Reduktion af plejepersonales stress og søvnforstyrrelser hos patienter med progressiv demens
26. maj 2015 opdateret af: Kathy Kennedy
AgeWise Projekt 2: Reduktion af stress og søvnforstyrrelser hos plejere til patienter med progressiv demens
Mennesker under stress, såsom dem, der tager sig af et sygt familiemedlem, har ofte problemer med deres søvn.
Formålet med denne undersøgelse er at se, om reduktion af stress og ændring af en omsorgspersons søvn- og vågnemønstre vil forbedre hans/hendes søvn.
Efterforskerne vil også se, om forbedringer i søvn resulterer i forbedret humør, sundhed og generel funktion.
Studieoversigt
Status
Afsluttet
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
Det generelle formål med denne undersøgelse er at karakterisere stress-relaterede søvnforstyrrelser hos ægtefælleplejere til patienter med progressiv demens og at teste effektiviteten af en intervention designet til at reducere stress og søvnforstyrrelser. Vi vil sammenligne effektiviteten af en Stress Management Plus Health Sleep Practices (SM+HSP) intervention med en kontroltilstand, der kun er opmærksomhedskrævende, hos ægtefælleplejere til patienter med progressiv demens.
Specifikke mål for denne undersøgelse er:
Mål 1: At karakterisere stress-relaterede søvnforstyrrelser hos ægtefælleplejere til patienter med progressiv demens.
Mål 2: At teste den kortsigtede effektivitet af en Stress Management Plus Healthy Sleep Practices (SM+HSP) intervention versus en opmærksomhedskontrol for at forbedre søvn- og sundhedsresultater hos plejere til patienter med progressiv demens.
Mål 3: At teste holdbarheden af SM+HSP-interventionen blandt ægtefælleplejere til patienter med progressiv demens.
Mål 4: At karakterisere:
- indvirkningen af stress-relaterede søvnforstyrrelser på sundheden hos ældre voksne, og
- søvninterventionernes effekt på sundhed og funktion.
Undersøgelsestype
Observationel
Tilmelding (Faktiske)
60
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
-
-
Pennsylvania
-
Pittsburgh, Pennsylvania, Forenede Stater, 15213
- University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
60 år og ældre (VOKSEN, OLDER_ADULT)
Tager imod sunde frivillige
Ja
Køn, der er berettiget til at studere
Alle
Prøveudtagningsmetode
Ikke-sandsynlighedsprøve
Studiebefolkning
Mænd og kvinder over 60 år, som er primær omsorgsperson for ægtefælle/partner diagnosticeret med progressiv demens.
Beskrivelse
Inklusionskriterier:
- Alder 60 eller ældre
- Ægtefælleplejere til patienter med progressiv demens
- Patienter har en diagnose af mulig eller sandsynlig Alzheimers sygdom eller anden progressiv demens
- Bekræft, at det er en fysisk og følelsesmæssig belastning at tage sig af ægtefællen
- Pittsburgh Sleep Quality Index score på 5 eller derover eller en polysomnografisk bestemt søvneffektivitet på 90 % eller dårligere.
Ekskluderingskriterier:
- Psykotisk lidelse eller stofmisbrugslidelse
- Apnø-hypopnø-indeks på mere end 30
- Score på mindre end 24 på Mini-Mental State Exam
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Polysomnografi før og efter intervention
Tidsramme: 18 måneder
|
indsamling af fysiologiske og psykologiske variabler før og efter BBTI søvnforstyrrelser og stress hos pårørende
|
18 måneder
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Efterforskere
- Ledende efterforsker: Martica Hall, Ph.D., University of Pittsburgh Medical Center
- Studieleder: Lynn Martire, Ph.D., University of Pittsburgh Medical Center
- Studieleder: Greg Seigel, Ph.D., University of Pittsburgh Medical Center
- Studieleder: Richard Schulz, Ph.D., University of Pittsburgh Medical Center
- Studieleder: Charles F. Reynolds, III, M.D., University of Pittsburgh Medical Center
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Generelle publikationer
- Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989 May;28(2):193-213. doi: 10.1016/0165-1781(89)90047-4.
- Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975 Nov;12(3):189-98. doi: 10.1016/0022-3956(75)90026-6. No abstract available.
- Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav. 1983 Dec;24(4):385-96. No abstract available.
- Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992 Jun;30(6):473-83.
- McHorney CA, Ware JE Jr, Raczek AE. The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. Med Care. 1993 Mar;31(3):247-63. doi: 10.1097/00005650-199303000-00006.
- HAMILTON M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960 Feb;23(1):56-62. doi: 10.1136/jnnp.23.1.56. No abstract available.
- Spiegel K, Leproult R, Van Cauter E. Impact of sleep debt on metabolic and endocrine function. Lancet. 1999 Oct 23;354(9188):1435-9. doi: 10.1016/S0140-6736(99)01376-8.
- Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373-83. doi: 10.1016/0021-9681(87)90171-8.
- Pagani M, Lombardi F, Guzzetti S, Rimoldi O, Furlan R, Pizzinelli P, Sandrone G, Malfatto G, Dell'Orto S, Piccaluga E, et al. Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circ Res. 1986 Aug;59(2):178-93. doi: 10.1161/01.res.59.2.178.
- Adler NE, Ostrove JM. Socioeconomic status and health: what we know and what we don't. Ann N Y Acad Sci. 1999;896:3-15. doi: 10.1111/j.1749-6632.1999.tb08101.x.
- Aspinwall LG, Taylor SE. A stitch in time: self-regulation and proactive coping. Psychol Bull. 1997 May;121(3):417-36. doi: 10.1037/0033-2909.121.3.417.
- Baron RM, Kenny DA. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 1986 Dec;51(6):1173-82. doi: 10.1037//0022-3514.51.6.1173.
- Beharka AA, Meydani M, Wu D, Leka LS, Meydani A, Meydani SN. Interleukin-6 production does not increase with age. J Gerontol A Biol Sci Med Sci. 2001 Feb;56(2):B81-8. doi: 10.1093/gerona/56.2.b81.
- Beneke M. Methodological investigations of the Hamilton Anxiety Scale. Pharmacopsychiatry. 1987 Nov;20(6):249-55. doi: 10.1055/s-2007-1017116.
- Bernstein E, Kaye D, Abrutyn E, Gross P, Dorfman M, Murasko DM. Immune response to influenza vaccination in a large healthy elderly population. Vaccine. 1999 Jan;17(1):82-94. doi: 10.1016/s0264-410x(98)00117-0.
- Bixler EO, Vgontzas AN, Lin HM, Ten Have T, Rein J, Vela-Bueno A, Kales A. Prevalence of sleep-disordered breathing in women: effects of gender. Am J Respir Crit Care Med. 2001 Mar;163(3 Pt 1):608-13. doi: 10.1164/ajrccm.163.3.9911064.
- Bixler EO, Vgontzas AN, Ten Have T, Tyson K, Kales A. Effects of age on sleep apnea in men: I. Prevalence and severity. Am J Respir Crit Care Med. 1998 Jan;157(1):144-8. doi: 10.1164/ajrccm.157.1.9706079.
- Brunner DP, Vasko RC, Detka CS, Monahan JP, Reynolds CF 3rd, Kupfer DJ. Muscle artifacts in the sleep EEG: automated detection and effect on all-night EEG power spectra. J Sleep Res. 1996 Sep;5(3):155-64. doi: 10.1046/j.1365-2869.1996.00009.x.
- Burkman RT, Collins JA, Greene RA. Current perspectives on benefits and risks of hormone replacement therapy. Am J Obstet Gynecol. 2001 Aug;185(2 Suppl):S13-23. doi: 10.1067/mob.2001.117414.
- Carrier J, Monk TH, Buysse DJ, Kupfer DJ. Sleep and morningness-eveningness in the 'middle' years of life (20-59 y). J Sleep Res. 1997 Dec;6(4):230-7. doi: 10.1111/j.1365-2869.1997.00230.x.
- Coleman RM, Roffwarg HP, Kennedy SJ, Guilleminault C, Cinque J, Cohn MA, Karacan I, Kupfer DJ, Lemmi H, Miles LE, Orr WC, Phillips ER, Roth T, Sassin JF, Schmidt HS, Weitzman ED, Dement WC. Sleep-wake disorders based on a polysomnographic diagnosis. A national cooperative study. JAMA. 1982 Feb 19;247(7):997-1003. No abstract available.
- Dew MA, Hoch CC, Buysse DJ, Monk TH, Begley AE, Houck PR, Hall M, Kupfer DJ, Reynolds CF 3rd. Healthy older adults' sleep predicts all-cause mortality at 4 to 19 years of follow-up. Psychosom Med. 2003 Jan-Feb;65(1):63-73. doi: 10.1097/01.psy.0000039756.23250.7c. Erratum In: Psychosom Med. 2003 Mar-Apr;65(2):210.
- Dipietro L, Caspersen CJ, Ostfeld AM, Nadel ER. A survey for assessing physical activity among older adults. Med Sci Sports Exerc. 1993 May;25(5):628-42.
- Doman J, Detka C, Hoffman T, Kesicki D, Monahan JP, Buysse DJ, Reynolds CF 3rd, Coble PA, Matzzie J, Kupfer DJ. Automating the sleep laboratory: implementation and validation of digital recording and analysis. Int J Biomed Comput. 1995 Mar;38(3):277-90. doi: 10.1016/s0020-7101(05)80010-8.
- Ershler WB. Interleukin-6: a cytokine for gerontologists. J Am Geriatr Soc. 1993 Feb;41(2):176-81. doi: 10.1111/j.1532-5415.1993.tb02054.x.
- Foley DJ, Monjan AA, Brown SL, Simonsick EM, Wallace RB, Blazer DG. Sleep complaints among elderly persons: an epidemiologic study of three communities. Sleep. 1995 Jul;18(6):425-32. doi: 10.1093/sleep/18.6.425.
- Foster JR. Successful coping, adaptation and resilience in the elderly: an interpretation of epidemiologic data. Psychiatr Q. 1997 Fall;68(3):189-219. doi: 10.1023/a:1025432106406.
- Friesen GM, Jannett TC, Jadallah MA, Yates SL, Quint SR, Nagle HT. A comparison of the noise sensitivity of nine QRS detection algorithms. IEEE Trans Biomed Eng. 1990 Jan;37(1):85-98. doi: 10.1109/10.43620.
- Gardner EM, Bernstein ED, Dorfman M, Abrutyn E, Murasko DM. The age-associated decline in immune function of healthy individuals is not related to changes in plasma concentrations of beta-carotene, retinol, alpha-tocopherol or zinc. Mech Ageing Dev. 1997 Mar;94(1-3):55-69. doi: 10.1016/s0047-6374(96)01838-6.
- Gibbon M, McDonald-Scott P, Endicott J. Mastering the art of research interviewing. A model training procedure for diagnostic evaluation. Arch Gen Psychiatry. 1981 Nov;38(11):1259-62. doi: 10.1001/archpsyc.1981.01780360075007.
- Gibson EL, Checkley S, Papadopoulos A, Poon L, Daley S, Wardle J. Increased salivary cortisol reliably induced by a protein-rich midday meal. Psychosom Med. 1999 Mar-Apr;61(2):214-24. doi: 10.1097/00006842-199903000-00014.
- Glaser R, Kiecolt-Glaser JK, Bonneau RH, Malarkey W, Kennedy S, Hughes J. Stress-induced modulation of the immune response to recombinant hepatitis B vaccine. Psychosom Med. 1992 Jan-Feb;54(1):22-9. doi: 10.1097/00006842-199201000-00005.
- Gurland BJ, Wilder DE. The CARE interview revisited: development of an efficient, systematic clinical assessment. J Gerontol. 1984 Mar;39(2):129-37. doi: 10.1093/geronj/39.2.129.
- HAMILTON M. The assessment of anxiety states by rating. Br J Med Psychol. 1959;32(1):50-5. doi: 10.1111/j.2044-8341.1959.tb00467.x. No abstract available.
- Horne JA, Ostberg O. A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. Int J Chronobiol. 1976;4(2):97-110.
- Janssens JP, Pautex S, Hilleret H, Michel JP. Sleep disordered breathing in the elderly. Aging (Milano). 2000 Dec;12(6):417-29. doi: 10.1007/BF03339872.
- Jenkins CD, Kreger BE, Rose RM, Hurst M. Use of a monthly health review to ascertain illness and injuries. Am J Public Health. 1980 Jan;70(1):82-4. doi: 10.2105/ajph.70.1.82.
- Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991 Dec;14(6):540-5. doi: 10.1093/sleep/14.6.540.
- Johns MW. Reliability and factor analysis of the Epworth Sleepiness Scale. Sleep. 1992 Aug;15(4):376-81. doi: 10.1093/sleep/15.4.376.
- Johns MW. Daytime sleepiness, snoring, and obstructive sleep apnea. The Epworth Sleepiness Scale. Chest. 1993 Jan;103(1):30-6. doi: 10.1378/chest.103.1.30.
- Kania DM, Binkley N, Checovich M, Havighurst T, Schilling M, Ershler WB. Elevated plasma levels of interleukin-6 in postmenopausal women do not correlate with bone density. J Am Geriatr Soc. 1995 Mar;43(3):236-9. doi: 10.1111/j.1532-5415.1995.tb07328.x.
- Katz DA, McHorney CA. Clinical correlates of insomnia in patients with chronic illness. Arch Intern Med. 1998 May 25;158(10):1099-107. doi: 10.1001/archinte.158.10.1099.
- Katz JN, Chang LC, Sangha O, Fossel AH, Bates DW. Can comorbidity be measured by questionnaire rather than medical record review? Med Care. 1996 Jan;34(1):73-84. doi: 10.1097/00005650-199601000-00006.
- Kawachi I, Berkman LF. Social ties and mental health. J Urban Health. 2001 Sep;78(3):458-67. doi: 10.1093/jurban/78.3.458.
- Kiecolt-Glaser JK, Dura JR, Speicher CE, Trask OJ, Glaser R. Spousal caregivers of dementia victims: longitudinal changes in immunity and health. Psychosom Med. 1991 Jul-Aug;53(4):345-62. doi: 10.1097/00006842-199107000-00001.
- Kiecolt-Glaser JK, Marucha PT, Malarkey WB, Mercado AM, Glaser R. Slowing of wound healing by psychological stress. Lancet. 1995 Nov 4;346(8984):1194-6. doi: 10.1016/s0140-6736(95)92899-5.
- Kirschbaum C, Hellhammer DH. Salivary cortisol in psychoneuroendocrine research: recent developments and applications. Psychoneuroendocrinology. 1994;19(4):313-33. doi: 10.1016/0306-4530(94)90013-2.
- Kirschbaum C, Kudielka BM, Gaab J, Schommer NC, Hellhammer DH. Impact of gender, menstrual cycle phase, and oral contraceptives on the activity of the hypothalamus-pituitary-adrenal axis. Psychosom Med. 1999 Mar-Apr;61(2):154-62. doi: 10.1097/00006842-199903000-00006.
- Kramer M. Hypnotic medication in the treatment of chronic insomnia: non nocere! Doesn't anyone care? Sleep Med Rev. 2000 Dec;4(6):529-541. doi: 10.1053/smrv.2000.0122.
- Krueger JM, Obal F Jr, Fang J. Humoral regulation of physiological sleep: cytokines and GHRH. J Sleep Res. 1999 Jun;8 Suppl 1:53-9. doi: 10.1046/j.1365-2869.1999.00009.x.
- Kudielka BM, Schmidt-Reinwald AK, Hellhammer DH, Kirschbaum C. Psychological and endocrine responses to psychosocial stress and dexamethasone/corticotropin-releasing hormone in healthy postmenopausal women and young controls: the impact of age and a two-week estradiol treatment. Neuroendocrinology. 1999 Dec;70(6):422-30. doi: 10.1159/000054504.
- Kudielka BM, Schmidt-Reinwald AK, Hellhammer DH, Schurmeyer T, Kirschbaum C. Psychosocial stress and HPA functioning: no evidence for a reduced resilience in healthy elderly men. Stress. 2000 May;3(3):229-40. doi: 10.3109/10253890009001127.
- Lacks P, Rotert M. Knowledge and practice of sleep hygiene techniques in insomniacs and good sleepers. Behav Res Ther. 1986;24(3):365-8. doi: 10.1016/0005-7967(86)90197-x. No abstract available.
- Magnano CL, Diamond EJ, Gardner JM. Use of salivary cortisol measurements in young infants: a note of caution. Child Dev. 1989 Oct;60(5):1099-101.
- Miller MD, Paradis CF, Houck PR, Mazumdar S, Stack JA, Rifai AH, Mulsant B, Reynolds CF 3rd. Rating chronic medical illness burden in geropsychiatric practice and research: application of the Cumulative Illness Rating Scale. Psychiatry Res. 1992 Mar;41(3):237-48. doi: 10.1016/0165-1781(92)90005-n.
- Monk TH, Buysse DJ, Rose LR. Wrist actigraphic measures of sleep in space. Sleep. 1999 Nov 1;22(7):948-54.
- Monk TH, Flaherty JF, Frank E, Hoskinson K, Kupfer DJ. The Social Rhythm Metric. An instrument to quantify the daily rhythms of life. J Nerv Ment Dis. 1990 Feb;178(2):120-6. doi: 10.1097/00005053-199002000-00007.
- Monk TH, Petrie SR, Hayes AJ, Kupfer DJ. Regularity of daily life in relation to personality, age, gender, sleep quality and circadian rhythms. J Sleep Res. 1994 Dec;3(4):196-205. doi: 10.1111/j.1365-2869.1994.tb00132.x.
- Monk TH, Reynolds CF 3rd, Kupfer DJ, Buysse DJ, Coble PA, Hayes AJ, Machen MA, Petrie SR, Ritenour AM. The Pittsburgh Sleep Diary. J Sleep Res. 1994;3:111-20.
- Monk TH, Reynolds CF, Kupfer DJ, Buysse DJ, Coble PA, Hayes AJ, MacHen MA, Petrie SR, Ritenour AM. The Pittsburgh Sleep Diary. J Sleep Res. 1994 Jun;3(2):111-120.
- Murasko DM, Nelson BJ, Matour D, Goonewardene IM, Kaye D. Heterogeneity of changes in lymphoproliferative ability with increasing age. Exp Gerontol. 1991;26(2-3):269-79. doi: 10.1016/0531-5565(91)90020-m.
- Murasko DM, Weiner P, Kaye D. Decline in mitogen induced proliferation of lymphocytes with increasing age. Clin Exp Immunol. 1987 Nov;70(2):440-8.
- Newman AB, Enright PL, Manolio TA, Haponik EF, Wahl PW. Sleep disturbance, psychosocial correlates, and cardiovascular disease in 5201 older adults: the Cardiovascular Health Study. J Am Geriatr Soc. 1997 Jan;45(1):1-7. doi: 10.1111/j.1532-5415.1997.tb00970.x.
- Nowell PD, Buysse DJ, Reynolds CF 3rd, Hauri PJ, Roth T, Stepanski EJ, Thorpy MJ, Bixler E, Kales A, Manfredi RL, Vgontzas AN, Stapf DM, Houck PR, Kupfer DJ. Clinical factors contributing to the differential diagnosis of primary insomnia and insomnia related to mental disorders. Am J Psychiatry. 1997 Oct;154(10):1412-6. doi: 10.1176/ajp.154.10.1412.
- Nowell PD, Mazumdar S, Buysse DJ, Dew MA, Reynolds CF 3rd, Kupfer DJ. Benzodiazepines and zolpidem for chronic insomnia: a meta-analysis of treatment efficacy. JAMA. 1997 Dec 24-31;278(24):2170-7.
- Ockenfels MC, Porter L, Smyth J, Kirschbaum C, Hellhammer DH, Stone AA. Effect of chronic stress associated with unemployment on salivary cortisol: overall cortisol levels, diurnal rhythm, and acute stress reactivity. Psychosom Med. 1995 Sep-Oct;57(5):460-7. doi: 10.1097/00006842-199509000-00008.
- Ostrove JM, Adler NE, Kuppermann M, Washington AE. Objective and subjective assessments of socioeconomic status and their relationship to self-rated health in an ethnically diverse sample of pregnant women. Health Psychol. 2000 Nov;19(6):613-8. doi: 10.1037//0278-6133.19.6.613.
- Pilcher JJ, Bergmann BM, Refetoff S, Fang VS, Rechtschaffen A. Sleep deprivation in the rat: XIII. The effect of hypothyroidism on sleep deprivation symptoms. Sleep. 1991 Jun;14(3):201-10. doi: 10.1093/sleep/14.3.201.
- Pilcher JJ, Huffcutt AI. Effects of sleep deprivation on performance: a meta-analysis. Sleep. 1996 May;19(4):318-26. doi: 10.1093/sleep/19.4.318.
- Prinz PN, Bailey SL, Woods DL. Sleep impairments in healthy seniors: roles of stress, cortisol, and interleukin-1 beta. Chronobiol Int. 2000 May;17(3):391-404. doi: 10.1081/cbi-100101053.
- Redwine L, Hauger RL, Gillin JC, Irwin M. Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans. J Clin Endocrinol Metab. 2000 Oct;85(10):3597-603. doi: 10.1210/jcem.85.10.6871.
- Rogers NL, Szuba MP, Staab JP, Evans DL, Dinges DF. Neuroimmunologic aspects of sleep and sleep loss. Semin Clin Neuropsychiatry. 2001 Oct;6(4):295-307. doi: 10.1053/scnp.2001.27907.
- Russo J, Vitaliano PP. Life events as correlates of burden in spouse caregivers of persons with Alzheimer's disease. Exp Aging Res. 1995 Jul-Sep;21(3):273-94. doi: 10.1080/03610739508253985.
- Scheier MF, Bridges MW. Person variables and health: personality predispositions and acute psychological states as shared determinants for disease. Psychosom Med. 1995 May-Jun;57(3):255-68. doi: 10.1097/00006842-199505000-00007.
- Schein OD, Hochberg MC, Munoz B, Tielsch JM, Bandeen-Roche K, Provost T, Anhalt GJ, West S. Dry eye and dry mouth in the elderly: a population-based assessment. Arch Intern Med. 1999 Jun 28;159(12):1359-63. doi: 10.1001/archinte.159.12.1359.
- Schramm E, Hohagen F, Grasshoff U, Riemann D, Hajak G, Weess HG, Berger M. Test-retest reliability and validity of the Structured Interview for Sleep Disorders According to DSM-III-R. Am J Psychiatry. 1993 Jun;150(6):867-72. doi: 10.1176/ajp.150.6.867.
- Shearer WT, Reuben JM, Mullington JM, Price NJ, Lee BN, Smith EO, Szuba MP, Van Dongen HP, Dinges DF. Soluble TNF-alpha receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight. J Allergy Clin Immunol. 2001 Jan;107(1):165-70. doi: 10.1067/mai.2001.112270.
- Smith CS, Reilly C, Midkiff K. Evaluation of three circadian rhythm questionnaires with suggestions for an improved measure of morningness. J Appl Psychol. 1989 Oct;74(5):728-38. doi: 10.1037/0021-9010.74.5.728.
- Smyth J, Ockenfels MC, Porter L, Kirschbaum C, Hellhammer DH, Stone AA. Stressors and mood measured on a momentary basis are associated with salivary cortisol secretion. Psychoneuroendocrinology. 1998 May;23(4):353-70. doi: 10.1016/s0306-4530(98)00008-0.
- Spitzer RL, Kroenke K, Williams JB. Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. JAMA. 1999 Nov 10;282(18):1737-44. doi: 10.1001/jama.282.18.1737.
- Vasko RC Jr, Brunner DP, Monahan JP, Doman J, Boston JR, el-Jaroudi A, Miewald J, Buysse DJ, Reynolds CF 3rd, Kupfer DJ. Power spectral analysis of EEG in a multiple-bedroom, multiple-polygraph sleep laboratory. Int J Med Inform. 1997 Oct;46(3):175-84. doi: 10.1016/s1386-5056(97)00064-6.
- Vgontzas AN, Papanicolaou DA, Bixler EO, Kales A, Tyson K, Chrousos GP. Elevation of plasma cytokines in disorders of excessive daytime sleepiness: role of sleep disturbance and obesity. J Clin Endocrinol Metab. 1997 May;82(5):1313-6. doi: 10.1210/jcem.82.5.3950.
- Vgontzas AN, Papanicolaou DA, Bixler EO, Lotsikas A, Zachman K, Kales A, Prolo P, Wong ML, Licinio J, Gold PW, Hermida RC, Mastorakos G, Chrousos GP. Circadian interleukin-6 secretion and quantity and depth of sleep. J Clin Endocrinol Metab. 1999 Aug;84(8):2603-7. doi: 10.1210/jcem.84.8.5894.
- Wedzicha JA. Mechanisms of exacerbations. Novartis Found Symp. 2001;234:84-93; discussion 93-103. doi: 10.1002/0470868678.ch6.
- Williamson GM, Shaffer DR. Relationship quality and potentially harmful behaviors by spousal caregivers: how we were then, how we are now. The Family Relationships in Late Life Project. Psychol Aging. 2001 Jun;16(2):217-26.
- Wust S, Federenko I, Hellhammer DH, Kirschbaum C. Genetic factors, perceived chronic stress, and the free cortisol response to awakening. Psychoneuroendocrinology. 2000 Oct;25(7):707-20. doi: 10.1016/s0306-4530(00)00021-4.
- Zetterberg LH. A mathematical model for analysis of EEG. Electroencephalogr Clin Neurophysiol. 1969 Mar;26(3):338. No abstract available.
- Callan JA, Siegle GJ, Abebe K, Black B, Martire L, Schulz R, Reynolds C 3rd, Hall MH. Feasibility of a pocket-PC based cognitive control intervention in dementia spousal caregivers. Aging Ment Health. 2016;20(6):575-82. doi: 10.1080/13607863.2015.1031635. Epub 2015 May 6.
Hjælpsomme links
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart
1. februar 2003
Primær færdiggørelse (FAKTISKE)
1. november 2008
Studieafslutning (FAKTISKE)
1. november 2009
Datoer for studieregistrering
Først indsendt
13. september 2005
Først indsendt, der opfyldte QC-kriterier
13. september 2005
Først opslået (SKØN)
15. september 2005
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (SKØN)
28. maj 2015
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
26. maj 2015
Sidst verificeret
1. maj 2015
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- 021117
- 1P01AG020677-01 (NIH)
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .