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Docetaxel eller paklitaxel för att minska kemoterapi-inducerad perifer neuropati hos afroamerikanska patienter med stadium I-III bröstcancer

14 september 2026 uppdaterad av: ECOG-ACRIN Cancer Research Group

Prospektiv valideringsstudie av taxanterapi (docetaxel eller veckopaklitaxel) och risk för kemoterapiinducerad perifer neuropati hos afroamerikanska kvinnor

This phase II trial studies how well docetaxel or paclitaxel work in reducing chemotherapy-induced peripheral neuropathy in African American patients with stages I-III breast cancer. Drugs used in chemotherapy, such as docetaxel and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving docetaxel or paclitaxel may work better than other methods in reducing chemotherapy-induced peripheral neuropathy in patients with breast cancer.

Studieöversikt

Status

Aktiv, inte rekryterande

Betingelser

Intervention / Behandling

Detaljerad beskrivning

PRIMARY OBJECTIVE:

I. Prospectively validate a prior germline predictor of paclitaxel-induced peripheral neuropathy (TIPN) using the Common Terminology Criteria for Adverse Events (CTCAE). Specifically, this study will demonstrate that patients with a high-risk TIPN genotype have significantly more grade 2-4 TIPN than patients with a low risk genotype.

SECONDARY OBJECTIVES:

I. Validate a prior germline predictor of TIPN using the Functional Assessment of Cancer Therapy (FACT)/Gynecologic Oncology Group (GOG)-Neurotoxicity (NTX) neurotoxicity subscale in Arm A.

II. Compare grade 2-4 TIPN based on CTCAE between weekly paclitaxel (Arm A) versus (vs.) every three-week docetaxel (Arm B).

III. Prospectively confirm dose reductions due to TIPN are lower for every three-week docetaxel compared with weekly paclitaxel in a prospective cohort of patients of African ancestry.

IV. Prospectively confirm dose reductions due to any cause are lower for every three-week docetaxel compared with weekly paclitaxel in a prospective cohort of patients of African ancestry.

V. Assess the ability of the high-risk genotype to predict TIPN risk for docetaxel.

CORRELATIVE STUDY OBJECTIVES:

I. Identify novel markers of TIPN and elucidate the mechanism. II. Whole genome sequencing of germline blood to evaluate for additional predictors of TIPN.

III. Create induced pluripotent stem cell (iPSC) derived neurons from patient samples.

IIIa. Evaluate whether clinical findings can be mimicked in vitro. IIIb. Evaluate gene expression (ribonucleic acid [RNA] sequencing [seq]) and the epigenome at baseline versus after exposure in those prone to TIPN versus those not.

IV. Create a biorepository of patient derived samples for future translational research.

PATIENT REPORTED OUTCOME OBJECTIVES:

I. Compare grade 2-4 TIPN (moderate to life threatening) based on Patient Reported Outcomes (PRO)-CTCAE items between weekly paclitaxel (Arm A) vs. every three-week docetaxel (Arm B).

II. Prospectively compare FACT/GOG-NTX Health-Related Quality of Life (HRQoL) scores (from the FACT-General [G] portion and Patient-Reported Outcomes Measurement Information System [PROMIS] Physical Function version [v.]2 Short Form [SF] 10a, scores between every three-week docetaxel and weekly paclitaxel and between high risk and low risk genotypes (Arm A) in a cohort of African ancestry.

III. Compare Chemotherapy-Induced Peripheral Neuropathy (CIPN)-20 sensory neuropathy score between weekly paclitaxel (Arm A) vs. every three-week docetaxel (Arm B).

IV. Compare the impact on financial toxicity (Comprehensive Score for Financial Toxicity [COST] scores) for every three-week docetaxel compared with weekly paclitaxel.

V. Examine associations between social determinants of health (zip code, marital status, education, income & insurance status) and dose reductions and treatment discontinuation.

OUTLINE: Patients are assigned to 1 of 2 arms.

ARM A: Patients receive paclitaxel intravenously (IV) over 3 hours once weekly. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. Patients may also receive trastuzumab and/or pertuzumab per institution routine care per treating physician's discretion.

ARM B: Patients receive docetaxel IV over 1 hour once every 3 weeks. Treatment repeats every 21 days for 4-6 cycles in the absence of disease progression or unacceptable toxicity. Patients may also receive cyclophosphamide, doxorubicin, trastuzumab, and/or pertuzumab per institution routine care per treating physician's discretion.

After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.

Studietyp

Interventionell

Inskrivning (Faktisk)

249

Fas

Fas 2

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Studieorter

Förenta staterna
- Alabama
  - Birmingham, Alabama, Förenta staterna, 35233
    - University of Alabama at Birmingham Cancer Center
- Alaska
  - Anchorage, Alaska, Förenta staterna, 98508
    - Anchorage Associates in Radiation Medicine
  - Anchorage, Alaska, Förenta staterna, 99508
    - Alaska Breast Care and Surgery LLC
  - Anchorage, Alaska, Förenta staterna, 99508
    - Alaska Oncology and Hematology LLC
  - Anchorage, Alaska, Förenta staterna, 99508
    - Alaska Women's Cancer Care
  - Anchorage, Alaska, Förenta staterna, 99508
    - Anchorage Oncology Centre
  - Anchorage, Alaska, Förenta staterna, 99508
    - Katmai Oncology Group
  - Anchorage, Alaska, Förenta staterna, 99508
    - Providence Alaska Medical Center
  - Anchorage, Alaska, Förenta staterna, 99504
    - Anchorage Radiation Therapy Center
  - Fairbanks, Alaska, Förenta staterna, 99701
    - Fairbanks Memorial Hospital
- Arizona
  - Kingman, Arizona, Förenta staterna, 86401
    - Kingman Regional Medical Center
- Arkansas
  - Fort Smith, Arkansas, Förenta staterna, 72903
    - Mercy Hospital Fort Smith
  - Jonesboro, Arkansas, Förenta staterna, 72401
    - NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
- California
  - Arroyo Grande, California, Förenta staterna, 93420
    - PCR Oncology
  - Burbank, California, Förenta staterna, 91505
    - Providence Saint Joseph Medical Center/Disney Family Cancer Center
  - Dublin, California, Förenta staterna, 94568
    - Epic Care-Dublin
  - Emeryville, California, Förenta staterna, 94608
    - Bay Area Breast Surgeons Inc
  - Emeryville, California, Förenta staterna, 94608
    - Epic Care Partners in Cancer Care
  - Martinez, California, Förenta staterna, 94553-3156
    - Contra Costa Regional Medical Center
  - Oakland, California, Förenta staterna, 94609
    - Alta Bates Summit Medical Center - Summit Campus
  - Oakland, California, Förenta staterna, 94609
    - Bay Area Tumor Institute
  - Walnut Creek, California, Förenta staterna, 94597
    - Epic Care Cyberknife Center
- Colorado
  - Aurora, Colorado, Förenta staterna, 80012
    - Rocky Mountain Cancer Centers-Aurora
  - Aurora, Colorado, Förenta staterna, 80012
    - The Medical Center of Aurora
  - Boulder, Colorado, Förenta staterna, 80303
    - Boulder Community Foothills Hospital
  - Boulder, Colorado, Förenta staterna, 80304
    - Rocky Mountain Cancer Centers-Boulder
  - Centennial, Colorado, Förenta staterna, 80112
    - Rocky Mountain Cancer Centers - Centennial
  - Denver, Colorado, Förenta staterna, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Förenta staterna, 80220
    - Rose Medical Center
  - Denver, Colorado, Förenta staterna, 80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver, Colorado, Förenta staterna, 80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver, Colorado, Förenta staterna, 80218
    - Colorado Blood Cancer Institute
  - Denver, Colorado, Förenta staterna, 80204
    - Cancer Center of Colorado at Sloan's Lake
  - Denver, Colorado, Förenta staterna, 80209
    - The Women's Imaging Center
  - Denver, Colorado, Förenta staterna, 80206
    - National Jewish Health-Main Campus
  - Denver, Colorado, Förenta staterna, 80220
    - Western Surgical Care
  - Denver, Colorado, Förenta staterna, 80218
    - Saint Joseph Hospital - Cancer Centers of Colorado
  - Englewood, Colorado, Förenta staterna, 80113
    - Mountain Blue Cancer Care Center - Swedish
  - Englewood, Colorado, Förenta staterna, 80113
    - Swedish Medical Center
  - Englewood, Colorado, Förenta staterna, 80113
    - Rocky Mountain Cancer Centers - Swedish
  - Englewood, Colorado, Förenta staterna, 80113
    - The Melanoma and Skin Cancer Institute
  - Golden, Colorado, Förenta staterna, 80401
    - National Jewish Health-Western Hematology Oncology
  - Grand Junction, Colorado, Förenta staterna, 81501
    - Saint Mary's Hospital and Regional Medical Center
  - Greeley, Colorado, Förenta staterna, 80631
    - Banner North Colorado Medical Center
  - Lafayette, Colorado, Förenta staterna, 80026
    - Good Samaritan Hospital - Cancer Centers of Colorado
  - Lakewood, Colorado, Förenta staterna, 80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Littleton, Colorado, Förenta staterna, 80120
    - Rocky Mountain Cancer Centers-Littleton
  - Lone Tree, Colorado, Förenta staterna, 80124
    - Sky Ridge Medical Center
  - Lone Tree, Colorado, Förenta staterna, 80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Loveland, Colorado, Förenta staterna, 80539
    - Banner North Colorado Medical Center - Loveland Campus
  - Thornton, Colorado, Förenta staterna, 80260
    - Rocky Mountain Cancer Centers-Thornton
  - Thornton, Colorado, Förenta staterna, 80260
    - National Jewish Health-Northern Hematology Oncology
  - Wheat Ridge, Colorado, Förenta staterna, 80401
    - Intermountain Health Lutheran Hospital
- Delaware
  - Lewes, Delaware, Förenta staterna, 19958
    - Beebe Medical Center
  - Millville, Delaware, Förenta staterna, 19967
    - Beebe South Coastal Health Campus
  - Newark, Delaware, Förenta staterna, 19713
    - Helen F Graham Cancer Center
  - Newark, Delaware, Förenta staterna, 19713
    - Delaware Clinical and Laboratory Physicians PA
  - Newark, Delaware, Förenta staterna, 19713
    - Medical Oncology Hematology Consultants PA
  - Newark, Delaware, Förenta staterna, 19718
    - Christiana Care Health System-Christiana Hospital
  - Rehoboth Beach, Delaware, Förenta staterna, 19971
    - Beebe Health Campus
  - Seaford, Delaware, Förenta staterna, 19973
    - TidalHealth Nanticoke / Allen Cancer Center
  - Wilmington, Delaware, Förenta staterna, 19801
    - Christiana Care Health System-Wilmington Hospital
- District of Columbia
  - Washington D.C., District of Columbia, Förenta staterna, 20010
    - MedStar Washington Hospital Center
  - Washington D.C., District of Columbia, Förenta staterna, 20016
    - Sibley Memorial Hospital
- Florida
  - Fort Lauderdale, Florida, Förenta staterna, 33308
    - Holy Cross Hospital
  - Gainesville, Florida, Förenta staterna, 32610
    - UF Health Cancer Institute - Gainesville
- Georgia
  - Atlanta, Georgia, Förenta staterna, 30308
    - Emory University Hospital Midtown
  - Atlanta, Georgia, Förenta staterna, 30322
    - Emory University Hospital/Winship Cancer Institute
  - Atlanta, Georgia, Förenta staterna, 30342
    - Emory Saint Joseph's Hospital
  - Atlanta, Georgia, Förenta staterna, 30303
    - Grady Health System
  - Atlanta, Georgia, Förenta staterna, 30342
    - Northside Hospital
  - Columbus, Georgia, Förenta staterna, 31904
    - John B Amos Cancer Center
  - Duluth, Georgia, Förenta staterna, 30096
    - Northside Hospital - Duluth
  - Lawrenceville, Georgia, Förenta staterna, 30046
    - Northside Hospital - Gwinnett
  - Savannah, Georgia, Förenta staterna, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
  - Snellville, Georgia, Förenta staterna, 30078
    - Suburban Hematology Oncology Associates - Snellville
- Idaho
  - Boise, Idaho, Förenta staterna, 83712
    - Saint Luke's Cancer Institute - Boise
  - Fruitland, Idaho, Förenta staterna, 83619
    - Saint Luke's Cancer Institute - Fruitland
  - Meridian, Idaho, Förenta staterna, 83642
    - Saint Luke's Cancer Institute - Meridian
  - Nampa, Idaho, Förenta staterna, 83687
    - Saint Luke's Cancer Institute - Nampa
  - Twin Falls, Idaho, Förenta staterna, 83301
    - Saint Luke's Cancer Institute - Twin Falls
- Illinois
  - Alton, Illinois, Förenta staterna, 62002
    - OSF Saint Anthony's Health Center
  - Aurora, Illinois, Förenta staterna, 60504
    - Rush-Copley Medical Center
  - Bloomington, Illinois, Förenta staterna, 61704
    - Illinois CancerCare-Bloomington
  - Canton, Illinois, Förenta staterna, 61520
    - Illinois CancerCare-Canton
  - Carbondale, Illinois, Förenta staterna, 62902
    - Memorial Hospital of Carbondale
  - Carterville, Illinois, Förenta staterna, 62918
    - SIH Cancer Institute
  - Carthage, Illinois, Förenta staterna, 62321
    - Illinois CancerCare-Carthage
  - Centralia, Illinois, Förenta staterna, 62801
    - Centralia Oncology Clinic
  - Chicago, Illinois, Förenta staterna, 60611
    - Northwestern University
  - Chicago, Illinois, Förenta staterna, 60612
    - John H Stroger Jr Hospital of Cook County
  - Danville, Illinois, Förenta staterna, 61832
    - Carle at The Riverfront
  - Decatur, Illinois, Förenta staterna, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Förenta staterna, 62526
    - Cancer Care Specialists of Illinois - Decatur
  - Dixon, Illinois, Förenta staterna, 61021
    - Illinois CancerCare-Dixon
  - Effingham, Illinois, Förenta staterna, 62401
    - Crossroads Cancer Center
  - Effingham, Illinois, Förenta staterna, 62401
    - Carle Physician Group-Effingham
  - Eureka, Illinois, Förenta staterna, 61530
    - Illinois CancerCare-Eureka
  - Galesburg, Illinois, Förenta staterna, 61401
    - Western Illinois Cancer Treatment Center
  - Galesburg, Illinois, Förenta staterna, 61401
    - Illinois CancerCare-Galesburg
  - Kewanee, Illinois, Förenta staterna, 61443
    - Illinois CancerCare-Kewanee Clinic
  - Macomb, Illinois, Förenta staterna, 61455
    - Illinois CancerCare-Macomb
  - Mattoon, Illinois, Förenta staterna, 61938
    - Carle Physician Group-Mattoon/Charleston
  - Mount Vernon, Illinois, Förenta staterna, 62864
    - SSM Health Good Samaritan
  - O'Fallon, Illinois, Förenta staterna, 62269
    - Cancer Care Center of O'Fallon
  - Ottawa, Illinois, Förenta staterna, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Pekin, Illinois, Förenta staterna, 61554
    - Illinois CancerCare-Pekin
  - Peoria, Illinois, Förenta staterna, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Förenta staterna, 61615
    - Illinois CancerCare-Peoria
  - Peru, Illinois, Förenta staterna, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Förenta staterna, 61354
    - Valley Radiation Oncology
  - Princeton, Illinois, Förenta staterna, 61356
    - Illinois CancerCare-Princeton
  - Springfield, Illinois, Förenta staterna, 62702
    - Southern Illinois University School of Medicine
  - Springfield, Illinois, Förenta staterna, 62702
    - Springfield Clinic
  - Springfield, Illinois, Förenta staterna, 62781
    - Springfield Memorial Hospital
  - Swansea, Illinois, Förenta staterna, 62226
    - Southwest Illinois Health Services LLP
  - Urbana, Illinois, Förenta staterna, 61801
    - Carle Cancer Center
  - Urbana, Illinois, Förenta staterna, 61801
    - The Carle Foundation Hospital
  - Washington, Illinois, Förenta staterna, 61571
    - Illinois CancerCare - Washington
  - Yorkville, Illinois, Förenta staterna, 60560
    - Rush-Copley Healthcare Center
- Indiana
  - Avon, Indiana, Förenta staterna, 46123
    - IU Health West Hospital
  - Carmel, Indiana, Förenta staterna, 46032
    - IU Health North Hospital
  - Crown Point, Indiana, Förenta staterna, 46307
    - Northwest Cancer Center - Crown Point
  - Dyer, Indiana, Förenta staterna, 46311
    - Northwest Oncology LLC
  - Hobart, Indiana, Förenta staterna, 46342
    - Northwest Cancer Center - Hobart
  - Hobart, Indiana, Förenta staterna, 46342
    - Saint Mary Medical Center
  - Indianapolis, Indiana, Förenta staterna, 46202
    - Indiana University/Melvin and Bren Simon Cancer Center
  - Indianapolis, Indiana, Förenta staterna, 46202
    - Sidney and Lois Eskenazi Hospital
  - Indianapolis, Indiana, Förenta staterna, 46290
    - Springmill Medical Center
  - Indianapolis, Indiana, Förenta staterna, 46202
    - IU Health Methodist Hospital
  - Indianapolis, Indiana, Förenta staterna, 46312
    - Saint Catherine Hospital
  - Munster, Indiana, Förenta staterna, 46321
    - The Community Hospital
  - Munster, Indiana, Förenta staterna, 46321
    - Women's Diagnostic Center - Munster
  - Valparaiso, Indiana, Förenta staterna, 46383
    - Northwest Cancer Center - Valparaiso
- Kansas
  - Garden City, Kansas, Förenta staterna, 67846
    - Central Care Cancer Center - Garden City
  - Great Bend, Kansas, Förenta staterna, 67530
    - Central Care Cancer Center - Great Bend
- Louisiana
  - Baton Rouge, Louisiana, Förenta staterna, 70805
    - LSU Health Baton Rouge-North Clinic
  - Baton Rouge, Louisiana, Förenta staterna, 70809
    - Louisiana Hematology Oncology Associates LLC
  - Baton Rouge, Louisiana, Förenta staterna, 70809
    - Mary Bird Perkins Cancer Center
  - Baton Rouge, Louisiana, Förenta staterna, 70808
    - Our Lady of The Lake
  - Baton Rouge, Louisiana, Förenta staterna, 70817
    - Woman's Hospital
  - Baton Rouge, Louisiana, Förenta staterna, 70817
    - Our Lady of the Lake Medical Oncology
  - Baton Rouge, Louisiana, Förenta staterna, 70817
    - Louisiana Hematology Oncology Associates
  - Baton Rouge, Louisiana, Förenta staterna, 70808
    - Our Lady of the Lake Physician Group
  - Covington, Louisiana, Förenta staterna, 70433
    - Northshore Oncology Associates-Covington
  - Houma, Louisiana, Förenta staterna, 70360
    - Terrebonne General Medical Center
  - New Orleans, Louisiana, Förenta staterna, 70112
    - University Medical Center New Orleans
  - New Orleans, Louisiana, Förenta staterna, 70112
    - Louisiana State University Health Science Center
- Maryland
  - Baltimore, Maryland, Förenta staterna, 21287
    - Johns Hopkins University/Sidney Kimmel Cancer Center
  - Baltimore, Maryland, Förenta staterna, 21215
    - Sinai Hospital of Baltimore
  - Baltimore, Maryland, Förenta staterna, 21229
    - Saint Agnes Hospital
  - Baltimore, Maryland, Förenta staterna, 21239
    - MedStar Good Samaritan Hospital
  - Easton, Maryland, Förenta staterna, 21601
    - University of Maryland Shore Medical Center at Easton
  - Randallstown, Maryland, Förenta staterna, 21133
    - Northwest Hospital Center
  - Westminster, Maryland, Förenta staterna, 21157
    - William E Kahlert Regional Cancer Center/Sinai Hospital
- Massachusetts
  - Springfield, Massachusetts, Förenta staterna, 01199
    - Baystate Medical Center
  - Springfield, Massachusetts, Förenta staterna, 01104
    - Mercy Medical Center
- Michigan
  - Ann Arbor, Michigan, Förenta staterna, 48106
    - Trinity Health Saint Joseph Mercy Hospital Ann Arbor
  - Battle Creek, Michigan, Förenta staterna, 49017
    - Bronson Battle Creek
  - Brighton, Michigan, Förenta staterna, 48114
    - Trinity Health IHA Medical Group Hematology Oncology - Brighton
  - Brighton, Michigan, Förenta staterna, 48114
    - Trinity Health Medical Center - Brighton
  - Canton, Michigan, Förenta staterna, 48188
    - Trinity Health IHA Medical Group Hematology Oncology - Canton
  - Canton, Michigan, Förenta staterna, 48188
    - Trinity Health Medical Center - Canton
  - Caro, Michigan, Förenta staterna, 48723
    - Caro Cancer Center
  - Chelsea, Michigan, Förenta staterna, 48118
    - Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
  - Chelsea, Michigan, Förenta staterna, 48118
    - Chelsea Hospital
  - Clarkston, Michigan, Förenta staterna, 48346
    - Hematology Oncology Consultants-Clarkston
  - Clarkston, Michigan, Förenta staterna, 48346
    - Newland Medical Associates-Clarkston
  - Detroit, Michigan, Förenta staterna, 48236
    - Henry Ford Health Saint John Hospital
  - East China, Michigan, Förenta staterna, 48054
    - Henry Ford River District Hospital
  - Flint, Michigan, Förenta staterna, 48503
    - Hurley Medical Center
  - Flint, Michigan, Förenta staterna, 48503
    - Genesee Hematology Oncology PC
  - Flint, Michigan, Förenta staterna, 48503
    - Genesys Hurley Cancer Institute
  - Flint, Michigan, Förenta staterna, 48503
    - Cancer Hematology Centers - Flint
  - Grand Rapids, Michigan, Förenta staterna, 49503
    - Trinity Health Grand Rapids Hospital
  - Grand Rapids, Michigan, Förenta staterna, 49503
    - Corewell Health Grand Rapids Hospitals - Butterworth Hospital
  - Grand Rapids, Michigan, Förenta staterna, 49503
    - Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
  - Grosse Pointe Woods, Michigan, Förenta staterna, 48236
    - Henry Ford Saint John Hospital - Academic
  - Grosse Pointe Woods, Michigan, Förenta staterna, 48236
    - Henry Ford Saint John Hospital - Breast
  - Grosse Pointe Woods, Michigan, Förenta staterna, 48236
    - Henry Ford Saint John Hospital - Van Elslander
  - Kalamazoo, Michigan, Förenta staterna, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Förenta staterna, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Förenta staterna, 49009
    - Beacon Kalamazoo Cancer Center
  - Kalamazoo, Michigan, Förenta staterna, 49048
    - Beacon Kalamazoo
  - Lansing, Michigan, Förenta staterna, 48912
    - University of Michigan Health - Sparrow Lansing
  - Livonia, Michigan, Förenta staterna, 48154
    - Trinity Health Saint Mary Mercy Livonia Hospital
  - Livonia, Michigan, Förenta staterna, 48154
    - Hope Cancer Clinic
  - Macomb, Michigan, Förenta staterna, 48044
    - Henry Ford Warren Hospital - Breast Macomb
  - Macomb, Michigan, Förenta staterna, 48044
    - Henry Ford Saint John Hospital - Macomb Medical
  - Marlette, Michigan, Förenta staterna, 48453
    - Saint Mary's Oncology/Hematology Associates of Marlette
  - Muskegon, Michigan, Förenta staterna, 49444
    - Trinity Health Muskegon Hospital
  - Niles, Michigan, Förenta staterna, 49120
    - Corewell Health Lakeland Hospitals - Niles Hospital
  - Norton Shores, Michigan, Förenta staterna, 49444
    - Cancer and Hematology Centers of Western Michigan - Norton Shores
  - Pontiac, Michigan, Förenta staterna, 48341
    - Hope Cancer Center
  - Pontiac, Michigan, Förenta staterna, 48341
    - Newland Medical Associates-Pontiac
  - Pontiac, Michigan, Förenta staterna, 48341
    - Trinity Health Saint Joseph Mercy Oakland Hospital
  - Pontiac, Michigan, Förenta staterna, 48341
    - Michigan Healthcare Professionals Pontiac
  - Reed City, Michigan, Förenta staterna, 49677
    - Corewell Health Reed City Hospital
  - Rochester Hills, Michigan, Förenta staterna, 48309
    - Henry Ford Rochester Hospital
  - Saginaw, Michigan, Förenta staterna, 48604
    - Oncology Hematology Associates of Saginaw Valley PC
  - Saginaw, Michigan, Förenta staterna, 48601
    - MyMichigan Medical Center Saginaw
  - Saint Joseph, Michigan, Förenta staterna, 49085
    - Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
  - Saint Joseph, Michigan, Förenta staterna, 49085
    - Corewell Health Lakeland Hospitals - Saint Joseph Hospital
  - Sterling Heights, Michigan, Förenta staterna, 48312
    - Bhadresh Nayak MD PC-Sterling Heights
  - Tawas City, Michigan, Förenta staterna, 48764
    - MyMichigan Medical Center Tawas
  - Traverse City, Michigan, Förenta staterna, 49684
    - Munson Medical Center
  - Warren, Michigan, Förenta staterna, 48088
    - Advanced Breast Care Center PLLC
  - Warren, Michigan, Förenta staterna, 48093
    - Macomb Hematology Oncology PC
  - Warren, Michigan, Förenta staterna, 48093
    - Henry Ford Madison Heights Hospital - Breast
  - Warren, Michigan, Förenta staterna, 48093
    - Henry Ford Health Warren Hospital
  - Warren, Michigan, Förenta staterna, 48093
    - Henry Ford Warren Hospital - GLCMS
  - West Branch, Michigan, Förenta staterna, 48661
    - Saint Mary's Oncology/Hematology Associates of West Branch
  - Wyoming, Michigan, Förenta staterna, 49519
    - University of Michigan Health - West
  - Ypsilanti, Michigan, Förenta staterna, 48197
    - Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
  - Ypsilanti, Michigan, Förenta staterna, 48106
    - Huron Gastroenterology PC
- Minnesota
  - Burnsville, Minnesota, Förenta staterna, 55337
    - Fairview Ridges Hospital
  - Burnsville, Minnesota, Förenta staterna, 55337
    - Minnesota Oncology - Burnsville
  - Cambridge, Minnesota, Förenta staterna, 55008
    - Cambridge Medical Center
  - Coon Rapids, Minnesota, Förenta staterna, 55433
    - Mercy Hospital
  - Edina, Minnesota, Förenta staterna, 55435
    - Fairview Southdale Hospital
  - Fridley, Minnesota, Förenta staterna, 55432
    - Unity Hospital
  - Maple Grove, Minnesota, Förenta staterna, 55369
    - Fairview Clinics and Surgery Center Maple Grove
  - Maplewood, Minnesota, Förenta staterna, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Förenta staterna, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Förenta staterna, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Förenta staterna, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Förenta staterna, 55454
    - Health Partners Inc
  - Monticello, Minnesota, Förenta staterna, 55362
    - Monticello Cancer Center
  - New Ulm, Minnesota, Förenta staterna, 56073
    - New Ulm Medical Center
  - Princeton, Minnesota, Förenta staterna, 55371
    - Fairview Northland Medical Center
  - Robbinsdale, Minnesota, Förenta staterna, 55422
    - North Memorial Medical Health Center
  - Saint Louis Park, Minnesota, Förenta staterna, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Paul, Minnesota, Förenta staterna, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Förenta staterna, 55102
    - United Hospital
  - Shakopee, Minnesota, Förenta staterna, 55379
    - Saint Francis Regional Medical Center
  - Stillwater, Minnesota, Förenta staterna, 55082
    - Lakeview Hospital
  - Waconia, Minnesota, Förenta staterna, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Förenta staterna, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Förenta staterna, 55125
    - Minnesota Oncology Hematology PA-Woodbury
  - Wyoming, Minnesota, Förenta staterna, 55092
    - Fairview Lakes Medical Center
- Mississippi
  - Columbus, Mississippi, Förenta staterna, 39705
    - Baptist Memorial Hospital and Cancer Center-Golden Triangle
  - Grenada, Mississippi, Förenta staterna, 38901
    - Baptist Cancer Center-Grenada
  - New Albany, Mississippi, Förenta staterna, 38652
    - Baptist Memorial Hospital and Cancer Center-Union County
  - Oxford, Mississippi, Förenta staterna, 38655
    - Baptist Memorial Hospital and Cancer Center-Oxford
  - Southhaven, Mississippi, Förenta staterna, 38671
    - Baptist Memorial Hospital and Cancer Center-Desoto
- Missouri
  - Ballwin, Missouri, Förenta staterna, 63011
    - Mercy Oncology and Hematology - Clayton-Clarkson
  - Bolivar, Missouri, Förenta staterna, 65613
    - Central Care Cancer Center - Bolivar
  - Bonne Terre, Missouri, Förenta staterna, 63628
    - Parkland Health Center-Bonne Terre
  - Branson, Missouri, Förenta staterna, 65616
    - Cox Cancer Center Branson
  - Cape Girardeau, Missouri, Förenta staterna, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Förenta staterna, 63703
    - Mercy Cancer Center - Cape Girardeau
  - City of Saint Peters, Missouri, Förenta staterna, 63376
    - Siteman Cancer Center at Saint Peters Hospital
  - Creve Coeur, Missouri, Förenta staterna, 63141
    - Siteman Cancer Center at West County Hospital
  - Farmington, Missouri, Förenta staterna, 63640
    - Parkland Health Center - Farmington
  - Jefferson City, Missouri, Förenta staterna, 65109
    - MU Health Care Goldschmidt Cancer Center
  - Joplin, Missouri, Förenta staterna, 64804
    - Freeman Health System
  - Joplin, Missouri, Förenta staterna, 64804
    - Mercy Hospital Joplin
  - Rolla, Missouri, Förenta staterna, 65401
    - Mercy Clinic-Rolla-Cancer and Hematology
  - Rolla, Missouri, Förenta staterna, 65401
    - Phelps Health Delbert Day Cancer Institute
  - Saint Joseph, Missouri, Förenta staterna, 64506
    - Heartland Regional Medical Center
  - Sainte Genevieve, Missouri, Förenta staterna, 63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield, Missouri, Förenta staterna, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Förenta staterna, 65804
    - Mercy Hospital Springfield
  - St Louis, Missouri, Förenta staterna, 63110
    - Washington University School of Medicine
  - St Louis, Missouri, Förenta staterna, 63129
    - Siteman Cancer Center-South County
  - St Louis, Missouri, Förenta staterna, 63136
    - Siteman Cancer Center at Christian Hospital
  - St Louis, Missouri, Förenta staterna, 63131
    - Missouri Baptist Medical Center
  - St Louis, Missouri, Förenta staterna, 63109
    - Mercy Infusion Center - Chippewa
  - St Louis, Missouri, Förenta staterna, 63141
    - Mercy Hospital Saint Louis
  - St Louis, Missouri, Förenta staterna, 63128
    - Mercy Hospital South
  - Sullivan, Missouri, Förenta staterna, 63080
    - Missouri Baptist Sullivan Hospital
  - Washington, Missouri, Förenta staterna, 63090
    - Mercy Hospital Washington
- Montana
  - Billings, Montana, Förenta staterna, 59101
    - Saint Vincent Healthcare
  - Billings, Montana, Förenta staterna, 59102
    - Saint Vincent Frontier Cancer Center
  - Butte, Montana, Förenta staterna, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Missoula, Montana, Förenta staterna, 59802
    - Saint Patrick Hospital - Community Hospital
- Nebraska
  - Bellevue, Nebraska, Förenta staterna, 68123
    - Nebraska Medicine-Bellevue
  - Omaha, Nebraska, Förenta staterna, 68198
    - University of Nebraska Medical Center
  - Omaha, Nebraska, Förenta staterna, 68118
    - Nebraska Medicine-Village Pointe
- Nevada
  - Carson City, Nevada, Förenta staterna, 89703
    - Carson Tahoe Regional Medical Center
  - Henderson, Nevada, Förenta staterna, 89052
    - Comprehensive Cancer Centers of Nevada - Henderson
  - Henderson, Nevada, Förenta staterna, 89052
    - Cancer and Blood Specialists-Henderson
  - Henderson, Nevada, Förenta staterna, 89052
    - Las Vegas Cancer Center-Henderson
  - Henderson, Nevada, Förenta staterna, 89074
    - Comprehensive Cancer Centers of Nevada-Southeast Henderson
  - Henderson, Nevada, Förenta staterna, 89052
    - Comprehensive Cancer Centers of Nevada-Horizon Ridge
  - Henderson, Nevada, Förenta staterna, 89074
    - Las Vegas Urology - Green Valley
  - Henderson, Nevada, Förenta staterna, 89074
    - Las Vegas Urology - Pebble
  - Henderson, Nevada, Förenta staterna, 89074
    - Urology Specialists of Nevada - Green Valley
  - Henderson, Nevada, Förenta staterna, 89074
    - Oncology Las Vegas - Henderson
  - Las Vegas, Nevada, Förenta staterna, 89144
    - Summerlin Hospital Medical Center
  - Las Vegas, Nevada, Förenta staterna, 89109
    - Sunrise Hospital and Medical Center
  - Las Vegas, Nevada, Förenta staterna, 89102
    - OptumCare Cancer Care at Charleston
  - Las Vegas, Nevada, Förenta staterna, 89106
    - Radiation Oncology Centers of Nevada Central
  - Las Vegas, Nevada, Förenta staterna, 89119
    - Radiation Oncology Centers of Nevada Southeast
  - Las Vegas, Nevada, Förenta staterna, 89128
    - Comprehensive Cancer Centers of Nevada - Northwest
  - Las Vegas, Nevada, Förenta staterna, 89128
    - OptumCare Cancer Care at MountainView
  - Las Vegas, Nevada, Förenta staterna, 89135
    - Alliance for Childhood Diseases/Cure 4 the Kids Foundation
  - Las Vegas, Nevada, Förenta staterna, 89144
    - Comprehensive Cancer Centers of Nevada - Town Center
  - Las Vegas, Nevada, Förenta staterna, 89144
    - Comprehensive Cancer Centers of Nevada-Summerlin
  - Las Vegas, Nevada, Förenta staterna, 89148
    - Comprehensive Cancer Centers of Nevada
  - Las Vegas, Nevada, Förenta staterna, 89169
    - Comprehensive Cancer Centers of Nevada - Central Valley
  - Las Vegas, Nevada, Förenta staterna, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Förenta staterna, 89148-2405
    - Las Vegas Cancer Center-Medical Center
  - Las Vegas, Nevada, Förenta staterna, 89128
    - Ann M Wierman MD LTD
  - Las Vegas, Nevada, Förenta staterna, 89074
    - Las Vegas Urology - Pecos
  - Las Vegas, Nevada, Förenta staterna, 89102
    - Desert West Surgery
  - Las Vegas, Nevada, Förenta staterna, 89103
    - Hope Cancer Care of Nevada
  - Las Vegas, Nevada, Förenta staterna, 89106
    - Urology Specialists of Nevada - Central
  - Las Vegas, Nevada, Förenta staterna, 89113
    - Las Vegas Prostate Cancer Center
  - Las Vegas, Nevada, Förenta staterna, 89113
    - Las Vegas Urology - Sunset
  - Las Vegas, Nevada, Förenta staterna, 89128
    - Las Vegas Urology - Cathedral Rock
  - Las Vegas, Nevada, Förenta staterna, 89128
    - Las Vegas Urology - Smoke Ranch
  - Las Vegas, Nevada, Förenta staterna, 89128
    - Urology Specialists of Nevada - Northwest
  - Las Vegas, Nevada, Förenta staterna, 89169
    - University Cancer Center
  - Las Vegas, Nevada, Förenta staterna, 89113
    - Urology Specialists of Nevada - Southwest
  - Las Vegas, Nevada, Förenta staterna, 89128
    - Oncology Las Vegas - Tenaya
  - Las Vegas, Nevada, Förenta staterna, 89183
    - OptumCare Cancer Care at Fort Apache
  - Pahrump, Nevada, Förenta staterna, 89048
    - Hope Cancer Care of Nevada-Pahrump
  - Reno, Nevada, Förenta staterna, 89502
    - Renown Regional Medical Center
  - Reno, Nevada, Förenta staterna, 89503
    - Saint Mary's Regional Medical Center
  - Reno, Nevada, Förenta staterna, 89509
    - Radiation Oncology Associates
- New Jersey
  - Englewood, New Jersey, Förenta staterna, 07631
    - Englewood Hospital and Medical Center
  - Hamilton, New Jersey, Förenta staterna, 08690
    - The Cancer Institute of New Jersey Hamilton
  - Morristown, New Jersey, Förenta staterna, 07960
    - Morristown Medical Center
  - Mullica Hill, New Jersey, Förenta staterna, 08062
    - Inspira Medical Center Mullica Hill
  - New Brunswick, New Jersey, Förenta staterna, 08903
    - Rutgers Cancer Institute of New Jersey
  - Sewell, New Jersey, Förenta staterna, 08080
    - Sidney Kimmel Cancer Center Washington Township
  - Somerville, New Jersey, Förenta staterna, 08876
    - Robert Wood Johnson University Hospital Somerset
  - Summit, New Jersey, Förenta staterna, 07902
    - Overlook Hospital
  - Teaneck, New Jersey, Förenta staterna, 07666
    - Holy Name Hospital
  - Vineland, New Jersey, Förenta staterna, 08360
    - Inspira Medical Center Vineland
- New York
  - Rochester, New York, Förenta staterna, 14642
    - University of Rochester
  - The Bronx, New York, Förenta staterna, 10461
    - Montefiore Medical Center-Einstein Campus
  - The Bronx, New York, Förenta staterna, 10467
    - Montefiore Medical Center - Moses Campus
  - The Bronx, New York, Förenta staterna, 10461
    - Montefiore Medical Center-Weiler Hospital
- Ohio
  - Akron, Ohio, Förenta staterna, 44307
    - Cleveland Clinic Akron General
  - Beachwood, Ohio, Förenta staterna, 44122
    - UHHS-Chagrin Highlands Medical Center
  - Belpre, Ohio, Förenta staterna, 45714
    - Strecker Cancer Center-Belpre
  - Chardon, Ohio, Förenta staterna, 44024
    - Geauga Hospital
  - Chillicothe, Ohio, Förenta staterna, 45601
    - Adena Regional Medical Center
  - Cleveland, Ohio, Förenta staterna, 44106
    - Case Western Reserve University
  - Cleveland, Ohio, Förenta staterna, 44109
    - MetroHealth Medical Center
  - Columbus, Ohio, Förenta staterna, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Förenta staterna, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, Förenta staterna, 43214
    - Columbus Oncology and Hematology Associates Inc
  - Columbus, Ohio, Förenta staterna, 43228
    - Doctors Hospital
  - Columbus, Ohio, Förenta staterna, 43213
    - Mount Carmel East Hospital
  - Columbus, Ohio, Förenta staterna, 43215
    - Grant Medical Center
  - Columbus, Ohio, Förenta staterna, 43222
    - Mount Carmel Health Center West
  - Delaware, Ohio, Förenta staterna, 43015
    - Delaware Health Center-Grady Cancer Center
  - Delaware, Ohio, Förenta staterna, 43015
    - Grady Memorial Hospital
  - Dublin, Ohio, Förenta staterna, 43016
    - Dublin Methodist Hospital
  - Dublin, Ohio, Förenta staterna, 43016
    - Columbus Oncology and Hematology Associates
  - Gahanna, Ohio, Förenta staterna, 43230
    - Central Ohio Breast and Endocrine Surgery
  - Grove City, Ohio, Förenta staterna, 43123
    - Mount Carmel Grove City Hospital
  - Lancaster, Ohio, Förenta staterna, 43130
    - Fairfield Medical Center
  - Lima, Ohio, Förenta staterna, 45801
    - Saint Rita's Medical Center
  - Mansfield, Ohio, Förenta staterna, 44903
    - OhioHealth Mansfield Hospital
  - Marietta, Ohio, Förenta staterna, 45750
    - Marietta Memorial Hospital
  - Marion, Ohio, Förenta staterna, 43302
    - OhioHealth Marion General Hospital
  - Mentor, Ohio, Förenta staterna, 44060
    - UH Seidman Cancer Center at Lake Health Mentor Campus
  - Middleburg Heights, Ohio, Förenta staterna, 44130
    - UH Seidman Cancer Center at Southwest General Hospital
  - Mount Vernon, Ohio, Förenta staterna, 43050
    - Knox Community Hospital
  - Newark, Ohio, Förenta staterna, 43055
    - Licking Memorial Hospital
  - Newark, Ohio, Förenta staterna, 43055
    - Newark Radiation Oncology
  - Parma, Ohio, Förenta staterna, 44129
    - University Hospitals Parma Medical Center
  - Perrysburg, Ohio, Förenta staterna, 43551
    - Mercy Health - Perrysburg Hospital
  - Portsmouth, Ohio, Förenta staterna, 45662
    - Southern Ohio Medical Center
  - Ravenna, Ohio, Förenta staterna, 44266
    - University Hospitals Portage Medical Center
  - Sandusky, Ohio, Förenta staterna, 44870
    - UH Seidman Cancer Center at Firelands Regional Medical Center
  - Toledo, Ohio, Förenta staterna, 43623
    - Mercy Health - Saint Anne Hospital
  - Toledo, Ohio, Förenta staterna, 43608
    - Mercy Health - Saint Vincent Hospital
  - Toledo, Ohio, Förenta staterna, 43623
    - Mercy Health Sylvania Radiation Oncology Center
  - Wadsworth, Ohio, Förenta staterna, 44281
    - University Hospitals Sharon Health Center
  - Westerville, Ohio, Förenta staterna, 43081
    - Saint Ann's Hospital
  - Westlake, Ohio, Förenta staterna, 44145
    - UH Seidman Cancer Center at Saint John Medical Center
  - Zanesville, Ohio, Förenta staterna, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Oklahoma City, Oklahoma, Förenta staterna, 73120
    - Mercy Hospital Oklahoma City
- Oregon
  - Bend, Oregon, Förenta staterna, 97701
    - Saint Charles Health System
  - Clackamas, Oregon, Förenta staterna, 97015
    - Clackamas Radiation Oncology Center
  - Clackamas, Oregon, Förenta staterna, 97015
    - Providence Cancer Institute Clackamas Clinic
  - Coos Bay, Oregon, Förenta staterna, 97420
    - Bay Area Hospital
  - Newberg, Oregon, Förenta staterna, 97132
    - Providence Newberg Medical Center
  - Portland, Oregon, Förenta staterna, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Förenta staterna, 97225
    - Providence Saint Vincent Medical Center
  - Redmond, Oregon, Förenta staterna, 97756
    - Saint Charles Health System-Redmond
- Pennsylvania
  - Allentown, Pennsylvania, Förenta staterna, 18103
    - Lehigh Valley Hospital-Cedar Crest
  - Bethlehem, Pennsylvania, Förenta staterna, 18017
    - Lehigh Valley Hospital - Muhlenberg
  - Bryn Mawr, Pennsylvania, Förenta staterna, 19010
    - Bryn Mawr Hospital
  - Chadds Ford, Pennsylvania, Förenta staterna, 19317
    - Christiana Care Health System-Concord Health Center
  - Collegeville, Pennsylvania, Förenta staterna, 19426
    - Main Line Health Center-Collegeville
  - East Norriton, Pennsylvania, Förenta staterna, 19401
    - Fox Chase Cancer Center - East Norriton Hospital Outpatient Center
  - East Stroudsburg, Pennsylvania, Förenta staterna, 18301
    - Pocono Medical Center
  - Exton, Pennsylvania, Förenta staterna, 19341
    - Main Line Health Center-Exton
  - Hazleton, Pennsylvania, Förenta staterna, 18201
    - Lehigh Valley Hospital-Hazleton
  - Media, Pennsylvania, Förenta staterna, 19063
    - Riddle Memorial Hospital
  - Paoli, Pennsylvania, Förenta staterna, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Förenta staterna, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Förenta staterna, 19107
    - Thomas Jefferson University Hospital
  - Philadelphia, Pennsylvania, Förenta staterna, 19114
    - Jefferson Torresdale Hospital
  - Philadelphia, Pennsylvania, Förenta staterna, 19140
    - Temple University Hospital
  - Wynnewood, Pennsylvania, Förenta staterna, 19096
    - Lankenau Medical Center
- South Carolina
  - Bluffton, South Carolina, Förenta staterna, 29910
    - Saint Joseph's/Candler - Bluffton Campus
  - Charleston, South Carolina, Förenta staterna, 29425
    - Medical University of South Carolina
  - Georgetown, South Carolina, Förenta staterna, 29440
    - Tidelands Georgetown Memorial Hospital
  - Greenwood, South Carolina, Förenta staterna, 29646
    - Self Regional Healthcare
  - Hilton Head Island, South Carolina, Förenta staterna, 29926-3827
    - South Carolina Cancer Specialists PC
  - West Columbia, South Carolina, Förenta staterna, 29169
    - Lexington Medical Center
- Tennessee
  - Collierville, Tennessee, Förenta staterna, 38017
    - Baptist Memorial Hospital and Cancer Center-Collierville
  - Memphis, Tennessee, Förenta staterna, 38120
    - Baptist Memorial Hospital and Cancer Center-Memphis
  - Memphis, Tennessee, Förenta staterna, 38120
    - Baptist Memorial Hospital for Women
- Texas
  - Beaumont, Texas, Förenta staterna, 77701
    - Baptist Hospitals of Southeast Texas Cancer Center
  - Port Arthur, Texas, Förenta staterna, 77642
    - Baptist Regional Cancer Network-Cancer Center of Southeast Texas
- Utah
  - American Fork, Utah, Förenta staterna, 84003
    - American Fork Hospital / Huntsman Intermountain Cancer Center
  - Cedar City, Utah, Förenta staterna, 84720
    - Sandra L Maxwell Cancer Center
  - Logan, Utah, Förenta staterna, 84321
    - Logan Regional Hospital
  - Murray, Utah, Förenta staterna, 84107
    - Intermountain Medical Center
  - Ogden, Utah, Förenta staterna, 84403
    - McKay-Dee Hospital Center
  - Provo, Utah, Förenta staterna, 84604
    - Utah Valley Regional Medical Center
  - Riverton, Utah, Förenta staterna, 84065
    - Riverton Hospital
  - Salt Lake City, Utah, Förenta staterna, 84106
    - Utah Cancer Specialists-Salt Lake City
  - Salt Lake City, Utah, Förenta staterna, 84143
    - LDS Hospital
  - St. George, Utah, Förenta staterna, 84770
    - Saint George Regional Medical Center
- Virginia
  - Fishersville, Virginia, Förenta staterna, 22939
    - Augusta Health Center for Cancer and Blood Disorders
  - Mechanicsville, Virginia, Förenta staterna, 23116
    - Bon Secours Memorial Regional Medical Center
  - Midlothian, Virginia, Förenta staterna, 23114
    - Bon Secours Saint Francis Medical Center
  - Midlothian, Virginia, Förenta staterna, 23113
    - Bon Secours Westchester Emergency Center
  - Norfolk, Virginia, Förenta staterna, 23505
    - Bon Secours DePaul Medical Center
  - Portsmouth, Virginia, Förenta staterna, 23707
    - Bon Secours Maryview Medical Center
  - Richmond, Virginia, Förenta staterna, 23226
    - Bon Secours Saint Mary's Hospital
  - Richmond, Virginia, Förenta staterna, 23230
    - Bon Secours Cancer Institute at Reynolds Crossing
  - Suffolk, Virginia, Förenta staterna, 23435
    - Bon Secours Health Center at Harbour View
- Washington
  - Aberdeen, Washington, Förenta staterna, 98520
    - Providence Regional Cancer System-Aberdeen
  - Auburn, Washington, Förenta staterna, 98001
    - MultiCare Auburn Medical Center
  - Bellevue, Washington, Förenta staterna, 98004
    - Overlake Medical Center
  - Bellingham, Washington, Förenta staterna, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Centralia, Washington, Förenta staterna, 98531
    - Providence Regional Cancer System-Centralia
  - Edmonds, Washington, Förenta staterna, 98026
    - Swedish Cancer Institute-Edmonds
  - Everett, Washington, Förenta staterna, 98201
    - Providence Regional Cancer Partnership
  - Gig Harbor, Washington, Förenta staterna, 98335
    - MultiCare Gig Harbor Medical Park
  - Issaquah, Washington, Förenta staterna, 98029
    - Swedish Cancer Institute-Issaquah
  - Kennewick, Washington, Förenta staterna, 99336
    - Kadlec Clinic Hematology and Oncology
  - Lacey, Washington, Förenta staterna, 98503
    - Providence Regional Cancer System-Lacey
  - Longview, Washington, Förenta staterna, 98632
    - PeaceHealth Saint John Medical Center
  - Port Townsend, Washington, Förenta staterna, 98368
    - Jefferson Healthcare
  - Puyallup, Washington, Förenta staterna, 98372
    - MultiCare Good Samaritan Hospital
  - Renton, Washington, Förenta staterna, 98055
    - Valley Medical Center
  - Seattle, Washington, Förenta staterna, 98107
    - Swedish Medical Center-Ballard Campus
  - Seattle, Washington, Förenta staterna, 98122
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Förenta staterna, 98104
    - Pacific Gynecology Specialists
  - Seattle, Washington, Förenta staterna, 98122-5711
    - Swedish Medical Center-Cherry Hill
  - Sedro-Woolley, Washington, Förenta staterna, 98284
    - PeaceHealth United General Medical Center
  - Shelton, Washington, Förenta staterna, 98584
    - Providence Regional Cancer System-Shelton
  - Spokane, Washington, Förenta staterna, 99204
    - MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
  - Spokane, Washington, Förenta staterna, 99218
    - MultiCare Deaconess Cancer and Blood Specialty Center - North
  - Spokane Valley, Washington, Förenta staterna, 99216
    - MultiCare Deaconess Cancer and Blood Specialty Center - Valley
  - Tacoma, Washington, Förenta staterna, 98405
    - Mary Bridge Children's Hospital and Health Center
  - Tacoma, Washington, Förenta staterna, 98405
    - MultiCare Tacoma General Hospital
  - Vancouver, Washington, Förenta staterna, 98664
    - PeaceHealth Southwest Medical Center
  - Walla Walla, Washington, Förenta staterna, 99362
    - Providence Saint Mary Regional Cancer Center
  - Yakima, Washington, Förenta staterna, 98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
  - Yelm, Washington, Förenta staterna, 98597
    - Providence Regional Cancer System-Yelm
- Wisconsin
  - Burlington, Wisconsin, Förenta staterna, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Cudahy, Wisconsin, Förenta staterna, 53110
    - Aurora Saint Luke's South Shore
  - Fond du Lac, Wisconsin, Förenta staterna, 54937
    - Aurora Health Center-Fond du Lac
  - Germantown, Wisconsin, Förenta staterna, 53022
    - Aurora Health Care Germantown Health Center
  - Grafton, Wisconsin, Förenta staterna, 53024
    - Aurora Cancer Care-Grafton
  - Green Bay, Wisconsin, Förenta staterna, 54311
    - Aurora BayCare Medical Center
  - Kenosha, Wisconsin, Förenta staterna, 53142
    - Aurora Cancer Care-Kenosha South
  - Marinette, Wisconsin, Förenta staterna, 54143
    - Aurora Bay Area Medical Group-Marinette
  - Milwaukee, Wisconsin, Förenta staterna, 53209
    - Aurora Cancer Care-Milwaukee
  - Milwaukee, Wisconsin, Förenta staterna, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Förenta staterna, 53233
    - Aurora Sinai Medical Center
  - New Richmond, Wisconsin, Förenta staterna, 54017
    - Cancer Center of Western Wisconsin
  - Oshkosh, Wisconsin, Förenta staterna, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Förenta staterna, 53406
    - Aurora Cancer Care-Racine
  - Sheboygan, Wisconsin, Förenta staterna, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Summit, Wisconsin, Förenta staterna, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Förenta staterna, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Wauwatosa, Wisconsin, Förenta staterna, 53226
    - Aurora Cancer Care-Milwaukee West
  - West Allis, Wisconsin, Förenta staterna, 53227
    - Aurora West Allis Medical Center
- Wyoming
  - Cheyenne, Wyoming, Förenta staterna, 82001
    - Cheyenne Regional Medical Center-West

Deltagandekriterier

Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.

Urvalskriterier

Åldrar som är berättigade till studier

18 år och äldre (Vuxen, Äldre vuxen)

Tar emot friska volontärer

Nej

Kön som är behöriga för studier

Kvinna

Beskrivning

Inclusion Criteria:

Patients must be women with a known stage I-III invasive breast cancer diagnosis
Patients must be capable and willing to provide informed consent
Patients must have plans to receive either neoadjuvant or adjuvant:
- Every 3-week docetaxel x 4-6 cycles OR
- Weekly paclitaxel x 4 cycles
- NOTE: Recommended therapies for various therapy regimens are outlined based on estrogen receptor (ER)/progesterone receptor (PR)/HER2 and nodal status. Where there are options, the treating physician will choose a regimen best fitted for that patient. If the physician does not feel any of the regimens are the best fit for the patient, the patient should not be enrolled. Physicians will also document why a regimen was felt to be inappropriate when an option. Patients who have already started the anthracycline portion of their therapy are eligible assuming they have not yet begun the taxane portion and assuming they will be receiving one of the regimens deemed appropriate for her disease setting
Patients must self-identify their race as black, African American, or of African descent; patients may be of any ethnicity
Patients with a history of other cancers are eligible if they have not received prior taxane or platinum or vinca alkaloid therapy
Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1
Patients of childbearing potential must be strongly advised to use an accepted and effective method of contraception or to abstain from sexual intercourse for the duration of their participation in the study

Exclusion Criteria:

Patients must not have received prior taxane or prior/concurrent platinum therapy
Patients must not have received neoadjuvant anti-HER2 therapy
Patients must not have pre-existing peripheral neuropathy
Patients must not have a total bilirubin > upper limit of normal (ULN) (must be obtained within 3 weeks prior to registration)
Patients must not have aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) above 1.5 times the ULN concomitant with alkaline phosphatase above 2.5 times the ULN (must be obtained within 3 weeks prior to registration)
Patients must not be pregnant or lactating
- All patients of childbearing potential must have a blood test or urine study within 2 weeks prior to registration to rule out pregnancy
- A patient of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy, or 3) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)

Studieplan

Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.

Hur är studien utformad?

Designdetaljer

Primärt syfte: Stödjande vård
Tilldelning: Icke-randomiserad
Interventionsmodell: Parallellt uppdrag
Maskning: Ingen (Open Label)

Antal vapen

Vapen och interventioner

Deltagargrupp / Arm	Intervention / Behandling
Experimentell: Arm A (paclitaxel) Patients receive paclitaxel IV over 3 hours once weekly. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. Patients may also receive trastuzumab and/or pertuzumab per institution routine care per treating physician's discretion.	Läkemedel: Paclitaxel Given IV Andra namn: Taxol Anzatax Asotax Bristaxol Praxel Taxol Konzentrat Övrig: Quality-of-Life Assessment Ancillary studies Andra namn: Livskvalitetsbedömning Övrig: Questionnaire Administration Ancillary studies
Experimentell: Arm B (docetaxel) Patients receive docetaxel IV over 1 hour once every 3 weeks. Treatment repeats every 21 days for 4-6 cycles in the absence of disease progression or unacceptable toxicity. Patients may also receive cyclophosphamide, doxorubicin, trastuzumab, and/or pertuzumab per institution routine care per treating physician's discretion.	Övrig: Quality-of-Life Assessment Ancillary studies Andra namn: Livskvalitetsbedömning Läkemedel: Docetaxel Given IV Andra namn: Taxotere Docecad RP56976 Taxotere injektionskoncentrat RP 56976 RP-56976 Övrig: Questionnaire Administration Ancillary studies

Vad mäter studien?

Primära resultatmått

Resultatmått	Åtgärdsbeskrivning	Tidsram
Percentage of Participants With Grade 2-4 Taxane-Induced Peripheral Neuropathy (TIPN) by Genotype Risk Group in Arm A Tidsram: assessed at baseline, an end of each cycle, at 6 months and 1 year post registration	Grade 2-4 TIPN was assessed by treating physician using National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. All patients who started protocol therapy on arm A (paclitaxel) were included in the analysis. The percentage of participants with grade 2-4 TIPN was calculated based on binomial distribution and was compared between high-risk vs low-risk genotype groups using Fisher exact test. Genotype risk group (high vs. low) was determined by genotyping. High-risk genotype was defined by FCAMR GG genotype (homozygous wild type) or SBF2 mutated. Low-risk genotype was defined by carriage of at least one variant allele in FCAMR (AG or AA) and SBF2 wild-type status.	assessed at baseline, an end of each cycle, at 6 months and 1 year post registration

Sekundära resultatmått

Resultatmått	Åtgärdsbeskrivning	Tidsram
Patient-Reported Neuropathy Score Change Between Baseline and End of Treatment by Genotype Risk Group in Patients on Arm A Tidsram: assessed at baseline and at end of treatment, an average of 3 months	The patient-reported neurotoxicity was assessed using the 11 items about neurotoxicity in the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group - Neurotoxicity (FACT/GOG-Ntx) questionnaire (i.e., FACT/GOG-Ntx additional concerns subscale). The neurotoxicity total score was the sum of the scores for the 11 items, ranging from 0 to 44. Higher values of the FACT/GOG-Ntx neurotoxicity total score indicate less neurotoxicity. The FACT/GOG-Ntx neurotoxicity total score change between the baseline and at end of treatment (negative value indicates worsening symptom, positive value indicates improving symptom) was calculated and compared using two-sample t test. Genotype risk group (high vs. low) was determined by genotyping. High-risk genotype was defined by FCAMR GG genotype (homozygous wild type) or SBF2 mutated. Low-risk genotype was defined by carriage of at least one variant allele in FCAMR (AG or AA) and SBF2 wild-type status.	assessed at baseline and at end of treatment, an average of 3 months
Percentage of Participants With Grade 2-4 TIPN Based on CTCAE Between Arm A and Arm B Tidsram: assessed at baseline, an end of each cycle, at 6 months and 1 year post registration	Grade 2-4 TIPN was assessed by treating physician using CTCAE version 4.0. All patients who started protocol therapy were included in the analysis. The percentage of participants with grade 2-4 TIPN was calculated based on binomial distribution and was compared between treatment arms using Fisher exact test.	assessed at baseline, an end of each cycle, at 6 months and 1 year post registration
Percentage of Participants With Dose Reduction Due to TIPN Between Arm A and Arm B Tidsram: Dose reduction due to TIPN was assessed at end of each cycle, up to 4 cycles in arm A and 6 cycles in arm B	The percentage of patients with dose reduction due to TIPN was calculated as number of patients with dose reduction due to peripheral neuropathy for any dose of any cycle divided by total number of patients who started protocol therapy. The percentages were calculated along with exact 95% CI based on binomial distribution and were compared between arms using Fisher exact test.	Dose reduction due to TIPN was assessed at end of each cycle, up to 4 cycles in arm A and 6 cycles in arm B
Percentage of Participants With Dose Reduction Due to Any Reason Between Arm A and Arm B Tidsram: Dose reduction due to any reason was assessed at end of each cycle, up to 4 cycles in arm A and 6 cycles in arm B	The percentage of patients with dose reduction due to any reason was calculated as number of patients with any dose reduction for any dose of any cycle, regardless of the reason, divided by total number of patients who started protocol therapy. The percentages were calculated along with exact 95% CI based on binomial distribution and were compared between arms using Fisher exact test.	Dose reduction due to any reason was assessed at end of each cycle, up to 4 cycles in arm A and 6 cycles in arm B
Percentage of Participants With Grade 2-4 TIPN by Genotype Risk Group in Arm B Tidsram: assessed at baseline, at end of each cycle, at 6 months and 1 year post registration	Grade 2-4 TIPN was assessed by treating physician using CTCAE version 4.0. All patients who started protocol therapy on arm B were included in the analysis. The percentage of participants with grade 2-4 TIPN was calculated based on binomial distribution and was compared between high-risk vs low-risk genotype groups using Fisher exact test. Genotype risk group (high vs. low) was determined by genotyping. High-risk genotype was defined by FCAMR GG genotype (homozygous wild type) or SBF2 mutated. Low-risk genotype was defined by carriage of at least one variant allele in FCAMR (AG or AA) and SBF2 wild-type status.	assessed at baseline, at end of each cycle, at 6 months and 1 year post registration

Samarbetspartners och utredare

Det är här du hittar personer och organisationer som är involverade i denna studie.

Sponsor

ECOG-ACRIN Cancer Research Group

Samarbetspartners

National Cancer Institute (NCI)

Utredare

Huvudutredare: Bryan P Schneider, ECOG-ACRIN Cancer Research Group

Publikationer och användbara länkar

Den som ansvarar för att lägga in information om studien tillhandahåller frivilligt dessa publikationer. Dessa kan handla om allt som har med studien att göra.

Allmänna publikationer

Schneider BP, Zhao F, Ballinger TJ, Garcia SF, Shen F, Virani S, Cella D, Bales C, Jiang G, Hayes L, Miller N, Srinivasiah J, Stringer-Reasor EM, Chitalia A, Davis AA, Makower DF, Incorvati J, Simon MA, Mitchell EP, DeMichele A, Miller KD, Sparano JA, Wagner LI, Wolff AC. ECOG-ACRIN EAZ171: Prospective Validation Trial of Germline Predictors of Taxane-Induced Peripheral Neuropathy in Black Women With Early-Stage Breast Cancer. J Clin Oncol. 2024 Aug 20;42(24):2899-2907. doi: 10.1200/JCO.24.00526. Epub 2024 Jun 3.

Studieavstämningsdatum

Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.

Studera stora datum

Studiestart (Faktisk)

9 augusti 2019

Primärt slutförande (Faktisk)

19 september 2023

Avslutad studie (Beräknad)

5 april 2027

Studieregistreringsdatum

Först inskickad

19 juni 2019

Först inskickad som uppfyllde QC-kriterierna

27 juni 2019

Första postat (Faktisk)

28 juni 2019

Uppdateringar av studier

Senaste uppdatering publicerad (Faktisk)

6 oktober 2026

Senaste inskickade uppdateringen som uppfyllde QC-kriterierna

14 september 2026

Senast verifierad

1 september 2026

Mer information

Termer relaterade till denna studie

Ytterligare relevanta MeSH-villkor

Andra studie-ID-nummer

EAZ171
UG1CA189828 (U.S.S. NIH-anslag/kontrakt)
EAZ171 (Annan identifierare: CTEP)
NCI-2019-00266 (Registeridentifierare: CTRP (Clinical Trial Reporting Program))
ECOG-ACRIN-EAZ171 (Annan identifierare: DCP)
EAZ171 (Annan identifierare: ECOG-ACRIN Cancer Research Group)

Läkemedels- och apparatinformation, studiedokument

Studerar en amerikansk FDA-reglerad läkemedelsprodukt

Nej

Studerar en amerikansk FDA-reglerad produktprodukt

Nej

Denna information hämtades direkt från webbplatsen clinicaltrials.gov utan några ändringar. Om du har några önskemål om att ändra, ta bort eller uppdatera dina studieuppgifter, vänligen kontakta register@clinicaltrials.gov. Så snart en ändring har implementerats på clinicaltrials.gov, kommer denna att uppdateras automatiskt även på vår webbplats .

Docetaxel eller paklitaxel för att minska kemoterapi-inducerad perifer neuropati hos afroamerikanska patienter med stadium I-III bröstcancer

Prospektiv valideringsstudie av taxanterapi (docetaxel eller veckopaklitaxel) och risk för kemoterapiinducerad perifer neuropati hos afroamerikanska kvinnor

Studieöversikt

Status

Betingelser

Intervention / Behandling

Detaljerad beskrivning

Studietyp

Inskrivning (Faktisk)

Fas

Kontakter och platser

Studieorter

Deltagandekriterier

Urvalskriterier

Åldrar som är berättigade till studier

Tar emot friska volontärer

Kön som är behöriga för studier

Beskrivning

Studieplan

Hur är studien utformad?

Designdetaljer

Antal vapen

Vapen och interventioner

Deltagargrupp / Arm

Intervention / Behandling

Vad mäter studien?

Primära resultatmått

Resultatmått

Åtgärdsbeskrivning

Tidsram

Sekundära resultatmått

Resultatmått

Åtgärdsbeskrivning

Tidsram

Samarbetspartners och utredare

Sponsor

Samarbetspartners

Utredare

Publikationer och användbara länkar

Allmänna publikationer

Studieavstämningsdatum

Studera stora datum

Studiestart (Faktisk)

Primärt slutförande (Faktisk)

Avslutad studie (Beräknad)

Studieregistreringsdatum

Först inskickad

Först inskickad som uppfyllde QC-kriterierna

Första postat (Faktisk)

Uppdateringar av studier

Senaste uppdatering publicerad (Faktisk)

Senaste inskickade uppdateringen som uppfyllde QC-kriterierna

Senast verifierad

Mer information

Termer relaterade till denna studie

Ytterligare relevanta MeSH-villkor

Andra studie-ID-nummer

Läkemedels- och apparatinformation, studiedokument

Studerar en amerikansk FDA-reglerad läkemedelsprodukt

Studerar en amerikansk FDA-reglerad produktprodukt