 97701
- Saint Charles Health System
-
Clackamas, Oregon, Forenede Stater, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, Forenede Stater, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Forenede Stater, 97420
- Bay Area Hospital
-
Newberg, Oregon, Forenede Stater, 97132
- Providence Newberg Medical Center
-
Portland, Oregon, Forenede Stater, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Forenede Stater, 97225
- Providence Saint Vincent Medical Center
-
Redmond, Oregon, Forenede Stater, 97756
- Saint Charles Health System-Redmond
-
-
Pennsylvania
-
Allentown, Pennsylvania, Forenede Stater, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, Forenede Stater, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bryn Mawr, Pennsylvania, Forenede Stater, 19010
- Bryn Mawr Hospital
-
Chadds Ford, Pennsylvania, Forenede Stater, 19317
- Christiana Care Health System-Concord Health Center
-
Collegeville, Pennsylvania, Forenede Stater, 19426
- Main Line Health Center-Collegeville
-
East Norriton, Pennsylvania, Forenede Stater, 19401
- Fox Chase Cancer Center - East Norriton Hospital Outpatient Center
-
East Stroudsburg, Pennsylvania, Forenede Stater, 18301
- Pocono Medical Center
-
Exton, Pennsylvania, Forenede Stater, 19341
- Main Line Health Center-Exton
-
Hazleton, Pennsylvania, Forenede Stater, 18201
- Lehigh Valley Hospital-Hazleton
-
Media, Pennsylvania, Forenede Stater, 19063
- Riddle Memorial Hospital
-
Paoli, Pennsylvania, Forenede Stater, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, Forenede Stater, 19111
- Fox Chase Cancer Center
-
Philadelphia, Pennsylvania, Forenede Stater, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Forenede Stater, 19114
- Jefferson Torresdale Hospital
-
Philadelphia, Pennsylvania, Forenede Stater, 19140
- Temple University Hospital
-
Wynnewood, Pennsylvania, Forenede Stater, 19096
- Lankenau Medical Center
-
-
South Carolina
-
Bluffton, South Carolina, Forenede Stater, 29910
- Saint Joseph's/Candler - Bluffton Campus
-
Charleston, South Carolina, Forenede Stater, 29425
- Medical University of South Carolina
-
Georgetown, South Carolina, Forenede Stater, 29440
- Tidelands Georgetown Memorial Hospital
-
Greenwood, South Carolina, Forenede Stater, 29646
- Self Regional Healthcare
-
Hilton Head Island, South Carolina, Forenede Stater, 29926-3827
- South Carolina Cancer Specialists PC
-
West Columbia, South Carolina, Forenede Stater, 29169
- Lexington Medical Center
-
-
Tennessee
-
Collierville, Tennessee, Forenede Stater, 38017
- Baptist Memorial Hospital and Cancer Center-Collierville
-
Memphis, Tennessee, Forenede Stater, 38120
- Baptist Memorial Hospital and Cancer Center-Memphis
-
Memphis, Tennessee, Forenede Stater, 38120
- Baptist Memorial Hospital for Women
-
-
Texas
-
Beaumont, Texas, Forenede Stater, 77701
- Baptist Hospitals of Southeast Texas Cancer Center
-
Port Arthur, Texas, Forenede Stater, 77642
- Baptist Regional Cancer Network-Cancer Center of Southeast Texas
-
-
Utah
-
American Fork, Utah, Forenede Stater, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, Forenede Stater, 84720
- Sandra L Maxwell Cancer Center
-
Logan, Utah, Forenede Stater, 84321
- Logan Regional Hospital
-
Murray, Utah, Forenede Stater, 84107
- Intermountain Medical Center
-
Ogden, Utah, Forenede Stater, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, Forenede Stater, 84604
- Utah Valley Regional Medical Center
-
Riverton, Utah, Forenede Stater, 84065
- Riverton Hospital
-
Saint George, Utah, Forenede Stater, 84770
- Dixie Medical Center Regional Cancer Center
-
Salt Lake City, Utah, Forenede Stater, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, Forenede Stater, 84143
- LDS Hospital
-
-
Virginia
-
Fishersville, Virginia, Forenede Stater, 22939
- Augusta Health Center for Cancer and Blood Disorders
-
Mechanicsville, Virginia, Forenede Stater, 23116
- Bon Secours Memorial Regional Medical Center
-
Midlothian, Virginia, Forenede Stater, 23114
- Bon Secours Saint Francis Medical Center
-
Midlothian, Virginia, Forenede Stater, 23113
- Bon Secours Westchester Emergency Center
-
Norfolk, Virginia, Forenede Stater, 23505
- Bon Secours DePaul Medical Center
-
Portsmouth, Virginia, Forenede Stater, 23707
- Bon Secours Maryview Medical Center
-
Richmond, Virginia, Forenede Stater, 23226
- Bon Secours Saint Mary's Hospital
-
Richmond, Virginia, Forenede Stater, 23230
- Bon Secours Cancer Institute at Reynolds Crossing
-
Suffolk, Virginia, Forenede Stater, 23435
- Bon Secours Health Center at Harbour View
-
-
Washington
-
Aberdeen, Washington, Forenede Stater, 98520
- Providence Regional Cancer System-Aberdeen
-
Auburn, Washington, Forenede Stater, 98001
- MultiCare Auburn Medical Center
-
Bellevue, Washington, Forenede Stater, 98004
- Overlake Medical Center
-
Bellingham, Washington, Forenede Stater, 98225
- PeaceHealth Saint Joseph Medical Center
-
Centralia, Washington, Forenede Stater, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Forenede Stater, 98026
- Swedish Cancer Institute-Edmonds
-
Everett, Washington, Forenede Stater, 98201
- Providence Regional Cancer Partnership
-
Gig Harbor, Washington, Forenede Stater, 98335
- MultiCare Gig Harbor Medical Park
-
Issaquah, Washington, Forenede Stater, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, Forenede Stater, 99336
- Kadlec Clinic Hematology and Oncology
-
Lacey, Washington, Forenede Stater, 98503
- Providence Regional Cancer System-Lacey
-
Longview, Washington, Forenede Stater, 98632
- PeaceHealth Saint John Medical Center
-
Port Townsend, Washington, Forenede Stater, 98368
- Jefferson Healthcare
-
Puyallup, Washington, Forenede Stater, 98372
- MultiCare Good Samaritan Hospital
-
Renton, Washington, Forenede Stater, 98055
- Valley Medical Center
-
Seattle, Washington, Forenede Stater, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, Forenede Stater, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, Forenede Stater, 98122-4307
- Swedish Medical Center-First Hill
-
Seattle, Washington, Forenede Stater, 98122-5711
- Swedish Medical Center-Cherry Hill
-
Sedro-Woolley, Washington, Forenede Stater, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, Forenede Stater, 98584
- Providence Regional Cancer System-Shelton
-
Spokane, Washington, Forenede Stater, 99204
- MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
-
Spokane, Washington, Forenede Stater, 99218
- MultiCare Deaconess Cancer and Blood Specialty Center - North
-
Spokane Valley, Washington, Forenede Stater, 99216
- MultiCare Deaconess Cancer and Blood Specialty Center - Valley
-
Tacoma, Washington, Forenede Stater, 98405
- Mary Bridge Children's Hospital and Health Center
-
Tacoma, Washington, Forenede Stater, 98405
- MultiCare Tacoma General Hospital
-
Vancouver, Washington, Forenede Stater, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, Forenede Stater, 99362
- Providence Saint Mary Regional Cancer Center
-
Yakima, Washington, Forenede Stater, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
Yelm, Washington, Forenede Stater, 98597
- Providence Regional Cancer System-Yelm
-
-
Wisconsin
-
Burlington, Wisconsin, Forenede Stater, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Cudahy, Wisconsin, Forenede Stater, 53110
- Aurora Saint Luke's South Shore
-
Fond Du Lac, Wisconsin, Forenede Stater, 54937
- Aurora Health Center-Fond du Lac
-
Germantown, Wisconsin, Forenede Stater, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Forenede Stater, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Forenede Stater, 54311
- Aurora BayCare Medical Center
-
Kenosha, Wisconsin, Forenede Stater, 53142
- Aurora Cancer Care-Kenosha South
-
Marinette, Wisconsin, Forenede Stater, 54143
- Aurora Bay Area Medical Group-Marinette
-
Milwaukee, Wisconsin, Forenede Stater, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Forenede Stater, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Forenede Stater, 53233
- Aurora Sinai Medical Center
-
New Richmond, Wisconsin, Forenede Stater, 54017
- Cancer Center of Western Wisconsin
-
Oshkosh, Wisconsin, Forenede Stater, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Forenede Stater, 53406
- Aurora Cancer Care-Racine
-
Sheboygan, Wisconsin, Forenede Stater, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Summit, Wisconsin, Forenede Stater, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Forenede Stater, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Wauwatosa, Wisconsin, Forenede Stater, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, Forenede Stater, 53227
- Aurora West Allis Medical Center
-
-
Wyoming
-
Cheyenne, Wyoming, Forenede Stater, 82001
- Cheyenne Regional Medical Center-West
-
-
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Beskrivelse
Inklusionskriterier:
- Patienterne skal være kvinder med en kendt stadium I-III invasiv brystkræftdiagnose. Tilmelding skal ske inden for 84 dage fra datoen for diagnosen
- Patienter skal være i stand til og villige til at give informeret samtykke
Patienter skal have planer om at modtage enten neoadjuvans eller adjuvans:
- Hver 3. uge docetaxel x 4-6 cyklusser ELLER
- Ugentlig paclitaxel x 4 cyklusser
- BEMÆRK: Anbefalede behandlinger til forskellige behandlingsregimer er skitseret baseret på østrogenreceptor (ER)/progesteronreceptor (PR)/HER2 og nodalstatus. Hvor der er muligheder, vil den behandlende læge vælge en kur, der passer bedst til den pågældende patient. Hvis lægen ikke føler, at nogen af kurene passer bedst til patienten, bør patienten ikke indskrives. Læger vil også dokumentere, hvorfor en kur blev anset for at være upassende, når en mulighed
- Patienter skal selv identificere deres race som sort, afroamerikansk eller af afrikansk afstamning; patienter kan være af enhver etnicitet
- Patienter må ikke have modtaget tidligere taxan eller tidligere/samtidig platinbehandling
- Patienter med en historie med andre kræftformer er berettigede, hvis de ikke tidligere har modtaget taxan- eller platin- eller vinca-alkaloidbehandling
- Patienter må ikke have eksisterende perifer neuropati
- Eastern Cooperative Oncology Group (ECOG) præstationsstatus 0-1
- Patienter må ikke have en total bilirubin > øvre normalgrænse (ULN)
- Patienter må ikke have aspartataminotransferase (AST) og/eller alaninaminotransferase (ALT) over 1,5 gange ULN samtidig med alkalisk fosfatase over 2,5 gange ULN
Patienter må ikke være gravide eller ammende
- Alle kvinder i den fødedygtige alder skal have en blodprøve eller urinundersøgelse inden for 2 uger før registrering for at udelukke graviditet
- En kvinde i den fødedygtige alder er enhver kvinde, uanset seksuel orientering eller om de har gennemgået tubal ligering, som opfylder følgende kriterier: 1) har opnået menarche på et tidspunkt, 2) ikke har gennemgået en hysterektomi eller bilateral ooforektomi, eller 3) ikke har været naturligt postmenopausal i mindst 24 på hinanden følgende måneder (dvs. har haft menstruation på noget tidspunkt i de foregående 24 på hinanden følgende måneder)
- Kvinder i den fødedygtige alder skal kraftigt rådes til at bruge en accepteret og effektiv præventionsmetode eller at afholde sig fra samleje i hele deres deltagelse i undersøgelsen
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Støttende pleje
- Tildeling: Ikke-randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
---|---|
Eksperimentel: Arm A (paclitaxel)
Patienter får paclitaxel IV over 3 timer en gang om ugen.
Behandlingen gentages hver 21. dag i 4 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet.
Patienter kan også modtage trastuzumab og/eller pertuzumab pr. institution rutinemæssig behandling efter behandlende læges skøn.
|
Hjælpestudier
Andre navne:
Hjælpestudier
Givet IV
Andre navne:
|
Eksperimentel: Arm B (docetaxel)
Patienterne får docetaxel IV over 1 time en gang hver 3. uge.
Behandlingen gentages hver 21. dag i 4-6 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet.
Patienter kan også modtage cyclophosphamid, doxorubicin, trastuzumab og/eller pertuzumab pr. institution rutinemæssig behandling efter behandlende læges skøn.
|
Hjælpestudier
Andre navne:
Hjælpestudier
Givet IV
Andre navne:
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
Validering af en tidligere kimlinjeprædiktor for paclitaxel-induceret perifer neuropati (arm A)
Tidsramme: Baseline
|
Patienter vil blive kodet til at have hændelsen, så længe grad 2-4 neuropati baseret på Common Terminology Criteria for Adverse Events (CTCAE) version 5.0 forekom på et hvilket som helst tidspunkt i observationsperioden.
Patienter uden neuropati eller med maksimalt grad 1 neuropati i hele observationsperioden vil blive kodet som ingen hændelse.
|
Baseline
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
Grad 2-4 taxan-induceret perifer neuropati (TIPN)
Tidsramme: Op til 3 år efter tilmelding
|
Vil være baseret på CTCAE mellem både arm A versus (vs.)
Arm.
|
Op til 3 år efter tilmelding
|
Patientrelateret udfald (PRO)-baseret neurotoksicitet
Tidsramme: Op til 3 år efter tilmelding
|
Vil blive vurderet ved hjælp af Functional Assessment of Cancer Therapy (FACT)/Gynecologic Oncology Group (GOG)-Neurotoxicity (NTX) spørgeskema.
Den totale score for FACT/GOG-Ntx neurotoksicitet vil blive analyseret som en kontinuerlig variabel.
Lineære blandet effektmodeller med tilfældig intercept (gentagne målinger inden for enkeltpatienter med ustrukturerede kovariansmatricer) vil være egnede til at estimere den gennemsnitlige forskel i FACT/GOG-Ntx neurotoksicitet total score mellem høj versus (vs.) lavrisiko genotype grupper i paclitaxel armen .
Tid og patient- og sygdomskarakteristika vil blive inkluderet som kovariater i den lineære mixed effect model.
Genotype gruppe for tid interaktion vil blive testet for at se, om forskellen mellem de to genotype grupper afhænger af tid.
Til sammenligning mellem arm A og arm B vil FACT/GOG-Ntx-neurotoksicitetens totale scoreændring mellem baseline og ved afslutning af behandlingen blive sammenlignet ved brug af to prøver t-test.
|
Op til 3 år efter tilmelding
|
Sundhedsrelateret livskvalitet (HRQoL) mellem begge arme
Tidsramme: Op til 3 år efter tilmelding
|
Den samlede HRQoL-score vil blive analyseret som en kontinuerlig variabel og sammenlignet mellem lav- og højrisiko genotypegrupper i paclitaxel-armen og mellem paclitaxel-armen og docetaxel-armgrupperne ved hjælp af to-prøver t-tests.
Multivariable lineære blandet effektmodeller vil også være egnede til at evaluere tidstrenden for HRQoL og til at estimere den gennemsnitlige gruppeforskel i HRQoL efter justering for andre kovariater.
Gruppevis interaktion vil blive testet for at se, om forskellen i HRQoL mellem grupper afhænger af tid.
|
Op til 3 år efter tilmelding
|
Fysisk funktion mellem begge arme
Tidsramme: Op til 3 år efter tilmelding
|
Vil blive målt ved hjælp af (PROMIS) Physical Function version (v)2.0
Kort Fra 10a.
PROMIS Physical Function T-scoren vil blive analyseret som en kontinuert variabel, og den vil blive sammenlignet mellem de to behandlingsarme (A&B) og for genotyperne med høj risiko vs. lavrisiko (i arm A) ved hjælp af to-prøver t-tests
|
Op til 3 år efter tilmelding
|
Økonomisk toksicitet mellem begge arme
Tidsramme: Op til 6 måneder efter tilmelding
|
Vil blive vurderet ved hjælp af Comprehensive Score for Financial Toxicity (COST)-score og sammenlignet ved hjælp af en to-prøve t-test.
|
Op til 6 måneder efter tilmelding
|
PRO-CTCAE-score af følelsesløshed, snurren og generel smerte mellem begge arme
Tidsramme: Op til 3 år efter tilmelding
|
Vil præsentere PRO-CTCAE-score for hver egenskab (frekvens, sværhedsgrad og/eller interferens) separat og sammenligne PRO-CTCAE-sværhedsgrad (kodet 0-4) med CTCAE-karakterer for den tilsvarende tidsperiode.
|
Op til 3 år efter tilmelding
|
Andre resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
Sammenhæng mellem socialøkonomiske determinanter for sundhed og behandlingsgennemførelse
Tidsramme: Baseline
|
Sociale sundhedsdeterminanter (postnummer, civilstand, uddannelse, indkomst og forsikringsstatus) vil være forbundet med behandlingsafslutning pr.
|
Baseline
|
Socialøkonomiske determinanter for sundhed og FACT-Ntx neurotoksicitetsscore
Tidsramme: Baseline
|
Sociale determinanter for sundhed (postnummer, civilstand, uddannelse, indkomst og forsikringsstatus) vil være forbundet med FACT-Ntx neurotoksicitetsscores
|
Baseline
|
Sammenhæng mellem sociale determinanter for sundhed og FACT-Ntx HRQoL-score
Tidsramme: Baseline
|
Sociale determinanter for sundhed (postnummer, civilstand, uddannelse, indkomst og forsikringsstatus) vil være forbundet med FACT-Ntx HRQoL-scores
|
Baseline
|
Samarbejdspartnere og efterforskere
Sponsor
Samarbejdspartnere
Efterforskere
- Ledende efterforsker: Bryan P Schneider, ECOG-ACRIN Cancer Research Group
Datoer for undersøgelser
Studer store datoer
Studiestart (Faktiske)
Primær færdiggørelse (Anslået)
Studieafslutning (Anslået)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Faktiske)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Sygdomme i nervesystemet
- Hudsygdomme
- Neoplasmer
- Neoplasmer efter sted
- Brystsygdomme
- Neuromuskulære sygdomme
- Brystneoplasmer
- Sygdomme i det perifere nervesystem
- Molekylære mekanismer for farmakologisk virkning
- Antineoplastiske midler
- Tubulin modulatorer
- Antimitotiske midler
- Mitose modulatorer
- Antineoplastiske midler, fytogene
- Docetaxel
- Paclitaxel
- Albumin-bundet Paclitaxel
Andre undersøgelses-id-numre
- EAZ171 (Anden identifikator: CTEP)
- UG1CA189828 (U.S. NIH-bevilling/kontrakt)
- NCI-2019-00266 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
- ECOG-ACRIN-EAZ171 (Anden identifikator: DCP)
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Studerer et amerikansk FDA-reguleret enhedsprodukt
produkt fremstillet i og eksporteret fra U.S.A.
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
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