Kombinasjonskjemoterapi ved behandling av pasienter med avansert tykktarmskreft
28. april 2020 oppdatert av: Alliance for Clinical Trials in Oncology
En randomisert fase III-studie av tre forskjellige regimer av CPT-11 Plus 5-Fluorouracil og Leucovorin sammenlignet med 5-Fluorouracil og Leucovorin hos pasienter med avansert adenokarsinom i tykktarmen og endetarmen
BAKGRUNN: Legemidler som brukes i kjemoterapi bruker forskjellige måter å stoppe tumorceller i å dele seg slik at de slutter å vokse eller dør. Å kombinere mer enn ett medikament kan drepe flere tumorceller. Det er ennå ikke kjent hvilket regime med kombinasjonskjemoterapi som er mest effektivt i behandling av avansert tykktarmskreft.
FORMÅL: Randomisert fase III-studie for å sammenligne effektiviteten av ulike kombinasjonskjemoterapiregimer ved behandling av pasienter som har avansert, tilbakevendende eller metastatisk kolorektal kreft som ikke kan behandles med kirurgi eller strålebehandling.
Studieoversikt
Status
Fullført
Forhold
Intervensjon / Behandling
Detaljert beskrivelse
MÅL:
- Sammenlign tiden til progresjon hos pasienter med lokalt avansert, lokalt tilbakevendende eller metastatisk kolorektalt adenokarsinom behandlet med kombinasjoner av oksaliplatin, fluorouracil, leukovorinksium og irinotekan.
- Sammenlign livskvalitet, responsrate, tid til behandlingssvikt og total overlevelse hos pasienter behandlet med disse regimene.
- Sammenlign toksisiteten til disse regimene hos disse pasientene.
OVERSIKT: Dette er en randomisert, multisenterstudie. Pasientene er stratifisert i henhold til ECOG-ytelsesstatus (0-1 mot 2), tidligere adjuvant kjemoterapi (ja mot nei), tidligere immunterapi (ja mot nei) og alder (under 65 vs 65 og over). Pasientene er randomisert til en av tre behandlingsarmer.
Bare arm II forblir åpen for periodisering.
- Arm I (Saltz-regime): Pasienter får irinotecan IV over 90 minutter etterfulgt av leucovorin calcium IV over 15 minutter og fluorouracil IV en gang i uken i 4 uker etterfulgt av 2 ukers hvile. Kursene gjentas hver 6. uke. (Arm I stengte for periodisering per 15. mars 2002.)
- Arm II (FOLFOX4-regime): Pasienter får oksaliplatin IV over 2 timer på dag 1 og leucovorin kalsium IV over 2 timer pluss fluorouracil IV over 22 timer på dag 1 og 2. Kursene gjentas hver 2. uke.
- Arm III (oksaliplatin pluss irinotekan): Pasienter får oksaliplatin IV over 2 timer og irinotekan IV over 30 minutter på dag 1. Kursene gjentas hver 3. uke. (Arm III stengt for periodisering fra 15. mars 2002.) Behandlingen fortsetter i fravær av sykdomsprogresjon eller uakseptabel toksisitet.
Livskvalitet vurderes før behandling, under behandling (armspesifikk), og etter avsluttet behandling.
Pasientene følges hver 3. måned i 1 år, hver 6. måned i 2 år, og deretter årlig.
PROSJEKTERT PASSING: Totalt 825 pasienter (275 per arm) er påløpt for denne studien så langt. Ytterligere pasienter samles på arm II. (Arm I og III stengte for periodisering fra 15. mars 2002.)
Studietype
Intervensjonell
Registrering (Faktiske)
1691
Fase
- Fase 3
Kontakter og plasseringer
Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.
Studiesteder
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North Vancouver, Canada, V7L 2P9
- Lions Gate Hospital
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Alberta
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Edmonton, Alberta, Canada, T6G 1Z2
- Cross Cancer Institute
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British Columbia
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Kelowna, British Columbia, Canada, V1Y 5L3
- British Columbia Cancer Agency - Centre for the Southern Interior
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Nanaimo, British Columbia, Canada, V9S 2B7
- Nanaimo Cancer Clinic
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Surrey, British Columbia, Canada, V3V 1Z2
- British Columbia Cancer Agency - Fraser Valley Cancer Centre
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Vancouver, British Columbia, Canada, V5Z 4E6
- British Columbia Cancer Agency
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Victoria, British Columbia, Canada, V8R 6V5
- British Columbia Cancer Agency - Vancouver Island Cancer Centre
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Manitoba
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Winnipeg, Manitoba, Canada, R2H 2A6
- St. Boniface General Hospital
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Nova Scotia
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Halifax, Nova Scotia, Canada, B3H 1V7
- Nova Scotia Cancer Centre
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Ontario
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Brampton, Ontario, Canada, L6W 2Z8
- William Osler Health Centre
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London, Ontario, Canada, N6A 4L6
- Cancer Care Ontario-London Regional Cancer Centre
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Mississauga, Ontario, Canada, L5B 1B8
- Trillium Health Centre
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Mississauga, Ontario, Canada, L5M 2N1
- Credit Valley Hospital
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Newmarket, Ontario, Canada, L3Y 2P9
- Southlake Regional Health Centre
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Peterborough, Ontario, Canada, K9H 7B6
- Peterborough Oncology Clinic
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Sault Sainte Marie, Ontario, Canada, P6B 1Y5
- Algoma District Medical Group
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St. Catharines, Ontario, Canada, L2R 5K3
- Hotel Dieu Health Sciences Hospital - Niagara
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Sudbury, Ontario, Canada, P3E 5J1
- Northeastern Ontario Regional Cancer Centre, Sudbury
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Thunder Bay, Ontario, Canada, P7A 7T1
- Northwestern Ontario Regional Cancer Centre, Thunder Bay
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Toronto, Ontario, Canada, M5G 1X5
- Mount Sinai Hospital - Toronto
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Toronto, Ontario, Canada, M6R 1B5
- Saint Joseph's Health Centre - Toronto
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Weston, Ontario, Canada, M9N 1N8
- Humber River Regional Hospital
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Prince Edward Island
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Charlottetown, Prince Edward Island, Canada, C1A 8T5
- Queen Elizabeth Hospital, PEI
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Quebec
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Greenfield Park, Quebec, Canada, J4V 2H1
- Hôpital Charles LeMoyne
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Montreal, Quebec, Canada, H1T 2M4
- Maisonneuve-Rosemont Hospital
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Montreal, Quebec, Canada, H2L-4M1
- Centre Hospitalier de l'Université de Montréal
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Montreal, Quebec, Canada, H2X 3J4
- CHUM Hopital Saint-Luc
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Ste-Foy, Quebec, Canada, G1V 4G5
- L'Hopital Laval
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Saskatchewan
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Regina, Saskatchewan, Canada, S4T 7T1
- Allan Blair Cancer Centre
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Regina, Saskatchewan, Canada, S4T 7T1
- Pasqua Hospital
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Saskatoon, Saskatchewan, Canada, S7N 4H4
- Saskatoon Cancer Centre
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Alabama
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Birmingham, Alabama, Forente stater, 35233-1996
- Veterans Affairs Medical Center - Birmingham
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Mobile, Alabama, Forente stater, 36688
- MBCCOP - Gulf Coast
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Arizona
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Phoenix, Arizona, Forente stater, 85006-2726
- CCOP - Greater Phoenix
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Phoenix, Arizona, Forente stater, 85012
- Veterans Affairs Medical Center - Phoenix (Hayden)
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Phoenix, Arizona, Forente stater, 85054-4502
- Mayo Clinic Hospital
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Scottsdale, Arizona, Forente stater, 85259
- Mayo Clinic Scottsdale
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Tucson, Arizona, Forente stater, 85724
- Arizona Cancer Center
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Tucson, Arizona, Forente stater, 85723
- Veterans Affairs Medical Center - Tucson
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Arkansas
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Little Rock, Arkansas, Forente stater, 72205
- University of Arkansas for Medical Sciences
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Little Rock, Arkansas, Forente stater, 72205
- Veterans Affairs Medical Center - Little Rock (McClellan)
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California
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Duarte, California, Forente stater, 91010-3000
- Cancer Center and Beckman Research Institute, City of Hope
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La Jolla, California, Forente stater, 92093-0658
- University of California San Diego Cancer Center
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Long Beach, California, Forente stater, 90822
- Veterans Affairs Medical Center - Long Beach
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Los Angeles, California, Forente stater, 90095-1781
- Jonsson Comprehensive Cancer Center, UCLA
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Los Angeles, California, Forente stater, 90033-0804
- USC/Norris Comprehensive Cancer Center and Hospital
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Los Angeles, California, Forente stater, 90073
- Veterans Affairs Medical Center - West Los Angeles
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Martinez, California, Forente stater, 94553
- Veterans Affairs Outpatient Clinic - Martinez
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Monterey, California, Forente stater, 93940
- Community Hospital of the Monterey Peninsula
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Oakland, California, Forente stater, 94609-3305
- CCOP - Bay Area Tumor Institute
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Orange, California, Forente stater, 92868
- Chao Family Comprehensive Cancer Center
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Palo Alto, California, Forente stater, 94304
- Veterans Affairs Medical Center - Palo Alto
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Sacramento, California, Forente stater, 95817
- University of California Davis Medical Center
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San Francisco, California, Forente stater, 94121
- Veterans Affairs Medical Center - San Francisco
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San Francisco, California, Forente stater, 94143-0128
- UCSF Cancer Center and Cancer Research Institute
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Santa Rosa, California, Forente stater, 95403
- CCOP - Santa Rosa Memorial Hospital
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Stanford, California, Forente stater, 94305-5408
- Stanford University Medical Center
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Travis Air Force Base, California, Forente stater, 94535
- David Grant Medical Center
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Colorado
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Aurora, Colorado, Forente stater, 80011
- Columbia Medical Center of Aurora North Campus
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Colorado Springs, Colorado, Forente stater, 80933
- Penrose Cancer Center
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Denver, Colorado, Forente stater, 80210
- Porter Adventist Hospital
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Denver, Colorado, Forente stater, 80220
- Veterans Affairs Medical Center - Denver
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Denver, Colorado, Forente stater, 80218
- Presbyterian-St Luke's Medical Center
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Denver, Colorado, Forente stater, 80010
- University of Colorado Cancer Center
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Denver, Colorado, Forente stater, 80218
- St. Joseph Hospital
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Denver, Colorado, Forente stater, 80209-5031
- CCOP - Colorado Cancer Research Program, Inc.
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Denver, Colorado, Forente stater, 80220
- HealthOne Rose Medical Center
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Englewood, Colorado, Forente stater, 80110
- Swedish Medical Center
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Fort Collins, Colorado, Forente stater, 80524
- Poudre Valley Hospital
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Fort Collins, Colorado, Forente stater, 80528
- Poudre Valley Radiation Oncology
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Fort Collins, Colorado, Forente stater, 80524-4038
- Rocky Mountain Cancer Centers - Northern Colorado
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Pueblo, Colorado, Forente stater, 81004
- St. Mary-Corwin Regional Medical Center
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Connecticut
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Bristol, Connecticut, Forente stater, 06011-0977
- Bristol Hospital
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Farmington, Connecticut, Forente stater, 06360-7106
- University of Connecticut Health Center
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Hartford, Connecticut, Forente stater, 06105
- St. Francis Hospital and Medical Center
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New Britain, Connecticut, Forente stater, 06050
- New Britain General Hospital
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New London, Connecticut, Forente stater, 06320
- Lawrence and Memorial Hospital
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Norwich, Connecticut, Forente stater, 06360
- William W. Backus Hospital
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Torrington, Connecticut, Forente stater, 06790
- Northwestern Connecticut Oncology-Hematology Associates
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Delaware
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Wilmington, Delaware, Forente stater, 19899
- CCOP - Christiana Care Health Services
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District of Columbia
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Washington, District of Columbia, Forente stater, 20307-5000
- Walter Reed Army Medical Center
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Florida
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Gainesville, Florida, Forente stater, 32610-0277
- University of Florida - Gainesville
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Jacksonville, Florida, Forente stater, 32224
- Mayo Clinic
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Jacksonville, Florida, Forente stater, 32209
- University of Florida Health Science Center - Jacksonville
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Jacksonville, Florida, Forente stater, 32207
- Baptist Regional Cancer Institute - Jacksonville
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Miami Beach, Florida, Forente stater, 33140
- CCOP - Mount Sinai Medical Center
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Tampa, Florida, Forente stater, 33612-9497
- H. Lee Moffitt Cancer Center and Research Institute
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Georgia
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Atlanta, Georgia, Forente stater, 30322
- Emory University Hospital - Atlanta
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Atlanta, Georgia, Forente stater, 30342-1701
- CCOP - Atlanta Regional
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Atlanta, Georgia, Forente stater, 30335
- Grady Memorial Hospital
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Decatur, Georgia, Forente stater, 30033
- Veterans Affairs Medical Center - Atlanta (Decatur)
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Fort Gordon, Georgia, Forente stater, 30905-5650
- Dwight David Eisenhower Army Medical Center
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Hawaii
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Honolulu, Hawaii, Forente stater, 96813
- Cancer Research Center of Hawaii
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Illinois
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Bloomington, Illinois, Forente stater, 61701-3081
- Bromenn Lifecare Center
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Bloomington, Illinois, Forente stater, 61701
- St. Joseph's Hospital Medical Center
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Canton, Illinois, Forente stater, 61520
- Graham Hospital Association
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Carthage, Illinois, Forente stater, 62321
- Memorial Hospital
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Chicago, Illinois, Forente stater, 60612
- Veterans Affairs Medical Center - Chicago (Westside Hospital)
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Chicago, Illinois, Forente stater, 60637-1470
- University of Chicago Cancer Research Center
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Chicago, Illinois, Forente stater, 60611-3013
- Robert H. Lurie Comprehensive Cancer Center, Northwestern University
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Chicago, Illinois, Forente stater, 60611
- Veterans Affairs Medical Center - Lakeside Chicago
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Chicago, Illinois, Forente stater, 60616
- Mercy Hospital and Medical Center
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Chicago, Illinois, Forente stater, 60611-2998
- Hematology-Oncology Associates of Illinois
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Chicago, Illinois, Forente stater, 60611
- Hematology Oncology Associates of Illinois - Lake Shore Dr
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Decatur, Illinois, Forente stater, 62526
- CCOP - Central Illinois
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Des Plaines, Illinois, Forente stater, 60016
- Holy Family Medical Center
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Effingham, Illinois, Forente stater, 62401
- St. Anthony's Memorial Hospital
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Elk Grove Village, Illinois, Forente stater, 60007
- Northwest Oncology and Hematology, S.C.
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Eureka, Illinois, Forente stater, 61530
- Eureka Hospital
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Evanston, Illinois, Forente stater, 60201
- CCOP - Evanston
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Galesburg, Illinois, Forente stater, 61401
- Galesburg Clinic
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Galesburg, Illinois, Forente stater, 61401
- InterCommunity Cancer Center of Western Illinois
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Galesburg, Illinois, Forente stater, 61402
- Galesburg Cottage Hospital
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Glenview, Illinois, Forente stater, 60025
- Glenbrook Hospital
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Harvey, Illinois, Forente stater, 60426
- Ingalls Memorial Hospital
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Havana, Illinois, Forente stater, 62644
- Mason District Hospital
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Highland Park, Illinois, Forente stater, 60035
- Hematology Oncology Associates of Illinois-Highland Park
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Hines, Illinois, Forente stater, 60141
- Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital)
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Hinsdale, Illinois, Forente stater, 60521
- Hinsdale Hematology Oncology Associates
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Hopedale, Illinois, Forente stater, 61747
- Hopedale Medical Complex Hospital
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Joliet, Illinois, Forente stater, 60432
- Silver Cross Hospital
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Joliet, Illinois, Forente stater, 60435
- Joliet Oncology/Hematology Associates, Ltd.
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Joliet, Illinois, Forente stater, 60435
- Saint Joseph Medical Center
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Kewanee, Illinois, Forente stater, 61443
- Kewanee Hospital
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Lake Forest, Illinois, Forente stater, 60045
- Deerpath Medical Associates
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Libertyville, Illinois, Forente stater, 60048
- North Shore Oncology Hematology Associates
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Macomb, Illinois, Forente stater, 61455
- Mcdonough District Hospital
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Maywood, Illinois, Forente stater, 60153
- Loyola University Medical Center
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Melrose Park, Illinois, Forente stater, 60160
- Hematology/Oncology Associates of Illinois, LLC
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Mendota, Illinois, Forente stater, 61342
- Mendota Community Hospital
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Moline, Illinois, Forente stater, 61265-1291
- Trinity Medical Center
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Morris, Illinois, Forente stater, 60450
- Morris Hospital
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Normal, Illinois, Forente stater, 61761
- Bromenn Regional Medical Center
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Normal, Illinois, Forente stater, 61761
- Community Cancer Center
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Oak Park, Illinois, Forente stater, 60304
- Hematology Oncology Associates of Illinois, LLC
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Ottawa, Illinois, Forente stater, 61350
- Community Hospital of Ottawa
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Pekin, Illinois, Forente stater, 61554
- Pekin Hospital
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Peoria, Illinois, Forente stater, 61636
- Methodist Medical Center of Illinois
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Peoria, Illinois, Forente stater, 61614
- Proctor Hospital
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Peoria, Illinois, Forente stater, 61602
- Oncology/Hematology Associates of Central Illinois, P.C.
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Peoria, Illinois, Forente stater, 61637
- St. Francis Medical Center
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Peoria, Illinois, Forente stater, 61614
- Peoria Urological Associates
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Peoria, Illinois, Forente stater, 61602
- Illinois Oncology Research Association
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Peoria, Illinois, Forente stater, 61603
- Affiliated Urology Specialists
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Peoria, Illinois, Forente stater, 61603
- Midwest Urological Group
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Peoria, Illinois, Forente stater, 61636
- Midwest Radiation Oncology Physicians
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Peru, Illinois, Forente stater, 61354
- Illinois Valley Community Hospital
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Pontiac, Illinois, Forente stater, 61764
- St. James Hospital
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Princeton, Illinois, Forente stater, 61356
- Perry Memorial Hospital
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Rock Island, Illinois, Forente stater, 61201
- Trinity Medical Center
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Rockford, Illinois, Forente stater, 61104-2315
- Swedish-American Health System
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Rushville, Illinois, Forente stater, 62681
- Sarah D. Culbertson Memorial Hospital
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Skokie, Illinois, Forente stater, 60076
- Hematology Oncology Associates - Skokie
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Skokie, Illinois, Forente stater, 60076
- Edward H. Kaplan MD and Associates
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Skokie, Illinois, Forente stater, 60077
- Midwest Cancer Research Group, Inc.
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Spring Valley, Illinois, Forente stater, 61362
- St. Margaret's Hospital
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Spring Valley, Illinois, Forente stater, 61362
- Valley Cancer Center
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Urbana, Illinois, Forente stater, 61801
- Carle Cancer Center
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Urbana, Illinois, Forente stater, 61801
- Carle Foundation Hospital
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Indiana
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Evansville, Indiana, Forente stater, 47715
- Therapy Associates Hematology/Oncology
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Lafayette, Indiana, Forente stater, 47904
- Oncology Institute of Greater Lafayette
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Iowa
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Ames, Iowa, Forente stater, 50010
- McFarland Clinic, P.C.
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Ames, Iowa, Forente stater, 50010
- William R. Bliss Cancer Center
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Bettendorf, Iowa, Forente stater, 52722
- Hematology Oncology Associates of the Quad Cities
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Carroll, Iowa, Forente stater, 51401
- Saint Anthony Regional Hospital
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Cedar Rapids, Iowa, Forente stater, 52403
- Cedar Rapids Oncology Associates
-
Cedar Rapids, Iowa, Forente stater, 52403
- Mercy Medical Center
-
Cedar Rapids, Iowa, Forente stater, 52406
- St. Luke's Hospital
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Council Bluffs, Iowa, Forente stater, 51503
- Alegent Health Southwest Iowa Medical Center
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Des Moines, Iowa, Forente stater, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Forente stater, 50314
- Medical Oncology and Hematology Associates
-
Des Moines, Iowa, Forente stater, 50314
- Mercy Hospital Medical Center
-
Des Moines, Iowa, Forente stater, 50309
- Medical Oncology and Hematology Associates
-
Des Moines, Iowa, Forente stater, 50309
- Des Moines General Hospital
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Des Moines, Iowa, Forente stater, 50316-2392
- Iowa Lutheran Hospital
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Iowa City, Iowa, Forente stater, 52242-1009
- Holden Comprehensive Cancer Center at the University of Iowa
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Mason City, Iowa, Forente stater, 50401
- Mercy Cancer Center
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Missouri Valley, Iowa, Forente stater, 51555-1199
- Community Memorial Hospital
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Onawa, Iowa, Forente stater, 51040
- Burgess Health Center
-
Ottumwa, Iowa, Forente stater, 52501
- Ottumwa Regional Health Center
-
Ottumwa, Iowa, Forente stater, 52501
- Oncology & Hematology of Ottumwa, PC
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Sioux City, Iowa, Forente stater, 51101-1733
- Siouxland Hematology-Oncology
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Sioux City, Iowa, Forente stater, 51104
- St. Luke's Regional Medical Center
-
Sioux City, Iowa, Forente stater, 51101
- Mercy Medical Center - Sioux City
-
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Kansas
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Arkansas City, Kansas, Forente stater, 67005
- Cancer Center of Kansas - Arkansas City
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Chanute, Kansas, Forente stater, 66720
- Cancer Center of Kansas - Chanute
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Dodge City, Kansas, Forente stater, 67801
- Cancer Center of Kansas - Dodge City
-
Dodge City, Kansas, Forente stater, 67801
- Radiation Oncology Center
-
Halstead, Kansas, Forente stater, 67056
- Halstead Cancer Center of Kansas
-
Kansas City, Kansas, Forente stater, 66160-7357
- University of Kansas Medical Center
-
Kingman, Kansas, Forente stater, 67068
- Cancer Center of Kansas - Kingman
-
Liberal, Kansas, Forente stater, 67901
- Liberal Cancer Center of Kansas
-
Newton, Kansas, Forente stater, 67114
- Cancer Center of Kansas - Newton
-
Pratt, Kansas, Forente stater, 67124
- Pratt Cancer Center of Kansas
-
Salina, Kansas, Forente stater, 67401
- Cancer Center of Kansas - Salina
-
Wellington, Kansas, Forente stater, 67152
- Cancer Center of Kansas - Wellington
-
Wichita, Kansas, Forente stater, 67214
- Cancer Center of Kansas - Wichita
-
Wichita, Kansas, Forente stater, 67214-3882
- CCOP - Wichita
-
Wichita, Kansas, Forente stater, 67218
- Veterans Affairs Medical Center - Wichita
-
Wichita, Kansas, Forente stater, 67214
- Via Christi Regional Medical Center
-
Wichita, Kansas, Forente stater, 67208
- Associates in Women's Health - Wichita
-
Wichita, Kansas, Forente stater, 67208
- Wichita Clinic Cancer Medicine Associates, P.A.
-
Winfield, Kansas, Forente stater, 67156
- Cancer Center of Kansas - Winfield
-
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Kentucky
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Lexington, Kentucky, Forente stater, 40511-1093
- Veterans Affairs Medical Center - Lexington
-
Lexington, Kentucky, Forente stater, 40536-0084
- Albert B. Chandler Medical Center, University of Kentucky
-
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Louisiana
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New Orleans, Louisiana, Forente stater, 70112
- Tulane University School of Medicine
-
New Orleans, Louisiana, Forente stater, 70112
- MBCCOP - LSU Health Sciences Center
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Shreveport, Louisiana, Forente stater, 71130-3932
- Louisiana State University Health Sciences Center - Shreveport
-
Shreveport, Louisiana, Forente stater, 71130
- Veterans Affairs Medical Center - Shreveport
-
-
Maine
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Togus, Maine, Forente stater, 04330
- Veterans Affairs Medical Center - Togus
-
-
Maryland
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Annapolis, Maryland, Forente stater, 21401
- Anne Arundel Medical Center
-
-
Massachusetts
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Boston, Massachusetts, Forente stater, 02115
- Dana-Farber Cancer Institute
-
Boston, Massachusetts, Forente stater, 02118
- Boston Medical Center
-
Boston, Massachusetts, Forente stater, 02111
- New England Medical Center Hospital
-
Jamaica Plain, Massachusetts, Forente stater, 02130
- Veterans Affairs Medical Center - Boston (Jamaica Plain)
-
Jamaica Plain, Massachusetts, Forente stater, 02130
- Faulkner Hospital
-
Medford, Massachusetts, Forente stater, 02155
- Lawrence Memorial Hospital of Medford/Hallmark Health Systems
-
Taunton, Massachusetts, Forente stater, 02780
- Morton Hospital & Medical Center
-
Worcester, Massachusetts, Forente stater, 01655
- University of Massachusetts Memorial Medical Center
-
-
Michigan
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Adrian, Michigan, Forente stater, 49221
- Bixby Medical Center
-
Ann Arbor, Michigan, Forente stater, 48109-0752
- University Of Michigan Comprehensive Cancer Center
-
Ann Arbor, Michigan, Forente stater, 48105
- Veterans Affairs Medical Center - Ann Arbor
-
Ann Arbor, Michigan, Forente stater, 48106
- Saint Joseph Mercy Hospital
-
Detroit, Michigan, Forente stater, 48202
- Henry Ford Hospital
-
Detroit, Michigan, Forente stater, 48201-1379
- Barbara Ann Karmanos Cancer Institute
-
Detroit, Michigan, Forente stater, 48201-1932
- Veterans Affairs Medical Center - Detroit
-
Detroit, Michigan, Forente stater, 48236
- St. John Hospital and Medical Center
-
Flint, Michigan, Forente stater, 48503
- Genesee Regional Medical Center
-
Grand Rapids, Michigan, Forente stater, 49503
- CCOP - Grand Rapids Clinical Oncology Program
-
Kalamazoo, Michigan, Forente stater, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, Forente stater, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, Forente stater, 49048-1666
- Borgess Medical Center
-
Lansing, Michigan, Forente stater, 48909
- Sparrow Regional Cancer Center
-
Madison Heights, Michigan, Forente stater, 48071-3457
- Office of E. Michael Lodish
-
Monroe, Michigan, Forente stater, 48162
- Community Cancer Center of Monroe
-
Saginaw, Michigan, Forente stater, 48601
- St. Mary's Medical Center
-
Saginaw, Michigan, Forente stater, 48602
- Balcueva Clinic
-
Southfield, Michigan, Forente stater, 48075-9975
- Providence Hospital - Southfield
-
Warren, Michigan, Forente stater, 48093-3494
- St. John Macomb Hospital
-
-
Minnesota
-
Alexandria, Minnesota, Forente stater, 56308
- Alexandria Clinic
-
Alexandria, Minnesota, Forente stater, 56308
- Alexandria Radiation Oncology
-
Brainerd, Minnesota, Forente stater, 56401
- Brainerd Medical Center
-
Brainerd, Minnesota, Forente stater, 56401
- St. Joseph's Medical Center
-
Burnsville, Minnesota, Forente stater, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, Forente stater, 55433
- Mercy Hospital
-
Duluth, Minnesota, Forente stater, 55805
- Miller-Dwan Medical Center
-
Duluth, Minnesota, Forente stater, 55805
- St. Mary's/Duluth Clinic Health System
-
Duluth, Minnesota, Forente stater, 55805
- Duluth Clinic
-
Edina, Minnesota, Forente stater, 55435
- Fairview-Southdale Hospital
-
Fergus Falls, Minnesota, Forente stater, 56537
- Fergus Falls Medical Group
-
Fridley, Minnesota, Forente stater, 55432
- Mercy/Unity Hospitals
-
Hibbing, Minnesota, Forente stater, 55746
- Central Mesabi Medical Center
-
Hibbing, Minnesota, Forente stater, 55746
- Duluth Clinic - Hibbing
-
Hibbing, Minnesota, Forente stater, 55746
- Radiation Therapy Center
-
Hutchinson, Minnesota, Forente stater, 55350
- Hutchinson Area Health Care
-
Litchfield, Minnesota, Forente stater, 55355
- Meeker County Memorial Hospital
-
Maplewood, Minnesota, Forente stater, 55109
- St. John's Hospital
-
Minneapolis, Minnesota, Forente stater, 55417
- Veterans Affairs Medical Center - Minneapolis
-
Minneapolis, Minnesota, Forente stater, 55455
- University of Minnesota Cancer Center
-
Minneapolis, Minnesota, Forente stater, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Forente stater, 55407
- Virginia Piper Cancer Institute
-
Minneapolis, Minnesota, Forente stater, 55415
- Hennepin County Medical Center - Minneapolis
-
Minneapolis, Minnesota, Forente stater, 55442-2900
- North Memorial Research Center
-
Minneapolis, Minnesota, Forente stater, 55454-1395
- Fairview University Medical Center - Riverside Campus
-
Rochester, Minnesota, Forente stater, 55905
- Mayo Clinic Cancer Center
-
Saint Cloud, Minnesota, Forente stater, 56303
- St. Cloud Hospital
-
Saint Cloud, Minnesota, Forente stater, 56303
- CentraCare Health Plaza
-
Saint Louis Park, Minnesota, Forente stater, 55416
- CCOP - Metro-Minnesota
-
Saint Louis Park, Minnesota, Forente stater, 55416
- Park Nicollet Clinic
-
Saint Paul, Minnesota, Forente stater, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Forente stater, 55102
- United Hospital
-
Saint Paul, Minnesota, Forente stater, 55102
- Healtheast Cancer Care
-
Shakopee, Minnesota, Forente stater, 55379
- Saint Francis Regional Medical Center
-
Waconia, Minnesota, Forente stater, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Forente stater, 56201
- Rice Memorial Hospital
-
-
Mississippi
-
Biloxi, Mississippi, Forente stater, 39531-2410
- Veterans Affairs Medical Center - Biloxi
-
Jackson, Mississippi, Forente stater, 39216-4505
- University of Mississippi Medical Center
-
Jackson, Mississippi, Forente stater, 39216
- Veterans Affairs Medical Center - Jackson
-
Keesler Air Force Base, Mississippi, Forente stater, 39534-2576
- Keesler Medical Center - Keesler AFB
-
-
Missouri
-
Columbia, Missouri, Forente stater, 65201
- Veterans Affairs Medical Center - Columbia (Truman Memorial)
-
Columbia, Missouri, Forente stater, 65203
- Ellis Fischel Cancer Center - Columbia
-
Kansas City, Missouri, Forente stater, 64128
- Veterans Affairs Medical Center - Kansas City
-
Kansas City, Missouri, Forente stater, 64131
- CCOP - Kansas City
-
Saint Louis, Missouri, Forente stater, 63110
- Barnes-Jewish Hospital
-
Saint Louis, Missouri, Forente stater, 63110-0250
- St. Louis University Health Sciences Center
-
Saint Louis, Missouri, Forente stater, 63141
- CCOP - St. Louis-Cape Girardeau
-
Springfield, Missouri, Forente stater, 65807
- CCOP - Cancer Research for the Ozarks
-
-
Montana
-
Billings, Montana, Forente stater, 59101
- CCOP - Montana Cancer Consortium
-
-
Nebraska
-
Fremont, Nebraska, Forente stater, 68025-2387
- Fremont Area Medical Center
-
Lincoln, Nebraska, Forente stater, 68506
- Bryan LGH Medical Center East
-
Lincoln, Nebraska, Forente stater, 68510
- St. Elizabeth Regional Medical Center
-
Lincoln, Nebraska, Forente stater, 68502-3780
- Bryan LGH Medical Center
-
Lincoln, Nebraska, Forente stater, 68506-5247
- Prairie View Clinic
-
Lincoln, Nebraska, Forente stater, 68506
- Office of Susan Hansen, M.D.
-
Lincoln, Nebraska, Forente stater, 68510
- Wedgewood Medical Center
-
Lincoln, Nebraska, Forente stater, 68516
- Southeast Nebraska Hematology
-
Lincoln, Nebraska, Forente stater, 68516
- Southeast Nebreska Hematology-Oncology Consultants, PC
-
Lincoln, Nebraska, Forente stater, 68516
- Williamsburg Radiation Oncology Center
-
Omaha, Nebraska, Forente stater, 68198-3330
- University of Nebraska Medical Center
-
Omaha, Nebraska, Forente stater, 68105
- Veterans Affairs Medical Center - Omaha
-
Omaha, Nebraska, Forente stater, 68124
- Bergan Mercy Medical Center
-
Omaha, Nebraska, Forente stater, 68122
- Alegent Health - Immanuel Medical Center
-
Omaha, Nebraska, Forente stater, 68114
- Oncology Hematology West, P.C.
-
Omaha, Nebraska, Forente stater, 68131-2197
- Creighton University Cancer Center
-
Omaha, Nebraska, Forente stater, 68131-2197
- St. Joseph Hospital
-
Papillion, Nebraska, Forente stater, 68046-4194
- Alegent Health-Midlands Community Hospital
-
-
Nevada
-
Las Vegas, Nevada, Forente stater, 89106
- CCOP - Southern Nevada Cancer Research Foundation
-
-
New Hampshire
-
Lebanon, New Hampshire, Forente stater, 03756-0002
- Norris Cotton Cancer Center
-
-
New Jersey
-
Cherry Hill, New Jersey, Forente stater, 08046
- Center for Cancer and Hematologic Disease
-
Elizabeth, New Jersey, Forente stater, 07201
- Trinitas Hospital - Jersey Street Campus
-
Flemington, New Jersey, Forente stater, 08822
- Hunterdon Regional Cancer Center
-
Millville, New Jersey, Forente stater, 08332
- South Jersey Regional Cancer Center
-
Mount Holly, New Jersey, Forente stater, 08060
- Fox Chase Cancer Center at Virtua Memorial Hospital Burlington County
-
New Brunswick, New Jersey, Forente stater, 08903
- Cancer Institute Of New Jersey
-
Red Bank, New Jersey, Forente stater, 07701
- Riverview Medical Center - Booker Cancer Center
-
Trenton, New Jersey, Forente stater, 08629
- St. Francis Medical Center
-
Vineland, New Jersey, Forente stater, 08360
- Southern Oncology-Hematology Associates, P.A.
-
Voorhees, New Jersey, Forente stater, 08043
- Comprehensive Cancer and Hematology Associates
-
Willingboro, New Jersey, Forente stater, 08046
- Burlington County Hematology Oncology Association, P.A.
-
-
New Mexico
-
Albuquerque, New Mexico, Forente stater, 87108-5138
- Veterans Affairs Medical Center - Albuquerque
-
Albuquerque, New Mexico, Forente stater, 87131
- MBCCOP - University of New Mexico HSC
-
-
New York
-
Bronx, New York, Forente stater, 10461
- Albert Einstein Comprehensive Cancer Center
-
Buffalo, New York, Forente stater, 14215
- Veterans Affairs Medical Center - Buffalo
-
Cooperstown, New York, Forente stater, 13326
- Mary Imogene Bassett Hospital
-
Manhasset, New York, Forente stater, 11030
- CCOP - North Shore University Hospital
-
Manhasset, New York, Forente stater, 11030
- Schneider Children's Hospital at North Shore
-
New York, New York, Forente stater, 10021
- Memorial Sloan-Kettering Cancer Center
-
New York, New York, Forente stater, 10016
- NYU School of Medicine's Kaplan Comprehensive Cancer Center
-
New York, New York, Forente stater, 10021
- New York Presbyterian Hospital - Cornell Campus
-
New York, New York, Forente stater, 10029
- Mount Sinai Medical Center, NY
-
New York, New York, Forente stater, 10032
- Herbert Irving Comprehensive Cancer Center
-
New York, New York, Forente stater, 10010
- Veterans Affairs Medical Center - New York
-
Rochester, New York, Forente stater, 14621
- Rochester General Hospital
-
Syracuse, New York, Forente stater, 13210
- State University of New York - Upstate Medical University
-
Syracuse, New York, Forente stater, 13210
- Veterans Affairs Medical Center - Syracuse
-
Syracuse, New York, Forente stater, 13217
- CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
-
-
North Carolina
-
Chapel Hill, North Carolina, Forente stater, 27599-7295
- Lineberger Comprehensive Cancer Center, UNC
-
Durham, North Carolina, Forente stater, 27705
- Veterans Affairs Medical Center - Durham
-
Durham, North Carolina, Forente stater, 27710
- Duke Comprehensive Cancer Center
-
Winston-Salem, North Carolina, Forente stater, 27104-4241
- CCOP - Southeast Cancer Control Consortium
-
Winston-Salem, North Carolina, Forente stater, 27157-1082
- Comprehensive Cancer Center at Wake Forest University
-
-
North Dakota
-
Bismarck, North Dakota, Forente stater, 58501
- Medcenter One Health System
-
Bismarck, North Dakota, Forente stater, 58501
- Mid Dakota Clinic, P.C.
-
Bismarck, North Dakota, Forente stater, 58502
- St. Alexius Medical Center
-
Bismarck, North Dakota, Forente stater, 58501-4445
- Bismarck Cancer Center
-
Fargo, North Dakota, Forente stater, 58122
- Meritcare Roger Maris Cancer Center
-
Fargo, North Dakota, Forente stater, 58122
- CCOP - Merit Care Hospital
-
Grand Forks, North Dakota, Forente stater, 58201
- Altru Health Systems
-
Grand Forks, North Dakota, Forente stater, 58206
- Altru Cancer Center
-
-
Ohio
-
Akron, Ohio, Forente stater, 44309
- Akron City Hospital
-
Bowling Green, Ohio, Forente stater, 43402
- Wood County Oncology Center
-
Canton, Ohio, Forente stater, 44710
- Aultman Cancer Center
-
Canton, Ohio, Forente stater, 44708
- Mercy Ireland Cancer Center
-
Cincinnati, Ohio, Forente stater, 45220-2288
- Veterans Affairs Medical Center - Cincinnati
-
Cincinnati, Ohio, Forente stater, 45267-0502
- Barrett Cancer Center, The University Hospital
-
Cleveland, Ohio, Forente stater, 44195
- Cleveland Clinic Taussig Cancer Center
-
Cleveland, Ohio, Forente stater, 44106-5065
- Ireland Cancer Center
-
Columbus, Ohio, Forente stater, 43210-1240
- Arthur G. James Cancer Hospital - Ohio State University
-
Columbus, Ohio, Forente stater, 43206
- CCOP - Columbus
-
Dayton, Ohio, Forente stater, 45428
- Veterans Affairs Medical Center - Dayton
-
Findlay, Ohio, Forente stater, 45840
- Woman Wise Blanchard Valley Regional Health Center
-
Fremont, Ohio, Forente stater, 43420
- Fremont Memorial Hospital
-
Kenton, Ohio, Forente stater, 43326
- Office of Sharon Cole, M.D.
-
Kettering, Ohio, Forente stater, 45429
- CCOP - Dayton
-
Lima, Ohio, Forente stater, 45804
- Lima Memorial Hospital
-
Lima, Ohio, Forente stater, 45801
- St. Rita's Medical Center
-
Maumee, Ohio, Forente stater, 43537
- Saint Luke's Hospital
-
Maumee, Ohio, Forente stater, 43537
- North West Ohio Oncology Center
-
Oregon, Ohio, Forente stater, 43616
- St. Charles Hospital
-
Sandusky, Ohio, Forente stater, 44870
- Firelands Regional Medical Center
-
Sandusky, Ohio, Forente stater, 44870
- North Coast Cancer Care, Inc.
-
Sylvania, Ohio, Forente stater, 43560
- Flower Hospital - Pro Medica Health System
-
Toledo, Ohio, Forente stater, 43608
- St. Vincent Mercy Medical Center
-
Toledo, Ohio, Forente stater, 43606
- Toledo Hospital
-
Toledo, Ohio, Forente stater, 43623
- Toledo Clinic, Inc.
-
Toledo, Ohio, Forente stater, 43604
- Riverside Hospital
-
Toledo, Ohio, Forente stater, 43614-0008
- Medical College of Ohio Hospital
-
Toledo, Ohio, Forente stater, 43614
- MCO Cancer Institute
-
Toledo, Ohio, Forente stater, 43623-4474
- Haematology-Oncology Associates, Inc.
-
Wauseon, Ohio, Forente stater, 43567
- Fulton County Health Center
-
-
Oklahoma
-
Oklahoma City, Oklahoma, Forente stater, 73104
- Oklahoma Medical Research Foundation
-
Oklahoma City, Oklahoma, Forente stater, 73104
- Veterans Affairs Medical Center - Oklahoma City
-
Tulsa, Oklahoma, Forente stater, 74136
- CCOP - Oklahoma
-
-
Oregon
-
Portland, Oregon, Forente stater, 97207
- Veterans Affairs Medical Center - Portland
-
Portland, Oregon, Forente stater, 97213
- CCOP - Columbia River Program
-
Portland, Oregon, Forente stater, 97201-3098
- Oregon Cancer Center
-
-
Pennsylvania
-
Allentown, Pennsylvania, Forente stater, 18103
- LeHigh Valley Hospital
-
Bethlehem, Pennsylvania, Forente stater, 18017
- Muhlenberg Hospital Center
-
Carbondale, Pennsylvania, Forente stater, 18407
- Marion Community Hospital
-
Danville, Pennsylvania, Forente stater, 17822-2001
- Geisinger Medical Center
-
Drexel Hill, Pennsylvania, Forente stater, 19026
- Delaware County Memorial Hospital
-
DuBois, Pennsylvania, Forente stater, 15801-0447
- Dubois Regional Medical Center
-
Greenville, Pennsylvania, Forente stater, 16125
- UPMC Horizon
-
Harrisburg, Pennsylvania, Forente stater, 17105-8700
- Pinnacle Health Hospitals
-
Honesdale, Pennsylvania, Forente stater, 18431-1498
- Wayne Memorial Hospital
-
Johnstown, Pennsylvania, Forente stater, 15901
- UPCI @ UPMC Lee Hospital
-
Johnstown, Pennsylvania, Forente stater, 15905
- Conemaugh Memorial Hospital
-
Kittanning, Pennsylvania, Forente stater, 16201-8808
- Armstrong County Memorial Hospital
-
Lancaster, Pennsylvania, Forente stater, 17604-3555
- Lancaster General Hospital
-
Langhorne, Pennsylvania, Forente stater, 19047
- Saint Mary Regional Center
-
Latrobe, Pennsylvania, Forente stater, 15650
- Latrobe Area Hospital
-
Lemoyne, Pennsylvania, Forente stater, 17043
- Central Pennsylvania Hematology and Medical Oncology Associates
-
Philadelphia, Pennsylvania, Forente stater, 19141
- Albert Einstein Cancer Center
-
Philadelphia, Pennsylvania, Forente stater, 19102-1192
- Hahnemann University Hospital
-
Philadelphia, Pennsylvania, Forente stater, 19104-4283
- University of Pennsylvania Cancer Center
-
Pittsburgh, Pennsylvania, Forente stater, 15213
- University of Pittsburgh Medical Center
-
Pittsburgh, Pennsylvania, Forente stater, 15213-3180
- Magee-Womens Hospital
-
Pittsburgh, Pennsylvania, Forente stater, 15237
- UPMC/Passavant Hospital
-
Pottstown, Pennsylvania, Forente stater, 19464
- Pottstown Memorial Regional Cancer Center
-
Reading, Pennsylvania, Forente stater, 19612-6052
- Reading Hospital and Medical Center
-
Scranton, Pennsylvania, Forente stater, 18501
- Mercy Hospital Cancer Center - Scranton
-
Scranton, Pennsylvania, Forente stater, 18510
- Moses Taylor Hospital
-
Scranton, Pennsylvania, Forente stater, 18510
- Scranton Hematology-Oncology
-
State College, Pennsylvania, Forente stater, 16801
- Geisinger Medical Group
-
West Chester, Pennsylvania, Forente stater, 19380
- Chester County Hospital
-
Wilkes-Barre, Pennsylvania, Forente stater, 18711
- Geisinger Wyoming Valley Medical Center
-
-
Rhode Island
-
Providence, Rhode Island, Forente stater, 02903
- Rhode Island Hospital
-
-
South Carolina
-
Greenville, South Carolina, Forente stater, 29615
- CCOP - Greenville
-
Spartanburg, South Carolina, Forente stater, 29303
- CCOP - Upstate Carolina
-
-
South Dakota
-
Rapid City, South Dakota, Forente stater, 57709
- Rapid City Regional Hospital
-
Sioux Falls, South Dakota, Forente stater, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Forente stater, 57117
- Sioux Valley Hospital
-
Sioux Falls, South Dakota, Forente stater, 57104
- Sioux Valley Clinic
-
Sioux Falls, South Dakota, Forente stater, 57105-1080
- Avera McKennan Hospital and University Health Center
-
-
Tennessee
-
Memphis, Tennessee, Forente stater, 38103
- University of Tennessee, Memphis Cancer Center
-
Memphis, Tennessee, Forente stater, 38104
- Veterans Affairs Medical Center - Memphis
-
-
Texas
-
Fort Sam Houston, Texas, Forente stater, 78234
- Brooke Army Medical Center
-
Galveston, Texas, Forente stater, 77555-0209
- University of Texas Medical Branch
-
San Antonio, Texas, Forente stater, 78284-7811
- University of Texas Health Science Center at San Antonio
-
San Antonio, Texas, Forente stater, 78284
- Veterans Affairs Medical Center - San Antonio (Murphy)
-
Temple, Texas, Forente stater, 76504
- Veterans Affairs Medical Center - Temple
-
Temple, Texas, Forente stater, 76508
- CCOP - Scott and White Hospital
-
-
Utah
-
Salt Lake City, Utah, Forente stater, 84148
- Veterans Affairs Medical Center - Salt Lake City
-
Salt Lake City, Utah, Forente stater, 84112
- Huntsman Cancer Institute
-
-
Vermont
-
Burlington, Vermont, Forente stater, 05401-3498
- Vermont Cancer Center
-
White River Junction, Vermont, Forente stater, 05009
- Veterans Affairs Medical Center - White River Junction
-
-
Virginia
-
Richmond, Virginia, Forente stater, 23298-0037
- MBCCOP - Massey Cancer Center
-
Richmond, Virginia, Forente stater, 23249
- Veterans Affairs Medical Center - Richmond
-
-
Washington
-
Seattle, Washington, Forente stater, 98101
- CCOP - Virginia Mason Research Center
-
Seattle, Washington, Forente stater, 98104
- Swedish Cancer Institute
-
Seattle, Washington, Forente stater, 98108
- Veterans Affairs Medical Center - Seattle
-
Tacoma, Washington, Forente stater, 98431-5000
- Madigan Army Medical Center
-
Tacoma, Washington, Forente stater, 98405-0986
- CCOP - Northwest
-
-
Wisconsin
-
Appleton, Wisconsin, Forente stater, 54911
- Fox Valley Hematology and Oncology
-
Ashland, Wisconsin, Forente stater, 54806
- Memorial Medical Center
-
Eau Claire, Wisconsin, Forente stater, 54703
- Luther Hospital
-
Eau Claire, Wisconsin, Forente stater, 54703
- Midelfort Clinic
-
Green Bay, Wisconsin, Forente stater, 54307-3508
- St. Vincent Hospital
-
La Crosse, Wisconsin, Forente stater, 54601
- Gundersen Lutheran Medical Center
-
La Crosse, Wisconsin, Forente stater, 54601-4796
- Franciscan Skemp Healthcare
-
Madison, Wisconsin, Forente stater, 53792-6164
- University of Wisconsin Comprehensive Cancer Center
-
Madison, Wisconsin, Forente stater, 53705
- Veterans Affairs Medical Center - Madison
-
Madison, Wisconsin, Forente stater, 53715
- Meriter Hospital
-
Madison, Wisconsin, Forente stater, 53715
- Dean Medical Center
-
Marshfield, Wisconsin, Forente stater, 54449
- CCOP - Marshfield Medical Research and Education Foundation
-
Milwaukee, Wisconsin, Forente stater, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Forente stater, 53295
- Veterans Affairs Medical Center - Milwaukee (Zablocki)
-
Milwaukee, Wisconsin, Forente stater, 53201-0342
- Aurora Sinai Samaritan Medical Center
-
Oconomowoc, Wisconsin, Forente stater, 53066
- Oconomowoc Memorial Hospital
-
Waukesha, Wisconsin, Forente stater, 53188
- Waukesha Memorial Hospital
-
Wausau, Wisconsin, Forente stater, 54401
- UW Cancer Center Wausau Hospital
-
-
-
-
-
Hato Rey, Puerto Rico, 00919-1811
- Centro Mamografia Hospital Oncologico
-
San Juan, Puerto Rico, 00936-7344
- San Juan City Hospital
-
San Juan, Puerto Rico, 00927-5800
- Veterans Affairs Medical Center - San Juan
-
-
-
-
-
Johannesburg, Sør-Afrika, 2193
- Medical Oncology Centre of Rosebank
-
Pretoria, Sør-Afrika, 0001
- Pretoria Academic Hospitals
-
-
Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
18 år og eldre (Voksen, Eldre voksen)
Tar imot friske frivillige
Nei
Kjønn som er kvalifisert for studier
Alle
Beskrivelse
SYKDOMENS KARAKTERISTIKA:
Histologisk eller cytologisk bekreftet lokalt avansert, lokalt tilbakevendende eller metastatisk kolorektalt adenokarsinom som ikke kan kureres ved kirurgi eller strålebehandling
Histologiske eller cytologiske krav fravikes hos pasienter som utviklet radiologiske eller kliniske tegn på metastatisk kreft etter en tidligere kirurgisk reseksjon med mindre:
- Mer enn 5 år har gått siden primæroperasjonen ELLER
- Primær kreft var stadium I eller II
- Stedet for primær lesjon må være eller ha blitt bekreftet endoskopisk, radiologisk eller kirurgisk å være eller ha vært i tykktarmen
- Målbar eller evaluerbar sykdom
- Ingen CNS-metastaser eller karsinomatøs meningitt
PASIENT KARAKTERISTIKA:
Alder:
- 18 og over
Ytelsesstatus:
- ECOG 0-2
Forventet levealder:
- Minst 12 uker
Hematopoetisk:
- Absolutt granulocyttantall minst 1500/mm^3
- Blodplateantall minst 100 000/mm^3
- Hemoglobin minst 9,0 g/dL (transfusjon tillatt)
Hepatisk:
- Bilirubin ikke høyere enn 1,5 mg/dL
- AST ikke større enn 5 ganger øvre normalgrense (ULN)
- Alkalisk fosfatase ikke høyere enn 5 ganger ULN
Nyre:
- Kreatinin ikke høyere enn 1,5 ganger ULN
Kardiovaskulær:
- Ingen ukontrollert hypertensjon
- Ingen ustabil angina
- Ingen symptomatisk kongestiv hjertesvikt
- Ingen hjerteinfarkt de siste 6 månedene
- Ingen alvorlig ukontrollert arytmi
- Ingen New York Heart Association klasse III eller IV hjertesykdom
Lunge:
- Ingen interstitiell lungebetennelse eller omfattende og symptomatisk interstitiell fibrose i lungen
- Ingen pleural effusjon eller ascites som forårsaker respiratorisk kompromittering (grad 2 eller verre dyspné)
Annen:
- Ikke gravid eller ammende
- Negativ graviditetstest
- Fertile pasienter må bruke effektiv prevensjon
- Ingen aktiv eller ukontrollert infeksjon
- Ingen symptomatisk sensorisk perifer nevropati
- Ingen kjent allergi mot platinaforbindelser
- Ingen historie med gastrointestinal blødning med mindre det er bestemt å være akseptabelt av den innmeldte legen
- Ingen annen tidligere eller samtidig malignitet i løpet av de siste 3 årene bortsett fra ikke-melanom hudkreft, karsinom in situ i livmorhalsen eller annen resekert ondartet svulst med mindre enn 10 % sannsynlighet for tilbakefall av tumor innen 3 år etter diagnosen
- Ingen medisinske eller psykiatriske tilstander som utelukker studier
- Ingen tykktarms- eller tynntarmsykdommer med ukontrollerte symptomer på mer enn 3 løs avføring per dag
- Kolostomi eller ileostomi tillatt etter etterforskerens skjønn
FØR SAMTIDIG TERAPI:
Biologisk terapi:
- Tidligere adjuvant immunterapi for reseksjonert stadium II-IV sykdom tillatt dersom adjuvant behandling avsluttet minst 1 år før dokumentasjon av tilbakevendende sykdom
- Ingen samtidig sargramostim (GM-CSF)
Kjemoterapi:
- Ingen tidligere kjemoterapi for avansert tykktarmskreft
- Ingen tidligere standard adjuvant kjemoterapi for endetarmskreft
- Tidligere adjuvant fluorouracil for reseksjonert stadium II-IV sykdom tillatt dersom adjuvant behandling avsluttet minst 1 år før dokumentasjon av tilbakevendende sykdom
Strålebehandling:
- Se Sykdomskarakteristikker
- Minst 4 uker siden tidligere større strålebehandling (f.eks. palliativ strålebehandling med bryst eller ben)
- Ingen tidligere strålebehandling til mer enn 15 % av benmargen
- Ingen tidligere standard adjuvant strålebehandling for endetarmskreft
Kirurgi:
- Se Sykdomskarakteristikker
- Minst 4 uker siden forrige større operasjon (f.eks. laparotomi) (2 uker for mindre operasjon) og ble frisk
- Innsetting av en vaskulær tilgangsenhet som ikke anses som større eller mindre operasjon
Annen:
- Ingen andre samtidige etterforskningsmidler
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Behandling
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Ingen (Open Label)
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
|
Eksperimentell: irinotekan + leukovorin + fluoruracil
Pasienter får irinotekan IV over 90 minutter etterfulgt av leucovorin kalsium IV over 15 minutter og fluorouracil IV en gang i uken i 4 uker etterfulgt av 2 ukers hvile. Kursene gjentas hver 6. uke. Behandlingen fortsetter i fravær av sykdomsprogresjon eller uakseptabel toksisitet. Livskvalitet vurderes før behandling, under behandling (armspesifikk), og etter avsluttet behandling. Pasientene følges hver 3. måned i 1 år, hver 6. måned i 2 år, og deretter årlig. |
|
|
Eksperimentell: oksaliplatin + leukovorin + fluoruracil
Pasienter får oxaliplatin IV over 2 timer på dag 1 og leucovorin calcium IV over 2 timer pluss fluorouracil IV over 22 timer på dag 1 og 2. Kursene gjentas hver 2. uke. Behandlingen fortsetter i fravær av sykdomsprogresjon eller uakseptabel toksisitet. Livskvalitet vurderes før behandling, under behandling (armspesifikk), og etter avsluttet behandling. Pasientene følges hver 3. måned i 1 år, hver 6. måned i 2 år, og deretter årlig. |
|
|
Eksperimentell: oksaliplatin + irinotekan
Pasienter får oksaliplatin IV over 2 timer og irinotecan IV over 30 minutter på dag 1. Kursene gjentas hver 3. uke. Behandlingen fortsetter i fravær av sykdomsprogresjon eller uakseptabel toksisitet. Livskvalitet vurderes før behandling, under behandling (armspesifikk), og etter avsluttet behandling. Pasientene følges hver 3. måned i 1 år, hver 6. måned i 2 år, og deretter årlig. |
Hva måler studien?
Primære resultatmål
Resultatmål |
Tidsramme |
|---|---|
|
tid til progresjon
Tidsramme: Inntil 5 år
|
Inntil 5 år
|
Sekundære resultatmål
Resultatmål |
Tidsramme |
|---|---|
|
svarprosent
Tidsramme: Inntil 5 år
|
Inntil 5 år
|
|
total overlevelse
Tidsramme: Inntil 5 år
|
Inntil 5 år
|
|
livskvalitet
Tidsramme: Inntil 5 år
|
Inntil 5 år
|
|
tid til behandlingssvikt
Tidsramme: Inntil 5 år
|
Inntil 5 år
|
Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Etterforskere
- Studiestol: Henry C. Pitot, MD, Mayo Clinic
Publikasjoner og nyttige lenker
Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.
Generelle publikasjoner
- Franko J, Shi Q, Goldman CD, Pockaj BA, Nelson GD, Goldberg RM, Pitot HC, Grothey A, Alberts SR, Sargent DJ. Treatment of colorectal peritoneal carcinomatosis with systemic chemotherapy: a pooled analysis of north central cancer treatment group phase III trials N9741 and N9841. J Clin Oncol. 2012 Jan 20;30(3):263-7. doi: 10.1200/JCO.2011.37.1039. Epub 2011 Dec 12.
- An MW, Mandrekar SJ, Branda ME, Hillman SL, Adjei AA, Pitot HC, Goldberg RM, Sargent DJ. Comparison of continuous versus categorical tumor measurement-based metrics to predict overall survival in cancer treatment trials. Clin Cancer Res. 2011 Oct 15;17(20):6592-9. doi: 10.1158/1078-0432.CCR-11-0822. Epub 2011 Aug 31.
- Campbell ME, Mandrekar SJ, Hillman SL, et al.: What is the added value of actual tumor measurements (TM) in predicting overall survival (OS)? The North Central Cancer Treatment Group (NCCTG) findings. [Abstract] J Clin Oncol 26 (Suppl 15): A-6520, 2008.
- Grothey A, Hedrick EE, Mass RD, Sarkar S, Suzuki S, Ramanathan RK, Hurwitz HI, Goldberg RM, Sargent DJ. Response-independent survival benefit in metastatic colorectal cancer: a comparative analysis of N9741 and AVF2107. J Clin Oncol. 2008 Jan 10;26(2):183-9. doi: 10.1200/JCO.2007.13.8099.
- Grothey A, Hedrick EE, Mass RD, et al.: Response rate using conventional criteria is a poor surrogate for clinical benefit on progression-free (PFS) and overall survival (OS) in metastatic colorectal cancer (mCRC): a comparative analysis of N9741 and AVF2107. [Abstract] J Clin Oncol 24 (Suppl 18): A-3516, 2006.
- Goldberg R. Oxaliplatin in colorectal cancer: current studies. Oncology (Williston Park). 2000 Dec;14(12 Suppl 11):42-7.
- Heun JM, Grothey A, Branda ME, Goldberg RM, Sargent DJ. Tumor status at 12 weeks predicts survival in advanced colorectal cancer: findings from NCCTG N9741. Oncologist. 2011;16(6):859-67. doi: 10.1634/theoncologist.2011-0064. Epub 2011 May 31.
- Ng K, Sargent DJ, Goldberg RM, Meyerhardt JA, Green EM, Pitot HC, Hollis BW, Pollak MN, Fuchs CS. Vitamin D status in patients with stage IV colorectal cancer: findings from Intergroup trial N9741. J Clin Oncol. 2011 Apr 20;29(12):1599-606. doi: 10.1200/JCO.2010.31.7255. Epub 2011 Mar 21.
- Goldberg RM, Sargent DJ, McLeod H. Leveraging learning from a phase III colorectal cancer clinical trial: outcomes, methodology, meta-analysis and pharmacogenetics. Trans Am Clin Climatol Assoc. 2010;121:21-32; discussion 32-3.
- McLeod HL, Sargent DJ, Marsh S, Green EM, King CR, Fuchs CS, Ramanathan RK, Williamson SK, Findlay BP, Thibodeau SN, Grothey A, Morton RF, Goldberg RM. Pharmacogenetic predictors of adverse events and response to chemotherapy in metastatic colorectal cancer: results from North American Gastrointestinal Intergroup Trial N9741. J Clin Oncol. 2010 Jul 10;28(20):3227-33. doi: 10.1200/JCO.2009.21.7943. Epub 2010 Jun 7.
- Goldberg RM, Sargent DJ, Morton RF, Green E, Sanoff HK, McLeod H, Buckner J. NCCTG Study N9741: leveraging learning from an NCI Cooperative Group phase III trial. Oncologist. 2009 Oct;14(10):970-8. doi: 10.1634/theoncologist.2009-0175. Epub 2009 Oct 14.
- Sanoff HK, Sargent DJ, Green EM, McLeod HL, Goldberg RM. Racial differences in advanced colorectal cancer outcomes and pharmacogenetics: a subgroup analysis of a large randomized clinical trial. J Clin Oncol. 2009 Sep 1;27(25):4109-15. doi: 10.1200/JCO.2009.21.9527. Epub 2009 Jul 27.
- Fuchs CS, Goldberg RM, Sargent DJ, Meyerhardt JA, Wolpin BM, Green EM, Pitot HC, Pollak M. Plasma insulin-like growth factors, insulin-like binding protein-3, and outcome in metastatic colorectal cancer: results from intergroup trial N9741. Clin Cancer Res. 2008 Dec 15;14(24):8263-9. doi: 10.1158/1078-0432.CCR-08-0480. Epub 2008 Dec 10.
- Sanoff HK, Sargent DJ, Campbell ME, Morton RF, Fuchs CS, Ramanathan RK, Williamson SK, Findlay BP, Pitot HC, Goldberg RM. Five-year data and prognostic factor analysis of oxaliplatin and irinotecan combinations for advanced colorectal cancer: N9741. J Clin Oncol. 2008 Dec 10;26(35):5721-7. doi: 10.1200/JCO.2008.17.7147. Epub 2008 Nov 10.
- Sargent DJ, Campbell M, Grothey A, et al.: Overall and 12 week tumor response versus actual tumor measurements as predictors of overall survival (OS) in advanced colorectal cancer (ACRC): findings from NCCTG N9741. [Abstract] American Society of Clinical Oncology 2008 Gastrointestinal Cancers Symposium, 25-27 January 2008, Orlando, FL. A-446, 2008.
- Dy GK, Krook JE, Green EM, Sargent DJ, Delaunoit T, Morton RF, Fuchs CS, Ramanathan RK, Williamson SK, Findlay BP, Pockaj BA, Sticca RP, Alberts SR, Pitot HC 4th, Goldberg RM; Intergroup N9741. Impact of complete response to chemotherapy on overall survival in advanced colorectal cancer: results from Intergroup N9741. J Clin Oncol. 2007 Aug 10;25(23):3469-74. doi: 10.1200/JCO.2007.10.7128. Erratum In: J Clin Oncol. 2007 Nov 20;25(33):5339.
- Grothey A, Sargent DJ, Campbell ME, et al.: Waterfall plots provide detailed information on magnitude of response to conventional chemotherapy in colorectal cancer: lessons learned from N9741. [Abstract] American Society of Clinical Oncology 2007 Gastrointestinal Cancers Symposium, 19 -21 January 2007, Orlando, Florida A-337, 2007.
- Goldberg RM, McLeod HL, Sargent DJ, et al.: Genetic polymorphisms, toxicity, and response rate in African Americans (AA) with metastatic colorectal cancer (MCRC) compared to Caucasians (C) when treated with IFL, FOLFOX or IROX in Intergroup N9741. [Abstract] J Clin Oncol 24 (Suppl 18): A-3503, 2006.
- Goldberg RM, Sargent DJ, Morton RF, Fuchs CS, Ramanathan RK, Williamson SK, Findlay BP, Pitot HC, Alberts S. Randomized controlled trial of reduced-dose bolus fluorouracil plus leucovorin and irinotecan or infused fluorouracil plus leucovorin and oxaliplatin in patients with previously untreated metastatic colorectal cancer: a North American Intergroup Trial. J Clin Oncol. 2006 Jul 20;24(21):3347-53. doi: 10.1200/JCO.2006.06.1317.
- McLeod HL, Parodi L, Sargent DJ, et al.: UGT1A1*28, toxicity and outcome in advanced colorectal cancer: results from trial N9741. [Abstract] J Clin Oncol 24 (Suppl 18): A-3520, 2006.
- Delaunoit T, Alberts SR, Sargent DJ, Green E, Goldberg RM, Krook J, Fuchs C, Ramanathan RK, Williamson SK, Morton RF, Findlay BP. Chemotherapy permits resection of metastatic colorectal cancer: experience from Intergroup N9741. Ann Oncol. 2005 Mar;16(3):425-9. doi: 10.1093/annonc/mdi092. Epub 2005 Jan 27.
- Delaunoit T, Goldberg RM, Sargent DJ, Morton RF, Fuchs CS, Findlay BP, Thomas SP, Salim M, Schaefer PL, Stella PJ, Green E, Mailliard JA. Mortality associated with daily bolus 5-fluorouracil/leucovorin administered in combination with either irinotecan or oxaliplatin: results from Intergroup Trial N9741. Cancer. 2004 Nov 15;101(10):2170-6. doi: 10.1002/cncr.20594.
- Goldberg RM, Sargent DJ, Morton RF, Fuchs CS, Ramanathan RK, Williamson SK, Findlay BP, Pitot HC, Alberts SR. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol. 2004 Jan 1;22(1):23-30. doi: 10.1200/JCO.2004.09.046. Epub 2003 Dec 9.
- Goldberg RM, Morton RF, Sargent DJ, et al.: N9741: oxaliplatin (Oxal) or CPT-11 + 5-fluorouracil (5FU)/leucovorin (LV) or oxal + CPT-11 in advanced colorectal cancer (CRC). Updated efficacy and quality of life (QOL) data from an intergroup study. [Abstract] Proceedings of the American Society of Clinical Oncology 22: A-1009, 252, 2003.
- Goldberg RM, Morton RF, Sargent D, et al.: N9741: oxaliplatin (oxal) or CPT-11 + 5-fluorouracil (5FU)/leucovorin (LV) or oxal + CPT-11 in advanced colorectal cancer (CRC). Initial toxicity and response data from a GI Intergroup study. [Abstract] Proceedings of the American Society of Clinical Oncology 21: A-511, 2002.
- Morton RF, Goldberg RM, Sargent DJ, et al.: Oxaliplatin (OXAL) or CPT-11 Combined with 5FU/Leucovorin (LV) in Advanced Colorectal Cancer (CRC): an NCCTG/CALGB Study. [Abstract] Proceedings of the American Society of Clinical Oncology 20: A-495, 2001.
- Yuan C, Renfro L, Ambadwar PB, Ou FS, McLeod HL, Innocenti F, Meyerhardt JA, Wolpin BM, Goldberg RM, Grothey A, Fuchs CS, Ng K. Influence of genetic variation in the vitamin D pathway on plasma 25-hydroxyvitamin D3 levels and survival among patients with metastatic colorectal cancer. Cancer Causes Control. 2019 Jul;30(7):757-765. doi: 10.1007/s10552-019-01183-1. Epub 2019 May 18.
Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart
1. oktober 1998
Primær fullføring (Faktiske)
1. oktober 2004
Studiet fullført (Faktiske)
1. oktober 2004
Datoer for studieregistrering
Først innsendt
1. november 1999
Først innsendt som oppfylte QC-kriteriene
24. september 2003
Først lagt ut (Anslag)
25. september 2003
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
29. april 2020
Siste oppdatering sendt inn som oppfylte QC-kriteriene
28. april 2020
Sist bekreftet
1. april 2020
Mer informasjon
Begreper knyttet til denne studien
Nøkkelord
Ytterligere relevante MeSH-vilkår
- Sykdommer i fordøyelsessystemet
- Neoplasmer
- Neoplasmer etter nettsted
- Gastrointestinale neoplasmer
- Neoplasmer i fordøyelsessystemet
- Gastrointestinale sykdommer
- Kolonsykdommer
- Tarmsykdommer
- Intestinale neoplasmer
- Rektale sykdommer
- Kolorektale neoplasmer
- Fysiologiske effekter av legemidler
- Molekylære mekanismer for farmakologisk virkning
- Enzymhemmere
- Antimetabolitter, antineoplastisk
- Antimetabolitter
- Antineoplastiske midler
- Immunsuppressive midler
- Immunologiske faktorer
- Beskyttende agenter
- Topoisomerasehemmere
- Mikronæringsstoffer
- Vitaminer
- Kalsiumregulerende hormoner og midler
- Topoisomerase I-hemmere
- Motgift
- Vitamin B kompleks
- Fluorouracil
- Oksaliplatin
- Leucovorin
- Irinotekan
- Kalsium
- Levoleucovorin
Andre studie-ID-numre
- NCCTG-N9741
- CDR0000066665 (Registeridentifikator: PDQ (Physician Data Query))
- CAN-NCIC-CO13
Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .