- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT00005988
Bone Marrow Transplantation With Specially Treated Bone Marrow in Treating Patients With Hematologic Cancer That Have Not Responded to Previous Therapy
A Phase I Open-Label, Safety Study of Haploidentical Bone Marrow Transplantation (BMT) After Ex Vivo Treatment of Bone Marrow With Anti-B7.1 and Anti-B7.2 Antibodies
RATIONALE: Bone marrow transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy used to kill tumor cells. Sometimes the transplanted cells can make an immune response against the body's normal tissues. Treatment of the donor bone marrow with the patient's white blood cells and a monoclonal antibody may prevent this from happening.
PURPOSE: Phase I trial to study the effectiveness of bone marrow transplantation with specially treated bone marrow in treating patients who have hematologic cancer that has not responded to previous therapy.
Studieoversigt
Status
Detaljeret beskrivelse
OBJECTIVES: I. Determine if patients with refractory, high risk hematologic malignancies or bone marrow failure who receive HLA haploidentical bone marrow treated with anti-B7 antibody have normal engraftment. II. Determine if these patients are free of hyperacute graft versus host disease (GVHD), defined as grade D GVHD in the first 10 posttransplant days, when treated with this regimen. III. Determine if these patients have an acceptable incidence of life threatening grade D GHVD in the first 50 posttransplant days following this treatment regimen. IV. Determine the safety and tolerability of this treatment regimen in this patient population.
OUTLINE: This is a multicenter study. Patients undergo leukapheresis to collect white blood cells which are incubated with donor bone marrow cells in the presence of anti-B7.1 and anti-B7.2 antibodies for 36 hours. Patients receive total body irradiation twice daily on days -6 to -3, cyclophosphamide IV daily on days -2 and -1, and methylprednisolone IV every 12 hours for a total of 4 doses on days -2 to 0. Patients are infused with the treated donor bone marrow on day 0. Patients then receive methotrexate IV on days 1, 3, 6, and 11 and leucovorin calcium IV 24 hours after each dose of methotrexate every 6 hours for 3-8 doses each time. Patients also receive cyclosporine IV or orally twice daily on days -2 to 100. Patients are followed every 2 months for 1 year.
PROJECTED ACCRUAL: A total of 20 patients will be accrued for this study.
Undersøgelsestype
Tilmelding (Faktiske)
Fase
- Fase 1
Kontakter og lokationer
Studiesteder
-
-
Massachusetts
-
Boston, Massachusetts, Forenede Stater, 02115
- Dana-Farber Cancer Institute
-
-
Minnesota
-
Minneapolis, Minnesota, Forenede Stater, 55455
- University of Minnesota Cancer Center
-
-
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Beskrivelse
Inclusion Criteria:
- Age ≤40 years.
Diagnoses-patients with the following hematologic malignancies and bone marrow failure syndromes:
- Acute myelogenous leukemia-induction failure, relapse, second or greater complete remission (CR)
- Acute lymphocytic leukemia-induction failure, relapse, second or greater CR, first CR with t(9;22), t(8;14), or t(4;11)
- Non-Hodgkin's lymphoma (intermediate or high grade) which has failed to achieve CR with at least two induction regimens, relapse, second or greater CR
- Multiple myeloma with poor prognostic features (elevated 0-2 microglobulin or high labeling index)
- Hodgkin's disease in relapse or which fails to achieve CR after two chemotherapy regimens
- Congenital or acquired bone marrow failure - poorly responsive to or intolerant of current therapy
- Myelodysplastic syndrome of all subtypes except refractory anemia (RA)
- Patient has a haploidentical family member that meets medical criteria for donation.
Eligibility for other transplant types:
- Patient considered likely to have clinical deterioration and rapid disease progression during an unrelated donor search, or
- Patient who has already had an unproductive donor search or
- Patient ineligible for or has refused autologous transplant
Adequate renal and hepatic function for age:
- Serum creatinine <2 x ULN
- Alanine aminotransferase (ALT, SGPT) x ULN
- Aspartate aminotransferase (AST, SGOT) x ULN
- Total bilirubin 5_2 x ULN except if bilirubin is elevated due to Gilbert's syndrome or hemolytic anemia
- Adequate cardiac and pulmonary function for age.
- ECOG Performance Status 0, 1, or 2 or Lansky performance scale >50% for patients <16 years of age.
- Voluntary witnessed written informed consent. Children will be asked for assent where appropriate.
- The patient, if female, must be post-menopausal, premenarcheal, or sterile, or if the patient is of childbearing potential, she must be practicing a method of birth control considered effective and medically acceptable by the investigator for a minimum of 1 month prior to study entry and at least 2 months after the study end.
- Patient must have undergone successful leukapheresis to obtain adequate antigen presenting cells.
- Any patient who enters the study in a relapse state, with evidence of end organ (pulmonary, renal, or hepatic) toxicity, or with recent recovery from infection, who may potentially have little benefit from this protocol, must have his/her eligibility status discussed with the Principal Investigator.
- Patient must have life expectancy of at least 12 weeks.
Exclusion Criteria
Eligibility for other transplant types:
- Patient has family donor who is matched or single antigen mismatched at HLA-A, HLA-B, HLA-DR, and HLA-DQ. Donorrecipient matching must be evaluated via both phenotype and genotype.
- Patient has available unrelated donor who is matched at HLA-A, HLA-B, and HLA-DR. Donor-recipient matching must be evaluated via both phenotype and genotype.
- Active uncontrolled infection (continued positive blood or soft tissue cultures despite appropriate antibiotic treatment)
- Positive 13-HCG in a female of childbearing potential
- Evidence of HIV infection or known HIV positive serology
- Any prior bone marrow transplant
- A peripheral blood differential count at the time of leukapheresis with greater than 25% blasts. This exclusion criterion is valid only for the first four patients enrolled.
- Patients with Fanconi's anemia
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: N/A
- Interventionel model: Enkelt gruppeopgave
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Eksperimentel: in vitro-treated bone marrow transplantation
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Tidsramme |
|---|---|
|
Incidence of primary graft failure
Tidsramme: up to 30 days post-transplant
|
up to 30 days post-transplant
|
Sekundære resultatmål
Resultatmål |
Tidsramme |
|---|---|
|
Incidence of hyperacute GVHD
Tidsramme: up to 100 days post-transplant
|
up to 100 days post-transplant
|
|
Incidence of Grade D acute GVHD
Tidsramme: up to 50 days post-transplant
|
up to 50 days post-transplant
|
|
Incidence of adverse events
Tidsramme: up to 100 days post-transplant
|
up to 100 days post-transplant
|
Samarbejdspartnere og efterforskere
Sponsor
Samarbejdspartnere
Efterforskere
- Studiestol: Eva Guinan, MD, Dana-Farber Cancer Institute
Publikationer og nyttige links
Datoer for undersøgelser
Studer store datoer
Studiestart (Faktiske)
Primær færdiggørelse (Faktiske)
Studieafslutning (Faktiske)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Skøn)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
- stadium III voksent diffust storcellet lymfom
- stadium III voksen immunoblastisk storcellet lymfom
- stadium III voksen Burkitt lymfom
- stadium IV grad 3 follikulært lymfom
- stadium IV voksent diffust storcellet lymfom
- stadium IV voksen immunoblastisk storcellet lymfom
- stadium IV voksen Burkitt lymfom
- tilbagevendende grad 3 follikulært lymfom
- tilbagevendende voksent diffust storcellet lymfom
- tilbagevendende voksen immunoblastisk storcellet lymfom
- recidiverende voksen Burkitt lymfom
- stadium III barndoms små ikke-spaltede celle lymfom
- stadium IV barndom små non-cleaved cell lymfom
- stadium IV storcellet lymfom i barndommen
- tilbagevendende små ikke-spaltede celle lymfomer i barndommen
- tilbagevendende storcellet lymfom i barndommen
- kronisk myelomonocytisk leukæmi
- de novo myelodysplastiske syndromer
- tidligere behandlede myelodysplastiske syndromer
- sekundære myelodysplastiske syndromer
- akut lymfatisk leukæmi i barndommen i remission
- akut myeloid leukæmi i barndommen i remission
- barndoms myelodysplastiske syndromer
- tilbagevendende akut myeloid leukæmi hos voksne
- akut myeloid leukæmi hos voksne i remission
- recidiverende voksen Hodgkin lymfom
- barndoms immunoblastisk storcellet lymfom
- tilbagevendende/refraktær Hodgkin-lymfom i barndommen
- recidiverende voksent diffust små spaltet celle lymfom
- recidiverende voksent diffust blandet celle lymfom
- stadium III grad 3 follikulært lymfom
- stadium III voksent diffust små spaltet celle lymfom
- stadium III voksent diffust blandet celle lymfom
- stadium IV voksent diffust blandet celle lymfom
- stadium II myelomatose
- stadium III myelomatose
- stadium I voksent diffust små spaltet celle lymfom
- sammenhængende stadium II voksent diffust små spaltet celle lymfom
- ikke-sammenhængende stadium II voksent diffust små spaltet celle lymfom
- stadium I myelomatose
- tilbagevendende lymfoblastisk lymfom hos voksne
- stadium III voksen lymfoblastisk lymfom
- stadium IV voksen lymfoblastisk lymfom
- refraktær myelomatose
- tilbagevendende akut lymfatisk leukæmi hos voksne
- tilbagevendende akut lymfatisk leukæmi hos børn
- stadium I barndom storcellet lymfom
- stadium II storcellet lymfom i barndommen
- stadium III barndoms storcellet lymfom
- stadium I barndoms lymfoblastisk lymfom
- stadium II barndoms lymfoblastisk lymfom
- stadium III barndoms lymfoblastisk lymfom
- stadium IV barndoms lymfoblastisk lymfom
- stadium I barndom små non-cleaved cell lymfom
- stadium II barndom små ikke-spaltede celle lymfom
- ikke-sammenhængende stadium II voksent diffust storcellet lymfom
- ikke-sammenhængende stadium II voksent diffust blandet celle lymfom
- ikke-sammenhængende stadium II voksen lymfoblastisk lymfom
- ikke-sammenhængende stadium II grad 3 follikulært lymfom
- akut lymfatisk leukæmi hos voksne i remission
- tilbagevendende akut myeloid leukæmi i barndommen
- ikke-sammenhængende stadium II voksen Burkitt lymfom
- ikke-sammenhængende stadium II voksent immunoblastisk storcellet lymfom
- tilbagevendende lymfoblastisk lymfom i barndommen
- stadium I voksen Burkitt lymfom
- sammenhængende stadium II voksen Burkitt lymfom
- sammenhængende stadium II voksent immunoblastisk storcellet lymfom
- stadium I voksen immunoblastisk storcellet lymfom
- diffust storcellet lymfom i barndommen
- sammenhængende stadium II grad 3 follikulært lymfom
- stadium I grad 3 follikulært lymfom
- sammenhængende stadium II voksent diffust storcellet lymfom
- sammenhængende stadium II voksent diffust blandet celle lymfom
- stadium I voksent diffust storcellet lymfom
- stadium I voksent diffust blandet celle lymfom
- sammenhængende stadium II voksen lymfoblastisk lymfom
- stadium I voksen lymfoblastisk lymfom
- refraktær cytopeni med multilineage dysplasi
- graft versus host sygdom
Yderligere relevante MeSH-vilkår
- Patologiske processer
- Sygdomme i immunsystemet
- Neoplasmer efter histologisk type
- Neoplasmer
- Lymfoproliferative lidelser
- Lymfesygdomme
- Immunproliferative lidelser
- Sygdom
- Knoglemarvssygdomme
- Hæmatologiske sygdomme
- Forstadier til kræft
- Lymfom
- Syndrom
- Myelodysplastiske syndromer
- Leukæmi
- Præleukæmi
- Graft vs værtssygdom
- Lægemidlers fysiologiske virkninger
- Molekylære mekanismer for farmakologisk virkning
- Anti-infektionsmidler
- Autonome agenter
- Agenter fra det perifere nervesystem
- Nukleinsyresyntesehæmmere
- Enzymhæmmere
- Anti-inflammatoriske midler
- Antirheumatiske midler
- Antimetabolitter, Antineoplastisk
- Antimetabolitter
- Antineoplastiske midler
- Immunsuppressive midler
- Immunologiske faktorer
- Antiemetika
- Gastrointestinale midler
- Glukokortikoider
- Hormoner
- Hormoner, hormonsubstitutter og hormonantagonister
- Neuroprotektive midler
- Beskyttelsesagenter
- Antineoplastiske midler, Alkylering
- Alkyleringsmidler
- Myeloablative agonister
- Dermatologiske midler
- Mikronæringsstoffer
- Vitaminer
- Antifungale midler
- Reproduktive kontrolmidler
- Modgift
- Vitamin B kompleks
- Abortfremkaldende midler, ikke-steroide
- Aborterende midler
- Folinsyreantagonister
- Calcineurin-hæmmere
- Methylprednisolon
- Cyclofosfamid
- Leucovorin
- Levoleucovorin
- Methotrexat
- Cyclosporin
- Cyclosporiner
Andre undersøgelses-id-numre
- 99-205
- P30CA006516 (U.S. NIH-bevilling/kontrakt)
- GENE-C9909-38
- NCI-G00-1801
- CDR0000067977 (Anden identifikator: other)
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
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