Denne siden ble automatisk oversatt og nøyaktigheten av oversettelsen er ikke garantert. Vennligst referer til engelsk versjon for en kildetekst.

Docetaxel eller Paclitaxel for å redusere kjemoterapi-indusert perifer nevropati hos afroamerikanske pasienter med stadium I-III brystkreft

14. september 2026 oppdatert av: ECOG-ACRIN Cancer Research Group

Prospektiv valideringsforsøk av taxanterapi (docetaxel eller ukentlig paklitaksel) og risiko for kjemoterapi-indusert perifer nevropati hos afroamerikanske kvinner

This phase II trial studies how well docetaxel or paclitaxel work in reducing chemotherapy-induced peripheral neuropathy in African American patients with stages I-III breast cancer. Drugs used in chemotherapy, such as docetaxel and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving docetaxel or paclitaxel may work better than other methods in reducing chemotherapy-induced peripheral neuropathy in patients with breast cancer.

Studieoversikt

Status

Aktiv, ikke rekrutterende

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

PRIMARY OBJECTIVE:

I. Prospectively validate a prior germline predictor of paclitaxel-induced peripheral neuropathy (TIPN) using the Common Terminology Criteria for Adverse Events (CTCAE). Specifically, this study will demonstrate that patients with a high-risk TIPN genotype have significantly more grade 2-4 TIPN than patients with a low risk genotype.

SECONDARY OBJECTIVES:

I. Validate a prior germline predictor of TIPN using the Functional Assessment of Cancer Therapy (FACT)/Gynecologic Oncology Group (GOG)-Neurotoxicity (NTX) neurotoxicity subscale in Arm A.

II. Compare grade 2-4 TIPN based on CTCAE between weekly paclitaxel (Arm A) versus (vs.) every three-week docetaxel (Arm B).

III. Prospectively confirm dose reductions due to TIPN are lower for every three-week docetaxel compared with weekly paclitaxel in a prospective cohort of patients of African ancestry.

IV. Prospectively confirm dose reductions due to any cause are lower for every three-week docetaxel compared with weekly paclitaxel in a prospective cohort of patients of African ancestry.

V. Assess the ability of the high-risk genotype to predict TIPN risk for docetaxel.

CORRELATIVE STUDY OBJECTIVES:

I. Identify novel markers of TIPN and elucidate the mechanism. II. Whole genome sequencing of germline blood to evaluate for additional predictors of TIPN.

III. Create induced pluripotent stem cell (iPSC) derived neurons from patient samples.

IIIa. Evaluate whether clinical findings can be mimicked in vitro. IIIb. Evaluate gene expression (ribonucleic acid [RNA] sequencing [seq]) and the epigenome at baseline versus after exposure in those prone to TIPN versus those not.

IV. Create a biorepository of patient derived samples for future translational research.

PATIENT REPORTED OUTCOME OBJECTIVES:

I. Compare grade 2-4 TIPN (moderate to life threatening) based on Patient Reported Outcomes (PRO)-CTCAE items between weekly paclitaxel (Arm A) vs. every three-week docetaxel (Arm B).

II. Prospectively compare FACT/GOG-NTX Health-Related Quality of Life (HRQoL) scores (from the FACT-General [G] portion and Patient-Reported Outcomes Measurement Information System [PROMIS] Physical Function version [v.]2 Short Form [SF] 10a, scores between every three-week docetaxel and weekly paclitaxel and between high risk and low risk genotypes (Arm A) in a cohort of African ancestry.

III. Compare Chemotherapy-Induced Peripheral Neuropathy (CIPN)-20 sensory neuropathy score between weekly paclitaxel (Arm A) vs. every three-week docetaxel (Arm B).

IV. Compare the impact on financial toxicity (Comprehensive Score for Financial Toxicity [COST] scores) for every three-week docetaxel compared with weekly paclitaxel.

V. Examine associations between social determinants of health (zip code, marital status, education, income & insurance status) and dose reductions and treatment discontinuation.

OUTLINE: Patients are assigned to 1 of 2 arms.

ARM A: Patients receive paclitaxel intravenously (IV) over 3 hours once weekly. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. Patients may also receive trastuzumab and/or pertuzumab per institution routine care per treating physician's discretion.

ARM B: Patients receive docetaxel IV over 1 hour once every 3 weeks. Treatment repeats every 21 days for 4-6 cycles in the absence of disease progression or unacceptable toxicity. Patients may also receive cyclophosphamide, doxorubicin, trastuzumab, and/or pertuzumab per institution routine care per treating physician's discretion.

After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.

Studietype

Intervensjonell

Registrering (Faktiske)

249

Fase

Fase 2

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

Forente stater
- Alabama
  - Birmingham, Alabama, Forente stater, 35233
    - University of Alabama at Birmingham Cancer Center
- Alaska
  - Anchorage, Alaska, Forente stater, 98508
    - Anchorage Associates in Radiation Medicine
  - Anchorage, Alaska, Forente stater, 99508
    - Alaska Breast Care and Surgery LLC
  - Anchorage, Alaska, Forente stater, 99508
    - Alaska Oncology and Hematology LLC
  - Anchorage, Alaska, Forente stater, 99508
    - Alaska Women's Cancer Care
  - Anchorage, Alaska, Forente stater, 99508
    - Anchorage Oncology Centre
  - Anchorage, Alaska, Forente stater, 99508
    - Katmai Oncology Group
  - Anchorage, Alaska, Forente stater, 99508
    - Providence Alaska Medical Center
  - Anchorage, Alaska, Forente stater, 99504
    - Anchorage Radiation Therapy Center
  - Fairbanks, Alaska, Forente stater, 99701
    - Fairbanks Memorial Hospital
- Arizona
  - Kingman, Arizona, Forente stater, 86401
    - Kingman Regional Medical Center
- Arkansas
  - Fort Smith, Arkansas, Forente stater, 72903
    - Mercy Hospital Fort Smith
  - Jonesboro, Arkansas, Forente stater, 72401
    - NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
- California
  - Arroyo Grande, California, Forente stater, 93420
    - PCR Oncology
  - Burbank, California, Forente stater, 91505
    - Providence Saint Joseph Medical Center/Disney Family Cancer Center
  - Dublin, California, Forente stater, 94568
    - Epic Care-Dublin
  - Emeryville, California, Forente stater, 94608
    - Bay Area Breast Surgeons Inc
  - Emeryville, California, Forente stater, 94608
    - Epic Care Partners in Cancer Care
  - Martinez, California, Forente stater, 94553-3156
    - Contra Costa Regional Medical Center
  - Oakland, California, Forente stater, 94609
    - Alta Bates Summit Medical Center - Summit Campus
  - Oakland, California, Forente stater, 94609
    - Bay Area Tumor Institute
  - Walnut Creek, California, Forente stater, 94597
    - Epic Care Cyberknife Center
- Colorado
  - Aurora, Colorado, Forente stater, 80012
    - Rocky Mountain Cancer Centers-Aurora
  - Aurora, Colorado, Forente stater, 80012
    - The Medical Center of Aurora
  - Boulder, Colorado, Forente stater, 80303
    - Boulder Community Foothills Hospital
  - Boulder, Colorado, Forente stater, 80304
    - Rocky Mountain Cancer Centers-Boulder
  - Centennial, Colorado, Forente stater, 80112
    - Rocky Mountain Cancer Centers - Centennial
  - Denver, Colorado, Forente stater, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Forente stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forente stater, 80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver, Colorado, Forente stater, 80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver, Colorado, Forente stater, 80218
    - Colorado Blood Cancer Institute
  - Denver, Colorado, Forente stater, 80204
    - Cancer Center of Colorado at Sloan's Lake
  - Denver, Colorado, Forente stater, 80209
    - The Women's Imaging Center
  - Denver, Colorado, Forente stater, 80206
    - National Jewish Health-Main Campus
  - Denver, Colorado, Forente stater, 80220
    - Western Surgical Care
  - Denver, Colorado, Forente stater, 80218
    - Saint Joseph Hospital - Cancer Centers of Colorado
  - Englewood, Colorado, Forente stater, 80113
    - Mountain Blue Cancer Care Center - Swedish
  - Englewood, Colorado, Forente stater, 80113
    - Swedish Medical Center
  - Englewood, Colorado, Forente stater, 80113
    - Rocky Mountain Cancer Centers - Swedish
  - Englewood, Colorado, Forente stater, 80113
    - The Melanoma and Skin Cancer Institute
  - Golden, Colorado, Forente stater, 80401
    - National Jewish Health-Western Hematology Oncology
  - Grand Junction, Colorado, Forente stater, 81501
    - Saint Mary's Hospital and Regional Medical Center
  - Greeley, Colorado, Forente stater, 80631
    - Banner North Colorado Medical Center
  - Lafayette, Colorado, Forente stater, 80026
    - Good Samaritan Hospital - Cancer Centers of Colorado
  - Lakewood, Colorado, Forente stater, 80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Littleton, Colorado, Forente stater, 80120
    - Rocky Mountain Cancer Centers-Littleton
  - Lone Tree, Colorado, Forente stater, 80124
    - Sky Ridge Medical Center
  - Lone Tree, Colorado, Forente stater, 80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Loveland, Colorado, Forente stater, 80539
    - Banner North Colorado Medical Center - Loveland Campus
  - Thornton, Colorado, Forente stater, 80260
    - Rocky Mountain Cancer Centers-Thornton
  - Thornton, Colorado, Forente stater, 80260
    - National Jewish Health-Northern Hematology Oncology
  - Wheat Ridge, Colorado, Forente stater, 80401
    - Intermountain Health Lutheran Hospital
- Delaware
  - Lewes, Delaware, Forente stater, 19958
    - Beebe Medical Center
  - Millville, Delaware, Forente stater, 19967
    - Beebe South Coastal Health Campus
  - Newark, Delaware, Forente stater, 19713
    - Helen F Graham Cancer Center
  - Newark, Delaware, Forente stater, 19713
    - Delaware Clinical and Laboratory Physicians PA
  - Newark, Delaware, Forente stater, 19713
    - Medical Oncology Hematology Consultants PA
  - Newark, Delaware, Forente stater, 19718
    - Christiana Care Health System-Christiana Hospital
  - Rehoboth Beach, Delaware, Forente stater, 19971
    - Beebe Health Campus
  - Seaford, Delaware, Forente stater, 19973
    - TidalHealth Nanticoke / Allen Cancer Center
  - Wilmington, Delaware, Forente stater, 19801
    - Christiana Care Health System-Wilmington Hospital
- District of Columbia
  - Washington D.C., District of Columbia, Forente stater, 20010
    - MedStar Washington Hospital Center
  - Washington D.C., District of Columbia, Forente stater, 20016
    - Sibley Memorial Hospital
- Florida
  - Fort Lauderdale, Florida, Forente stater, 33308
    - Holy Cross Hospital
  - Gainesville, Florida, Forente stater, 32610
    - UF Health Cancer Institute - Gainesville
- Georgia
  - Atlanta, Georgia, Forente stater, 30308
    - Emory University Hospital Midtown
  - Atlanta, Georgia, Forente stater, 30322
    - Emory University Hospital/Winship Cancer Institute
  - Atlanta, Georgia, Forente stater, 30342
    - Emory Saint Joseph's Hospital
  - Atlanta, Georgia, Forente stater, 30303
    - Grady Health System
  - Atlanta, Georgia, Forente stater, 30342
    - Northside Hospital
  - Columbus, Georgia, Forente stater, 31904
    - John B Amos Cancer Center
  - Duluth, Georgia, Forente stater, 30096
    - Northside Hospital - Duluth
  - Lawrenceville, Georgia, Forente stater, 30046
    - Northside Hospital - Gwinnett
  - Savannah, Georgia, Forente stater, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
  - Snellville, Georgia, Forente stater, 30078
    - Suburban Hematology Oncology Associates - Snellville
- Idaho
  - Boise, Idaho, Forente stater, 83712
    - Saint Luke's Cancer Institute - Boise
  - Fruitland, Idaho, Forente stater, 83619
    - Saint Luke's Cancer Institute - Fruitland
  - Meridian, Idaho, Forente stater, 83642
    - Saint Luke's Cancer Institute - Meridian
  - Nampa, Idaho, Forente stater, 83687
    - Saint Luke's Cancer Institute - Nampa
  - Twin Falls, Idaho, Forente stater, 83301
    - Saint Luke's Cancer Institute - Twin Falls
- Illinois
  - Alton, Illinois, Forente stater, 62002
    - OSF Saint Anthony's Health Center
  - Aurora, Illinois, Forente stater, 60504
    - Rush-Copley Medical Center
  - Bloomington, Illinois, Forente stater, 61704
    - Illinois CancerCare-Bloomington
  - Canton, Illinois, Forente stater, 61520
    - Illinois CancerCare-Canton
  - Carbondale, Illinois, Forente stater, 62902
    - Memorial Hospital of Carbondale
  - Carterville, Illinois, Forente stater, 62918
    - SIH Cancer Institute
  - Carthage, Illinois, Forente stater, 62321
    - Illinois CancerCare-Carthage
  - Centralia, Illinois, Forente stater, 62801
    - Centralia Oncology Clinic
  - Chicago, Illinois, Forente stater, 60611
    - Northwestern University
  - Chicago, Illinois, Forente stater, 60612
    - John H Stroger Jr Hospital of Cook County
  - Danville, Illinois, Forente stater, 61832
    - Carle at The Riverfront
  - Decatur, Illinois, Forente stater, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Forente stater, 62526
    - Cancer Care Specialists of Illinois - Decatur
  - Dixon, Illinois, Forente stater, 61021
    - Illinois CancerCare-Dixon
  - Effingham, Illinois, Forente stater, 62401
    - Crossroads Cancer Center
  - Effingham, Illinois, Forente stater, 62401
    - Carle Physician Group-Effingham
  - Eureka, Illinois, Forente stater, 61530
    - Illinois CancerCare-Eureka
  - Galesburg, Illinois, Forente stater, 61401
    - Western Illinois Cancer Treatment Center
  - Galesburg, Illinois, Forente stater, 61401
    - Illinois CancerCare-Galesburg
  - Kewanee, Illinois, Forente stater, 61443
    - Illinois CancerCare-Kewanee Clinic
  - Macomb, Illinois, Forente stater, 61455
    - Illinois CancerCare-Macomb
  - Mattoon, Illinois, Forente stater, 61938
    - Carle Physician Group-Mattoon/Charleston
  - Mount Vernon, Illinois, Forente stater, 62864
    - SSM Health Good Samaritan
  - O'Fallon, Illinois, Forente stater, 62269
    - Cancer Care Center of O'Fallon
  - Ottawa, Illinois, Forente stater, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Pekin, Illinois, Forente stater, 61554
    - Illinois CancerCare-Pekin
  - Peoria, Illinois, Forente stater, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Forente stater, 61615
    - Illinois CancerCare-Peoria
  - Peru, Illinois, Forente stater, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Forente stater, 61354
    - Valley Radiation Oncology
  - Princeton, Illinois, Forente stater, 61356
    - Illinois CancerCare-Princeton
  - Springfield, Illinois, Forente stater, 62702
    - Southern Illinois University School of Medicine
  - Springfield, Illinois, Forente stater, 62702
    - Springfield Clinic
  - Springfield, Illinois, Forente stater, 62781
    - Springfield Memorial Hospital
  - Swansea, Illinois, Forente stater, 62226
    - Southwest Illinois Health Services LLP
  - Urbana, Illinois, Forente stater, 61801
    - Carle Cancer Center
  - Urbana, Illinois, Forente stater, 61801
    - The Carle Foundation Hospital
  - Washington, Illinois, Forente stater, 61571
    - Illinois CancerCare - Washington
  - Yorkville, Illinois, Forente stater, 60560
    - Rush-Copley Healthcare Center
- Indiana
  - Avon, Indiana, Forente stater, 46123
    - IU Health West Hospital
  - Carmel, Indiana, Forente stater, 46032
    - IU Health North Hospital
  - Crown Point, Indiana, Forente stater, 46307
    - Northwest Cancer Center - Crown Point
  - Dyer, Indiana, Forente stater, 46311
    - Northwest Oncology LLC
  - Hobart, Indiana, Forente stater, 46342
    - Northwest Cancer Center - Hobart
  - Hobart, Indiana, Forente stater, 46342
    - Saint Mary Medical Center
  - Indianapolis, Indiana, Forente stater, 46202
    - Indiana University/Melvin and Bren Simon Cancer Center
  - Indianapolis, Indiana, Forente stater, 46202
    - Sidney and Lois Eskenazi Hospital
  - Indianapolis, Indiana, Forente stater, 46290
    - Springmill Medical Center
  - Indianapolis, Indiana, Forente stater, 46202
    - IU Health Methodist Hospital
  - Indianapolis, Indiana, Forente stater, 46312
    - Saint Catherine Hospital
  - Munster, Indiana, Forente stater, 46321
    - The Community Hospital
  - Munster, Indiana, Forente stater, 46321
    - Women's Diagnostic Center - Munster
  - Valparaiso, Indiana, Forente stater, 46383
    - Northwest Cancer Center - Valparaiso
- Kansas
  - Garden City, Kansas, Forente stater, 67846
    - Central Care Cancer Center - Garden City
  - Great Bend, Kansas, Forente stater, 67530
    - Central Care Cancer Center - Great Bend
- Louisiana
  - Baton Rouge, Louisiana, Forente stater, 70805
    - LSU Health Baton Rouge-North Clinic
  - Baton Rouge, Louisiana, Forente stater, 70809
    - Louisiana Hematology Oncology Associates LLC
  - Baton Rouge, Louisiana, Forente stater, 70809
    - Mary Bird Perkins Cancer Center
  - Baton Rouge, Louisiana, Forente stater, 70808
    - Our Lady of The Lake
  - Baton Rouge, Louisiana, Forente stater, 70817
    - Woman's Hospital
  - Baton Rouge, Louisiana, Forente stater, 70817
    - Our Lady of the Lake Medical Oncology
  - Baton Rouge, Louisiana, Forente stater, 70817
    - Louisiana Hematology Oncology Associates
  - Baton Rouge, Louisiana, Forente stater, 70808
    - Our Lady of the Lake Physician Group
  - Covington, Louisiana, Forente stater, 70433
    - Northshore Oncology Associates-Covington
  - Houma, Louisiana, Forente stater, 70360
    - Terrebonne General Medical Center
  - New Orleans, Louisiana, Forente stater, 70112
    - University Medical Center New Orleans
  - New Orleans, Louisiana, Forente stater, 70112
    - Louisiana State University Health Science Center
- Maryland
  - Baltimore, Maryland, Forente stater, 21287
    - Johns Hopkins University/Sidney Kimmel Cancer Center
  - Baltimore, Maryland, Forente stater, 21215
    - Sinai Hospital of Baltimore
  - Baltimore, Maryland, Forente stater, 21229
    - Saint Agnes Hospital
  - Baltimore, Maryland, Forente stater, 21239
    - MedStar Good Samaritan Hospital
  - Easton, Maryland, Forente stater, 21601
    - University of Maryland Shore Medical Center at Easton
  - Randallstown, Maryland, Forente stater, 21133
    - Northwest Hospital Center
  - Westminster, Maryland, Forente stater, 21157
    - William E Kahlert Regional Cancer Center/Sinai Hospital
- Massachusetts
  - Springfield, Massachusetts, Forente stater, 01199
    - Baystate Medical Center
  - Springfield, Massachusetts, Forente stater, 01104
    - Mercy Medical Center
- Michigan
  - Ann Arbor, Michigan, Forente stater, 48106
    - Trinity Health Saint Joseph Mercy Hospital Ann Arbor
  - Battle Creek, Michigan, Forente stater, 49017
    - Bronson Battle Creek
  - Brighton, Michigan, Forente stater, 48114
    - Trinity Health IHA Medical Group Hematology Oncology - Brighton
  - Brighton, Michigan, Forente stater, 48114
    - Trinity Health Medical Center - Brighton
  - Canton, Michigan, Forente stater, 48188
    - Trinity Health IHA Medical Group Hematology Oncology - Canton
  - Canton, Michigan, Forente stater, 48188
    - Trinity Health Medical Center - Canton
  - Caro, Michigan, Forente stater, 48723
    - Caro Cancer Center
  - Chelsea, Michigan, Forente stater, 48118
    - Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
  - Chelsea, Michigan, Forente stater, 48118
    - Chelsea Hospital
  - Clarkston, Michigan, Forente stater, 48346
    - Hematology Oncology Consultants-Clarkston
  - Clarkston, Michigan, Forente stater, 48346
    - Newland Medical Associates-Clarkston
  - Detroit, Michigan, Forente stater, 48236
    - Henry Ford Health Saint John Hospital
  - East China, Michigan, Forente stater, 48054
    - Henry Ford River District Hospital
  - Flint, Michigan, Forente stater, 48503
    - Hurley Medical Center
  - Flint, Michigan, Forente stater, 48503
    - Genesee Hematology Oncology PC
  - Flint, Michigan, Forente stater, 48503
    - Genesys Hurley Cancer Institute
  - Flint, Michigan, Forente stater, 48503
    - Cancer Hematology Centers - Flint
  - Grand Rapids, Michigan, Forente stater, 49503
    - Trinity Health Grand Rapids Hospital
  - Grand Rapids, Michigan, Forente stater, 49503
    - Corewell Health Grand Rapids Hospitals - Butterworth Hospital
  - Grand Rapids, Michigan, Forente stater, 49503
    - Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
  - Grosse Pointe Woods, Michigan, Forente stater, 48236
    - Henry Ford Saint John Hospital - Academic
  - Grosse Pointe Woods, Michigan, Forente stater, 48236
    - Henry Ford Saint John Hospital - Breast
  - Grosse Pointe Woods, Michigan, Forente stater, 48236
    - Henry Ford Saint John Hospital - Van Elslander
  - Kalamazoo, Michigan, Forente stater, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Forente stater, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Forente stater, 49009
    - Beacon Kalamazoo Cancer Center
  - Kalamazoo, Michigan, Forente stater, 49048
    - Beacon Kalamazoo
  - Lansing, Michigan, Forente stater, 48912
    - University of Michigan Health - Sparrow Lansing
  - Livonia, Michigan, Forente stater, 48154
    - Trinity Health Saint Mary Mercy Livonia Hospital
  - Livonia, Michigan, Forente stater, 48154
    - Hope Cancer Clinic
  - Macomb, Michigan, Forente stater, 48044
    - Henry Ford Warren Hospital - Breast Macomb
  - Macomb, Michigan, Forente stater, 48044
    - Henry Ford Saint John Hospital - Macomb Medical
  - Marlette, Michigan, Forente stater, 48453
    - Saint Mary's Oncology/Hematology Associates of Marlette
  - Muskegon, Michigan, Forente stater, 49444
    - Trinity Health Muskegon Hospital
  - Niles, Michigan, Forente stater, 49120
    - Corewell Health Lakeland Hospitals - Niles Hospital
  - Norton Shores, Michigan, Forente stater, 49444
    - Cancer and Hematology Centers of Western Michigan - Norton Shores
  - Pontiac, Michigan, Forente stater, 48341
    - Hope Cancer Center
  - Pontiac, Michigan, Forente stater, 48341
    - Newland Medical Associates-Pontiac
  - Pontiac, Michigan, Forente stater, 48341
    - Trinity Health Saint Joseph Mercy Oakland Hospital
  - Pontiac, Michigan, Forente stater, 48341
    - Michigan Healthcare Professionals Pontiac
  - Reed City, Michigan, Forente stater, 49677
    - Corewell Health Reed City Hospital
  - Rochester Hills, Michigan, Forente stater, 48309
    - Henry Ford Rochester Hospital
  - Saginaw, Michigan, Forente stater, 48604
    - Oncology Hematology Associates of Saginaw Valley PC
  - Saginaw, Michigan, Forente stater, 48601
    - MyMichigan Medical Center Saginaw
  - Saint Joseph, Michigan, Forente stater, 49085
    - Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
  - Saint Joseph, Michigan, Forente stater, 49085
    - Corewell Health Lakeland Hospitals - Saint Joseph Hospital
  - Sterling Heights, Michigan, Forente stater, 48312
    - Bhadresh Nayak MD PC-Sterling Heights
  - Tawas City, Michigan, Forente stater, 48764
    - MyMichigan Medical Center Tawas
  - Traverse City, Michigan, Forente stater, 49684
    - Munson Medical Center
  - Warren, Michigan, Forente stater, 48088
    - Advanced Breast Care Center PLLC
  - Warren, Michigan, Forente stater, 48093
    - Macomb Hematology Oncology PC
  - Warren, Michigan, Forente stater, 48093
    - Henry Ford Madison Heights Hospital - Breast
  - Warren, Michigan, Forente stater, 48093
    - Henry Ford Health Warren Hospital
  - Warren, Michigan, Forente stater, 48093
    - Henry Ford Warren Hospital - GLCMS
  - West Branch, Michigan, Forente stater, 48661
    - Saint Mary's Oncology/Hematology Associates of West Branch
  - Wyoming, Michigan, Forente stater, 49519
    - University of Michigan Health - West
  - Ypsilanti, Michigan, Forente stater, 48197
    - Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
  - Ypsilanti, Michigan, Forente stater, 48106
    - Huron Gastroenterology PC
- Minnesota
  - Burnsville, Minnesota, Forente stater, 55337
    - Fairview Ridges Hospital
  - Burnsville, Minnesota, Forente stater, 55337
    - Minnesota Oncology - Burnsville
  - Cambridge, Minnesota, Forente stater, 55008
    - Cambridge Medical Center
  - Coon Rapids, Minnesota, Forente stater, 55433
    - Mercy Hospital
  - Edina, Minnesota, Forente stater, 55435
    - Fairview Southdale Hospital
  - Fridley, Minnesota, Forente stater, 55432
    - Unity Hospital
  - Maple Grove, Minnesota, Forente stater, 55369
    - Fairview Clinics and Surgery Center Maple Grove
  - Maplewood, Minnesota, Forente stater, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Forente stater, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Forente stater, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Forente stater, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Forente stater, 55454
    - Health Partners Inc
  - Monticello, Minnesota, Forente stater, 55362
    - Monticello Cancer Center
  - New Ulm, Minnesota, Forente stater, 56073
    - New Ulm Medical Center
  - Princeton, Minnesota, Forente stater, 55371
    - Fairview Northland Medical Center
  - Robbinsdale, Minnesota, Forente stater, 55422
    - North Memorial Medical Health Center
  - Saint Louis Park, Minnesota, Forente stater, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Paul, Minnesota, Forente stater, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Forente stater, 55102
    - United Hospital
  - Shakopee, Minnesota, Forente stater, 55379
    - Saint Francis Regional Medical Center
  - Stillwater, Minnesota, Forente stater, 55082
    - Lakeview Hospital
  - Waconia, Minnesota, Forente stater, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Forente stater, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Forente stater, 55125
    - Minnesota Oncology Hematology PA-Woodbury
  - Wyoming, Minnesota, Forente stater, 55092
    - Fairview Lakes Medical Center
- Mississippi
  - Columbus, Mississippi, Forente stater, 39705
    - Baptist Memorial Hospital and Cancer Center-Golden Triangle
  - Grenada, Mississippi, Forente stater, 38901
    - Baptist Cancer Center-Grenada
  - New Albany, Mississippi, Forente stater, 38652
    - Baptist Memorial Hospital and Cancer Center-Union County
  - Oxford, Mississippi, Forente stater, 38655
    - Baptist Memorial Hospital and Cancer Center-Oxford
  - Southhaven, Mississippi, Forente stater, 38671
    - Baptist Memorial Hospital and Cancer Center-Desoto
- Missouri
  - Ballwin, Missouri, Forente stater, 63011
    - Mercy Oncology and Hematology - Clayton-Clarkson
  - Bolivar, Missouri, Forente stater, 65613
    - Central Care Cancer Center - Bolivar
  - Bonne Terre, Missouri, Forente stater, 63628
    - Parkland Health Center-Bonne Terre
  - Branson, Missouri, Forente stater, 65616
    - Cox Cancer Center Branson
  - Cape Girardeau, Missouri, Forente stater, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Forente stater, 63703
    - Mercy Cancer Center - Cape Girardeau
  - City of Saint Peters, Missouri, Forente stater, 63376
    - Siteman Cancer Center at Saint Peters Hospital
  - Creve Coeur, Missouri, Forente stater, 63141
    - Siteman Cancer Center at West County Hospital
  - Farmington, Missouri, Forente stater, 63640
    - Parkland Health Center - Farmington
  - Jefferson City, Missouri, Forente stater, 65109
    - MU Health Care Goldschmidt Cancer Center
  - Joplin, Missouri, Forente stater, 64804
    - Freeman Health System
  - Joplin, Missouri, Forente stater, 64804
    - Mercy Hospital Joplin
  - Rolla, Missouri, Forente stater, 65401
    - Mercy Clinic-Rolla-Cancer and Hematology
  - Rolla, Missouri, Forente stater, 65401
    - Phelps Health Delbert Day Cancer Institute
  - Saint Joseph, Missouri, Forente stater, 64506
    - Heartland Regional Medical Center
  - Sainte Genevieve, Missouri, Forente stater, 63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield, Missouri, Forente stater, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Forente stater, 65804
    - Mercy Hospital Springfield
  - St Louis, Missouri, Forente stater, 63110
    - Washington University School of Medicine
  - St Louis, Missouri, Forente stater, 63129
    - Siteman Cancer Center-South County
  - St Louis, Missouri, Forente stater, 63136
    - Siteman Cancer Center at Christian Hospital
  - St Louis, Missouri, Forente stater, 63131
    - Missouri Baptist Medical Center
  - St Louis, Missouri, Forente stater, 63109
    - Mercy Infusion Center - Chippewa
  - St Louis, Missouri, Forente stater, 63141
    - Mercy Hospital Saint Louis
  - St Louis, Missouri, Forente stater, 63128
    - Mercy Hospital South
  - Sullivan, Missouri, Forente stater, 63080
    - Missouri Baptist Sullivan Hospital
  - Washington, Missouri, Forente stater, 63090
    - Mercy Hospital Washington
- Montana
  - Billings, Montana, Forente stater, 59101
    - Saint Vincent Healthcare
  - Billings, Montana, Forente stater, 59102
    - Saint Vincent Frontier Cancer Center
  - Butte, Montana, Forente stater, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Missoula, Montana, Forente stater, 59802
    - Saint Patrick Hospital - Community Hospital
- Nebraska
  - Bellevue, Nebraska, Forente stater, 68123
    - Nebraska Medicine-Bellevue
  - Omaha, Nebraska, Forente stater, 68198
    - University of Nebraska Medical Center
  - Omaha, Nebraska, Forente stater, 68118
    - Nebraska Medicine-Village Pointe
- Nevada
  - Carson City, Nevada, Forente stater, 89703
    - Carson Tahoe Regional Medical Center
  - Henderson, Nevada, Forente stater, 89052
    - Comprehensive Cancer Centers of Nevada - Henderson
  - Henderson, Nevada, Forente stater, 89052
    - Cancer and Blood Specialists-Henderson
  - Henderson, Nevada, Forente stater, 89052
    - Las Vegas Cancer Center-Henderson
  - Henderson, Nevada, Forente stater, 89074
    - Comprehensive Cancer Centers of Nevada-Southeast Henderson
  - Henderson, Nevada, Forente stater, 89052
    - Comprehensive Cancer Centers of Nevada-Horizon Ridge
  - Henderson, Nevada, Forente stater, 89074
    - Las Vegas Urology - Green Valley
  - Henderson, Nevada, Forente stater, 89074
    - Las Vegas Urology - Pebble
  - Henderson, Nevada, Forente stater, 89074
    - Urology Specialists of Nevada - Green Valley
  - Henderson, Nevada, Forente stater, 89074
    - Oncology Las Vegas - Henderson
  - Las Vegas, Nevada, Forente stater, 89144
    - Summerlin Hospital Medical Center
  - Las Vegas, Nevada, Forente stater, 89109
    - Sunrise Hospital and Medical Center
  - Las Vegas, Nevada, Forente stater, 89102
    - OptumCare Cancer Care at Charleston
  - Las Vegas, Nevada, Forente stater, 89106
    - Radiation Oncology Centers of Nevada Central
  - Las Vegas, Nevada, Forente stater, 89119
    - Radiation Oncology Centers of Nevada Southeast
  - Las Vegas, Nevada, Forente stater, 89128
    - Comprehensive Cancer Centers of Nevada - Northwest
  - Las Vegas, Nevada, Forente stater, 89128
    - OptumCare Cancer Care at MountainView
  - Las Vegas, Nevada, Forente stater, 89135
    - Alliance for Childhood Diseases/Cure 4 the Kids Foundation
  - Las Vegas, Nevada, Forente stater, 89144
    - Comprehensive Cancer Centers of Nevada - Town Center
  - Las Vegas, Nevada, Forente stater, 89144
    - Comprehensive Cancer Centers of Nevada-Summerlin
  - Las Vegas, Nevada, Forente stater, 89148
    - Comprehensive Cancer Centers of Nevada
  - Las Vegas, Nevada, Forente stater, 89169
    - Comprehensive Cancer Centers of Nevada - Central Valley
  - Las Vegas, Nevada, Forente stater, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Forente stater, 89148-2405
    - Las Vegas Cancer Center-Medical Center
  - Las Vegas, Nevada, Forente stater, 89128
    - Ann M Wierman MD LTD
  - Las Vegas, Nevada, Forente stater, 89074
    - Las Vegas Urology - Pecos
  - Las Vegas, Nevada, Forente stater, 89102
    - Desert West Surgery
  - Las Vegas, Nevada, Forente stater, 89103
    - Hope Cancer Care of Nevada
  - Las Vegas, Nevada, Forente stater, 89106
    - Urology Specialists of Nevada - Central
  - Las Vegas, Nevada, Forente stater, 89113
    - Las Vegas Prostate Cancer Center
  - Las Vegas, Nevada, Forente stater, 89113
    - Las Vegas Urology - Sunset
  - Las Vegas, Nevada, Forente stater, 89128
    - Las Vegas Urology - Cathedral Rock
  - Las Vegas, Nevada, Forente stater, 89128
    - Las Vegas Urology - Smoke Ranch
  - Las Vegas, Nevada, Forente stater, 89128
    - Urology Specialists of Nevada - Northwest
  - Las Vegas, Nevada, Forente stater, 89169
    - University Cancer Center
  - Las Vegas, Nevada, Forente stater, 89113
    - Urology Specialists of Nevada - Southwest
  - Las Vegas, Nevada, Forente stater, 89128
    - Oncology Las Vegas - Tenaya
  - Las Vegas, Nevada, Forente stater, 89183
    - OptumCare Cancer Care at Fort Apache
  - Pahrump, Nevada, Forente stater, 89048
    - Hope Cancer Care of Nevada-Pahrump
  - Reno, Nevada, Forente stater, 89502
    - Renown Regional Medical Center
  - Reno, Nevada, Forente stater, 89503
    - Saint Mary's Regional Medical Center
  - Reno, Nevada, Forente stater, 89509
    - Radiation Oncology Associates
- New Jersey
  - Englewood, New Jersey, Forente stater, 07631
    - Englewood Hospital and Medical Center
  - Hamilton, New Jersey, Forente stater, 08690
    - The Cancer Institute of New Jersey Hamilton
  - Morristown, New Jersey, Forente stater, 07960
    - Morristown Medical Center
  - Mullica Hill, New Jersey, Forente stater, 08062
    - Inspira Medical Center Mullica Hill
  - New Brunswick, New Jersey, Forente stater, 08903
    - Rutgers Cancer Institute of New Jersey
  - Sewell, New Jersey, Forente stater, 08080
    - Sidney Kimmel Cancer Center Washington Township
  - Somerville, New Jersey, Forente stater, 08876
    - Robert Wood Johnson University Hospital Somerset
  - Summit, New Jersey, Forente stater, 07902
    - Overlook Hospital
  - Teaneck, New Jersey, Forente stater, 07666
    - Holy Name Hospital
  - Vineland, New Jersey, Forente stater, 08360
    - Inspira Medical Center Vineland
- New York
  - Rochester, New York, Forente stater, 14642
    - University of Rochester
  - The Bronx, New York, Forente stater, 10461
    - Montefiore Medical Center-Einstein Campus
  - The Bronx, New York, Forente stater, 10467
    - Montefiore Medical Center - Moses Campus
  - The Bronx, New York, Forente stater, 10461
    - Montefiore Medical Center-Weiler Hospital
- Ohio
  - Akron, Ohio, Forente stater, 44307
    - Cleveland Clinic Akron General
  - Beachwood, Ohio, Forente stater, 44122
    - UHHS-Chagrin Highlands Medical Center
  - Belpre, Ohio, Forente stater, 45714
    - Strecker Cancer Center-Belpre
  - Chardon, Ohio, Forente stater, 44024
    - Geauga Hospital
  - Chillicothe, Ohio, Forente stater, 45601
    - Adena Regional Medical Center
  - Cleveland, Ohio, Forente stater, 44106
    - Case Western Reserve University
  - Cleveland, Ohio, Forente stater, 44109
    - MetroHealth Medical Center
  - Columbus, Ohio, Forente stater, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Forente stater, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, Forente stater, 43214
    - Columbus Oncology and Hematology Associates Inc
  - Columbus, Ohio, Forente stater, 43228
    - Doctors Hospital
  - Columbus, Ohio, Forente stater, 43213
    - Mount Carmel East Hospital
  - Columbus, Ohio, Forente stater, 43215
    - Grant Medical Center
  - Columbus, Ohio, Forente stater, 43222
    - Mount Carmel Health Center West
  - Delaware, Ohio, Forente stater, 43015
    - Delaware Health Center-Grady Cancer Center
  - Delaware, Ohio, Forente stater, 43015
    - Grady Memorial Hospital
  - Dublin, Ohio, Forente stater, 43016
    - Dublin Methodist Hospital
  - Dublin, Ohio, Forente stater, 43016
    - Columbus Oncology and Hematology Associates
  - Gahanna, Ohio, Forente stater, 43230
    - Central Ohio Breast and Endocrine Surgery
  - Grove City, Ohio, Forente stater, 43123
    - Mount Carmel Grove City Hospital
  - Lancaster, Ohio, Forente stater, 43130
    - Fairfield Medical Center
  - Lima, Ohio, Forente stater, 45801
    - Saint Rita's Medical Center
  - Mansfield, Ohio, Forente stater, 44903
    - OhioHealth Mansfield Hospital
  - Marietta, Ohio, Forente stater, 45750
    - Marietta Memorial Hospital
  - Marion, Ohio, Forente stater, 43302
    - OhioHealth Marion General Hospital
  - Mentor, Ohio, Forente stater, 44060
    - UH Seidman Cancer Center at Lake Health Mentor Campus
  - Middleburg Heights, Ohio, Forente stater, 44130
    - UH Seidman Cancer Center at Southwest General Hospital
  - Mount Vernon, Ohio, Forente stater, 43050
    - Knox Community Hospital
  - Newark, Ohio, Forente stater, 43055
    - Licking Memorial Hospital
  - Newark, Ohio, Forente stater, 43055
    - Newark Radiation Oncology
  - Parma, Ohio, Forente stater, 44129
    - University Hospitals Parma Medical Center
  - Perrysburg, Ohio, Forente stater, 43551
    - Mercy Health - Perrysburg Hospital
  - Portsmouth, Ohio, Forente stater, 45662
    - Southern Ohio Medical Center
  - Ravenna, Ohio, Forente stater, 44266
    - University Hospitals Portage Medical Center
  - Sandusky, Ohio, Forente stater, 44870
    - UH Seidman Cancer Center at Firelands Regional Medical Center
  - Toledo, Ohio, Forente stater, 43623
    - Mercy Health - Saint Anne Hospital
  - Toledo, Ohio, Forente stater, 43608
    - Mercy Health - Saint Vincent Hospital
  - Toledo, Ohio, Forente stater, 43623
    - Mercy Health Sylvania Radiation Oncology Center
  - Wadsworth, Ohio, Forente stater, 44281
    - University Hospitals Sharon Health Center
  - Westerville, Ohio, Forente stater, 43081
    - Saint Ann's Hospital
  - Westlake, Ohio, Forente stater, 44145
    - UH Seidman Cancer Center at Saint John Medical Center
  - Zanesville, Ohio, Forente stater, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Oklahoma City, Oklahoma, Forente stater, 73120
    - Mercy Hospital Oklahoma City
- Oregon
  - Bend, Oregon, Forente stater, 97701
    - Saint Charles Health System
  - Clackamas, Oregon, Forente stater, 97015
    - Clackamas Radiation Oncology Center
  - Clackamas, Oregon, Forente stater, 97015
    - Providence Cancer Institute Clackamas Clinic
  - Coos Bay, Oregon, Forente stater, 97420
    - Bay Area Hospital
  - Newberg, Oregon, Forente stater, 97132
    - Providence Newberg Medical Center
  - Portland, Oregon, Forente stater, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Forente stater, 97225
    - Providence Saint Vincent Medical Center
  - Redmond, Oregon, Forente stater, 97756
    - Saint Charles Health System-Redmond
- Pennsylvania
  - Allentown, Pennsylvania, Forente stater, 18103
    - Lehigh Valley Hospital-Cedar Crest
  - Bethlehem, Pennsylvania, Forente stater, 18017
    - Lehigh Valley Hospital - Muhlenberg
  - Bryn Mawr, Pennsylvania, Forente stater, 19010
    - Bryn Mawr Hospital
  - Chadds Ford, Pennsylvania, Forente stater, 19317
    - Christiana Care Health System-Concord Health Center
  - Collegeville, Pennsylvania, Forente stater, 19426
    - Main Line Health Center-Collegeville
  - East Norriton, Pennsylvania, Forente stater, 19401
    - Fox Chase Cancer Center - East Norriton Hospital Outpatient Center
  - East Stroudsburg, Pennsylvania, Forente stater, 18301
    - Pocono Medical Center
  - Exton, Pennsylvania, Forente stater, 19341
    - Main Line Health Center-Exton
  - Hazleton, Pennsylvania, Forente stater, 18201
    - Lehigh Valley Hospital-Hazleton
  - Media, Pennsylvania, Forente stater, 19063
    - Riddle Memorial Hospital
  - Paoli, Pennsylvania, Forente stater, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Forente stater, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Forente stater, 19107
    - Thomas Jefferson University Hospital
  - Philadelphia, Pennsylvania, Forente stater, 19114
    - Jefferson Torresdale Hospital
  - Philadelphia, Pennsylvania, Forente stater, 19140
    - Temple University Hospital
  - Wynnewood, Pennsylvania, Forente stater, 19096
    - Lankenau Medical Center
- South Carolina
  - Bluffton, South Carolina, Forente stater, 29910
    - Saint Joseph's/Candler - Bluffton Campus
  - Charleston, South Carolina, Forente stater, 29425
    - Medical University of South Carolina
  - Georgetown, South Carolina, Forente stater, 29440
    - Tidelands Georgetown Memorial Hospital
  - Greenwood, South Carolina, Forente stater, 29646
    - Self Regional Healthcare
  - Hilton Head Island, South Carolina, Forente stater, 29926-3827
    - South Carolina Cancer Specialists PC
  - West Columbia, South Carolina, Forente stater, 29169
    - Lexington Medical Center
- Tennessee
  - Collierville, Tennessee, Forente stater, 38017
    - Baptist Memorial Hospital and Cancer Center-Collierville
  - Memphis, Tennessee, Forente stater, 38120
    - Baptist Memorial Hospital and Cancer Center-Memphis
  - Memphis, Tennessee, Forente stater, 38120
    - Baptist Memorial Hospital for Women
- Texas
  - Beaumont, Texas, Forente stater, 77701
    - Baptist Hospitals of Southeast Texas Cancer Center
  - Port Arthur, Texas, Forente stater, 77642
    - Baptist Regional Cancer Network-Cancer Center of Southeast Texas
- Utah
  - American Fork, Utah, Forente stater, 84003
    - American Fork Hospital / Huntsman Intermountain Cancer Center
  - Cedar City, Utah, Forente stater, 84720
    - Sandra L Maxwell Cancer Center
  - Logan, Utah, Forente stater, 84321
    - Logan Regional Hospital
  - Murray, Utah, Forente stater, 84107
    - Intermountain Medical Center
  - Ogden, Utah, Forente stater, 84403
    - McKay-Dee Hospital Center
  - Provo, Utah, Forente stater, 84604
    - Utah Valley Regional Medical Center
  - Riverton, Utah, Forente stater, 84065
    - Riverton Hospital
  - Salt Lake City, Utah, Forente stater, 84106
    - Utah Cancer Specialists-Salt Lake City
  - Salt Lake City, Utah, Forente stater, 84143
    - LDS Hospital
  - St. George, Utah, Forente stater, 84770
    - Saint George Regional Medical Center
- Virginia
  - Fishersville, Virginia, Forente stater, 22939
    - Augusta Health Center for Cancer and Blood Disorders
  - Mechanicsville, Virginia, Forente stater, 23116
    - Bon Secours Memorial Regional Medical Center
  - Midlothian, Virginia, Forente stater, 23114
    - Bon Secours Saint Francis Medical Center
  - Midlothian, Virginia, Forente stater, 23113
    - Bon Secours Westchester Emergency Center
  - Norfolk, Virginia, Forente stater, 23505
    - Bon Secours DePaul Medical Center
  - Portsmouth, Virginia, Forente stater, 23707
    - Bon Secours Maryview Medical Center
  - Richmond, Virginia, Forente stater, 23226
    - Bon Secours Saint Mary's Hospital
  - Richmond, Virginia, Forente stater, 23230
    - Bon Secours Cancer Institute at Reynolds Crossing
  - Suffolk, Virginia, Forente stater, 23435
    - Bon Secours Health Center at Harbour View
- Washington
  - Aberdeen, Washington, Forente stater, 98520
    - Providence Regional Cancer System-Aberdeen
  - Auburn, Washington, Forente stater, 98001
    - MultiCare Auburn Medical Center
  - Bellevue, Washington, Forente stater, 98004
    - Overlake Medical Center
  - Bellingham, Washington, Forente stater, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Centralia, Washington, Forente stater, 98531
    - Providence Regional Cancer System-Centralia
  - Edmonds, Washington, Forente stater, 98026
    - Swedish Cancer Institute-Edmonds
  - Everett, Washington, Forente stater, 98201
    - Providence Regional Cancer Partnership
  - Gig Harbor, Washington, Forente stater, 98335
    - MultiCare Gig Harbor Medical Park
  - Issaquah, Washington, Forente stater, 98029
    - Swedish Cancer Institute-Issaquah
  - Kennewick, Washington, Forente stater, 99336
    - Kadlec Clinic Hematology and Oncology
  - Lacey, Washington, Forente stater, 98503
    - Providence Regional Cancer System-Lacey
  - Longview, Washington, Forente stater, 98632
    - PeaceHealth Saint John Medical Center
  - Port Townsend, Washington, Forente stater, 98368
    - Jefferson Healthcare
  - Puyallup, Washington, Forente stater, 98372
    - MultiCare Good Samaritan Hospital
  - Renton, Washington, Forente stater, 98055
    - Valley Medical Center
  - Seattle, Washington, Forente stater, 98107
    - Swedish Medical Center-Ballard Campus
  - Seattle, Washington, Forente stater, 98122
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Forente stater, 98104
    - Pacific Gynecology Specialists
  - Seattle, Washington, Forente stater, 98122-5711
    - Swedish Medical Center-Cherry Hill
  - Sedro-Woolley, Washington, Forente stater, 98284
    - PeaceHealth United General Medical Center
  - Shelton, Washington, Forente stater, 98584
    - Providence Regional Cancer System-Shelton
  - Spokane, Washington, Forente stater, 99204
    - MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
  - Spokane, Washington, Forente stater, 99218
    - MultiCare Deaconess Cancer and Blood Specialty Center - North
  - Spokane Valley, Washington, Forente stater, 99216
    - MultiCare Deaconess Cancer and Blood Specialty Center - Valley
  - Tacoma, Washington, Forente stater, 98405
    - Mary Bridge Children's Hospital and Health Center
  - Tacoma, Washington, Forente stater, 98405
    - MultiCare Tacoma General Hospital
  - Vancouver, Washington, Forente stater, 98664
    - PeaceHealth Southwest Medical Center
  - Walla Walla, Washington, Forente stater, 99362
    - Providence Saint Mary Regional Cancer Center
  - Yakima, Washington, Forente stater, 98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
  - Yelm, Washington, Forente stater, 98597
    - Providence Regional Cancer System-Yelm
- Wisconsin
  - Burlington, Wisconsin, Forente stater, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Cudahy, Wisconsin, Forente stater, 53110
    - Aurora Saint Luke's South Shore
  - Fond du Lac, Wisconsin, Forente stater, 54937
    - Aurora Health Center-Fond du Lac
  - Germantown, Wisconsin, Forente stater, 53022
    - Aurora Health Care Germantown Health Center
  - Grafton, Wisconsin, Forente stater, 53024
    - Aurora Cancer Care-Grafton
  - Green Bay, Wisconsin, Forente stater, 54311
    - Aurora BayCare Medical Center
  - Kenosha, Wisconsin, Forente stater, 53142
    - Aurora Cancer Care-Kenosha South
  - Marinette, Wisconsin, Forente stater, 54143
    - Aurora Bay Area Medical Group-Marinette
  - Milwaukee, Wisconsin, Forente stater, 53209
    - Aurora Cancer Care-Milwaukee
  - Milwaukee, Wisconsin, Forente stater, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Forente stater, 53233
    - Aurora Sinai Medical Center
  - New Richmond, Wisconsin, Forente stater, 54017
    - Cancer Center of Western Wisconsin
  - Oshkosh, Wisconsin, Forente stater, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Forente stater, 53406
    - Aurora Cancer Care-Racine
  - Sheboygan, Wisconsin, Forente stater, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Summit, Wisconsin, Forente stater, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Forente stater, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Wauwatosa, Wisconsin, Forente stater, 53226
    - Aurora Cancer Care-Milwaukee West
  - West Allis, Wisconsin, Forente stater, 53227
    - Aurora West Allis Medical Center
- Wyoming
  - Cheyenne, Wyoming, Forente stater, 82001
    - Cheyenne Regional Medical Center-West

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

18 år og eldre (Voksen, Eldre voksen)

Tar imot friske frivillige

Nei

Kjønn som er kvalifisert for studier

Hunn

Beskrivelse

Inclusion Criteria:

Patients must be women with a known stage I-III invasive breast cancer diagnosis
Patients must be capable and willing to provide informed consent
Patients must have plans to receive either neoadjuvant or adjuvant:
- Every 3-week docetaxel x 4-6 cycles OR
- Weekly paclitaxel x 4 cycles
- NOTE: Recommended therapies for various therapy regimens are outlined based on estrogen receptor (ER)/progesterone receptor (PR)/HER2 and nodal status. Where there are options, the treating physician will choose a regimen best fitted for that patient. If the physician does not feel any of the regimens are the best fit for the patient, the patient should not be enrolled. Physicians will also document why a regimen was felt to be inappropriate when an option. Patients who have already started the anthracycline portion of their therapy are eligible assuming they have not yet begun the taxane portion and assuming they will be receiving one of the regimens deemed appropriate for her disease setting
Patients must self-identify their race as black, African American, or of African descent; patients may be of any ethnicity
Patients with a history of other cancers are eligible if they have not received prior taxane or platinum or vinca alkaloid therapy
Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1
Patients of childbearing potential must be strongly advised to use an accepted and effective method of contraception or to abstain from sexual intercourse for the duration of their participation in the study

Exclusion Criteria:

Patients must not have received prior taxane or prior/concurrent platinum therapy
Patients must not have received neoadjuvant anti-HER2 therapy
Patients must not have pre-existing peripheral neuropathy
Patients must not have a total bilirubin > upper limit of normal (ULN) (must be obtained within 3 weeks prior to registration)
Patients must not have aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) above 1.5 times the ULN concomitant with alkaline phosphatase above 2.5 times the ULN (must be obtained within 3 weeks prior to registration)
Patients must not be pregnant or lactating
- All patients of childbearing potential must have a blood test or urine study within 2 weeks prior to registration to rule out pregnancy
- A patient of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy, or 3) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

Primært formål: Støttende omsorg
Tildeling: Ikke-randomisert
Intervensjonsmodell: Parallell tildeling
Masking: Ingen (Open Label)

Antall våpen

Våpen og intervensjoner

Deltakergruppe / Arm	Intervensjon / Behandling
Eksperimentell: Arm A (paclitaxel) Patients receive paclitaxel IV over 3 hours once weekly. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. Patients may also receive trastuzumab and/or pertuzumab per institution routine care per treating physician's discretion.	Legemiddel: Paclitaxel Given IV Andre navn: Taxol Anzatax Asotax Bristaxol Praxel Taxol Konzentrat Annen: Quality-of-Life Assessment Ancillary studies Andre navn: Livskvalitetsvurdering Annen: Questionnaire Administration Ancillary studies
Eksperimentell: Arm B (docetaxel) Patients receive docetaxel IV over 1 hour once every 3 weeks. Treatment repeats every 21 days for 4-6 cycles in the absence of disease progression or unacceptable toxicity. Patients may also receive cyclophosphamide, doxorubicin, trastuzumab, and/or pertuzumab per institution routine care per treating physician's discretion.	Annen: Quality-of-Life Assessment Ancillary studies Andre navn: Livskvalitetsvurdering Legemiddel: Docetaxel Given IV Andre navn: Taxotere Docecad RP56976 Taxotere injeksjonskonsentrat RP 56976 RP-56976 Annen: Questionnaire Administration Ancillary studies

Hva måler studien?

Primære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Percentage of Participants With Grade 2-4 Taxane-Induced Peripheral Neuropathy (TIPN) by Genotype Risk Group in Arm A Tidsramme: assessed at baseline, an end of each cycle, at 6 months and 1 year post registration	Grade 2-4 TIPN was assessed by treating physician using National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. All patients who started protocol therapy on arm A (paclitaxel) were included in the analysis. The percentage of participants with grade 2-4 TIPN was calculated based on binomial distribution and was compared between high-risk vs low-risk genotype groups using Fisher exact test. Genotype risk group (high vs. low) was determined by genotyping. High-risk genotype was defined by FCAMR GG genotype (homozygous wild type) or SBF2 mutated. Low-risk genotype was defined by carriage of at least one variant allele in FCAMR (AG or AA) and SBF2 wild-type status.	assessed at baseline, an end of each cycle, at 6 months and 1 year post registration

Sekundære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Patient-Reported Neuropathy Score Change Between Baseline and End of Treatment by Genotype Risk Group in Patients on Arm A Tidsramme: assessed at baseline and at end of treatment, an average of 3 months	The patient-reported neurotoxicity was assessed using the 11 items about neurotoxicity in the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group - Neurotoxicity (FACT/GOG-Ntx) questionnaire (i.e., FACT/GOG-Ntx additional concerns subscale). The neurotoxicity total score was the sum of the scores for the 11 items, ranging from 0 to 44. Higher values of the FACT/GOG-Ntx neurotoxicity total score indicate less neurotoxicity. The FACT/GOG-Ntx neurotoxicity total score change between the baseline and at end of treatment (negative value indicates worsening symptom, positive value indicates improving symptom) was calculated and compared using two-sample t test. Genotype risk group (high vs. low) was determined by genotyping. High-risk genotype was defined by FCAMR GG genotype (homozygous wild type) or SBF2 mutated. Low-risk genotype was defined by carriage of at least one variant allele in FCAMR (AG or AA) and SBF2 wild-type status.	assessed at baseline and at end of treatment, an average of 3 months
Percentage of Participants With Grade 2-4 TIPN Based on CTCAE Between Arm A and Arm B Tidsramme: assessed at baseline, an end of each cycle, at 6 months and 1 year post registration	Grade 2-4 TIPN was assessed by treating physician using CTCAE version 4.0. All patients who started protocol therapy were included in the analysis. The percentage of participants with grade 2-4 TIPN was calculated based on binomial distribution and was compared between treatment arms using Fisher exact test.	assessed at baseline, an end of each cycle, at 6 months and 1 year post registration
Percentage of Participants With Dose Reduction Due to TIPN Between Arm A and Arm B Tidsramme: Dose reduction due to TIPN was assessed at end of each cycle, up to 4 cycles in arm A and 6 cycles in arm B	The percentage of patients with dose reduction due to TIPN was calculated as number of patients with dose reduction due to peripheral neuropathy for any dose of any cycle divided by total number of patients who started protocol therapy. The percentages were calculated along with exact 95% CI based on binomial distribution and were compared between arms using Fisher exact test.	Dose reduction due to TIPN was assessed at end of each cycle, up to 4 cycles in arm A and 6 cycles in arm B
Percentage of Participants With Dose Reduction Due to Any Reason Between Arm A and Arm B Tidsramme: Dose reduction due to any reason was assessed at end of each cycle, up to 4 cycles in arm A and 6 cycles in arm B	The percentage of patients with dose reduction due to any reason was calculated as number of patients with any dose reduction for any dose of any cycle, regardless of the reason, divided by total number of patients who started protocol therapy. The percentages were calculated along with exact 95% CI based on binomial distribution and were compared between arms using Fisher exact test.	Dose reduction due to any reason was assessed at end of each cycle, up to 4 cycles in arm A and 6 cycles in arm B
Percentage of Participants With Grade 2-4 TIPN by Genotype Risk Group in Arm B Tidsramme: assessed at baseline, at end of each cycle, at 6 months and 1 year post registration	Grade 2-4 TIPN was assessed by treating physician using CTCAE version 4.0. All patients who started protocol therapy on arm B were included in the analysis. The percentage of participants with grade 2-4 TIPN was calculated based on binomial distribution and was compared between high-risk vs low-risk genotype groups using Fisher exact test. Genotype risk group (high vs. low) was determined by genotyping. High-risk genotype was defined by FCAMR GG genotype (homozygous wild type) or SBF2 mutated. Low-risk genotype was defined by carriage of at least one variant allele in FCAMR (AG or AA) and SBF2 wild-type status.	assessed at baseline, at end of each cycle, at 6 months and 1 year post registration

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

ECOG-ACRIN Cancer Research Group

Samarbeidspartnere

National Cancer Institute (NCI)

Etterforskere

Hovedetterforsker: Bryan P Schneider, ECOG-ACRIN Cancer Research Group

Publikasjoner og nyttige lenker

Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.

Generelle publikasjoner

Schneider BP, Zhao F, Ballinger TJ, Garcia SF, Shen F, Virani S, Cella D, Bales C, Jiang G, Hayes L, Miller N, Srinivasiah J, Stringer-Reasor EM, Chitalia A, Davis AA, Makower DF, Incorvati J, Simon MA, Mitchell EP, DeMichele A, Miller KD, Sparano JA, Wagner LI, Wolff AC. ECOG-ACRIN EAZ171: Prospective Validation Trial of Germline Predictors of Taxane-Induced Peripheral Neuropathy in Black Women With Early-Stage Breast Cancer. J Clin Oncol. 2024 Aug 20;42(24):2899-2907. doi: 10.1200/JCO.24.00526. Epub 2024 Jun 3.

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

9. august 2019

Primær fullføring (Faktiske)

19. september 2023

Studiet fullført (Antatt)

5. april 2027

Datoer for studieregistrering

Først innsendt

19. juni 2019

Først innsendt som oppfylte QC-kriteriene

27. juni 2019

Først lagt ut (Faktiske)

28. juni 2019

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

6. oktober 2026

Siste oppdatering sendt inn som oppfylte QC-kriteriene

14. september 2026

Sist bekreftet

1. september 2026

Mer informasjon

Begreper knyttet til denne studien

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

EAZ171
UG1CA189828 (U.S. NIH-stipend/kontrakt)
EAZ171 (Annen identifikator: CTEP)
NCI-2019-00266 (Registeridentifikator: CTRP (Clinical Trial Reporting Program))
ECOG-ACRIN-EAZ171 (Annen identifikator: DCP)
EAZ171 (Annen identifikator: ECOG-ACRIN Cancer Research Group)

Legemiddel- og utstyrsinformasjon, studiedokumenter

Studerer et amerikansk FDA-regulert medikamentprodukt

Nei

Studerer et amerikansk FDA-regulert enhetsprodukt

Nei

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

Docetaxel eller Paclitaxel for å redusere kjemoterapi-indusert perifer nevropati hos afroamerikanske pasienter med stadium I-III brystkreft

Prospektiv valideringsforsøk av taxanterapi (docetaxel eller ukentlig paklitaksel) og risiko for kjemoterapi-indusert perifer nevropati hos afroamerikanske kvinner

Studieoversikt

Status

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

Studietype

Registrering (Faktiske)

Fase

Kontakter og plasseringer

Studiesteder

Deltakelseskriterier

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

Tar imot friske frivillige

Kjønn som er kvalifisert for studier

Beskrivelse

Studieplan

Hvordan er studiet utformet?

Designdetaljer

Antall våpen

Våpen og intervensjoner

Deltakergruppe / Arm

Intervensjon / Behandling

Hva måler studien?

Primære resultatmål

Resultatmål

Tiltaksbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Tiltaksbeskrivelse

Tidsramme

Samarbeidspartnere og etterforskere

Sponsor

Samarbeidspartnere

Etterforskere

Publikasjoner og nyttige lenker

Generelle publikasjoner

Studierekorddatoer

Studer hoveddatoer

Studiestart (Faktiske)

Primær fullføring (Faktiske)

Studiet fullført (Antatt)

Datoer for studieregistrering

Først innsendt

Først innsendt som oppfylte QC-kriteriene

Først lagt ut (Faktiske)

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

Siste oppdatering sendt inn som oppfylte QC-kriteriene

Sist bekreftet

Mer informasjon

Begreper knyttet til denne studien

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

Legemiddel- og utstyrsinformasjon, studiedokumenter

Studerer et amerikansk FDA-regulert medikamentprodukt

Studerer et amerikansk FDA-regulert enhetsprodukt