Denne side blev automatisk oversat, og nøjagtigheden af ​​oversættelsen er ikke garanteret. Der henvises til engelsk version for en kildetekst.

Kombination af kemoterapi til behandling af patienter med avanceret kolorektal cancer

28. april 2020 opdateret af: Alliance for Clinical Trials in Oncology

Et randomiseret fase III-forsøg med tre forskellige regimer af CPT-11 Plus 5-Fluorouracil og Leucovorin sammenlignet med 5-Fluorouracil og Leucovorin hos patienter med avanceret adenokarcinom i tyktarmen og endetarmen

RATIONALE: Lægemidler, der bruges i kemoterapi, bruger forskellige måder til at forhindre tumorceller i at dele sig, så de holder op med at vokse eller dør. Kombination af mere end et lægemiddel kan dræbe flere tumorceller. Det vides endnu ikke, hvilket regime af kombinationskemoterapi, der er mest effektivt til behandling af fremskreden kolorektal cancer.

FORMÅL: Randomiseret fase III-forsøg til at sammenligne effektiviteten af ​​forskellige kombinationskemoterapi-regimer til behandling af patienter, som har fremskreden, tilbagevendende eller metastatisk kolorektal cancer, som ikke kan behandles med kirurgi eller strålebehandling.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

MÅL:

  • Sammenlign tiden til progression hos patienter med lokalt fremskreden, lokalt tilbagevendende eller metastatisk kolorektal adenokarcinom behandlet med kombinationer af oxaliplatin, fluorouracil, leucovorin calcium og irinotecan.
  • Sammenlign livskvalitet, responsrate, tid til behandlingssvigt og overordnet overlevelse hos patienter behandlet med disse regimer.
  • Sammenlign toksiciteten af ​​disse regimer hos disse patienter.

OVERSIGT: Dette er en randomiseret, multicenter undersøgelse. Patienterne stratificeres efter ECOG-præstationsstatus (0-1 vs 2), tidligere adjuverende kemoterapi (ja vs nej), tidligere immunterapi (ja vs nej) og alder (under 65 vs 65 og derover). Patienterne randomiseres til en af ​​tre behandlingsarme.

Kun arm II forbliver åben for optjening.

  • Arm I (Saltz-kur): Patienterne får irinotecan IV over 90 minutter efterfulgt af leucovorin calcium IV over 15 minutter og fluorouracil IV en gang om ugen i 4 uger efterfulgt af 2 ugers hvile. Kurserne gentages hver 6. uge. (Arm I lukkede for periodisering pr. 15. marts 2002.)
  • Arm II (FOLFOX4-regimen): Patienterne får oxaliplatin IV over 2 timer på dag 1 og leucovorin calcium IV over 2 timer plus fluorouracil IV over 22 timer på dag 1 og 2. Kurser gentages hver 2. uge.
  • Arm III (oxaliplatin plus irinotecan): Patienterne får oxaliplatin IV over 2 timer og irinotecan IV over 30 minutter på dag 1. Kurserne gentages hver 3. uge. (Arm III lukket for periodisering pr. 15. marts 2002.) Behandlingen fortsætter i fravær af sygdomsprogression eller uacceptabel toksicitet.

Livskvalitet vurderes før behandling, under behandling (armspecifik) og efter endt behandling.

Patienterne følges hver 3. måned i 1 år, hver 6. måned i 2 år og derefter årligt.

PROJEKTERET TILSLUTNING: I alt 825 patienter (275 pr. arm) er indtil videre blevet indsamlet til denne undersøgelse. Yderligere patienter bliver samlet på arm II. (Arm I og III lukkede for periodisering pr. 15. marts 2002.)

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

1691

Fase

  • Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Canada
      • North Vancouver, Canada, V7L 2P9
        • Lions Gate Hospital
    • Alberta
      • Edmonton, Alberta, Canada, T6G 1Z2
        • Cross Cancer Institute
    • British Columbia
      • Kelowna, British Columbia, Canada, V1Y 5L3
        • British Columbia Cancer Agency - Centre for the Southern Interior
      • Nanaimo, British Columbia, Canada, V9S 2B7
        • Nanaimo Cancer Clinic
      • Surrey, British Columbia, Canada, V3V 1Z2
        • British Columbia Cancer Agency - Fraser Valley Cancer Centre
      • Vancouver, British Columbia, Canada, V5Z 4E6
        • British Columbia Cancer Agency
      • Victoria, British Columbia, Canada, V8R 6V5
        • British Columbia Cancer Agency - Vancouver Island Cancer Centre
    • Manitoba
      • Winnipeg, Manitoba, Canada, R2H 2A6
        • St. Boniface General Hospital
    • Nova Scotia
      • Halifax, Nova Scotia, Canada, B3H 1V7
        • Nova Scotia Cancer Centre
    • Ontario
      • Brampton, Ontario, Canada, L6W 2Z8
        • William Osler Health Centre
      • London, Ontario, Canada, N6A 4L6
        • Cancer Care Ontario-London Regional Cancer Centre
      • Mississauga, Ontario, Canada, L5B 1B8
        • Trillium Health Centre
      • Mississauga, Ontario, Canada, L5M 2N1
        • Credit Valley Hospital
      • Newmarket, Ontario, Canada, L3Y 2P9
        • Southlake Regional Health Centre
      • Peterborough, Ontario, Canada, K9H 7B6
        • Peterborough Oncology Clinic
      • Sault Sainte Marie, Ontario, Canada, P6B 1Y5
        • Algoma District Medical Group
      • St. Catharines, Ontario, Canada, L2R 5K3
        • Hotel Dieu Health Sciences Hospital - Niagara
      • Sudbury, Ontario, Canada, P3E 5J1
        • Northeastern Ontario Regional Cancer Centre, Sudbury
      • Thunder Bay, Ontario, Canada, P7A 7T1
        • Northwestern Ontario Regional Cancer Centre, Thunder Bay
      • Toronto, Ontario, Canada, M5G 1X5
        • Mount Sinai Hospital - Toronto
      • Toronto, Ontario, Canada, M6R 1B5
        • Saint Joseph's Health Centre - Toronto
      • Weston, Ontario, Canada, M9N 1N8
        • Humber River Regional Hospital
    • Prince Edward Island
      • Charlottetown, Prince Edward Island, Canada, C1A 8T5
        • Queen Elizabeth Hospital, PEI
    • Quebec
      • Greenfield Park, Quebec, Canada, J4V 2H1
        • Hopital Charles LeMoyne
      • Montreal, Quebec, Canada, H1T 2M4
        • Maisonneuve-Rosemont Hospital
      • Montreal, Quebec, Canada, H2L-4M1
        • Centre Hospitalier de l'Université de Montréal
      • Montreal, Quebec, Canada, H2X 3J4
        • CHUM Hopital Saint-Luc
      • Ste-Foy, Quebec, Canada, G1V 4G5
        • L'Hopital Laval
    • Saskatchewan
      • Regina, Saskatchewan, Canada, S4T 7T1
        • Allan Blair Cancer Centre
      • Regina, Saskatchewan, Canada, S4T 7T1
        • Pasqua Hospital
      • Saskatoon, Saskatchewan, Canada, S7N 4H4
        • Saskatoon Cancer Centre
  • Forenede Stater
    • Alabama
      • Birmingham, Alabama, Forenede Stater, 35233-1996
        • Veterans Affairs Medical Center - Birmingham
      • Mobile, Alabama, Forenede Stater, 36688
        • MBCCOP - Gulf Coast
    • Arizona
      • Phoenix, Arizona, Forenede Stater, 85006-2726
        • CCOP - Greater Phoenix
      • Phoenix, Arizona, Forenede Stater, 85012
        • Veterans Affairs Medical Center - Phoenix (Hayden)
      • Phoenix, Arizona, Forenede Stater, 85054-4502
        • Mayo Clinic Hospital
      • Scottsdale, Arizona, Forenede Stater, 85259
        • Mayo Clinic Scottsdale
      • Tucson, Arizona, Forenede Stater, 85724
        • Arizona Cancer Center
      • Tucson, Arizona, Forenede Stater, 85723
        • Veterans Affairs Medical Center - Tucson
    • Arkansas
      • Little Rock, Arkansas, Forenede Stater, 72205
        • University of Arkansas for Medical Sciences
      • Little Rock, Arkansas, Forenede Stater, 72205
        • Veterans Affairs Medical Center - Little Rock (McClellan)
    • California
      • Duarte, California, Forenede Stater, 91010-3000
        • Cancer Center and Beckman Research Institute, City of Hope
      • La Jolla, California, Forenede Stater, 92093-0658
        • University of California San Diego Cancer Center
      • Long Beach, California, Forenede Stater, 90822
        • Veterans Affairs Medical Center - Long Beach
      • Los Angeles, California, Forenede Stater, 90095-1781
        • Jonsson Comprehensive Cancer Center, UCLA
      • Los Angeles, California, Forenede Stater, 90033-0804
        • USC/Norris Comprehensive Cancer Center and Hospital
      • Los Angeles, California, Forenede Stater, 90073
        • Veterans Affairs Medical Center - West Los Angeles
      • Martinez, California, Forenede Stater, 94553
        • Veterans Affairs Outpatient Clinic - Martinez
      • Monterey, California, Forenede Stater, 93940
        • Community Hospital of the Monterey Peninsula
      • Oakland, California, Forenede Stater, 94609-3305
        • CCOP - Bay Area Tumor Institute
      • Orange, California, Forenede Stater, 92868
        • Chao Family Comprehensive Cancer Center
      • Palo Alto, California, Forenede Stater, 94304
        • Veterans Affairs Medical Center - Palo Alto
      • Sacramento, California, Forenede Stater, 95817
        • University of California Davis Medical Center
      • San Francisco, California, Forenede Stater, 94121
        • Veterans Affairs Medical Center - San Francisco
      • San Francisco, California, Forenede Stater, 94143-0128
        • UCSF Cancer Center and Cancer Research Institute
      • Santa Rosa, California, Forenede Stater, 95403
        • CCOP - Santa Rosa Memorial Hospital
      • Stanford, California, Forenede Stater, 94305-5408
        • Stanford University Medical Center
      • Travis Air Force Base, California, Forenede Stater, 94535
        • David Grant Medical Center
    • Colorado
      • Aurora, Colorado, Forenede Stater, 80011
        • Columbia Medical Center of Aurora North Campus
      • Colorado Springs, Colorado, Forenede Stater, 80933
        • Penrose Cancer Center
      • Denver, Colorado, Forenede Stater, 80210
        • Porter Adventist Hospital
      • Denver, Colorado, Forenede Stater, 80220
        • Veterans Affairs Medical Center - Denver
      • Denver, Colorado, Forenede Stater, 80218
        • Presbyterian-St Luke's Medical Center
      • Denver, Colorado, Forenede Stater, 80010
        • University of Colorado Cancer Center
      • Denver, Colorado, Forenede Stater, 80218
        • St. Joseph Hospital
      • Denver, Colorado, Forenede Stater, 80209-5031
        • CCOP - Colorado Cancer Research Program, Inc.
      • Denver, Colorado, Forenede Stater, 80220
        • HealthOne Rose Medical Center
      • Englewood, Colorado, Forenede Stater, 80110
        • Swedish Medical Center
      • Fort Collins, Colorado, Forenede Stater, 80524
        • Poudre Valley Hospital
      • Fort Collins, Colorado, Forenede Stater, 80528
        • Poudre Valley Radiation Oncology
      • Fort Collins, Colorado, Forenede Stater, 80524-4038
        • Rocky Mountain Cancer Centers - Northern Colorado
      • Pueblo, Colorado, Forenede Stater, 81004
        • St. Mary-Corwin Regional Medical Center
    • Connecticut
      • Bristol, Connecticut, Forenede Stater, 06011-0977
        • Bristol Hospital
      • Farmington, Connecticut, Forenede Stater, 06360-7106
        • University of Connecticut Health Center
      • Hartford, Connecticut, Forenede Stater, 06105
        • St. Francis Hospital and Medical Center
      • New Britain, Connecticut, Forenede Stater, 06050
        • New Britain General Hospital
      • New London, Connecticut, Forenede Stater, 06320
        • Lawrence and Memorial Hospital
      • Norwich, Connecticut, Forenede Stater, 06360
        • William W. Backus Hospital
      • Torrington, Connecticut, Forenede Stater, 06790
        • Northwestern Connecticut Oncology-Hematology Associates
    • Delaware
      • Wilmington, Delaware, Forenede Stater, 19899
        • CCOP - Christiana Care Health Services
    • District of Columbia
      • Washington, District of Columbia, Forenede Stater, 20307-5000
        • Walter Reed Army Medical Center
    • Florida
      • Gainesville, Florida, Forenede Stater, 32610-0277
        • University of Florida - Gainesville
      • Jacksonville, Florida, Forenede Stater, 32224
        • Mayo Clinic
      • Jacksonville, Florida, Forenede Stater, 32209
        • University of Florida Health Science Center - Jacksonville
      • Jacksonville, Florida, Forenede Stater, 32207
        • Baptist Regional Cancer Institute - Jacksonville
      • Miami Beach, Florida, Forenede Stater, 33140
        • CCOP - Mount Sinai Medical Center
      • Tampa, Florida, Forenede Stater, 33612-9497
        • H. Lee Moffitt Cancer Center and Research Institute
    • Georgia
      • Atlanta, Georgia, Forenede Stater, 30322
        • Emory University Hospital - Atlanta
      • Atlanta, Georgia, Forenede Stater, 30342-1701
        • CCOP - Atlanta Regional
      • Atlanta, Georgia, Forenede Stater, 30335
        • Grady Memorial Hospital
      • Decatur, Georgia, Forenede Stater, 30033
        • Veterans Affairs Medical Center - Atlanta (Decatur)
      • Fort Gordon, Georgia, Forenede Stater, 30905-5650
        • Dwight David Eisenhower Army Medical Center
    • Hawaii
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Cancer Research Center of Hawaii
    • Illinois
      • Bloomington, Illinois, Forenede Stater, 61701-3081
        • Bromenn Lifecare Center
      • Bloomington, Illinois, Forenede Stater, 61701
        • St. Joseph's Hospital Medical Center
      • Canton, Illinois, Forenede Stater, 61520
        • Graham Hospital Association
      • Carthage, Illinois, Forenede Stater, 62321
        • Memorial Hospital
      • Chicago, Illinois, Forenede Stater, 60612
        • Veterans Affairs Medical Center - Chicago (Westside Hospital)
      • Chicago, Illinois, Forenede Stater, 60637-1470
        • University of Chicago Cancer Research Center
      • Chicago, Illinois, Forenede Stater, 60611-3013
        • Robert H. Lurie Comprehensive Cancer Center, Northwestern University
      • Chicago, Illinois, Forenede Stater, 60611
        • Veterans Affairs Medical Center - Lakeside Chicago
      • Chicago, Illinois, Forenede Stater, 60616
        • Mercy Hospital and Medical Center
      • Chicago, Illinois, Forenede Stater, 60611-2998
        • Hematology-Oncology Associates of Illinois
      • Chicago, Illinois, Forenede Stater, 60611
        • Hematology Oncology Associates of Illinois - Lake Shore Dr
      • Decatur, Illinois, Forenede Stater, 62526
        • CCOP - Central Illinois
      • Des Plaines, Illinois, Forenede Stater, 60016
        • Holy Family Medical Center
      • Effingham, Illinois, Forenede Stater, 62401
        • St. Anthony's Memorial Hospital
      • Elk Grove Village, Illinois, Forenede Stater, 60007
        • Northwest Oncology and Hematology, S.C.
      • Eureka, Illinois, Forenede Stater, 61530
        • Eureka Hospital
      • Evanston, Illinois, Forenede Stater, 60201
        • CCOP - Evanston
      • Galesburg, Illinois, Forenede Stater, 61401
        • Galesburg Clinic
      • Galesburg, Illinois, Forenede Stater, 61401
        • InterCommunity Cancer Center of Western Illinois
      • Galesburg, Illinois, Forenede Stater, 61402
        • Galesburg Cottage Hospital
      • Glenview, Illinois, Forenede Stater, 60025
        • Glenbrook Hospital
      • Harvey, Illinois, Forenede Stater, 60426
        • Ingalls Memorial Hospital
      • Havana, Illinois, Forenede Stater, 62644
        • Mason District Hospital
      • Highland Park, Illinois, Forenede Stater, 60035
        • Hematology Oncology Associates of Illinois-Highland Park
      • Hines, Illinois, Forenede Stater, 60141
        • Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital)
      • Hinsdale, Illinois, Forenede Stater, 60521
        • Hinsdale Hematology Oncology Associates
      • Hopedale, Illinois, Forenede Stater, 61747
        • Hopedale Medical Complex Hospital
      • Joliet, Illinois, Forenede Stater, 60432
        • Silver Cross Hospital
      • Joliet, Illinois, Forenede Stater, 60435
        • Joliet Oncology/Hematology Associates, Ltd.
      • Joliet, Illinois, Forenede Stater, 60435
        • Saint Joseph Medical Center
      • Kewanee, Illinois, Forenede Stater, 61443
        • Kewanee Hospital
      • Lake Forest, Illinois, Forenede Stater, 60045
        • Deerpath Medical Associates
      • Libertyville, Illinois, Forenede Stater, 60048
        • North Shore Oncology Hematology Associates
      • Macomb, Illinois, Forenede Stater, 61455
        • Mcdonough District Hospital
      • Maywood, Illinois, Forenede Stater, 60153
        • Loyola University Medical Center
      • Melrose Park, Illinois, Forenede Stater, 60160
        • Hematology/Oncology Associates of Illinois, LLC
      • Mendota, Illinois, Forenede Stater, 61342
        • Mendota Community Hospital
      • Moline, Illinois, Forenede Stater, 61265-1291
        • Trinity Medical Center
      • Morris, Illinois, Forenede Stater, 60450
        • Morris Hospital
      • Normal, Illinois, Forenede Stater, 61761
        • Bromenn Regional Medical Center
      • Normal, Illinois, Forenede Stater, 61761
        • Community Cancer Center
      • Oak Park, Illinois, Forenede Stater, 60304
        • Hematology Oncology Associates of Illinois, LLC
      • Ottawa, Illinois, Forenede Stater, 61350
        • Community Hospital of Ottawa
      • Pekin, Illinois, Forenede Stater, 61554
        • Pekin Hospital
      • Peoria, Illinois, Forenede Stater, 61636
        • Methodist Medical Center of Illinois
      • Peoria, Illinois, Forenede Stater, 61614
        • Proctor Hospital
      • Peoria, Illinois, Forenede Stater, 61602
        • Oncology/Hematology Associates of Central Illinois, P.C.
      • Peoria, Illinois, Forenede Stater, 61637
        • St. Francis Medical Center
      • Peoria, Illinois, Forenede Stater, 61614
        • Peoria Urological Associates
      • Peoria, Illinois, Forenede Stater, 61602
        • Illinois Oncology Research Association
      • Peoria, Illinois, Forenede Stater, 61603
        • Affiliated Urology Specialists
      • Peoria, Illinois, Forenede Stater, 61603
        • Midwest Urological Group
      • Peoria, Illinois, Forenede Stater, 61636
        • Midwest Radiation Oncology Physicians
      • Peru, Illinois, Forenede Stater, 61354
        • Illinois Valley Community Hospital
      • Pontiac, Illinois, Forenede Stater, 61764
        • St. James Hospital
      • Princeton, Illinois, Forenede Stater, 61356
        • Perry Memorial Hospital
      • Rock Island, Illinois, Forenede Stater, 61201
        • Trinity Medical Center
      • Rockford, Illinois, Forenede Stater, 61104-2315
        • Swedish-American Health System
      • Rushville, Illinois, Forenede Stater, 62681
        • Sarah D. Culbertson Memorial Hospital
      • Skokie, Illinois, Forenede Stater, 60076
        • Hematology Oncology Associates - Skokie
      • Skokie, Illinois, Forenede Stater, 60076
        • Edward H. Kaplan MD and Associates
      • Skokie, Illinois, Forenede Stater, 60077
        • Midwest Cancer Research Group, Inc.
      • Spring Valley, Illinois, Forenede Stater, 61362
        • St. Margaret's Hospital
      • Spring Valley, Illinois, Forenede Stater, 61362
        • Valley Cancer Center
      • Urbana, Illinois, Forenede Stater, 61801
        • Carle Cancer Center
      • Urbana, Illinois, Forenede Stater, 61801
        • Carle Foundation Hospital
    • Indiana
      • Evansville, Indiana, Forenede Stater, 47715
        • Therapy Associates Hematology/Oncology
      • Lafayette, Indiana, Forenede Stater, 47904
        • Oncology Institute of Greater Lafayette
    • Iowa
      • Ames, Iowa, Forenede Stater, 50010
        • McFarland Clinic, P.C.
      • Ames, Iowa, Forenede Stater, 50010
        • William R. Bliss Cancer Center
      • Bettendorf, Iowa, Forenede Stater, 52722
        • Hematology Oncology Associates of the Quad Cities
      • Carroll, Iowa, Forenede Stater, 51401
        • Saint Anthony Regional Hospital
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Cedar Rapids Oncology Associates
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Mercy Medical Center
      • Cedar Rapids, Iowa, Forenede Stater, 52406
        • St. Luke's Hospital
      • Council Bluffs, Iowa, Forenede Stater, 51503
        • Alegent Health Southwest Iowa Medical Center
      • Des Moines, Iowa, Forenede Stater, 50309
        • Iowa Methodist Medical Center
      • Des Moines, Iowa, Forenede Stater, 50314
        • Medical Oncology and Hematology Associates
      • Des Moines, Iowa, Forenede Stater, 50314
        • Mercy Hospital Medical Center
      • Des Moines, Iowa, Forenede Stater, 50309
        • Medical Oncology and Hematology Associates
      • Des Moines, Iowa, Forenede Stater, 50309
        • Des Moines General Hospital
      • Des Moines, Iowa, Forenede Stater, 50316-2392
        • Iowa Lutheran Hospital
      • Iowa City, Iowa, Forenede Stater, 52242-1009
        • Holden Comprehensive Cancer Center at the University of Iowa
      • Mason City, Iowa, Forenede Stater, 50401
        • Mercy Cancer Center
      • Missouri Valley, Iowa, Forenede Stater, 51555-1199
        • Community Memorial Hospital
      • Onawa, Iowa, Forenede Stater, 51040
        • Burgess Health Center
      • Ottumwa, Iowa, Forenede Stater, 52501
        • Ottumwa Regional Health Center
      • Ottumwa, Iowa, Forenede Stater, 52501
        • Oncology & Hematology of Ottumwa, PC
      • Sioux City, Iowa, Forenede Stater, 51101-1733
        • Siouxland Hematology-Oncology
      • Sioux City, Iowa, Forenede Stater, 51104
        • St. Luke's Regional Medical Center
      • Sioux City, Iowa, Forenede Stater, 51101
        • Mercy Medical Center - Sioux City
    • Kansas
      • Arkansas City, Kansas, Forenede Stater, 67005
        • Cancer Center of Kansas - Arkansas City
      • Chanute, Kansas, Forenede Stater, 66720
        • Cancer Center of Kansas - Chanute
      • Dodge City, Kansas, Forenede Stater, 67801
        • Cancer Center of Kansas - Dodge City
      • Dodge City, Kansas, Forenede Stater, 67801
        • Radiation Oncology Center
      • Halstead, Kansas, Forenede Stater, 67056
        • Halstead Cancer Center of Kansas
      • Kansas City, Kansas, Forenede Stater, 66160-7357
        • University of Kansas Medical Center
      • Kingman, Kansas, Forenede Stater, 67068
        • Cancer Center of Kansas - Kingman
      • Liberal, Kansas, Forenede Stater, 67901
        • Liberal Cancer Center of Kansas
      • Newton, Kansas, Forenede Stater, 67114
        • Cancer Center of Kansas - Newton
      • Pratt, Kansas, Forenede Stater, 67124
        • Pratt Cancer Center of Kansas
      • Salina, Kansas, Forenede Stater, 67401
        • Cancer Center of Kansas - Salina
      • Wellington, Kansas, Forenede Stater, 67152
        • Cancer Center of Kansas - Wellington
      • Wichita, Kansas, Forenede Stater, 67214
        • Cancer Center of Kansas - Wichita
      • Wichita, Kansas, Forenede Stater, 67214-3882
        • CCOP - Wichita
      • Wichita, Kansas, Forenede Stater, 67218
        • Veterans Affairs Medical Center - Wichita
      • Wichita, Kansas, Forenede Stater, 67214
        • Via Christi Regional Medical Center
      • Wichita, Kansas, Forenede Stater, 67208
        • Associates in Women's Health - Wichita
      • Wichita, Kansas, Forenede Stater, 67208
        • Wichita Clinic Cancer Medicine Associates, P.A.
      • Winfield, Kansas, Forenede Stater, 67156
        • Cancer Center of Kansas - Winfield
    • Kentucky
      • Lexington, Kentucky, Forenede Stater, 40511-1093
        • Veterans Affairs Medical Center - Lexington
      • Lexington, Kentucky, Forenede Stater, 40536-0084
        • Albert B. Chandler Medical Center, University of Kentucky
    • Louisiana
      • New Orleans, Louisiana, Forenede Stater, 70112
        • Tulane University School of Medicine
      • New Orleans, Louisiana, Forenede Stater, 70112
        • MBCCOP - LSU Health Sciences Center
      • Shreveport, Louisiana, Forenede Stater, 71130-3932
        • Louisiana State University Health Sciences Center - Shreveport
      • Shreveport, Louisiana, Forenede Stater, 71130
        • Veterans Affairs Medical Center - Shreveport
    • Maine
      • Togus, Maine, Forenede Stater, 04330
        • Veterans Affairs Medical Center - Togus
    • Maryland
      • Annapolis, Maryland, Forenede Stater, 21401
        • Anne Arundel Medical Center
    • Massachusetts
      • Boston, Massachusetts, Forenede Stater, 02115
        • Dana-Farber Cancer Institute
      • Boston, Massachusetts, Forenede Stater, 02118
        • Boston Medical Center
      • Boston, Massachusetts, Forenede Stater, 02111
        • New England Medical Center Hospital
      • Jamaica Plain, Massachusetts, Forenede Stater, 02130
        • Veterans Affairs Medical Center - Boston (Jamaica Plain)
      • Jamaica Plain, Massachusetts, Forenede Stater, 02130
        • Faulkner Hospital
      • Medford, Massachusetts, Forenede Stater, 02155
        • Lawrence Memorial Hospital of Medford/Hallmark Health Systems
      • Taunton, Massachusetts, Forenede Stater, 02780
        • Morton Hospital & Medical Center
      • Worcester, Massachusetts, Forenede Stater, 01655
        • University of Massachusetts Memorial Medical Center
    • Michigan
      • Adrian, Michigan, Forenede Stater, 49221
        • Bixby Medical Center
      • Ann Arbor, Michigan, Forenede Stater, 48109-0752
        • University of Michigan Comprehensive Cancer Center
      • Ann Arbor, Michigan, Forenede Stater, 48105
        • Veterans Affairs Medical Center - Ann Arbor
      • Ann Arbor, Michigan, Forenede Stater, 48106
        • Saint Joseph Mercy Hospital
      • Detroit, Michigan, Forenede Stater, 48202
        • Henry Ford Hospital
      • Detroit, Michigan, Forenede Stater, 48201-1379
        • Barbara Ann Karmanos Cancer Institute
      • Detroit, Michigan, Forenede Stater, 48201-1932
        • Veterans Affairs Medical Center - Detroit
      • Detroit, Michigan, Forenede Stater, 48236
        • St. John Hospital and Medical Center
      • Flint, Michigan, Forenede Stater, 48503
        • Genesee Regional Medical Center
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • CCOP - Grand Rapids Clinical Oncology Program
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • West Michigan Cancer Center
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • Bronson Methodist Hospital
      • Kalamazoo, Michigan, Forenede Stater, 49048-1666
        • Borgess Medical Center
      • Lansing, Michigan, Forenede Stater, 48909
        • Sparrow Regional Cancer Center
      • Madison Heights, Michigan, Forenede Stater, 48071-3457
        • Office of E. Michael Lodish
      • Monroe, Michigan, Forenede Stater, 48162
        • Community Cancer Center of Monroe
      • Saginaw, Michigan, Forenede Stater, 48601
        • St. Mary's Medical Center
      • Saginaw, Michigan, Forenede Stater, 48602
        • Balcueva Clinic
      • Southfield, Michigan, Forenede Stater, 48075-9975
        • Providence Hospital - Southfield
      • Warren, Michigan, Forenede Stater, 48093-3494
        • St. John Macomb Hospital
    • Minnesota
      • Alexandria, Minnesota, Forenede Stater, 56308
        • Alexandria Clinic
      • Alexandria, Minnesota, Forenede Stater, 56308
        • Alexandria Radiation Oncology
      • Brainerd, Minnesota, Forenede Stater, 56401
        • Brainerd Medical Center
      • Brainerd, Minnesota, Forenede Stater, 56401
        • St. Joseph's Medical Center
      • Burnsville, Minnesota, Forenede Stater, 55337
        • Fairview Ridges Hospital
      • Coon Rapids, Minnesota, Forenede Stater, 55433
        • Mercy Hospital
      • Duluth, Minnesota, Forenede Stater, 55805
        • Miller-Dwan Medical Center
      • Duluth, Minnesota, Forenede Stater, 55805
        • St. Mary's/Duluth Clinic Health System
      • Duluth, Minnesota, Forenede Stater, 55805
        • Duluth Clinic
      • Edina, Minnesota, Forenede Stater, 55435
        • Fairview-Southdale Hospital
      • Fergus Falls, Minnesota, Forenede Stater, 56537
        • Fergus Falls Medical Group
      • Fridley, Minnesota, Forenede Stater, 55432
        • Mercy/Unity Hospitals
      • Hibbing, Minnesota, Forenede Stater, 55746
        • Central Mesabi Medical Center
      • Hibbing, Minnesota, Forenede Stater, 55746
        • Duluth Clinic - Hibbing
      • Hibbing, Minnesota, Forenede Stater, 55746
        • Radiation Therapy Center
      • Hutchinson, Minnesota, Forenede Stater, 55350
        • Hutchinson Area Health Care
      • Litchfield, Minnesota, Forenede Stater, 55355
        • Meeker County Memorial Hospital
      • Maplewood, Minnesota, Forenede Stater, 55109
        • St. John's Hospital
      • Minneapolis, Minnesota, Forenede Stater, 55417
        • Veterans Affairs Medical Center - Minneapolis
      • Minneapolis, Minnesota, Forenede Stater, 55455
        • University of Minnesota Cancer Center
      • Minneapolis, Minnesota, Forenede Stater, 55407
        • Abbott-Northwestern Hospital
      • Minneapolis, Minnesota, Forenede Stater, 55407
        • Virginia Piper Cancer Institute
      • Minneapolis, Minnesota, Forenede Stater, 55415
        • Hennepin County Medical Center - Minneapolis
      • Minneapolis, Minnesota, Forenede Stater, 55442-2900
        • North Memorial Research Center
      • Minneapolis, Minnesota, Forenede Stater, 55454-1395
        • Fairview University Medical Center - Riverside Campus
      • Rochester, Minnesota, Forenede Stater, 55905
        • Mayo Clinic Cancer Center
      • Saint Cloud, Minnesota, Forenede Stater, 56303
        • St. Cloud Hospital
      • Saint Cloud, Minnesota, Forenede Stater, 56303
        • CentraCare Health Plaza
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • CCOP - Metro-Minnesota
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Park Nicollet Clinic
      • Saint Paul, Minnesota, Forenede Stater, 55101
        • Regions Hospital
      • Saint Paul, Minnesota, Forenede Stater, 55102
        • United Hospital
      • Saint Paul, Minnesota, Forenede Stater, 55102
        • Healtheast Cancer Care
      • Shakopee, Minnesota, Forenede Stater, 55379
        • Saint Francis Regional Medical Center
      • Waconia, Minnesota, Forenede Stater, 55387
        • Ridgeview Medical Center
      • Willmar, Minnesota, Forenede Stater, 56201
        • Rice Memorial Hospital
    • Mississippi
      • Biloxi, Mississippi, Forenede Stater, 39531-2410
        • Veterans Affairs Medical Center - Biloxi
      • Jackson, Mississippi, Forenede Stater, 39216-4505
        • University of Mississippi Medical Center
      • Jackson, Mississippi, Forenede Stater, 39216
        • Veterans Affairs Medical Center - Jackson
      • Keesler Air Force Base, Mississippi, Forenede Stater, 39534-2576
        • Keesler Medical Center - Keesler AFB
    • Missouri
      • Columbia, Missouri, Forenede Stater, 65201
        • Veterans Affairs Medical Center - Columbia (Truman Memorial)
      • Columbia, Missouri, Forenede Stater, 65203
        • Ellis Fischel Cancer Center - Columbia
      • Kansas City, Missouri, Forenede Stater, 64128
        • Veterans Affairs Medical Center - Kansas City
      • Kansas City, Missouri, Forenede Stater, 64131
        • CCOP - Kansas City
      • Saint Louis, Missouri, Forenede Stater, 63110
        • Barnes-Jewish Hospital
      • Saint Louis, Missouri, Forenede Stater, 63110-0250
        • St. Louis University Health Sciences Center
      • Saint Louis, Missouri, Forenede Stater, 63141
        • CCOP - St. Louis-Cape Girardeau
      • Springfield, Missouri, Forenede Stater, 65807
        • CCOP - Cancer Research for the Ozarks
    • Montana
      • Billings, Montana, Forenede Stater, 59101
        • CCOP - Montana Cancer Consortium
    • Nebraska
      • Fremont, Nebraska, Forenede Stater, 68025-2387
        • Fremont Area Medical Center
      • Lincoln, Nebraska, Forenede Stater, 68506
        • Bryan LGH Medical Center East
      • Lincoln, Nebraska, Forenede Stater, 68510
        • St. Elizabeth Regional Medical Center
      • Lincoln, Nebraska, Forenede Stater, 68502-3780
        • Bryan LGH Medical Center
      • Lincoln, Nebraska, Forenede Stater, 68506-5247
        • Prairie View Clinic
      • Lincoln, Nebraska, Forenede Stater, 68506
        • Office of Susan Hansen, M.D.
      • Lincoln, Nebraska, Forenede Stater, 68510
        • Wedgewood Medical Center
      • Lincoln, Nebraska, Forenede Stater, 68516
        • Southeast Nebraska Hematology
      • Lincoln, Nebraska, Forenede Stater, 68516
        • Southeast Nebreska Hematology-Oncology Consultants, PC
      • Lincoln, Nebraska, Forenede Stater, 68516
        • Williamsburg Radiation Oncology Center
      • Omaha, Nebraska, Forenede Stater, 68198-3330
        • University of Nebraska Medical Center
      • Omaha, Nebraska, Forenede Stater, 68105
        • Veterans Affairs Medical Center - Omaha
      • Omaha, Nebraska, Forenede Stater, 68124
        • Bergan Mercy Medical Center
      • Omaha, Nebraska, Forenede Stater, 68122
        • Alegent Health - Immanuel Medical Center
      • Omaha, Nebraska, Forenede Stater, 68114
        • Oncology Hematology West, P.C.
      • Omaha, Nebraska, Forenede Stater, 68131-2197
        • Creighton University Cancer Center
      • Omaha, Nebraska, Forenede Stater, 68131-2197
        • St. Joseph Hospital
      • Papillion, Nebraska, Forenede Stater, 68046-4194
        • Alegent Health-Midlands Community Hospital
    • Nevada
      • Las Vegas, Nevada, Forenede Stater, 89106
        • CCOP - Southern Nevada Cancer Research Foundation
    • New Hampshire
      • Lebanon, New Hampshire, Forenede Stater, 03756-0002
        • Norris Cotton Cancer Center
    • New Jersey
      • Cherry Hill, New Jersey, Forenede Stater, 08046
        • Center for Cancer and Hematologic Disease
      • Elizabeth, New Jersey, Forenede Stater, 07201
        • Trinitas Hospital - Jersey Street Campus
      • Flemington, New Jersey, Forenede Stater, 08822
        • Hunterdon Regional Cancer Center
      • Millville, New Jersey, Forenede Stater, 08332
        • South Jersey Regional Cancer Center
      • Mount Holly, New Jersey, Forenede Stater, 08060
        • Fox Chase Cancer Center at Virtua Memorial Hospital Burlington County
      • New Brunswick, New Jersey, Forenede Stater, 08903
        • Cancer Institute Of New Jersey
      • Red Bank, New Jersey, Forenede Stater, 07701
        • Riverview Medical Center - Booker Cancer Center
      • Trenton, New Jersey, Forenede Stater, 08629
        • St. Francis Medical Center
      • Vineland, New Jersey, Forenede Stater, 08360
        • Southern Oncology-Hematology Associates, P.A.
      • Voorhees, New Jersey, Forenede Stater, 08043
        • Comprehensive Cancer and Hematology Associates
      • Willingboro, New Jersey, Forenede Stater, 08046
        • Burlington County Hematology Oncology Association, P.A.
    • New Mexico
      • Albuquerque, New Mexico, Forenede Stater, 87108-5138
        • Veterans Affairs Medical Center - Albuquerque
      • Albuquerque, New Mexico, Forenede Stater, 87131
        • MBCCOP - University of New Mexico HSC
    • New York
      • Bronx, New York, Forenede Stater, 10461
        • Albert Einstein Comprehensive Cancer Center
      • Buffalo, New York, Forenede Stater, 14215
        • Veterans Affairs Medical Center - Buffalo
      • Cooperstown, New York, Forenede Stater, 13326
        • Mary Imogene Bassett Hospital
      • Manhasset, New York, Forenede Stater, 11030
        • CCOP - North Shore University Hospital
      • Manhasset, New York, Forenede Stater, 11030
        • Schneider Children's Hospital at North Shore
      • New York, New York, Forenede Stater, 10021
        • Memorial Sloan-Kettering Cancer Center
      • New York, New York, Forenede Stater, 10016
        • NYU School of Medicine's Kaplan Comprehensive Cancer Center
      • New York, New York, Forenede Stater, 10021
        • New York Presbyterian Hospital - Cornell Campus
      • New York, New York, Forenede Stater, 10029
        • Mount Sinai Medical Center, NY
      • New York, New York, Forenede Stater, 10032
        • Herbert Irving Comprehensive Cancer Center
      • New York, New York, Forenede Stater, 10010
        • Veterans Affairs Medical Center - New York
      • Rochester, New York, Forenede Stater, 14621
        • Rochester General Hospital
      • Syracuse, New York, Forenede Stater, 13210
        • State University of New York - Upstate Medical University
      • Syracuse, New York, Forenede Stater, 13210
        • Veterans Affairs Medical Center - Syracuse
      • Syracuse, New York, Forenede Stater, 13217
        • CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
    • North Carolina
      • Chapel Hill, North Carolina, Forenede Stater, 27599-7295
        • Lineberger Comprehensive Cancer Center, UNC
      • Durham, North Carolina, Forenede Stater, 27705
        • Veterans Affairs Medical Center - Durham
      • Durham, North Carolina, Forenede Stater, 27710
        • Duke Comprehensive Cancer Center
      • Winston-Salem, North Carolina, Forenede Stater, 27104-4241
        • CCOP - Southeast Cancer Control Consortium
      • Winston-Salem, North Carolina, Forenede Stater, 27157-1082
        • Comprehensive Cancer Center at Wake Forest University
    • North Dakota
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Medcenter One Health System
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Mid Dakota Clinic, P.C.
      • Bismarck, North Dakota, Forenede Stater, 58502
        • St. Alexius Medical Center
      • Bismarck, North Dakota, Forenede Stater, 58501-4445
        • Bismarck Cancer Center
      • Fargo, North Dakota, Forenede Stater, 58122
        • Meritcare Roger Maris Cancer Center
      • Fargo, North Dakota, Forenede Stater, 58122
        • CCOP - Merit Care Hospital
      • Grand Forks, North Dakota, Forenede Stater, 58201
        • Altru Health Systems
      • Grand Forks, North Dakota, Forenede Stater, 58206
        • Altru Cancer Center
    • Ohio
      • Akron, Ohio, Forenede Stater, 44309
        • Akron City Hospital
      • Bowling Green, Ohio, Forenede Stater, 43402
        • Wood County Oncology Center
      • Canton, Ohio, Forenede Stater, 44710
        • Aultman Cancer Center
      • Canton, Ohio, Forenede Stater, 44708
        • Mercy Ireland Cancer Center
      • Cincinnati, Ohio, Forenede Stater, 45220-2288
        • Veterans Affairs Medical Center - Cincinnati
      • Cincinnati, Ohio, Forenede Stater, 45267-0502
        • Barrett Cancer Center, The University Hospital
      • Cleveland, Ohio, Forenede Stater, 44195
        • Cleveland Clinic Taussig Cancer Center
      • Cleveland, Ohio, Forenede Stater, 44106-5065
        • Ireland Cancer Center
      • Columbus, Ohio, Forenede Stater, 43210-1240
        • Arthur G. James Cancer Hospital - Ohio State University
      • Columbus, Ohio, Forenede Stater, 43206
        • CCOP - Columbus
      • Dayton, Ohio, Forenede Stater, 45428
        • Veterans Affairs Medical Center - Dayton
      • Findlay, Ohio, Forenede Stater, 45840
        • Woman Wise Blanchard Valley Regional Health Center
      • Fremont, Ohio, Forenede Stater, 43420
        • Fremont Memorial Hospital
      • Kenton, Ohio, Forenede Stater, 43326
        • Office of Sharon Cole, M.D.
      • Kettering, Ohio, Forenede Stater, 45429
        • CCOP - Dayton
      • Lima, Ohio, Forenede Stater, 45804
        • Lima Memorial Hospital
      • Lima, Ohio, Forenede Stater, 45801
        • St. Rita's Medical Center
      • Maumee, Ohio, Forenede Stater, 43537
        • Saint Luke's Hospital
      • Maumee, Ohio, Forenede Stater, 43537
        • North West Ohio Oncology Center
      • Oregon, Ohio, Forenede Stater, 43616
        • St. Charles Hospital
      • Sandusky, Ohio, Forenede Stater, 44870
        • Firelands Regional Medical Center
      • Sandusky, Ohio, Forenede Stater, 44870
        • North Coast Cancer Care, Inc.
      • Sylvania, Ohio, Forenede Stater, 43560
        • Flower Hospital - Pro Medica Health System
      • Toledo, Ohio, Forenede Stater, 43608
        • St. Vincent Mercy Medical Center
      • Toledo, Ohio, Forenede Stater, 43606
        • Toledo Hospital
      • Toledo, Ohio, Forenede Stater, 43623
        • Toledo Clinic, Inc.
      • Toledo, Ohio, Forenede Stater, 43604
        • Riverside Hospital
      • Toledo, Ohio, Forenede Stater, 43614-0008
        • Medical College of Ohio Hospital
      • Toledo, Ohio, Forenede Stater, 43614
        • MCO Cancer Institute
      • Toledo, Ohio, Forenede Stater, 43623-4474
        • Haematology-Oncology Associates, Inc.
      • Wauseon, Ohio, Forenede Stater, 43567
        • Fulton County Health Center
    • Oklahoma
      • Oklahoma City, Oklahoma, Forenede Stater, 73104
        • Oklahoma Medical Research Foundation
      • Oklahoma City, Oklahoma, Forenede Stater, 73104
        • Veterans Affairs Medical Center - Oklahoma City
      • Tulsa, Oklahoma, Forenede Stater, 74136
        • CCOP - Oklahoma
    • Oregon
      • Portland, Oregon, Forenede Stater, 97207
        • Veterans Affairs Medical Center - Portland
      • Portland, Oregon, Forenede Stater, 97213
        • CCOP - Columbia River Program
      • Portland, Oregon, Forenede Stater, 97201-3098
        • Oregon Cancer Center
    • Pennsylvania
      • Allentown, Pennsylvania, Forenede Stater, 18103
        • Lehigh Valley Hospital
      • Bethlehem, Pennsylvania, Forenede Stater, 18017
        • Muhlenberg Hospital Center
      • Carbondale, Pennsylvania, Forenede Stater, 18407
        • Marion Community Hospital
      • Danville, Pennsylvania, Forenede Stater, 17822-2001
        • Geisinger Medical Center
      • Drexel Hill, Pennsylvania, Forenede Stater, 19026
        • Delaware County Memorial Hospital
      • DuBois, Pennsylvania, Forenede Stater, 15801-0447
        • Dubois Regional Medical Center
      • Greenville, Pennsylvania, Forenede Stater, 16125
        • UPMC Horizon
      • Harrisburg, Pennsylvania, Forenede Stater, 17105-8700
        • Pinnacle Health Hospitals
      • Honesdale, Pennsylvania, Forenede Stater, 18431-1498
        • Wayne Memorial Hospital
      • Johnstown, Pennsylvania, Forenede Stater, 15901
        • UPCI @ UPMC Lee Hospital
      • Johnstown, Pennsylvania, Forenede Stater, 15905
        • Conemaugh Memorial Hospital
      • Kittanning, Pennsylvania, Forenede Stater, 16201-8808
        • Armstrong County Memorial Hospital
      • Lancaster, Pennsylvania, Forenede Stater, 17604-3555
        • Lancaster General Hospital
      • Langhorne, Pennsylvania, Forenede Stater, 19047
        • Saint Mary Regional Center
      • Latrobe, Pennsylvania, Forenede Stater, 15650
        • Latrobe Area Hospital
      • Lemoyne, Pennsylvania, Forenede Stater, 17043
        • Central Pennsylvania Hematology and Medical Oncology Associates
      • Philadelphia, Pennsylvania, Forenede Stater, 19141
        • Albert Einstein Cancer Center
      • Philadelphia, Pennsylvania, Forenede Stater, 19102-1192
        • Hahnemann University Hospital
      • Philadelphia, Pennsylvania, Forenede Stater, 19104-4283
        • University of Pennsylvania Cancer Center
      • Pittsburgh, Pennsylvania, Forenede Stater, 15213
        • University of Pittsburgh Medical Center
      • Pittsburgh, Pennsylvania, Forenede Stater, 15213-3180
        • Magee-Womens Hospital
      • Pittsburgh, Pennsylvania, Forenede Stater, 15237
        • UPMC/Passavant Hospital
      • Pottstown, Pennsylvania, Forenede Stater, 19464
        • Pottstown Memorial Regional Cancer Center
      • Reading, Pennsylvania, Forenede Stater, 19612-6052
        • Reading Hospital and Medical Center
      • Scranton, Pennsylvania, Forenede Stater, 18501
        • Mercy Hospital Cancer Center - Scranton
      • Scranton, Pennsylvania, Forenede Stater, 18510
        • Moses Taylor Hospital
      • Scranton, Pennsylvania, Forenede Stater, 18510
        • Scranton Hematology-Oncology
      • State College, Pennsylvania, Forenede Stater, 16801
        • Geisinger Medical Group
      • West Chester, Pennsylvania, Forenede Stater, 19380
        • Chester County Hospital
      • Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
        • Geisinger Wyoming Valley Medical Center
    • Rhode Island
      • Providence, Rhode Island, Forenede Stater, 02903
        • Rhode Island Hospital
    • South Carolina
      • Greenville, South Carolina, Forenede Stater, 29615
        • CCOP - Greenville
      • Spartanburg, South Carolina, Forenede Stater, 29303
        • CCOP - Upstate Carolina
    • South Dakota
      • Rapid City, South Dakota, Forenede Stater, 57709
        • Rapid City Regional Hospital
      • Sioux Falls, South Dakota, Forenede Stater, 57105
        • Avera Cancer Institute
      • Sioux Falls, South Dakota, Forenede Stater, 57117
        • Sioux Valley Hospital
      • Sioux Falls, South Dakota, Forenede Stater, 57104
        • Sioux Valley Clinic
      • Sioux Falls, South Dakota, Forenede Stater, 57105-1080
        • Avera McKennan Hospital and University Health Center
    • Tennessee
      • Memphis, Tennessee, Forenede Stater, 38103
        • University of Tennessee, Memphis Cancer Center
      • Memphis, Tennessee, Forenede Stater, 38104
        • Veterans Affairs Medical Center - Memphis
    • Texas
      • Fort Sam Houston, Texas, Forenede Stater, 78234
        • Brooke Army Medical Center
      • Galveston, Texas, Forenede Stater, 77555-0209
        • University of Texas Medical Branch
      • San Antonio, Texas, Forenede Stater, 78284-7811
        • University of Texas Health Science Center at San Antonio
      • San Antonio, Texas, Forenede Stater, 78284
        • Veterans Affairs Medical Center - San Antonio (Murphy)
      • Temple, Texas, Forenede Stater, 76504
        • Veterans Affairs Medical Center - Temple
      • Temple, Texas, Forenede Stater, 76508
        • CCOP - Scott and White Hospital
    • Utah
      • Salt Lake City, Utah, Forenede Stater, 84148
        • Veterans Affairs Medical Center - Salt Lake City
      • Salt Lake City, Utah, Forenede Stater, 84112
        • Huntsman Cancer Institute
    • Vermont
      • Burlington, Vermont, Forenede Stater, 05401-3498
        • Vermont Cancer Center
      • White River Junction, Vermont, Forenede Stater, 05009
        • Veterans Affairs Medical Center - White River Junction
    • Virginia
      • Richmond, Virginia, Forenede Stater, 23298-0037
        • MBCCOP - Massey Cancer Center
      • Richmond, Virginia, Forenede Stater, 23249
        • Veterans Affairs Medical Center - Richmond
    • Washington
      • Seattle, Washington, Forenede Stater, 98101
        • CCOP - Virginia Mason Research Center
      • Seattle, Washington, Forenede Stater, 98104
        • Swedish Cancer Institute
      • Seattle, Washington, Forenede Stater, 98108
        • Veterans Affairs Medical Center - Seattle
      • Tacoma, Washington, Forenede Stater, 98431-5000
        • Madigan Army Medical Center
      • Tacoma, Washington, Forenede Stater, 98405-0986
        • CCOP - Northwest
    • Wisconsin
      • Appleton, Wisconsin, Forenede Stater, 54911
        • Fox Valley Hematology and Oncology
      • Ashland, Wisconsin, Forenede Stater, 54806
        • Memorial Medical Center
      • Eau Claire, Wisconsin, Forenede Stater, 54703
        • Luther Hospital
      • Eau Claire, Wisconsin, Forenede Stater, 54703
        • Midelfort Clinic
      • Green Bay, Wisconsin, Forenede Stater, 54307-3508
        • St. Vincent Hospital
      • La Crosse, Wisconsin, Forenede Stater, 54601
        • Gundersen Lutheran Medical Center
      • La Crosse, Wisconsin, Forenede Stater, 54601-4796
        • Franciscan Skemp Healthcare
      • Madison, Wisconsin, Forenede Stater, 53792-6164
        • University of Wisconsin Comprehensive Cancer Center
      • Madison, Wisconsin, Forenede Stater, 53705
        • Veterans Affairs Medical Center - Madison
      • Madison, Wisconsin, Forenede Stater, 53715
        • Meriter Hospital
      • Madison, Wisconsin, Forenede Stater, 53715
        • Dean Medical Center
      • Marshfield, Wisconsin, Forenede Stater, 54449
        • CCOP - Marshfield Medical Research and Education Foundation
      • Milwaukee, Wisconsin, Forenede Stater, 53226
        • Medical College of Wisconsin
      • Milwaukee, Wisconsin, Forenede Stater, 53295
        • Veterans Affairs Medical Center - Milwaukee (Zablocki)
      • Milwaukee, Wisconsin, Forenede Stater, 53201-0342
        • Aurora Sinai Samaritan Medical Center
      • Oconomowoc, Wisconsin, Forenede Stater, 53066
        • Oconomowoc Memorial Hospital
      • Waukesha, Wisconsin, Forenede Stater, 53188
        • Waukesha Memorial Hospital
      • Wausau, Wisconsin, Forenede Stater, 54401
        • UW Cancer Center Wausau Hospital
  • Puerto Rico
      • Hato Rey, Puerto Rico, 00919-1811
        • Centro Mamografia Hospital Oncologico
      • San Juan, Puerto Rico, 00936-7344
        • San Juan City Hospital
      • San Juan, Puerto Rico, 00927-5800
        • Veterans Affairs Medical Center - San Juan
  • Sydafrika
      • Johannesburg, Sydafrika, 2193
        • Medical Oncology Centre of Rosebank
      • Pretoria, Sydafrika, 0001
        • Pretoria Academic Hospitals

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

SYGDOMS KARAKTERISTIKA:

  • Histologisk eller cytologisk bekræftet lokalt fremskreden, lokalt tilbagevendende eller metastatisk kolorektal adenokarcinom, der ikke kan helbredes ved kirurgi eller strålebehandling

    • Histologiske eller cytologiske krav frafaldes hos patienter, der udviklede radiologisk eller klinisk tegn på metastatisk cancer efter en tidligere kirurgisk resektion, medmindre:

      • Der er gået mere end 5 år siden primær operation ELLER
      • Primær cancer var stadium I eller II
  • Stedet for den primære læsion skal være eller være blevet bekræftet endoskopisk, radiologisk eller kirurgisk for at være eller have været i tyktarmen
  • Målbar eller evaluerbar sygdom
  • Ingen CNS-metastaser eller carcinomatøs meningitis

PATIENT KARAKTERISTIKA:

Alder:

  • 18 og derover

Ydeevnestatus:

  • ØKOG 0-2

Forventede levealder:

  • Mindst 12 uger

Hæmatopoietisk:

  • Absolut granulocyttal mindst 1.500/mm^3
  • Blodpladetal mindst 100.000/mm^3
  • Hæmoglobin mindst 9,0 g/dL (transfusion tilladt)

Hepatisk:

  • Bilirubin ikke større end 1,5 mg/dL
  • AST ikke større end 5 gange øvre normalgrænse (ULN)
  • Alkalisk fosfatase ikke mere end 5 gange ULN

Nyre:

  • Kreatinin ikke større end 1,5 gange ULN

Kardiovaskulær:

  • Ingen ukontrolleret hypertension
  • Ingen ustabil angina
  • Ingen symptomatisk kongestiv hjerteinsufficiens
  • Ingen myokardieinfarkt inden for de seneste 6 måneder
  • Ingen alvorlig ukontrolleret arytmi
  • Ingen New York Heart Association klasse III eller IV hjertesygdom

Lunge:

  • Ingen interstitiel lungebetændelse eller omfattende og symptomatisk interstitiel fibrose i lungen
  • Ingen pleural effusion eller ascites, der forårsager respiratorisk kompromittering (grad 2 eller værre dyspnø)

Andet:

  • Ikke gravid eller ammende
  • Negativ graviditetstest
  • Fertile patienter skal bruge effektiv prævention
  • Ingen aktiv eller ukontrolleret infektion
  • Ingen symptomatisk sensorisk perifer neuropati
  • Ingen kendt allergi over for platinforbindelser
  • Ingen anamnese med gastrointestinal blødning, medmindre den tilskrivende læge er bestemt til at være acceptabel
  • Ingen anden tidligere eller samtidig malignitet inden for de seneste 3 år undtagen non-melanom hudkræft, carcinom in situ i livmoderhalsen eller anden resekeret malign tumor med mindre end 10 % sandsynlighed for tumortilbagefald inden for 3 år efter diagnosen
  • Ingen medicinske eller psykiatriske tilstande, der ville udelukke studier
  • Ingen tyktarms- eller tyndtarmsforstyrrelser med ukontrollerede symptomer på mere end 3 løs afføring om dagen
  • Kolostomi eller ileostomi tilladt efter efterforskerens skøn

FORUDSÆTNING SAMTYDLIG TERAPI:

Biologisk terapi:

  • Forudgående adjuverende immunterapi for resekeret stadium II-IV sygdom tilladt, hvis adjuverende behandling afsluttes mindst 1 år før dokumentation for tilbagevendende sygdom
  • Ingen samtidig sargramostim (GM-CSF)

Kemoterapi:

  • Ingen forudgående kemoterapi for fremskreden tyktarmskræft
  • Ingen tidligere standard adjuverende kemoterapi til endetarmskræft
  • Forudgående adjuverende fluorouracil til resekeret stadium II-IV sygdom tilladt, hvis adjuverende behandling afsluttes mindst 1 år før dokumentation for tilbagevendende sygdom

Strålebehandling:

  • Se Sygdomskarakteristika
  • Mindst 4 uger siden tidligere større strålebehandling (f.eks. bryst- eller knoglepalliativ strålebehandling)
  • Ingen forudgående strålebehandling til mere end 15 % af knoglemarven
  • Ingen forudgående standard adjuverende strålebehandling til rektalcancer

Kirurgi:

  • Se Sygdomskarakteristika
  • Mindst 4 uger siden tidligere større operation (f.eks. laparotomi) (2 uger for mindre operation) og restitueret
  • Indsættelse af en vaskulær adgangsenhed betragtes ikke som større eller mindre operation

Andet:

  • Ingen andre samtidige undersøgelsesmidler

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: irinotecan + leucovorin + fluorouracil

Patienterne får irinotecan IV over 90 minutter efterfulgt af leucovorin calcium IV over 15 minutter og fluorouracil IV en gang om ugen i 4 uger efterfulgt af 2 ugers hvile. Kurserne gentages hver 6. uge.

Behandlingen fortsætter i fravær af sygdomsprogression eller uacceptabel toksicitet.

Livskvalitet vurderes før behandling, under behandling (armspecifik) og efter endt behandling.

Patienterne følges hver 3. måned i 1 år, hver 6. måned i 2 år og derefter årligt.
Medicin: fluorouracil
Medicin: leucovorin calcium
Medicin: irinotecan
Eksperimentel: oxaliplatin + leucovorin + fluorouracil

Patienterne får oxaliplatin IV over 2 timer på dag 1 og leucovorin calcium IV over 2 timer plus fluorouracil IV over 22 timer på dag 1 og 2. Kurser gentages hver 2. uge.

Behandlingen fortsætter i fravær af sygdomsprogression eller uacceptabel toksicitet.

Livskvalitet vurderes før behandling, under behandling (armspecifik) og efter endt behandling.

Patienterne følges hver 3. måned i 1 år, hver 6. måned i 2 år og derefter årligt.
Medicin: fluorouracil
Medicin: leucovorin calcium
Medicin: oxaliplatin
Eksperimentel: oxaliplatin + irinotecan

Patienterne får oxaliplatin IV over 2 timer og irinotecan IV over 30 minutter på dag 1. Kurserne gentages hver 3. uge.

Behandlingen fortsætter i fravær af sygdomsprogression eller uacceptabel toksicitet.

Livskvalitet vurderes før behandling, under behandling (armspecifik) og efter endt behandling.

Patienterne følges hver 3. måned i 1 år, hver 6. måned i 2 år og derefter årligt.
Medicin: oxaliplatin
Medicin: irinotecan

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Tidsramme
tid til progression
Tidsramme: Op til 5 år
Op til 5 år

Sekundære resultatmål

Resultatmål
Tidsramme
svarprocent
Tidsramme: Op til 5 år
Op til 5 år
samlet overlevelse
Tidsramme: Op til 5 år
Op til 5 år
livskvalitet
Tidsramme: Op til 5 år
Op til 5 år
tid til behandlingssvigt
Tidsramme: Op til 5 år
Op til 5 år

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Alliance for Clinical Trials in Oncology

Samarbejdspartnere

National Cancer Institute (NCI)
NCIC Clinical Trials Group

Efterforskere

  • Studiestol: Henry C. Pitot, MD, Mayo Clinic

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Hjælpsomme links

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. oktober 1998

Primær færdiggørelse (Faktiske)

1. oktober 2004

Studieafslutning (Faktiske)

1. oktober 2004

Datoer for studieregistrering

Først indsendt

1. november 1999

Først indsendt, der opfyldte QC-kriterier

24. september 2003

Først opslået (Skøn)

25. september 2003

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

29. april 2020

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

28. april 2020

Sidst verificeret

1. april 2020

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • NCCTG-N9741
  • CDR0000066665 (Registry Identifier: PDQ (Physician Data Query))
  • CAN-NCIC-CO13

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Kolorektal cancer

Kliniske forsøg med fluorouracil

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Trinidad & Tobago

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer

Abonner