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Docetaxel o paclitaxel para reducir la neuropatía periférica inducida por quimioterapia en pacientes afroamericanos con cáncer de mama en estadio I-III

14 de septiembre de 2026 actualizado por: ECOG-ACRIN Cancer Research Group

Ensayo de validación prospectiva de la terapia con taxanos (docetaxel o paclitaxel semanal) y riesgo de neuropatía periférica inducida por quimioterapia en mujeres afroamericanas

This phase II trial studies how well docetaxel or paclitaxel work in reducing chemotherapy-induced peripheral neuropathy in African American patients with stages I-III breast cancer. Drugs used in chemotherapy, such as docetaxel and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving docetaxel or paclitaxel may work better than other methods in reducing chemotherapy-induced peripheral neuropathy in patients with breast cancer.

Descripción general del estudio

Estado

Activo, no reclutando

Condiciones

Intervención / Tratamiento

Descripción detallada

PRIMARY OBJECTIVE:

I. Prospectively validate a prior germline predictor of paclitaxel-induced peripheral neuropathy (TIPN) using the Common Terminology Criteria for Adverse Events (CTCAE). Specifically, this study will demonstrate that patients with a high-risk TIPN genotype have significantly more grade 2-4 TIPN than patients with a low risk genotype.

SECONDARY OBJECTIVES:

I. Validate a prior germline predictor of TIPN using the Functional Assessment of Cancer Therapy (FACT)/Gynecologic Oncology Group (GOG)-Neurotoxicity (NTX) neurotoxicity subscale in Arm A.

II. Compare grade 2-4 TIPN based on CTCAE between weekly paclitaxel (Arm A) versus (vs.) every three-week docetaxel (Arm B).

III. Prospectively confirm dose reductions due to TIPN are lower for every three-week docetaxel compared with weekly paclitaxel in a prospective cohort of patients of African ancestry.

IV. Prospectively confirm dose reductions due to any cause are lower for every three-week docetaxel compared with weekly paclitaxel in a prospective cohort of patients of African ancestry.

V. Assess the ability of the high-risk genotype to predict TIPN risk for docetaxel.

CORRELATIVE STUDY OBJECTIVES:

I. Identify novel markers of TIPN and elucidate the mechanism. II. Whole genome sequencing of germline blood to evaluate for additional predictors of TIPN.

III. Create induced pluripotent stem cell (iPSC) derived neurons from patient samples.

IIIa. Evaluate whether clinical findings can be mimicked in vitro. IIIb. Evaluate gene expression (ribonucleic acid [RNA] sequencing [seq]) and the epigenome at baseline versus after exposure in those prone to TIPN versus those not.

IV. Create a biorepository of patient derived samples for future translational research.

PATIENT REPORTED OUTCOME OBJECTIVES:

I. Compare grade 2-4 TIPN (moderate to life threatening) based on Patient Reported Outcomes (PRO)-CTCAE items between weekly paclitaxel (Arm A) vs. every three-week docetaxel (Arm B).

II. Prospectively compare FACT/GOG-NTX Health-Related Quality of Life (HRQoL) scores (from the FACT-General [G] portion and Patient-Reported Outcomes Measurement Information System [PROMIS] Physical Function version [v.]2 Short Form [SF] 10a, scores between every three-week docetaxel and weekly paclitaxel and between high risk and low risk genotypes (Arm A) in a cohort of African ancestry.

III. Compare Chemotherapy-Induced Peripheral Neuropathy (CIPN)-20 sensory neuropathy score between weekly paclitaxel (Arm A) vs. every three-week docetaxel (Arm B).

IV. Compare the impact on financial toxicity (Comprehensive Score for Financial Toxicity [COST] scores) for every three-week docetaxel compared with weekly paclitaxel.

V. Examine associations between social determinants of health (zip code, marital status, education, income & insurance status) and dose reductions and treatment discontinuation.

OUTLINE: Patients are assigned to 1 of 2 arms.

ARM A: Patients receive paclitaxel intravenously (IV) over 3 hours once weekly. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. Patients may also receive trastuzumab and/or pertuzumab per institution routine care per treating physician's discretion.

ARM B: Patients receive docetaxel IV over 1 hour once every 3 weeks. Treatment repeats every 21 days for 4-6 cycles in the absence of disease progression or unacceptable toxicity. Patients may also receive cyclophosphamide, doxorubicin, trastuzumab, and/or pertuzumab per institution routine care per treating physician's discretion.

After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.

Tipo de estudio

Intervencionista

Inscripción (Actual)

249

Fase

  • Fase 2

Contactos y Ubicaciones

Esta sección proporciona los datos de contacto de quienes realizan el estudio e información sobre dónde se lleva a cabo este estudio.

Ubicaciones de estudio

  • Estados Unidos
    • Alabama
      • Birmingham, Alabama, Estados Unidos, 35233
        • University of Alabama at Birmingham Cancer Center
    • Alaska
      • Anchorage, Alaska, Estados Unidos, 98508
        • Anchorage Associates in Radiation Medicine
      • Anchorage, Alaska, Estados Unidos, 99508
        • Alaska Breast Care and Surgery LLC
      • Anchorage, Alaska, Estados Unidos, 99508
        • Alaska Oncology and Hematology LLC
      • Anchorage, Alaska, Estados Unidos, 99508
        • Alaska Women's Cancer Care
      • Anchorage, Alaska, Estados Unidos, 99508
        • Anchorage Oncology Centre
      • Anchorage, Alaska, Estados Unidos, 99508
        • Katmai Oncology Group
      • Anchorage, Alaska, Estados Unidos, 99508
        • Providence Alaska Medical Center
      • Anchorage, Alaska, Estados Unidos, 99504
        • Anchorage Radiation Therapy Center
      • Fairbanks, Alaska, Estados Unidos, 99701
        • Fairbanks Memorial Hospital
    • Arizona
      • Kingman, Arizona, Estados Unidos, 86401
        • Kingman Regional Medical Center
    • Arkansas
      • Fort Smith, Arkansas, Estados Unidos, 72903
        • Mercy Hospital Fort Smith
      • Jonesboro, Arkansas, Estados Unidos, 72401
        • NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
    • California
      • Arroyo Grande, California, Estados Unidos, 93420
        • PCR Oncology
      • Burbank, California, Estados Unidos, 91505
        • Providence Saint Joseph Medical Center/Disney Family Cancer Center
      • Dublin, California, Estados Unidos, 94568
        • Epic Care-Dublin
      • Emeryville, California, Estados Unidos, 94608
        • Bay Area Breast Surgeons Inc
      • Emeryville, California, Estados Unidos, 94608
        • Epic Care Partners in Cancer Care
      • Martinez, California, Estados Unidos, 94553-3156
        • Contra Costa Regional Medical Center
      • Oakland, California, Estados Unidos, 94609
        • Alta Bates Summit Medical Center - Summit Campus
      • Oakland, California, Estados Unidos, 94609
        • Bay Area Tumor Institute
      • Walnut Creek, California, Estados Unidos, 94597
        • Epic Care Cyberknife Center
    • Colorado
      • Aurora, Colorado, Estados Unidos, 80012
        • Rocky Mountain Cancer Centers-Aurora
      • Aurora, Colorado, Estados Unidos, 80012
        • The Medical Center of Aurora
      • Boulder, Colorado, Estados Unidos, 80303
        • Boulder Community Foothills Hospital
      • Boulder, Colorado, Estados Unidos, 80304
        • Rocky Mountain Cancer Centers-Boulder
      • Centennial, Colorado, Estados Unidos, 80112
        • Rocky Mountain Cancer Centers - Centennial
      • Denver, Colorado, Estados Unidos, 80218
        • Presbyterian - Saint Lukes Medical Center - Health One
      • Denver, Colorado, Estados Unidos, 80220
        • Rose Medical Center
      • Denver, Colorado, Estados Unidos, 80218
        • Rocky Mountain Cancer Centers-Midtown
      • Denver, Colorado, Estados Unidos, 80220
        • Rocky Mountain Cancer Centers-Rose
      • Denver, Colorado, Estados Unidos, 80218
        • Colorado Blood Cancer Institute
      • Denver, Colorado, Estados Unidos, 80204
        • Cancer Center of Colorado at Sloan's Lake
      • Denver, Colorado, Estados Unidos, 80209
        • The Women's Imaging Center
      • Denver, Colorado, Estados Unidos, 80206
        • National Jewish Health-Main Campus
      • Denver, Colorado, Estados Unidos, 80220
        • Western Surgical Care
      • Denver, Colorado, Estados Unidos, 80218
        • Saint Joseph Hospital - Cancer Centers of Colorado
      • Englewood, Colorado, Estados Unidos, 80113
        • Mountain Blue Cancer Care Center - Swedish
      • Englewood, Colorado, Estados Unidos, 80113
        • Swedish Medical Center
      • Englewood, Colorado, Estados Unidos, 80113
        • Rocky Mountain Cancer Centers - Swedish
      • Englewood, Colorado, Estados Unidos, 80113
        • The Melanoma and Skin Cancer Institute
      • Golden, Colorado, Estados Unidos, 80401
        • National Jewish Health-Western Hematology Oncology
      • Grand Junction, Colorado, Estados Unidos, 81501
        • Saint Mary's Hospital and Regional Medical Center
      • Greeley, Colorado, Estados Unidos, 80631
        • Banner North Colorado Medical Center
      • Lafayette, Colorado, Estados Unidos, 80026
        • Good Samaritan Hospital - Cancer Centers of Colorado
      • Lakewood, Colorado, Estados Unidos, 80228
        • Rocky Mountain Cancer Centers-Lakewood
      • Littleton, Colorado, Estados Unidos, 80120
        • Rocky Mountain Cancer Centers-Littleton
      • Lone Tree, Colorado, Estados Unidos, 80124
        • Sky Ridge Medical Center
      • Lone Tree, Colorado, Estados Unidos, 80124
        • Rocky Mountain Cancer Centers-Sky Ridge
      • Loveland, Colorado, Estados Unidos, 80539
        • Banner North Colorado Medical Center - Loveland Campus
      • Thornton, Colorado, Estados Unidos, 80260
        • Rocky Mountain Cancer Centers-Thornton
      • Thornton, Colorado, Estados Unidos, 80260
        • National Jewish Health-Northern Hematology Oncology
      • Wheat Ridge, Colorado, Estados Unidos, 80401
        • Intermountain Health Lutheran Hospital
    • Delaware
      • Lewes, Delaware, Estados Unidos, 19958
        • Beebe Medical Center
      • Millville, Delaware, Estados Unidos, 19967
        • Beebe South Coastal Health Campus
      • Newark, Delaware, Estados Unidos, 19713
        • Helen F Graham Cancer Center
      • Newark, Delaware, Estados Unidos, 19713
        • Delaware Clinical and Laboratory Physicians PA
      • Newark, Delaware, Estados Unidos, 19713
        • Medical Oncology Hematology Consultants PA
      • Newark, Delaware, Estados Unidos, 19718
        • Christiana Care Health System-Christiana Hospital
      • Rehoboth Beach, Delaware, Estados Unidos, 19971
        • Beebe Health Campus
      • Seaford, Delaware, Estados Unidos, 19973
        • TidalHealth Nanticoke / Allen Cancer Center
      • Wilmington, Delaware, Estados Unidos, 19801
        • Christiana Care Health System-Wilmington Hospital
    • District of Columbia
      • Washington D.C., District of Columbia, Estados Unidos, 20010
        • MedStar Washington Hospital Center
      • Washington D.C., District of Columbia, Estados Unidos, 20016
        • Sibley Memorial Hospital
    • Florida
      • Fort Lauderdale, Florida, Estados Unidos, 33308
        • Holy Cross Hospital
      • Gainesville, Florida, Estados Unidos, 32610
        • UF Health Cancer Institute - Gainesville
    • Georgia
      • Atlanta, Georgia, Estados Unidos, 30308
        • Emory University Hospital Midtown
      • Atlanta, Georgia, Estados Unidos, 30322
        • Emory University Hospital/Winship Cancer Institute
      • Atlanta, Georgia, Estados Unidos, 30342
        • Emory Saint Joseph's Hospital
      • Atlanta, Georgia, Estados Unidos, 30303
        • Grady Health System
      • Atlanta, Georgia, Estados Unidos, 30342
        • Northside Hospital
      • Columbus, Georgia, Estados Unidos, 31904
        • John B Amos Cancer Center
      • Duluth, Georgia, Estados Unidos, 30096
        • Northside Hospital - Duluth
      • Lawrenceville, Georgia, Estados Unidos, 30046
        • Northside Hospital - Gwinnett
      • Savannah, Georgia, Estados Unidos, 31405
        • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
      • Snellville, Georgia, Estados Unidos, 30078
        • Suburban Hematology Oncology Associates - Snellville
    • Idaho
      • Boise, Idaho, Estados Unidos, 83712
        • Saint Luke's Cancer Institute - Boise
      • Fruitland, Idaho, Estados Unidos, 83619
        • Saint Luke's Cancer Institute - Fruitland
      • Meridian, Idaho, Estados Unidos, 83642
        • Saint Luke's Cancer Institute - Meridian
      • Nampa, Idaho, Estados Unidos, 83687
        • Saint Luke's Cancer Institute - Nampa
      • Twin Falls, Idaho, Estados Unidos, 83301
        • Saint Luke's Cancer Institute - Twin Falls
    • Illinois
      • Alton, Illinois, Estados Unidos, 62002
        • OSF Saint Anthony's Health Center
      • Aurora, Illinois, Estados Unidos, 60504
        • Rush-Copley Medical Center
      • Bloomington, Illinois, Estados Unidos, 61704
        • Illinois CancerCare-Bloomington
      • Canton, Illinois, Estados Unidos, 61520
        • Illinois CancerCare-Canton
      • Carbondale, Illinois, Estados Unidos, 62902
        • Memorial Hospital of Carbondale
      • Carterville, Illinois, Estados Unidos, 62918
        • SIH Cancer Institute
      • Carthage, Illinois, Estados Unidos, 62321
        • Illinois CancerCare-Carthage
      • Centralia, Illinois, Estados Unidos, 62801
        • Centralia Oncology Clinic
      • Chicago, Illinois, Estados Unidos, 60611
        • Northwestern University
      • Chicago, Illinois, Estados Unidos, 60612
        • John H Stroger Jr Hospital of Cook County
      • Danville, Illinois, Estados Unidos, 61832
        • Carle at The Riverfront
      • Decatur, Illinois, Estados Unidos, 62526
        • Decatur Memorial Hospital
      • Decatur, Illinois, Estados Unidos, 62526
        • Cancer Care Specialists of Illinois - Decatur
      • Dixon, Illinois, Estados Unidos, 61021
        • Illinois CancerCare-Dixon
      • Effingham, Illinois, Estados Unidos, 62401
        • Crossroads Cancer Center
      • Effingham, Illinois, Estados Unidos, 62401
        • Carle Physician Group-Effingham
      • Eureka, Illinois, Estados Unidos, 61530
        • Illinois CancerCare-Eureka
      • Galesburg, Illinois, Estados Unidos, 61401
        • Western Illinois Cancer Treatment Center
      • Galesburg, Illinois, Estados Unidos, 61401
        • Illinois CancerCare-Galesburg
      • Kewanee, Illinois, Estados Unidos, 61443
        • Illinois CancerCare-Kewanee Clinic
      • Macomb, Illinois, Estados Unidos, 61455
        • Illinois CancerCare-Macomb
      • Mattoon, Illinois, Estados Unidos, 61938
        • Carle Physician Group-Mattoon/Charleston
      • Mount Vernon, Illinois, Estados Unidos, 62864
        • SSM Health Good Samaritan
      • O'Fallon, Illinois, Estados Unidos, 62269
        • Cancer Care Center of O'Fallon
      • Ottawa, Illinois, Estados Unidos, 61350
        • Illinois CancerCare-Ottawa Clinic
      • Pekin, Illinois, Estados Unidos, 61554
        • Illinois CancerCare-Pekin
      • Peoria, Illinois, Estados Unidos, 61636
        • Methodist Medical Center of Illinois
      • Peoria, Illinois, Estados Unidos, 61615
        • Illinois CancerCare-Peoria
      • Peru, Illinois, Estados Unidos, 61354
        • Illinois CancerCare-Peru
      • Peru, Illinois, Estados Unidos, 61354
        • Valley Radiation Oncology
      • Princeton, Illinois, Estados Unidos, 61356
        • Illinois CancerCare-Princeton
      • Springfield, Illinois, Estados Unidos, 62702
        • Southern Illinois University School of Medicine
      • Springfield, Illinois, Estados Unidos, 62702
        • Springfield Clinic
      • Springfield, Illinois, Estados Unidos, 62781
        • Springfield Memorial Hospital
      • Swansea, Illinois, Estados Unidos, 62226
        • Southwest Illinois Health Services LLP
      • Urbana, Illinois, Estados Unidos, 61801
        • Carle Cancer Center
      • Urbana, Illinois, Estados Unidos, 61801
        • The Carle Foundation Hospital
      • Washington, Illinois, Estados Unidos, 61571
        • Illinois CancerCare - Washington
      • Yorkville, Illinois, Estados Unidos, 60560
        • Rush-Copley Healthcare Center
    • Indiana
      • Avon, Indiana, Estados Unidos, 46123
        • IU Health West Hospital
      • Carmel, Indiana, Estados Unidos, 46032
        • IU Health North Hospital
      • Crown Point, Indiana, Estados Unidos, 46307
        • Northwest Cancer Center - Crown Point
      • Dyer, Indiana, Estados Unidos, 46311
        • Northwest Oncology LLC
      • Hobart, Indiana, Estados Unidos, 46342
        • Northwest Cancer Center - Hobart
      • Hobart, Indiana, Estados Unidos, 46342
        • Saint Mary Medical Center
      • Indianapolis, Indiana, Estados Unidos, 46202
        • Indiana University/Melvin and Bren Simon Cancer Center
      • Indianapolis, Indiana, Estados Unidos, 46202
        • Sidney and Lois Eskenazi Hospital
      • Indianapolis, Indiana, Estados Unidos, 46290
        • Springmill Medical Center
      • Indianapolis, Indiana, Estados Unidos, 46202
        • IU Health Methodist Hospital
      • Indianapolis, Indiana, Estados Unidos, 46312
        • Saint Catherine Hospital
      • Munster, Indiana, Estados Unidos, 46321
        • The Community Hospital
      • Munster, Indiana, Estados Unidos, 46321
        • Women's Diagnostic Center - Munster
      • Valparaiso, Indiana, Estados Unidos, 46383
        • Northwest Cancer Center - Valparaiso
    • Kansas
      • Garden City, Kansas, Estados Unidos, 67846
        • Central Care Cancer Center - Garden City
      • Great Bend, Kansas, Estados Unidos, 67530
        • Central Care Cancer Center - Great Bend
    • Louisiana
      • Baton Rouge, Louisiana, Estados Unidos, 70805
        • LSU Health Baton Rouge-North Clinic
      • Baton Rouge, Louisiana, Estados Unidos, 70809
        • Louisiana Hematology Oncology Associates LLC
      • Baton Rouge, Louisiana, Estados Unidos, 70809
        • Mary Bird Perkins Cancer Center
      • Baton Rouge, Louisiana, Estados Unidos, 70808
        • Our Lady of The Lake
      • Baton Rouge, Louisiana, Estados Unidos, 70817
        • Woman's Hospital
      • Baton Rouge, Louisiana, Estados Unidos, 70817
        • Our Lady of the Lake Medical Oncology
      • Baton Rouge, Louisiana, Estados Unidos, 70817
        • Louisiana Hematology Oncology Associates
      • Baton Rouge, Louisiana, Estados Unidos, 70808
        • Our Lady of the Lake Physician Group
      • Covington, Louisiana, Estados Unidos, 70433
        • Northshore Oncology Associates-Covington
      • Houma, Louisiana, Estados Unidos, 70360
        • Terrebonne General Medical Center
      • New Orleans, Louisiana, Estados Unidos, 70112
        • University Medical Center New Orleans
      • New Orleans, Louisiana, Estados Unidos, 70112
        • Louisiana State University Health Science Center
    • Maryland
      • Baltimore, Maryland, Estados Unidos, 21287
        • Johns Hopkins University/Sidney Kimmel Cancer Center
      • Baltimore, Maryland, Estados Unidos, 21215
        • Sinai Hospital of Baltimore
      • Baltimore, Maryland, Estados Unidos, 21229
        • Saint Agnes Hospital
      • Baltimore, Maryland, Estados Unidos, 21239
        • MedStar Good Samaritan Hospital
      • Easton, Maryland, Estados Unidos, 21601
        • University of Maryland Shore Medical Center at Easton
      • Randallstown, Maryland, Estados Unidos, 21133
        • Northwest Hospital Center
      • Westminster, Maryland, Estados Unidos, 21157
        • William E Kahlert Regional Cancer Center/Sinai Hospital
    • Massachusetts
      • Springfield, Massachusetts, Estados Unidos, 01199
        • Baystate Medical Center
      • Springfield, Massachusetts, Estados Unidos, 01104
        • Mercy Medical Center
    • Michigan
      • Ann Arbor, Michigan, Estados Unidos, 48106
        • Trinity Health Saint Joseph Mercy Hospital Ann Arbor
      • Battle Creek, Michigan, Estados Unidos, 49017
        • Bronson Battle Creek
      • Brighton, Michigan, Estados Unidos, 48114
        • Trinity Health IHA Medical Group Hematology Oncology - Brighton
      • Brighton, Michigan, Estados Unidos, 48114
        • Trinity Health Medical Center - Brighton
      • Canton, Michigan, Estados Unidos, 48188
        • Trinity Health IHA Medical Group Hematology Oncology - Canton
      • Canton, Michigan, Estados Unidos, 48188
        • Trinity Health Medical Center - Canton
      • Caro, Michigan, Estados Unidos, 48723
        • Caro Cancer Center
      • Chelsea, Michigan, Estados Unidos, 48118
        • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
      • Chelsea, Michigan, Estados Unidos, 48118
        • Chelsea Hospital
      • Clarkston, Michigan, Estados Unidos, 48346
        • Hematology Oncology Consultants-Clarkston
      • Clarkston, Michigan, Estados Unidos, 48346
        • Newland Medical Associates-Clarkston
      • Detroit, Michigan, Estados Unidos, 48236
        • Henry Ford Health Saint John Hospital
      • East China, Michigan, Estados Unidos, 48054
        • Henry Ford River District Hospital
      • Flint, Michigan, Estados Unidos, 48503
        • Hurley Medical Center
      • Flint, Michigan, Estados Unidos, 48503
        • Genesee Hematology Oncology PC
      • Flint, Michigan, Estados Unidos, 48503
        • Genesys Hurley Cancer Institute
      • Flint, Michigan, Estados Unidos, 48503
        • Cancer Hematology Centers - Flint
      • Grand Rapids, Michigan, Estados Unidos, 49503
        • Trinity Health Grand Rapids Hospital
      • Grand Rapids, Michigan, Estados Unidos, 49503
        • Corewell Health Grand Rapids Hospitals - Butterworth Hospital
      • Grand Rapids, Michigan, Estados Unidos, 49503
        • Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
      • Grosse Pointe Woods, Michigan, Estados Unidos, 48236
        • Henry Ford Saint John Hospital - Academic
      • Grosse Pointe Woods, Michigan, Estados Unidos, 48236
        • Henry Ford Saint John Hospital - Breast
      • Grosse Pointe Woods, Michigan, Estados Unidos, 48236
        • Henry Ford Saint John Hospital - Van Elslander
      • Kalamazoo, Michigan, Estados Unidos, 49007
        • West Michigan Cancer Center
      • Kalamazoo, Michigan, Estados Unidos, 49007
        • Bronson Methodist Hospital
      • Kalamazoo, Michigan, Estados Unidos, 49009
        • Beacon Kalamazoo Cancer Center
      • Kalamazoo, Michigan, Estados Unidos, 49048
        • Beacon Kalamazoo
      • Lansing, Michigan, Estados Unidos, 48912
        • University of Michigan Health - Sparrow Lansing
      • Livonia, Michigan, Estados Unidos, 48154
        • Trinity Health Saint Mary Mercy Livonia Hospital
      • Livonia, Michigan, Estados Unidos, 48154
        • Hope Cancer Clinic
      • Macomb, Michigan, Estados Unidos, 48044
        • Henry Ford Warren Hospital - Breast Macomb
      • Macomb, Michigan, Estados Unidos, 48044
        • Henry Ford Saint John Hospital - Macomb Medical
      • Marlette, Michigan, Estados Unidos, 48453
        • Saint Mary's Oncology/Hematology Associates of Marlette
      • Muskegon, Michigan, Estados Unidos, 49444
        • Trinity Health Muskegon Hospital
      • Niles, Michigan, Estados Unidos, 49120
        • Corewell Health Lakeland Hospitals - Niles Hospital
      • Norton Shores, Michigan, Estados Unidos, 49444
        • Cancer and Hematology Centers of Western Michigan - Norton Shores
      • Pontiac, Michigan, Estados Unidos, 48341
        • Hope Cancer Center
      • Pontiac, Michigan, Estados Unidos, 48341
        • Newland Medical Associates-Pontiac
      • Pontiac, Michigan, Estados Unidos, 48341
        • Trinity Health Saint Joseph Mercy Oakland Hospital
      • Pontiac, Michigan, Estados Unidos, 48341
        • Michigan Healthcare Professionals Pontiac
      • Reed City, Michigan, Estados Unidos, 49677
        • Corewell Health Reed City Hospital
      • Rochester Hills, Michigan, Estados Unidos, 48309
        • Henry Ford Rochester Hospital
      • Saginaw, Michigan, Estados Unidos, 48604
        • Oncology Hematology Associates of Saginaw Valley PC
      • Saginaw, Michigan, Estados Unidos, 48601
        • MyMichigan Medical Center Saginaw
      • Saint Joseph, Michigan, Estados Unidos, 49085
        • Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
      • Saint Joseph, Michigan, Estados Unidos, 49085
        • Corewell Health Lakeland Hospitals - Saint Joseph Hospital
      • Sterling Heights, Michigan, Estados Unidos, 48312
        • Bhadresh Nayak MD PC-Sterling Heights
      • Tawas City, Michigan, Estados Unidos, 48764
        • MyMichigan Medical Center Tawas
      • Traverse City, Michigan, Estados Unidos, 49684
        • Munson Medical Center
      • Warren, Michigan, Estados Unidos, 48088
        • Advanced Breast Care Center PLLC
      • Warren, Michigan, Estados Unidos, 48093
        • Macomb Hematology Oncology PC
      • Warren, Michigan, Estados Unidos, 48093
        • Henry Ford Madison Heights Hospital - Breast
      • Warren, Michigan, Estados Unidos, 48093
        • Henry Ford Health Warren Hospital
      • Warren, Michigan, Estados Unidos, 48093
        • Henry Ford Warren Hospital - GLCMS
      • West Branch, Michigan, Estados Unidos, 48661
        • Saint Mary's Oncology/Hematology Associates of West Branch
      • Wyoming, Michigan, Estados Unidos, 49519
        • University of Michigan Health - West
      • Ypsilanti, Michigan, Estados Unidos, 48197
        • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
      • Ypsilanti, Michigan, Estados Unidos, 48106
        • Huron Gastroenterology PC
    • Minnesota
      • Burnsville, Minnesota, Estados Unidos, 55337
        • Fairview Ridges Hospital
      • Burnsville, Minnesota, Estados Unidos, 55337
        • Minnesota Oncology - Burnsville
      • Cambridge, Minnesota, Estados Unidos, 55008
        • Cambridge Medical Center
      • Coon Rapids, Minnesota, Estados Unidos, 55433
        • Mercy Hospital
      • Edina, Minnesota, Estados Unidos, 55435
        • Fairview Southdale Hospital
      • Fridley, Minnesota, Estados Unidos, 55432
        • Unity Hospital
      • Maple Grove, Minnesota, Estados Unidos, 55369
        • Fairview Clinics and Surgery Center Maple Grove
      • Maplewood, Minnesota, Estados Unidos, 55109
        • Saint John's Hospital - Healtheast
      • Maplewood, Minnesota, Estados Unidos, 55109
        • Minnesota Oncology Hematology PA-Maplewood
      • Minneapolis, Minnesota, Estados Unidos, 55415
        • Hennepin County Medical Center
      • Minneapolis, Minnesota, Estados Unidos, 55407
        • Abbott-Northwestern Hospital
      • Minneapolis, Minnesota, Estados Unidos, 55454
        • Health Partners Inc
      • Monticello, Minnesota, Estados Unidos, 55362
        • Monticello Cancer Center
      • New Ulm, Minnesota, Estados Unidos, 56073
        • New Ulm Medical Center
      • Princeton, Minnesota, Estados Unidos, 55371
        • Fairview Northland Medical Center
      • Robbinsdale, Minnesota, Estados Unidos, 55422
        • North Memorial Medical Health Center
      • Saint Louis Park, Minnesota, Estados Unidos, 55416
        • Park Nicollet Clinic - Saint Louis Park
      • Saint Paul, Minnesota, Estados Unidos, 55101
        • Regions Hospital
      • Saint Paul, Minnesota, Estados Unidos, 55102
        • United Hospital
      • Shakopee, Minnesota, Estados Unidos, 55379
        • Saint Francis Regional Medical Center
      • Stillwater, Minnesota, Estados Unidos, 55082
        • Lakeview Hospital
      • Waconia, Minnesota, Estados Unidos, 55387
        • Ridgeview Medical Center
      • Willmar, Minnesota, Estados Unidos, 56201
        • Rice Memorial Hospital
      • Woodbury, Minnesota, Estados Unidos, 55125
        • Minnesota Oncology Hematology PA-Woodbury
      • Wyoming, Minnesota, Estados Unidos, 55092
        • Fairview Lakes Medical Center
    • Mississippi
      • Columbus, Mississippi, Estados Unidos, 39705
        • Baptist Memorial Hospital and Cancer Center-Golden Triangle
      • Grenada, Mississippi, Estados Unidos, 38901
        • Baptist Cancer Center-Grenada
      • New Albany, Mississippi, Estados Unidos, 38652
        • Baptist Memorial Hospital and Cancer Center-Union County
      • Oxford, Mississippi, Estados Unidos, 38655
        • Baptist Memorial Hospital and Cancer Center-Oxford
      • Southhaven, Mississippi, Estados Unidos, 38671
        • Baptist Memorial Hospital and Cancer Center-Desoto
    • Missouri
      • Ballwin, Missouri, Estados Unidos, 63011
        • Mercy Oncology and Hematology - Clayton-Clarkson
      • Bolivar, Missouri, Estados Unidos, 65613
        • Central Care Cancer Center - Bolivar
      • Bonne Terre, Missouri, Estados Unidos, 63628
        • Parkland Health Center-Bonne Terre
      • Branson, Missouri, Estados Unidos, 65616
        • Cox Cancer Center Branson
      • Cape Girardeau, Missouri, Estados Unidos, 63703
        • Saint Francis Medical Center
      • Cape Girardeau, Missouri, Estados Unidos, 63703
        • Mercy Cancer Center - Cape Girardeau
      • City of Saint Peters, Missouri, Estados Unidos, 63376
        • Siteman Cancer Center at Saint Peters Hospital
      • Creve Coeur, Missouri, Estados Unidos, 63141
        • Siteman Cancer Center at West County Hospital
      • Farmington, Missouri, Estados Unidos, 63640
        • Parkland Health Center - Farmington
      • Jefferson City, Missouri, Estados Unidos, 65109
        • MU Health Care Goldschmidt Cancer Center
      • Joplin, Missouri, Estados Unidos, 64804
        • Freeman Health System
      • Joplin, Missouri, Estados Unidos, 64804
        • Mercy Hospital Joplin
      • Rolla, Missouri, Estados Unidos, 65401
        • Mercy Clinic-Rolla-Cancer and Hematology
      • Rolla, Missouri, Estados Unidos, 65401
        • Phelps Health Delbert Day Cancer Institute
      • Saint Joseph, Missouri, Estados Unidos, 64506
        • Heartland Regional Medical Center
      • Sainte Genevieve, Missouri, Estados Unidos, 63670
        • Sainte Genevieve County Memorial Hospital
      • Springfield, Missouri, Estados Unidos, 65807
        • CoxHealth South Hospital
      • Springfield, Missouri, Estados Unidos, 65804
        • Mercy Hospital Springfield
      • St Louis, Missouri, Estados Unidos, 63110
        • Washington University School of Medicine
      • St Louis, Missouri, Estados Unidos, 63129
        • Siteman Cancer Center-South County
      • St Louis, Missouri, Estados Unidos, 63136
        • Siteman Cancer Center at Christian Hospital
      • St Louis, Missouri, Estados Unidos, 63131
        • Missouri Baptist Medical Center
      • St Louis, Missouri, Estados Unidos, 63109
        • Mercy Infusion Center - Chippewa
      • St Louis, Missouri, Estados Unidos, 63141
        • Mercy Hospital Saint Louis
      • St Louis, Missouri, Estados Unidos, 63128
        • Mercy Hospital South
      • Sullivan, Missouri, Estados Unidos, 63080
        • Missouri Baptist Sullivan Hospital
      • Washington, Missouri, Estados Unidos, 63090
        • Mercy Hospital Washington
    • Montana
      • Billings, Montana, Estados Unidos, 59101
        • Saint Vincent Healthcare
      • Billings, Montana, Estados Unidos, 59102
        • Saint Vincent Frontier Cancer Center
      • Butte, Montana, Estados Unidos, 59701
        • Saint James Community Hospital and Cancer Treatment Center
      • Missoula, Montana, Estados Unidos, 59802
        • Saint Patrick Hospital - Community Hospital
    • Nebraska
      • Bellevue, Nebraska, Estados Unidos, 68123
        • Nebraska Medicine-Bellevue
      • Omaha, Nebraska, Estados Unidos, 68198
        • University of Nebraska Medical Center
      • Omaha, Nebraska, Estados Unidos, 68118
        • Nebraska Medicine-Village Pointe
    • Nevada
      • Carson City, Nevada, Estados Unidos, 89703
        • Carson Tahoe Regional Medical Center
      • Henderson, Nevada, Estados Unidos, 89052
        • Comprehensive Cancer Centers of Nevada - Henderson
      • Henderson, Nevada, Estados Unidos, 89052
        • Cancer and Blood Specialists-Henderson
      • Henderson, Nevada, Estados Unidos, 89052
        • Las Vegas Cancer Center-Henderson
      • Henderson, Nevada, Estados Unidos, 89074
        • Comprehensive Cancer Centers of Nevada-Southeast Henderson
      • Henderson, Nevada, Estados Unidos, 89052
        • Comprehensive Cancer Centers of Nevada-Horizon Ridge
      • Henderson, Nevada, Estados Unidos, 89074
        • Las Vegas Urology - Green Valley
      • Henderson, Nevada, Estados Unidos, 89074
        • Las Vegas Urology - Pebble
      • Henderson, Nevada, Estados Unidos, 89074
        • Urology Specialists of Nevada - Green Valley
      • Henderson, Nevada, Estados Unidos, 89074
        • Oncology Las Vegas - Henderson
      • Las Vegas, Nevada, Estados Unidos, 89144
        • Summerlin Hospital Medical Center
      • Las Vegas, Nevada, Estados Unidos, 89109
        • Sunrise Hospital and Medical Center
      • Las Vegas, Nevada, Estados Unidos, 89102
        • OptumCare Cancer Care at Charleston
      • Las Vegas, Nevada, Estados Unidos, 89106
        • Radiation Oncology Centers of Nevada Central
      • Las Vegas, Nevada, Estados Unidos, 89119
        • Radiation Oncology Centers of Nevada Southeast
      • Las Vegas, Nevada, Estados Unidos, 89128
        • Comprehensive Cancer Centers of Nevada - Northwest
      • Las Vegas, Nevada, Estados Unidos, 89128
        • OptumCare Cancer Care at MountainView
      • Las Vegas, Nevada, Estados Unidos, 89135
        • Alliance for Childhood Diseases/Cure 4 the Kids Foundation
      • Las Vegas, Nevada, Estados Unidos, 89144
        • Comprehensive Cancer Centers of Nevada - Town Center
      • Las Vegas, Nevada, Estados Unidos, 89144
        • Comprehensive Cancer Centers of Nevada-Summerlin
      • Las Vegas, Nevada, Estados Unidos, 89148
        • Comprehensive Cancer Centers of Nevada
      • Las Vegas, Nevada, Estados Unidos, 89169
        • Comprehensive Cancer Centers of Nevada - Central Valley
      • Las Vegas, Nevada, Estados Unidos, 89102
        • University Medical Center of Southern Nevada
      • Las Vegas, Nevada, Estados Unidos, 89148-2405
        • Las Vegas Cancer Center-Medical Center
      • Las Vegas, Nevada, Estados Unidos, 89128
        • Ann M Wierman MD LTD
      • Las Vegas, Nevada, Estados Unidos, 89074
        • Las Vegas Urology - Pecos
      • Las Vegas, Nevada, Estados Unidos, 89102
        • Desert West Surgery
      • Las Vegas, Nevada, Estados Unidos, 89103
        • Hope Cancer Care of Nevada
      • Las Vegas, Nevada, Estados Unidos, 89106
        • Urology Specialists of Nevada - Central
      • Las Vegas, Nevada, Estados Unidos, 89113
        • Las Vegas Prostate Cancer Center
      • Las Vegas, Nevada, Estados Unidos, 89113
        • Las Vegas Urology - Sunset
      • Las Vegas, Nevada, Estados Unidos, 89128
        • Las Vegas Urology - Cathedral Rock
      • Las Vegas, Nevada, Estados Unidos, 89128
        • Las Vegas Urology - Smoke Ranch
      • Las Vegas, Nevada, Estados Unidos, 89128
        • Urology Specialists of Nevada - Northwest
      • Las Vegas, Nevada, Estados Unidos, 89169
        • University Cancer Center
      • Las Vegas, Nevada, Estados Unidos, 89113
        • Urology Specialists of Nevada - Southwest
      • Las Vegas, Nevada, Estados Unidos, 89128
        • Oncology Las Vegas - Tenaya
      • Las Vegas, Nevada, Estados Unidos, 89183
        • OptumCare Cancer Care at Fort Apache
      • Pahrump, Nevada, Estados Unidos, 89048
        • Hope Cancer Care of Nevada-Pahrump
      • Reno, Nevada, Estados Unidos, 89502
        • Renown Regional Medical Center
      • Reno, Nevada, Estados Unidos, 89503
        • Saint Mary's Regional Medical Center
      • Reno, Nevada, Estados Unidos, 89509
        • Radiation Oncology Associates
    • New Jersey
      • Englewood, New Jersey, Estados Unidos, 07631
        • Englewood Hospital and Medical Center
      • Hamilton, New Jersey, Estados Unidos, 08690
        • The Cancer Institute of New Jersey Hamilton
      • Morristown, New Jersey, Estados Unidos, 07960
        • Morristown Medical Center
      • Mullica Hill, New Jersey, Estados Unidos, 08062
        • Inspira Medical Center Mullica Hill
      • New Brunswick, New Jersey, Estados Unidos, 08903
        • Rutgers Cancer Institute of New Jersey
      • Sewell, New Jersey, Estados Unidos, 08080
        • Sidney Kimmel Cancer Center Washington Township
      • Somerville, New Jersey, Estados Unidos, 08876
        • Robert Wood Johnson University Hospital Somerset
      • Summit, New Jersey, Estados Unidos, 07902
        • Overlook Hospital
      • Teaneck, New Jersey, Estados Unidos, 07666
        • Holy Name Hospital
      • Vineland, New Jersey, Estados Unidos, 08360
        • Inspira Medical Center Vineland
    • New York
      • Rochester, New York, Estados Unidos, 14642
        • University of Rochester
      • The Bronx, New York, Estados Unidos, 10461
        • Montefiore Medical Center-Einstein Campus
      • The Bronx, New York, Estados Unidos, 10467
        • Montefiore Medical Center - Moses Campus
      • The Bronx, New York, Estados Unidos, 10461
        • Montefiore Medical Center-Weiler Hospital
    • Ohio
      • Akron, Ohio, Estados Unidos, 44307
        • Cleveland Clinic Akron General
      • Beachwood, Ohio, Estados Unidos, 44122
        • UHHS-Chagrin Highlands Medical Center
      • Belpre, Ohio, Estados Unidos, 45714
        • Strecker Cancer Center-Belpre
      • Chardon, Ohio, Estados Unidos, 44024
        • Geauga Hospital
      • Chillicothe, Ohio, Estados Unidos, 45601
        • Adena Regional Medical Center
      • Cleveland, Ohio, Estados Unidos, 44106
        • Case Western Reserve University
      • Cleveland, Ohio, Estados Unidos, 44109
        • MetroHealth Medical Center
      • Columbus, Ohio, Estados Unidos, 43214
        • Riverside Methodist Hospital
      • Columbus, Ohio, Estados Unidos, 43219
        • The Mark H Zangmeister Center
      • Columbus, Ohio, Estados Unidos, 43214
        • Columbus Oncology and Hematology Associates Inc
      • Columbus, Ohio, Estados Unidos, 43228
        • Doctors Hospital
      • Columbus, Ohio, Estados Unidos, 43213
        • Mount Carmel East Hospital
      • Columbus, Ohio, Estados Unidos, 43215
        • Grant Medical Center
      • Columbus, Ohio, Estados Unidos, 43222
        • Mount Carmel Health Center West
      • Delaware, Ohio, Estados Unidos, 43015
        • Delaware Health Center-Grady Cancer Center
      • Delaware, Ohio, Estados Unidos, 43015
        • Grady Memorial Hospital
      • Dublin, Ohio, Estados Unidos, 43016
        • Dublin Methodist Hospital
      • Dublin, Ohio, Estados Unidos, 43016
        • Columbus Oncology and Hematology Associates
      • Gahanna, Ohio, Estados Unidos, 43230
        • Central Ohio Breast and Endocrine Surgery
      • Grove City, Ohio, Estados Unidos, 43123
        • Mount Carmel Grove City Hospital
      • Lancaster, Ohio, Estados Unidos, 43130
        • Fairfield Medical Center
      • Lima, Ohio, Estados Unidos, 45801
        • Saint Rita's Medical Center
      • Mansfield, Ohio, Estados Unidos, 44903
        • OhioHealth Mansfield Hospital
      • Marietta, Ohio, Estados Unidos, 45750
        • Marietta Memorial Hospital
      • Marion, Ohio, Estados Unidos, 43302
        • OhioHealth Marion General Hospital
      • Mentor, Ohio, Estados Unidos, 44060
        • UH Seidman Cancer Center at Lake Health Mentor Campus
      • Middleburg Heights, Ohio, Estados Unidos, 44130
        • UH Seidman Cancer Center at Southwest General Hospital
      • Mount Vernon, Ohio, Estados Unidos, 43050
        • Knox Community Hospital
      • Newark, Ohio, Estados Unidos, 43055
        • Licking Memorial Hospital
      • Newark, Ohio, Estados Unidos, 43055
        • Newark Radiation Oncology
      • Parma, Ohio, Estados Unidos, 44129
        • University Hospitals Parma Medical Center
      • Perrysburg, Ohio, Estados Unidos, 43551
        • Mercy Health - Perrysburg Hospital
      • Portsmouth, Ohio, Estados Unidos, 45662
        • Southern Ohio Medical Center
      • Ravenna, Ohio, Estados Unidos, 44266
        • University Hospitals Portage Medical Center
      • Sandusky, Ohio, Estados Unidos, 44870
        • UH Seidman Cancer Center at Firelands Regional Medical Center
      • Toledo, Ohio, Estados Unidos, 43623
        • Mercy Health - Saint Anne Hospital
      • Toledo, Ohio, Estados Unidos, 43608
        • Mercy Health - Saint Vincent Hospital
      • Toledo, Ohio, Estados Unidos, 43623
        • Mercy Health Sylvania Radiation Oncology Center
      • Wadsworth, Ohio, Estados Unidos, 44281
        • University Hospitals Sharon Health Center
      • Westerville, Ohio, Estados Unidos, 43081
        • Saint Ann's Hospital
      • Westlake, Ohio, Estados Unidos, 44145
        • UH Seidman Cancer Center at Saint John Medical Center
      • Zanesville, Ohio, Estados Unidos, 43701
        • Genesis Healthcare System Cancer Care Center
    • Oklahoma
      • Oklahoma City, Oklahoma, Estados Unidos, 73120
        • Mercy Hospital Oklahoma City
    • Oregon
      • Bend, Oregon, Estados Unidos, 97701
        • Saint Charles Health System
      • Clackamas, Oregon, Estados Unidos, 97015
        • Clackamas Radiation Oncology Center
      • Clackamas, Oregon, Estados Unidos, 97015
        • Providence Cancer Institute Clackamas Clinic
      • Coos Bay, Oregon, Estados Unidos, 97420
        • Bay Area Hospital
      • Newberg, Oregon, Estados Unidos, 97132
        • Providence Newberg Medical Center
      • Portland, Oregon, Estados Unidos, 97213
        • Providence Portland Medical Center
      • Portland, Oregon, Estados Unidos, 97225
        • Providence Saint Vincent Medical Center
      • Redmond, Oregon, Estados Unidos, 97756
        • Saint Charles Health System-Redmond
    • Pennsylvania
      • Allentown, Pennsylvania, Estados Unidos, 18103
        • Lehigh Valley Hospital-Cedar Crest
      • Bethlehem, Pennsylvania, Estados Unidos, 18017
        • Lehigh Valley Hospital - Muhlenberg
      • Bryn Mawr, Pennsylvania, Estados Unidos, 19010
        • Bryn Mawr Hospital
      • Chadds Ford, Pennsylvania, Estados Unidos, 19317
        • Christiana Care Health System-Concord Health Center
      • Collegeville, Pennsylvania, Estados Unidos, 19426
        • Main Line Health Center-Collegeville
      • East Norriton, Pennsylvania, Estados Unidos, 19401
        • Fox Chase Cancer Center - East Norriton Hospital Outpatient Center
      • East Stroudsburg, Pennsylvania, Estados Unidos, 18301
        • Pocono Medical Center
      • Exton, Pennsylvania, Estados Unidos, 19341
        • Main Line Health Center-Exton
      • Hazleton, Pennsylvania, Estados Unidos, 18201
        • Lehigh Valley Hospital-Hazleton
      • Media, Pennsylvania, Estados Unidos, 19063
        • Riddle Memorial Hospital
      • Paoli, Pennsylvania, Estados Unidos, 19301
        • Paoli Memorial Hospital
      • Philadelphia, Pennsylvania, Estados Unidos, 19111
        • Fox Chase Cancer Center
      • Philadelphia, Pennsylvania, Estados Unidos, 19107
        • Thomas Jefferson University Hospital
      • Philadelphia, Pennsylvania, Estados Unidos, 19114
        • Jefferson Torresdale Hospital
      • Philadelphia, Pennsylvania, Estados Unidos, 19140
        • Temple University Hospital
      • Wynnewood, Pennsylvania, Estados Unidos, 19096
        • Lankenau Medical Center
    • South Carolina
      • Bluffton, South Carolina, Estados Unidos, 29910
        • Saint Joseph's/Candler - Bluffton Campus
      • Charleston, South Carolina, Estados Unidos, 29425
        • Medical University of South Carolina
      • Georgetown, South Carolina, Estados Unidos, 29440
        • Tidelands Georgetown Memorial Hospital
      • Greenwood, South Carolina, Estados Unidos, 29646
        • Self Regional Healthcare
      • Hilton Head Island, South Carolina, Estados Unidos, 29926-3827
        • South Carolina Cancer Specialists PC
      • West Columbia, South Carolina, Estados Unidos, 29169
        • Lexington Medical Center
    • Tennessee
      • Collierville, Tennessee, Estados Unidos, 38017
        • Baptist Memorial Hospital and Cancer Center-Collierville
      • Memphis, Tennessee, Estados Unidos, 38120
        • Baptist Memorial Hospital and Cancer Center-Memphis
      • Memphis, Tennessee, Estados Unidos, 38120
        • Baptist Memorial Hospital for Women
    • Texas
      • Beaumont, Texas, Estados Unidos, 77701
        • Baptist Hospitals of Southeast Texas Cancer Center
      • Port Arthur, Texas, Estados Unidos, 77642
        • Baptist Regional Cancer Network-Cancer Center of Southeast Texas
    • Utah
      • American Fork, Utah, Estados Unidos, 84003
        • American Fork Hospital / Huntsman Intermountain Cancer Center
      • Cedar City, Utah, Estados Unidos, 84720
        • Sandra L Maxwell Cancer Center
      • Logan, Utah, Estados Unidos, 84321
        • Logan Regional Hospital
      • Murray, Utah, Estados Unidos, 84107
        • Intermountain Medical Center
      • Ogden, Utah, Estados Unidos, 84403
        • McKay-Dee Hospital Center
      • Provo, Utah, Estados Unidos, 84604
        • Utah Valley Regional Medical Center
      • Riverton, Utah, Estados Unidos, 84065
        • Riverton Hospital
      • Salt Lake City, Utah, Estados Unidos, 84106
        • Utah Cancer Specialists-Salt Lake City
      • Salt Lake City, Utah, Estados Unidos, 84143
        • LDS Hospital
      • St. George, Utah, Estados Unidos, 84770
        • Saint George Regional Medical Center
    • Virginia
      • Fishersville, Virginia, Estados Unidos, 22939
        • Augusta Health Center for Cancer and Blood Disorders
      • Mechanicsville, Virginia, Estados Unidos, 23116
        • Bon Secours Memorial Regional Medical Center
      • Midlothian, Virginia, Estados Unidos, 23114
        • Bon Secours Saint Francis Medical Center
      • Midlothian, Virginia, Estados Unidos, 23113
        • Bon Secours Westchester Emergency Center
      • Norfolk, Virginia, Estados Unidos, 23505
        • Bon Secours DePaul Medical Center
      • Portsmouth, Virginia, Estados Unidos, 23707
        • Bon Secours Maryview Medical Center
      • Richmond, Virginia, Estados Unidos, 23226
        • Bon Secours Saint Mary's Hospital
      • Richmond, Virginia, Estados Unidos, 23230
        • Bon Secours Cancer Institute at Reynolds Crossing
      • Suffolk, Virginia, Estados Unidos, 23435
        • Bon Secours Health Center at Harbour View
    • Washington
      • Aberdeen, Washington, Estados Unidos, 98520
        • Providence Regional Cancer System-Aberdeen
      • Auburn, Washington, Estados Unidos, 98001
        • MultiCare Auburn Medical Center
      • Bellevue, Washington, Estados Unidos, 98004
        • Overlake Medical Center
      • Bellingham, Washington, Estados Unidos, 98225
        • PeaceHealth Saint Joseph Medical Center
      • Centralia, Washington, Estados Unidos, 98531
        • Providence Regional Cancer System-Centralia
      • Edmonds, Washington, Estados Unidos, 98026
        • Swedish Cancer Institute-Edmonds
      • Everett, Washington, Estados Unidos, 98201
        • Providence Regional Cancer Partnership
      • Gig Harbor, Washington, Estados Unidos, 98335
        • MultiCare Gig Harbor Medical Park
      • Issaquah, Washington, Estados Unidos, 98029
        • Swedish Cancer Institute-Issaquah
      • Kennewick, Washington, Estados Unidos, 99336
        • Kadlec Clinic Hematology and Oncology
      • Lacey, Washington, Estados Unidos, 98503
        • Providence Regional Cancer System-Lacey
      • Longview, Washington, Estados Unidos, 98632
        • PeaceHealth Saint John Medical Center
      • Port Townsend, Washington, Estados Unidos, 98368
        • Jefferson Healthcare
      • Puyallup, Washington, Estados Unidos, 98372
        • MultiCare Good Samaritan Hospital
      • Renton, Washington, Estados Unidos, 98055
        • Valley Medical Center
      • Seattle, Washington, Estados Unidos, 98107
        • Swedish Medical Center-Ballard Campus
      • Seattle, Washington, Estados Unidos, 98122
        • Swedish Medical Center-First Hill
      • Seattle, Washington, Estados Unidos, 98104
        • Pacific Gynecology Specialists
      • Seattle, Washington, Estados Unidos, 98122-5711
        • Swedish Medical Center-Cherry Hill
      • Sedro-Woolley, Washington, Estados Unidos, 98284
        • PeaceHealth United General Medical Center
      • Shelton, Washington, Estados Unidos, 98584
        • Providence Regional Cancer System-Shelton
      • Spokane, Washington, Estados Unidos, 99204
        • MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
      • Spokane, Washington, Estados Unidos, 99218
        • MultiCare Deaconess Cancer and Blood Specialty Center - North
      • Spokane Valley, Washington, Estados Unidos, 99216
        • MultiCare Deaconess Cancer and Blood Specialty Center - Valley
      • Tacoma, Washington, Estados Unidos, 98405
        • Mary Bridge Children's Hospital and Health Center
      • Tacoma, Washington, Estados Unidos, 98405
        • MultiCare Tacoma General Hospital
      • Vancouver, Washington, Estados Unidos, 98664
        • PeaceHealth Southwest Medical Center
      • Walla Walla, Washington, Estados Unidos, 99362
        • Providence Saint Mary Regional Cancer Center
      • Yakima, Washington, Estados Unidos, 98902
        • North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
      • Yelm, Washington, Estados Unidos, 98597
        • Providence Regional Cancer System-Yelm
    • Wisconsin
      • Burlington, Wisconsin, Estados Unidos, 53105
        • Aurora Cancer Care-Southern Lakes VLCC
      • Cudahy, Wisconsin, Estados Unidos, 53110
        • Aurora Saint Luke's South Shore
      • Fond du Lac, Wisconsin, Estados Unidos, 54937
        • Aurora Health Center-Fond du Lac
      • Germantown, Wisconsin, Estados Unidos, 53022
        • Aurora Health Care Germantown Health Center
      • Grafton, Wisconsin, Estados Unidos, 53024
        • Aurora Cancer Care-Grafton
      • Green Bay, Wisconsin, Estados Unidos, 54311
        • Aurora BayCare Medical Center
      • Kenosha, Wisconsin, Estados Unidos, 53142
        • Aurora Cancer Care-Kenosha South
      • Marinette, Wisconsin, Estados Unidos, 54143
        • Aurora Bay Area Medical Group-Marinette
      • Milwaukee, Wisconsin, Estados Unidos, 53209
        • Aurora Cancer Care-Milwaukee
      • Milwaukee, Wisconsin, Estados Unidos, 53215
        • Aurora Saint Luke's Medical Center
      • Milwaukee, Wisconsin, Estados Unidos, 53233
        • Aurora Sinai Medical Center
      • New Richmond, Wisconsin, Estados Unidos, 54017
        • Cancer Center of Western Wisconsin
      • Oshkosh, Wisconsin, Estados Unidos, 54904
        • Vince Lombardi Cancer Clinic - Oshkosh
      • Racine, Wisconsin, Estados Unidos, 53406
        • Aurora Cancer Care-Racine
      • Sheboygan, Wisconsin, Estados Unidos, 53081
        • Vince Lombardi Cancer Clinic-Sheboygan
      • Summit, Wisconsin, Estados Unidos, 53066
        • Aurora Medical Center in Summit
      • Two Rivers, Wisconsin, Estados Unidos, 54241
        • Vince Lombardi Cancer Clinic-Two Rivers
      • Wauwatosa, Wisconsin, Estados Unidos, 53226
        • Aurora Cancer Care-Milwaukee West
      • West Allis, Wisconsin, Estados Unidos, 53227
        • Aurora West Allis Medical Center
    • Wyoming
      • Cheyenne, Wyoming, Estados Unidos, 82001
        • Cheyenne Regional Medical Center-West

Criterios de participación

Los investigadores buscan personas que se ajusten a una determinada descripción, denominada criterio de elegibilidad. Algunos ejemplos de estos criterios son el estado de salud general de una persona o tratamientos previos.

Criterio de elegibilidad

Edades elegibles para estudiar

18 años y mayores (Adulto, Adulto Mayor)

Acepta Voluntarios Saludables

No

Géneros elegibles para el estudio

Femenino

Descripción

Inclusion Criteria:

  • Patients must be women with a known stage I-III invasive breast cancer diagnosis

  • Patients must be capable and willing to provide informed consent

  • Patients must have plans to receive either neoadjuvant or adjuvant:

    • Every 3-week docetaxel x 4-6 cycles OR
    • Weekly paclitaxel x 4 cycles
    • NOTE: Recommended therapies for various therapy regimens are outlined based on estrogen receptor (ER)/progesterone receptor (PR)/HER2 and nodal status. Where there are options, the treating physician will choose a regimen best fitted for that patient. If the physician does not feel any of the regimens are the best fit for the patient, the patient should not be enrolled. Physicians will also document why a regimen was felt to be inappropriate when an option. Patients who have already started the anthracycline portion of their therapy are eligible assuming they have not yet begun the taxane portion and assuming they will be receiving one of the regimens deemed appropriate for her disease setting

  • Patients must self-identify their race as black, African American, or of African descent; patients may be of any ethnicity

  • Patients with a history of other cancers are eligible if they have not received prior taxane or platinum or vinca alkaloid therapy

  • Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1

  • Patients of childbearing potential must be strongly advised to use an accepted and effective method of contraception or to abstain from sexual intercourse for the duration of their participation in the study

Exclusion Criteria:

  • Patients must not have received prior taxane or prior/concurrent platinum therapy

  • Patients must not have received neoadjuvant anti-HER2 therapy

  • Patients must not have pre-existing peripheral neuropathy

  • Patients must not have a total bilirubin > upper limit of normal (ULN) (must be obtained within 3 weeks prior to registration)

  • Patients must not have aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) above 1.5 times the ULN concomitant with alkaline phosphatase above 2.5 times the ULN (must be obtained within 3 weeks prior to registration)

  • Patients must not be pregnant or lactating

    • All patients of childbearing potential must have a blood test or urine study within 2 weeks prior to registration to rule out pregnancy
    • A patient of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy, or 3) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)

Plan de estudios

Esta sección proporciona detalles del plan de estudio, incluido cómo está diseñado el estudio y qué mide el estudio.

¿Cómo está diseñado el estudio?

Detalles de diseño

  • Propósito principal: Cuidados de apoyo
  • Asignación: No aleatorizado
  • Modelo Intervencionista: Asignación paralela
  • Enmascaramiento: Ninguno (etiqueta abierta)

Armas e Intervenciones

Grupo de participantes/brazo
Intervención / Tratamiento
Experimental: Arm A (paclitaxel)

Patients receive paclitaxel IV over 3 hours once weekly. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. Patients may also receive trastuzumab and/or pertuzumab per institution routine care per treating physician's discretion.
Droga: Paclitaxel

Given IV

Otros nombres:
  • Taxol
  • Anzatax
  • Asotax
  • Bristaxol
  • Praxel
  • Taxol Konzentrat
Otro: Quality-of-Life Assessment

Ancillary studies

Otros nombres:
  • Evaluación de la calidad de vida
Otro: Questionnaire Administration

Ancillary studies
Experimental: Arm B (docetaxel)

Patients receive docetaxel IV over 1 hour once every 3 weeks. Treatment repeats every 21 days for 4-6 cycles in the absence of disease progression or unacceptable toxicity. Patients may also receive cyclophosphamide, doxorubicin, trastuzumab, and/or pertuzumab per institution routine care per treating physician's discretion.
Otro: Quality-of-Life Assessment

Ancillary studies

Otros nombres:
  • Evaluación de la calidad de vida
Droga: Docetaxel

Given IV

Otros nombres:
  • Taxotere
  • Docecad
  • RP56976
  • Concentrado de inyección de taxotere
  • RP 56976
  • RP-56976
Otro: Questionnaire Administration

Ancillary studies

¿Qué mide el estudio?

Medidas de resultado primarias

Medida de resultado
Medida Descripción
Periodo de tiempo
Percentage of Participants With Grade 2-4 Taxane-Induced Peripheral Neuropathy (TIPN) by Genotype Risk Group in Arm A
Periodo de tiempo: assessed at baseline, an end of each cycle, at 6 months and 1 year post registration

Grade 2-4 TIPN was assessed by treating physician using National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. All patients who started protocol therapy on arm A (paclitaxel) were included in the analysis. The percentage of participants with grade 2-4 TIPN was calculated based on binomial distribution and was compared between high-risk vs low-risk genotype groups using Fisher exact test. Genotype risk group (high vs. low) was determined by genotyping. High-risk genotype was defined by FCAMR GG genotype (homozygous wild type) or SBF2 mutated. Low-risk genotype was defined by carriage of at least one variant allele in FCAMR (AG or AA) and SBF2 wild-type status.
assessed at baseline, an end of each cycle, at 6 months and 1 year post registration

Medidas de resultado secundarias

Medida de resultado
Medida Descripción
Periodo de tiempo
Patient-Reported Neuropathy Score Change Between Baseline and End of Treatment by Genotype Risk Group in Patients on Arm A
Periodo de tiempo: assessed at baseline and at end of treatment, an average of 3 months

The patient-reported neurotoxicity was assessed using the 11 items about neurotoxicity in the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group - Neurotoxicity (FACT/GOG-Ntx) questionnaire (i.e., FACT/GOG-Ntx additional concerns subscale). The neurotoxicity total score was the sum of the scores for the 11 items, ranging from 0 to 44. Higher values of the FACT/GOG-Ntx neurotoxicity total score indicate less neurotoxicity. The FACT/GOG-Ntx neurotoxicity total score change between the baseline and at end of treatment (negative value indicates worsening symptom, positive value indicates improving symptom) was calculated and compared using two-sample t test. Genotype risk group (high vs. low) was determined by genotyping. High-risk genotype was defined by FCAMR GG genotype (homozygous wild type) or SBF2 mutated. Low-risk genotype was defined by carriage of at least one variant allele in FCAMR (AG or AA) and SBF2 wild-type status.
assessed at baseline and at end of treatment, an average of 3 months
Percentage of Participants With Grade 2-4 TIPN Based on CTCAE Between Arm A and Arm B
Periodo de tiempo: assessed at baseline, an end of each cycle, at 6 months and 1 year post registration

Grade 2-4 TIPN was assessed by treating physician using CTCAE version 4.0. All patients who started protocol therapy were included in the analysis. The percentage of participants with grade 2-4 TIPN was calculated based on binomial distribution and was compared between treatment arms using Fisher exact test.
assessed at baseline, an end of each cycle, at 6 months and 1 year post registration
Percentage of Participants With Dose Reduction Due to TIPN Between Arm A and Arm B
Periodo de tiempo: Dose reduction due to TIPN was assessed at end of each cycle, up to 4 cycles in arm A and 6 cycles in arm B

The percentage of patients with dose reduction due to TIPN was calculated as number of patients with dose reduction due to peripheral neuropathy for any dose of any cycle divided by total number of patients who started protocol therapy. The percentages were calculated along with exact 95% CI based on binomial distribution and were compared between arms using Fisher exact test.
Dose reduction due to TIPN was assessed at end of each cycle, up to 4 cycles in arm A and 6 cycles in arm B
Percentage of Participants With Dose Reduction Due to Any Reason Between Arm A and Arm B
Periodo de tiempo: Dose reduction due to any reason was assessed at end of each cycle, up to 4 cycles in arm A and 6 cycles in arm B

The percentage of patients with dose reduction due to any reason was calculated as number of patients with any dose reduction for any dose of any cycle, regardless of the reason, divided by total number of patients who started protocol therapy. The percentages were calculated along with exact 95% CI based on binomial distribution and were compared between arms using Fisher exact test.
Dose reduction due to any reason was assessed at end of each cycle, up to 4 cycles in arm A and 6 cycles in arm B
Percentage of Participants With Grade 2-4 TIPN by Genotype Risk Group in Arm B
Periodo de tiempo: assessed at baseline, at end of each cycle, at 6 months and 1 year post registration

Grade 2-4 TIPN was assessed by treating physician using CTCAE version 4.0. All patients who started protocol therapy on arm B were included in the analysis. The percentage of participants with grade 2-4 TIPN was calculated based on binomial distribution and was compared between high-risk vs low-risk genotype groups using Fisher exact test. Genotype risk group (high vs. low) was determined by genotyping. High-risk genotype was defined by FCAMR GG genotype (homozygous wild type) or SBF2 mutated. Low-risk genotype was defined by carriage of at least one variant allele in FCAMR (AG or AA) and SBF2 wild-type status.
assessed at baseline, at end of each cycle, at 6 months and 1 year post registration

Colaboradores e Investigadores

Aquí es donde encontrará personas y organizaciones involucradas en este estudio.

Patrocinador

ECOG-ACRIN Cancer Research Group

Colaboradores

National Cancer Institute (NCI)

Investigadores

  • Investigador principal: Bryan P Schneider, ECOG-ACRIN Cancer Research Group

Publicaciones y enlaces útiles

La persona responsable de ingresar información sobre el estudio proporciona voluntariamente estas publicaciones. Estos pueden ser sobre cualquier cosa relacionada con el estudio.

Publicaciones Generales

Fechas de registro del estudio

Estas fechas rastrean el progreso del registro del estudio y los envíos de resultados resumidos a ClinicalTrials.gov. Los registros del estudio y los resultados informados son revisados ​​por la Biblioteca Nacional de Medicina (NLM) para asegurarse de que cumplan con los estándares de control de calidad específicos antes de publicarlos en el sitio web público.

Fechas importantes del estudio

Inicio del estudio (Actual)

9 de agosto de 2019

Finalización primaria (Actual)

19 de septiembre de 2023

Finalización del estudio (Estimado)

5 de abril de 2027

Fechas de registro del estudio

Enviado por primera vez

19 de junio de 2019

Primero enviado que cumplió con los criterios de control de calidad

27 de junio de 2019

Publicado por primera vez (Actual)

28 de junio de 2019

Actualizaciones de registros de estudio

Última actualización publicada (Actual)

6 de octubre de 2026

Última actualización enviada que cumplió con los criterios de control de calidad

14 de septiembre de 2026

Última verificación

1 de septiembre de 2026

Más información

Términos relacionados con este estudio

Términos MeSH relevantes adicionales

Otros números de identificación del estudio

  • EAZ171
  • UG1CA189828 (Subvención/contrato del NIH de EE. UU.)
  • EAZ171 (Otro identificador: CTEP)
  • NCI-2019-00266 (Identificador de registro: CTRP (Clinical Trial Reporting Program))
  • ECOG-ACRIN-EAZ171 (Otro identificador: DCP)
  • EAZ171 (Otro identificador: ECOG-ACRIN Cancer Research Group)

Información sobre medicamentos y dispositivos, documentos del estudio

Estudia un producto farmacéutico regulado por la FDA de EE. UU.

No

Estudia un producto de dispositivo regulado por la FDA de EE. UU.

No

Esta información se obtuvo directamente del sitio web clinicaltrials.gov sin cambios. Si tiene alguna solicitud para cambiar, eliminar o actualizar los detalles de su estudio, comuníquese con register@clinicaltrials.gov. Tan pronto como se implemente un cambio en clinicaltrials.gov, también se actualizará automáticamente en nuestro sitio web. .

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