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Standard eller omfattende strålebehandling til behandling af patienter med tidligt stadie af brystkræft, der tidligere er blevet behandlet med kemoterapi og kirurgi

20. december 2023 opdateret af: NSABP Foundation Inc

Et randomiseret fase III klinisk forsøg, der evaluerer postmastektomi brystvæg og regional nodal XRT og post-lumpektomi regional nodal XRT hos patienter med positive aksillære knuder før neoadjuverende kemoterapi, som konverterer til patologisk negative aksillære noder efter neoadjuverende kemoterapi

Dette randomiserede fase III-forsøg undersøger standard eller omfattende strålebehandling til behandling af patienter med tidligt stadie af brystkræft, som er blevet opereret. Strålebehandling bruger højenergi røntgenstråler til at dræbe tumorceller. Det vides endnu ikke, om omfattende strålebehandling er mere effektiv end standard strålebehandling til behandling af patienter med brystkræft

Studieoversigt

Status

Aktiv, ikke rekrutterende

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

PRIMÆRE MÅL:

At evaluere, om tilføjelsen af ​​brystvæg + regional nodal strålebehandling (XRT) efter mastektomi eller bryst + regional nodal XRT efter brystbevarende kirurgi vil signifikant reducere frekvensen af ​​hændelser for invasiv brystcancer recidivfrit interval (IBC-RFI) hos patienter som præsenterer med histologisk positive aksillære knuder, men omdannes til histologisk negative aksillære knuder efter neoadjuverende kemoterapi.

SEKUNDÆRE MÅL:

I. At evaluere, om tilføjelsen af ​​brystvæg + regional nodal XRT efter mastektomi eller bryst + regional nodal XRT efter brystbevarende operation vil forlænge den samlede overlevelse (OS) signifikant hos patienter, der præsenterer med histologisk positive aksillære knuder, men konverteres til histologisk negative aksillære knuder efter neoadjuverende kemoterapi.

II. For at evaluere, om tilføjelsen af ​​brystvæg + regional nodal XRT efter mastektomi eller bryst + regional nodal XRT efter brystbevarende kirurgi vil signifikant reducere frekvensen af ​​hændelser for lokalt-regionalt recidivfrit interval (LRRFI) hos patienter, der viser sig med histologisk positive aksillære noder, men omdannes til histologisk negative aksillære noder efter neoadjuverende kemoterapi.

III. At evaluere om tilføjelsen af ​​brystvæggen + regional nodal XRT efter mastektomi eller bryst + regional nodal XRT efter brystbevarende kirurgi vil signifikant reducere frekvensen af ​​hændelser for fjernt recidivfrit interval (DRFI) hos patienter med histologisk positive aksillære knuder, men konvertere til histologisk negative aksillære noder efter neoadjuverende kemoterapi.

IV. At sammenligne frekvensen af ​​sygdomsfri overlevelse (DFS)-ductal carcinoma in situ (DCIS) efter behandlingsarm.

V. At sammenligne frekvensen af ​​anden primær cancer (SPC) efter behandlingsarm.

VI. For at sammenligne effekten af ​​at tilføje XRT på de kosmetiske resultater hos mastektomipatienter, der har haft rekonstruktion.

VII. For at sammenligne effekten af ​​at tilføje XRT på livskvaliteten inklusive armproblemer, lymfødem, smerter og træthed.

VIII. For at evaluere toksiciteten forbundet med hver af strålebehandlingsregimerne.

IX. For at bestemme, om computertomografi (CT)-baserede konforme metoder (intensitetsmoduleret strålebehandling [IMRT] og 3-dimensionel konform strålebehandling [3DCRT]) til brystvæg + regional nodal XRT efter mastektomi og regional nodal XRT med bryst XRT efter brystkonservering kirurgi er mulig i multi-institutionelle omgivelser, og om dosis-volumen-analyser kan etableres for at vurdere behandlingens tilstrækkelighed og for at udvikle normal vævskomplikationssandsynlighed (NTCP) for sandsynligheden for toksicitet.

X. At sammenligne effekten af ​​XRT hos patienter, der får mastektomi, og hos patienter, der får lumpektomi.

XI. At undersøge rollen af ​​spredningsforanstaltninger som prognostator for patienter med resterende sygdom efter neoadjuverende kemoterapi.

XII. At udvikle prædiktorer for graden af ​​reduktion i lokalt regionalt tilbagefald (LRR).

OVERSIGT: Patienterne randomiseres til 1 ud af 2 behandlingsarme.

ARM 1: Patienter tildeles 1 ud af 2 behandlingsgrupper.

GRUPPE 1A: Lumpektomipatienter gennemgår strålebehandling af hele brystet ved hjælp af IMRT eller 3DCRT én gang dagligt 5 dage om ugen i 5 uger efterfulgt af et strålebehandlingsboost til lumpektomihulen én gang dagligt 5 dage om ugen i 1-1/2 uge.

GRUPPE 1B: Mastektomipatienter gennemgår ikke strålebehandling.

ARM 2: Patienterne tildeles 1 af 2 behandlingsgrupper.

GRUPPE 2A: Lumpektomipatienter gennemgår regional nodal strålebehandling med helbryststrålebehandling ved hjælp af IMRT eller 3DCRT en gang dagligt 5 dage om ugen i 5 uger efterfulgt af et stråleterapiboost til lumpektomihulen en gang dagligt 5 dage om ugen i 1-1/2 uger.

GRUPPE 2B: Mastektomipatienter gennemgår regional nodal strålebehandling og brystvæg XRT ved hjælp af IMRT eller 3DCRT en gang dagligt 5 dage om ugen i 5 uger.

Alle patienter modtager også systemisk terapi som planlagt (hormonbehandling til patienter med hormon-receptor positiv brystkræft og trastuzumab eller anden anti-human epidermal vækstfaktor receptor 2 [HER2] behandling til patienter med brystkræft, der er HER2-positiv).

Efter afslutning af undersøgelsesbehandlingen følges patienterne op efter 6, 12, 18 og 24 måneder og derefter årligt i 8 år.

Undersøgelsestype

Interventionel

Tilmelding (Anslået)

1636

Fase

  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Canada
    • Alberta
      • Calgary, Alberta, Canada, T2N 4N2
        • Tom Baker Cancer Centre
      • Edmonton, Alberta, Canada, T6G 1Z2
        • Cross Cancer Institute
    • Manitoba
      • Winnipeg, Manitoba, Canada, R3E 0V9
        • CancerCare Manitoba
    • New Brunswick
      • Saint John, New Brunswick, Canada, E2L 4L2
        • Atlantic Health Sciences Corporation-Saint John Regional Hospital
    • Ontario
      • Toronto, Ontario, Canada, M5G 2M9
        • University Health Network-Princess Margaret Hospital
    • Quebec
      • Montreal, Quebec, Canada, H3T 1E2
        • Jewish General Hospital
      • Montreal, Quebec, Canada, H2W 1S6
        • McGill University Department of Oncology
      • Montreal, Quebec, Canada, H1T 2M4
        • CIUSSSEMTL-Hopital Maisonneuve-Rosemont
      • Quebec City, Quebec, Canada, G1R 2J6
        • CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)
      • Sherbrooke, Quebec, Canada, J1H 5N4
        • Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
    • Saskatchewan
      • Regina, Saskatchewan, Canada, S4T 7T1
        • Allan Blair Cancer Centre
      • Saskatoon, Saskatchewan, Canada, S7N 4H4
        • Saskatoon Cancer Centre
  • Forenede Stater
    • Alabama
      • Birmingham, Alabama, Forenede Stater, 35233
        • University of Alabama at Birmingham Cancer Center
      • Mobile, Alabama, Forenede Stater, 36688
        • University of South Alabama Mitchell Cancer Institute
    • Alaska
      • Anchorage, Alaska, Forenede Stater, 99508
        • Providence Alaska Medical Center
    • Arizona
      • Gilbert, Arizona, Forenede Stater, 85297
        • Arizona Breast Cancer Specialists-Gilbert
      • Peoria, Arizona, Forenede Stater, 85381
        • Arizona Center for Cancer Care-Peoria
      • Phoenix, Arizona, Forenede Stater, 85027
        • Arizona Breast Cancer Specialists-Phoenix
      • Scottsdale, Arizona, Forenede Stater, 85258
        • Arizona Breast Cancer Specialists-Scottsdale
      • Surprise, Arizona, Forenede Stater, 85374
        • Arizona Center for Cancer Care-Surprise
      • Tucson, Arizona, Forenede Stater, 85724
        • The University of Arizona Medical Center-University Campus
      • Tucson, Arizona, Forenede Stater, 85704
        • Arizona Oncology Associates-West Orange Grove
    • Arkansas
      • Little Rock, Arkansas, Forenede Stater, 72205
        • University of Arkansas for Medical Sciences
    • California
      • Auburn, California, Forenede Stater, 95603
        • Sutter Cancer Centers Radiation Oncology Services-Auburn
      • Burlingame, California, Forenede Stater, 94010
        • Mills - Peninsula Hospitals
      • Cameron Park, California, Forenede Stater, 95682
        • Sutter Cancer Centers Radiation Oncology Services-Cameron Park
      • Castro Valley, California, Forenede Stater, 94546
        • Eden Hospital Medical Center
      • Duarte, California, Forenede Stater, 91010
        • City of Hope Comprehensive Cancer Center
      • Dublin, California, Forenede Stater, 94568
        • Epic Care-Dublin
      • Emeryville, California, Forenede Stater, 94608
        • Epic Care Partners in Cancer Care
      • Fresno, California, Forenede Stater, 93720
        • California Cancer Center - North Fresno
      • La Jolla, California, Forenede Stater, 92093
        • UC San Diego Moores Cancer Center
      • Lancaster, California, Forenede Stater, 93534
        • City of Hope Antelope Valley
      • Loma Linda, California, Forenede Stater, 92354
        • Loma Linda University Medical Center
      • Los Angeles, California, Forenede Stater, 90033
        • USC / Norris Comprehensive Cancer Center
      • Los Angeles, California, Forenede Stater, 90048
        • Cedars-Sinai Medical Center
      • Los Angeles, California, Forenede Stater, 90033
        • Los Angeles County-USC Medical Center
      • Newport Beach, California, Forenede Stater, 92663
        • Hoag Memorial Hospital
      • Oakland, California, Forenede Stater, 94611
        • Kaiser Permanente Oakland-Broadway
      • Oakland, California, Forenede Stater, 94609
        • Alta Bates Summit Medical Center - Summit Campus
      • Orange, California, Forenede Stater, 92868
        • UC Irvine Health/Chao Family Comprehensive Cancer Center
      • Orange, California, Forenede Stater, 92868
        • Saint Joseph Hospital - Orange
      • Palm Springs, California, Forenede Stater, 92262
        • Desert Regional Medical Center
      • Pasadena, California, Forenede Stater, 91105
        • Huntington Memorial Hospital
      • Pomona, California, Forenede Stater, 91767
        • Pomona Valley Hospital Medical Center
      • Rancho Cordova, California, Forenede Stater, 95670
        • Kaiser Permanente-Rancho Cordova Cancer Center
      • Rohnert Park, California, Forenede Stater, 94928
        • Rohnert Park Cancer Center
      • Roseville, California, Forenede Stater, 95678
        • The Permanente Medical Group-Roseville Radiation Oncology
      • Roseville, California, Forenede Stater, 95661
        • Kaiser Permanente-Roseville
      • Roseville, California, Forenede Stater, 95661
        • Sutter Cancer Centers Radiation Oncology Services-Roseville
      • Roseville, California, Forenede Stater, 95661
        • Sutter Roseville Medical Center
      • Sacramento, California, Forenede Stater, 95817
        • University of California Davis Comprehensive Cancer Center
      • Sacramento, California, Forenede Stater, 95816
        • Sutter General Hospital
      • Saint Helena, California, Forenede Stater, 94574
        • Saint Helena Hospital
      • San Diego, California, Forenede Stater, 92134
        • Naval Medical Center -San Diego
      • Santa Clara, California, Forenede Stater, 95051
        • Kaiser Permanente Medical Center - Santa Clara
      • South Pasadena, California, Forenede Stater, 91030
        • City of Hope South Pasadena
      • South San Francisco, California, Forenede Stater, 94080
        • Kaiser Permanente Cancer Treatment Center
      • South San Francisco, California, Forenede Stater, 94080
        • Kaiser Permanente-South San Francisco
      • Truckee, California, Forenede Stater, 96161
        • Gene Upshaw Memorial Tahoe Forest Cancer Center
      • Vacaville, California, Forenede Stater, 95687
        • Sutter Cancer Centers Radiation Oncology Services-Vacaville
      • Vallejo, California, Forenede Stater, 94589
        • Sutter Solano Medical Center/Cancer Center
    • Colorado
      • Aurora, Colorado, Forenede Stater, 80045
        • University of Colorado Cancer Center - Anschutz Cancer Pavilion
      • Aurora, Colorado, Forenede Stater, 80012
        • Rocky Mountain Cancer Centers-Aurora
      • Boulder, Colorado, Forenede Stater, 80304
        • Rocky Mountain Cancer Centers-Boulder
      • Colorado Springs, Colorado, Forenede Stater, 80907
        • Penrose-Saint Francis Healthcare
      • Colorado Springs, Colorado, Forenede Stater, 80909
        • Memorial Hospital Colorado Springs
      • Denver, Colorado, Forenede Stater, 80210
        • Porter Adventist Hospital
      • Edwards, Colorado, Forenede Stater, 81632
        • The Shaw Regional Cancer Center
      • Fort Collins, Colorado, Forenede Stater, 80524
        • Poudre Valley Hospital
      • Littleton, Colorado, Forenede Stater, 80120
        • Rocky Mountain Cancer Centers-Littleton
      • Pueblo, Colorado, Forenede Stater, 81004
        • Saint Mary Corwin Medical Center
      • Thornton, Colorado, Forenede Stater, 80260
        • Rocky Mountain Cancer Centers-Thornton
      • Wheat Ridge, Colorado, Forenede Stater, 80033
        • SCL Health Lutheran Medical Center
    • Connecticut
      • Hartford, Connecticut, Forenede Stater, 06102
        • Hartford Hospital
      • Middletown, Connecticut, Forenede Stater, 06457
        • Middlesex Hospital
      • New Britain, Connecticut, Forenede Stater, 06050
        • The Hospital of Central Connecticut
    • District of Columbia
      • Washington, District of Columbia, Forenede Stater, 20010
        • MedStar Washington Hospital Center
      • Washington, District of Columbia, Forenede Stater, 20007
        • Medstar Georgetown University Hospital
      • Washington, District of Columbia, Forenede Stater, 20016
        • Sibley Memorial Hospital
    • Florida
      • Altamonte Springs, Florida, Forenede Stater, 32701
        • Florida Hospital Cancer Institute Altamonte
      • Atlantis, Florida, Forenede Stater, 33462
        • John Fitzgerald Kennedy Medical Center
      • Clearwater, Florida, Forenede Stater, 33756
        • Morton Plant Hospital
      • Deerfield Beach, Florida, Forenede Stater, 33442
        • UM Sylvester Comprehensive Cancer Center at Deerfield Beach
      • Gainesville, Florida, Forenede Stater, 32610
        • University of Florida
      • Hollywood, Florida, Forenede Stater, 33021
        • Memorial Regional Hospital/Joe DiMaggio Children's Hospital
      • Miami, Florida, Forenede Stater, 33136
        • University of Miami Miller School of Medicine-Sylvester Cancer Center
      • Miami, Florida, Forenede Stater, 33176
        • Baptist Hospital of Miami
      • Miami, Florida, Forenede Stater, 33136
        • Jackson Memorial Hospital-Holtz Children's Hospital
      • Miami, Florida, Forenede Stater, 33143
        • South Miami Hospital
      • Orlando, Florida, Forenede Stater, 32803
        • Florida Hospital Orlando
      • Orlando, Florida, Forenede Stater, 32806
        • UF Cancer Center at Orlando Health
      • Palatka, Florida, Forenede Stater, 32177
        • 21st Century Oncology-Palatka
      • Tampa, Florida, Forenede Stater, 33612
        • Moffitt Cancer Center
      • Tampa, Florida, Forenede Stater, 33607
        • Saint Joseph's Hospital/Children's Hospital-Tampa
    • Georgia
      • Atlanta, Georgia, Forenede Stater, 30308
        • Emory University Hospital Midtown
      • Atlanta, Georgia, Forenede Stater, 30303
        • Grady Health System
      • Atlanta, Georgia, Forenede Stater, 30309
        • Piedmont Hospital
      • Atlanta, Georgia, Forenede Stater, 30322
        • Emory University/Winship Cancer Institute
      • Atlanta, Georgia, Forenede Stater, 30342
        • Saint Joseph's Hospital of Atlanta
      • Carrollton, Georgia, Forenede Stater, 30117
        • Tanner Medical Center/Carrollton
      • Decatur, Georgia, Forenede Stater, 30033
        • Dekalb Medical Center
      • Savannah, Georgia, Forenede Stater, 31405
        • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
      • Savannah, Georgia, Forenede Stater, 31404
        • Memorial University Medical Center
    • Hawaii
      • 'Ewa Beach, Hawaii, Forenede Stater, 96706
        • The Cancer Center of Hawaii-Leeward
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Queen's Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96817
        • The Cancer Center of Hawaii-Liliha
    • Idaho
      • Boise, Idaho, Forenede Stater, 83706
        • Saint Alphonsus Cancer Care Center-Boise
      • Post Falls, Idaho, Forenede Stater, 83854
        • Kootenai Cancer Center
    • Illinois
      • Chicago, Illinois, Forenede Stater, 60611
        • Northwestern University
      • Chicago, Illinois, Forenede Stater, 60637
        • University of Chicago Comprehensive Cancer Center
      • Chicago, Illinois, Forenede Stater, 60612
        • University of Illinois
      • Chicago, Illinois, Forenede Stater, 60612
        • John H Stroger Jr Hospital of Cook County
      • Chicago, Illinois, Forenede Stater, 60608
        • Mount Sinai Hospital Medical Center
      • Chicago, Illinois, Forenede Stater, 60657
        • Advocate Illinois Masonic Medical Center
      • Decatur, Illinois, Forenede Stater, 62526
        • Decatur Memorial Hospital
      • Elk Grove Village, Illinois, Forenede Stater, 60007
        • AMITA Health Alexian Brothers Medical Center
      • Elmhurst, Illinois, Forenede Stater, 60126
        • Elmhurst Memorial Hospital
      • Evanston, Illinois, Forenede Stater, 60201
        • NorthShore University HealthSystem-Evanston Hospital
      • Glenview, Illinois, Forenede Stater, 60026
        • NorthShore University HealthSystem-Glenbrook Hospital
      • Hazel Crest, Illinois, Forenede Stater, 60429
        • Advocate South Suburban Hospital
      • Highland Park, Illinois, Forenede Stater, 60035
        • NorthShore University HealthSystem-Highland Park Hospital
      • Kankakee, Illinois, Forenede Stater, 60901
        • Presence Saint Mary's Hospital
      • Libertyville, Illinois, Forenede Stater, 60048
        • Condell Memorial Hospital
      • Maywood, Illinois, Forenede Stater, 60153
        • Loyola University Medical Center
      • Naperville, Illinois, Forenede Stater, 60540
        • Edward Hospital/Cancer Center
      • New Lenox, Illinois, Forenede Stater, 60451
        • UC Comprehensive Cancer Center at Silver Cross
      • Oak Lawn, Illinois, Forenede Stater, 60453-2699
        • Advocate Christ Medical Center
      • Park Ridge, Illinois, Forenede Stater, 60068
        • Advocate Lutheran General Hospital
      • Peoria, Illinois, Forenede Stater, 61637
        • OSF Saint Francis Medical Center
      • Peoria, Illinois, Forenede Stater, 61615
        • Illinois CancerCare-Peoria
      • Peoria, Illinois, Forenede Stater, 61615
        • OSF Saint Francis Radiation Oncology at Peoria Cancer Center
      • Plainfield, Illinois, Forenede Stater, 60585
        • Edward Hospital/Cancer Center?Plainfield
      • Rockford, Illinois, Forenede Stater, 61114
        • SwedishAmerican Regional Cancer Center/ACT
      • Springfield, Illinois, Forenede Stater, 62781
        • Memorial Medical Center
      • Urbana, Illinois, Forenede Stater, 61801
        • Carle Cancer Center
      • Warrenville, Illinois, Forenede Stater, 60555
        • Northwestern Medicine Cancer Center Warrenville
    • Indiana
      • Anderson, Indiana, Forenede Stater, 46016
        • Saint Vincent Anderson Regional Hospital/Cancer Center
      • Fort Wayne, Indiana, Forenede Stater, 46805
        • Parkview Hospital Randallia
      • Goshen, Indiana, Forenede Stater, 46526
        • Goshen Center for Cancer Care
      • Indianapolis, Indiana, Forenede Stater, 46237
        • Franciscan Health Indianapolis
      • Indianapolis, Indiana, Forenede Stater, 46202
        • Indiana University/Melvin and Bren Simon Cancer Center
      • Indianapolis, Indiana, Forenede Stater, 46219
        • Community Cancer Center East
      • Indianapolis, Indiana, Forenede Stater, 46227
        • Community Cancer Center South
      • Indianapolis, Indiana, Forenede Stater, 46256
        • Community Cancer Center North
      • Indianapolis, Indiana, Forenede Stater, 46260
        • Saint Vincent Hospital and Health Care Center
      • Indianapolis, Indiana, Forenede Stater, 46202
        • IU Health Methodist Hospital
      • South Bend, Indiana, Forenede Stater, 46601
        • Memorial Hospital of South Bend
    • Iowa
      • Clive, Iowa, Forenede Stater, 50325
        • Mercy Cancer Center-West Lakes
      • Des Moines, Iowa, Forenede Stater, 50309
        • Iowa Methodist Medical Center
      • Des Moines, Iowa, Forenede Stater, 50314
        • Mercy Medical Center - Des Moines
      • Iowa City, Iowa, Forenede Stater, 52242
        • University of Iowa/Holden Comprehensive Cancer Center
    • Kansas
      • Kansas City, Kansas, Forenede Stater, 66160
        • University of Kansas Cancer Center
      • Overland Park, Kansas, Forenede Stater, 66210
        • University of Kansas Cancer Center-Overland Park
      • Wichita, Kansas, Forenede Stater, 67214
        • Wichita NCI Community Oncology Research Program
      • Wichita, Kansas, Forenede Stater, 67214
        • Via Christi Regional Medical Center
      • Wichita, Kansas, Forenede Stater, 67214
        • Wesley Medical Center
    • Kentucky
      • Edgewood, Kentucky, Forenede Stater, 41017
        • Saint Elizabeth Medical Center South
      • Fort Thomas, Kentucky, Forenede Stater, 41075
        • Saint Elizabeth Fort Thomas
      • Louisville, Kentucky, Forenede Stater, 40202
        • Norton Hospital Pavilion and Medical Campus
      • Louisville, Kentucky, Forenede Stater, 40202
        • The James Graham Brown Cancer Center at University of Louisville
      • Louisville, Kentucky, Forenede Stater, 40207
        • Norton Suburban Hospital and Medical Campus
      • Louisville, Kentucky, Forenede Stater, 40207
        • Baptist Health Louisville
      • Owensboro, Kentucky, Forenede Stater, 42303
        • Owensboro Health Mitchell Memorial Cancer Center
    • Louisiana
      • Baton Rouge, Louisiana, Forenede Stater, 70809
        • Mary Bird Perkins Cancer Center
      • Baton Rouge, Louisiana, Forenede Stater, 70806
        • Baton Rouge General Medical Center
      • Baton Rouge, Louisiana, Forenede Stater, 70817
        • Woman's Hospital
      • Covington, Louisiana, Forenede Stater, 70433
        • Mary Bird Cancer Center/Saint Tammany Parish
      • Houma, Louisiana, Forenede Stater, 70360
        • Mary Bird Perkins Cancer Center/Terrebonne General Medical Center
      • Kenner, Louisiana, Forenede Stater, 70065
        • Ochsner Medical Center Kenner
      • New Orleans, Louisiana, Forenede Stater, 70121
        • Ochsner Medical Center Jefferson
    • Maine
      • Bangor, Maine, Forenede Stater, 04401
        • Eastern Maine Medical Center
      • Scarborough, Maine, Forenede Stater, 04074
        • Maine Medical Center- Scarborough Campus
    • Maryland
      • Annapolis, Maryland, Forenede Stater, 21401
        • Anne Arundel Medical Center
      • Baltimore, Maryland, Forenede Stater, 21237
        • MedStar Franklin Square Medical Center/Weinberg Cancer Institute
      • Baltimore, Maryland, Forenede Stater, 21287
        • Johns Hopkins University/Sidney Kimmel Cancer Center
      • Baltimore, Maryland, Forenede Stater, 21204
        • Greater Baltimore Medical Center
      • Baltimore, Maryland, Forenede Stater, 21201
        • University of Maryland/Greenebaum Cancer Center
      • Bel Air, Maryland, Forenede Stater, 21014
        • Upper Chesapeake Medical Center
      • Columbia, Maryland, Forenede Stater, 21044
        • Central Maryland Radiation Oncology in Howard County
      • Glen Burnie, Maryland, Forenede Stater, 21061
        • Tate Cancer Center
    • Massachusetts
      • Boston, Massachusetts, Forenede Stater, 02215
        • Dana-Farber Cancer Institute
      • Boston, Massachusetts, Forenede Stater, 02118
        • Boston Medical Center
      • Fall River, Massachusetts, Forenede Stater, 02721
        • Saint Anne's Hospital
      • Lowell, Massachusetts, Forenede Stater, 01854
        • Lowell General Hospital
      • Springfield, Massachusetts, Forenede Stater, 01199
        • Baystate Medical Center
    • Michigan
      • Ann Arbor, Michigan, Forenede Stater, 48109
        • University of Michigan Comprehensive Cancer Center
      • Brownstown, Michigan, Forenede Stater, 48183
        • Henry Ford Cancer Institute¿Downriver
      • Clarkston, Michigan, Forenede Stater, 48346
        • 21st Century Oncology-Clarkston
      • Clinton Township, Michigan, Forenede Stater, 48038
        • Henry Ford Macomb Hospital-Clinton Township
      • Dearborn, Michigan, Forenede Stater, 48124
        • Beaumont Hospital-Dearborn
      • Detroit, Michigan, Forenede Stater, 48202
        • Henry Ford Hospital
      • Detroit, Michigan, Forenede Stater, 48236
        • Saint John Hospital and Medical Center
      • Detroit, Michigan, Forenede Stater, 48201
        • Wayne State University/Karmanos Cancer Institute
      • Flint, Michigan, Forenede Stater, 48502
        • Hurley Medical Center
      • Flint, Michigan, Forenede Stater, 48532
        • McLaren Cancer Institute-Flint
      • Flint, Michigan, Forenede Stater, 48503
        • Genesys Hurley Cancer Institute
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Spectrum Health at Butterworth Campus
      • Lansing, Michigan, Forenede Stater, 48912
        • Sparrow Hospital
      • Lapeer, Michigan, Forenede Stater, 48446
        • McLaren Cancer Institute-Lapeer Region
      • Mount Clemens, Michigan, Forenede Stater, 48043
        • McLaren Cancer Institute-Macomb
      • Mount Pleasant, Michigan, Forenede Stater, 48858
        • McLaren Cancer Institute-Central Michigan
      • Muskegon, Michigan, Forenede Stater, 49444
        • Mercy Health Mercy Campus
      • Novi, Michigan, Forenede Stater, 48374-1236
        • Assarian Cancer Center
      • Owosso, Michigan, Forenede Stater, 48867
        • McLaren Cancer Institute-Owosso
      • Petoskey, Michigan, Forenede Stater, 49770
        • McLaren Cancer Institute-Northern Michigan
      • Pontiac, Michigan, Forenede Stater, 48341
        • Saint Joseph Mercy Oakland
      • Royal Oak, Michigan, Forenede Stater, 48073
        • William Beaumont Hospital-Royal Oak
      • Southfield, Michigan, Forenede Stater, 48075
        • Providence Hospital-Southfield Cancer Center
      • Troy, Michigan, Forenede Stater, 48098
        • William Beaumont Hospital - Troy
      • Troy, Michigan, Forenede Stater, 48098
        • 21st Century Oncology-Troy
      • Warren, Michigan, Forenede Stater, 48093
        • Saint John Macomb-Oakland Hospital
      • West Bloomfield, Michigan, Forenede Stater, 48322
        • Henry Ford West Bloomfield Hospital
      • Wyoming, Michigan, Forenede Stater, 49519
        • Metro Health Hospital
    • Minnesota
      • Albert Lea, Minnesota, Forenede Stater, 56007
        • Mayo Clinic Health System in Albert Lea
      • Burnsville, Minnesota, Forenede Stater, 55337
        • Fairview Ridges Hospital
      • Fridley, Minnesota, Forenede Stater, 55432
        • Unity Hospital
      • Mankato, Minnesota, Forenede Stater, 56001
        • Mayo Clinic Health Systems-Mankato
      • Minneapolis, Minnesota, Forenede Stater, 55407
        • Abbott-Northwestern Hospital
      • Northfield, Minnesota, Forenede Stater, 55057
        • Mayo Clinic Radiation Therapy-Northfield
      • Rochester, Minnesota, Forenede Stater, 55905
        • Mayo Clinic
      • Saint Cloud, Minnesota, Forenede Stater, 56303
        • Coborn Cancer Center at Saint Cloud Hospital
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Park Nicollet Clinic - Saint Louis Park
      • Saint Paul, Minnesota, Forenede Stater, 55101
        • Regions Hospital
      • Saint Paul, Minnesota, Forenede Stater, 55102
        • United Hospital
      • Waconia, Minnesota, Forenede Stater, 55387
        • Ridgeview Medical Center
    • Mississippi
      • Jackson, Mississippi, Forenede Stater, 39216
        • University of Mississippi Medical Center
      • Southhaven, Mississippi, Forenede Stater, 38671
        • Baptist Memorial Hospital-DeSoto
    • Missouri
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Saint Francis Medical Center
      • Chesterfield, Missouri, Forenede Stater, 63017
        • Saint Luke's Hospital
      • Columbia, Missouri, Forenede Stater, 65212
        • University of Missouri - Ellis Fischel
      • Creve Coeur, Missouri, Forenede Stater, 63141
        • Barnes-Jewish West County Hospital
      • Kansas City, Missouri, Forenede Stater, 64116
        • North Kansas City Hospital
      • Kansas City, Missouri, Forenede Stater, 64131
        • The University of Kansas Cancer Center-South
      • Kansas City, Missouri, Forenede Stater, 64111
        • Saint Luke's Hospital of Kansas City
      • Kansas City, Missouri, Forenede Stater, 64132
        • Research Medical Center
      • Kansas City, Missouri, Forenede Stater, 64154
        • The University of Kansas Cancer Center-North
      • Lee's Summit, Missouri, Forenede Stater, 64086
        • Saint Luke's East - Lee's Summit
      • Lee's Summit, Missouri, Forenede Stater, 64064
        • The University of Kansas Cancer Center-Lee's Summit
      • Saint Louis, Missouri, Forenede Stater, 63110
        • Washington University School of Medicine
      • Saint Louis, Missouri, Forenede Stater, 63131
        • Missouri Baptist Medical Center
      • Saint Louis, Missouri, Forenede Stater, 63129
        • Siteman Cancer Center-South County
      • Saint Louis, Missouri, Forenede Stater, 63128
        • Saint Anthony's Medical Center
      • Saint Peters, Missouri, Forenede Stater, 63376
        • Siteman Cancer Center - Saint Peters
    • Montana
      • Billings, Montana, Forenede Stater, 59101
        • Billings Clinic Cancer Center
      • Great Falls, Montana, Forenede Stater, 59405
        • Benefis Healthcare- Sletten Cancer Institute
      • Kalispell, Montana, Forenede Stater, 59901
        • Kalispell Regional Medical Center
    • Nebraska
      • Grand Island, Nebraska, Forenede Stater, 68803
        • CHI Health Saint Francis
      • Omaha, Nebraska, Forenede Stater, 68198
        • University of Nebraska Medical Center
      • Omaha, Nebraska, Forenede Stater, 68124
        • Alegent Health Bergan Mercy Medical Center
      • Omaha, Nebraska, Forenede Stater, 68130
        • Alegent Health Lakeside Hospital
    • Nevada
      • Las Vegas, Nevada, Forenede Stater, 89106
        • Radiation Oncology Centers of Nevada Central
      • Reno, Nevada, Forenede Stater, 89502
        • Renown Regional Medical Center
    • New Hampshire
      • Concord, New Hampshire, Forenede Stater, 03301
        • Concord Hospital
      • Lebanon, New Hampshire, Forenede Stater, 03756
        • Dartmouth Hitchcock Medical Center
      • Manchester, New Hampshire, Forenede Stater, 03103
        • Elliot Hospital
    • New Jersey
      • Basking Ridge, New Jersey, Forenede Stater, 07920
        • Memorial Sloan Kettering Cancer Center at Basking Ridge
      • Brick, New Jersey, Forenede Stater, 08724
        • Ocean Medical Center
      • Camden, New Jersey, Forenede Stater, 08103
        • Cooper Hospital University Medical Center
      • Englewood, New Jersey, Forenede Stater, 07631
        • Englewood Hospital and Medical Center
      • Livingston, New Jersey, Forenede Stater, 07039
        • Saint Barnabas Medical Center
      • Mount Holly, New Jersey, Forenede Stater, 08060
        • Virtua Memorial
      • Neptune, New Jersey, Forenede Stater, 07753
        • Jersey Shore Medical Center
      • New Brunswick, New Jersey, Forenede Stater, 08903
        • Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
      • Paramus, New Jersey, Forenede Stater, 07652
        • The Valley Hospital-Luckow Pavilion
      • Pennington, New Jersey, Forenede Stater, 08534
        • Capital Health Medical Center-Hopewell
      • Red Bank, New Jersey, Forenede Stater, 07701
        • Riverview Medical Center/Booker Cancer Center
      • Ridgewood, New Jersey, Forenede Stater, 07450
        • Valley Hospital
      • Somerville, New Jersey, Forenede Stater, 08876
        • Robert Wood Johnson University Hospital Somerset
      • Sparta, New Jersey, Forenede Stater, 07871
        • Sparta Cancer Treatment Center
      • Voorhees, New Jersey, Forenede Stater, 08043
        • Virtua Voorhees
      • Voorhees, New Jersey, Forenede Stater, 08043
        • MD Anderson Cancer Center at Cooper-Voorhees
      • Westwood, New Jersey, Forenede Stater, 07675
        • Valley Health System-Hematology/Oncology
    • New Mexico
      • Albuquerque, New Mexico, Forenede Stater, 87102
        • University of New Mexico Cancer Center
      • Albuquerque, New Mexico, Forenede Stater, 87109
        • Lovelace Radiation Oncology
      • Albuquerque, New Mexico, Forenede Stater, 87109
        • New Mexico Oncology Hematology Consultants
      • Las Cruces, New Mexico, Forenede Stater, 88011
        • Memorial Medical Center - Las Cruces
      • Santa Fe, New Mexico, Forenede Stater, 87505
        • Christus Saint Vincent Regional Cancer Center
    • New York
      • Bronx, New York, Forenede Stater, 10467-2490
        • Montefiore Medical Center - Moses Campus
      • Brooklyn, New York, Forenede Stater, 11219
        • Maimonides Medical Center
      • Brooklyn, New York, Forenede Stater, 11215
        • New York-Presbyterian/Brooklyn Methodist Hospital
      • Carmel, New York, Forenede Stater, 10512
        • Putnam Hospital Center
      • Commack, New York, Forenede Stater, 11725
        • Memorial Sloan Kettering Commack
      • Cooperstown, New York, Forenede Stater, 13326
        • Mary Imogene Bassett Hospital
      • Fishkill, New York, Forenede Stater, 12524
        • Vassar Brothers Fishkill Radiation Oncology Center
      • Harrison, New York, Forenede Stater, 10604
        • Memorial Sloan Kettering Westchester
      • Kingston, New York, Forenede Stater, 12401
        • Ulster Radiation Oncology Center
      • New York, New York, Forenede Stater, 10065
        • Memorial Sloan-Kettering Cancer Center
      • New York, New York, Forenede Stater, 10032
        • Columbia University/Herbert Irving Cancer Center
      • Poughkeepsie, New York, Forenede Stater, 12601
        • Vassar Brothers Medical Center
      • Rochester, New York, Forenede Stater, 14621
        • Rochester General Hospital
      • Rochester, New York, Forenede Stater, 14623
        • Pluta Cancer Center
      • Rockville Centre, New York, Forenede Stater, 11570
        • Memorial Sloan Kettering Rockville Centre
      • Sleepy Hollow, New York, Forenede Stater, 10591
        • Memorial Sloan Kettering Sleepy Hollow
      • Syracuse, New York, Forenede Stater, 13210
        • State University of New York Upstate Medical University
    • North Carolina
      • Charlotte, North Carolina, Forenede Stater, 28203
        • Carolinas Medical Center/Levine Cancer Institute
      • Charlotte, North Carolina, Forenede Stater, 28204
        • Novant Health Presbyterian Medical Center
      • Charlotte, North Carolina, Forenede Stater, 28210
        • Carolinas Medical Center/Levine Cancer Institute-Pineville
      • Charlotte, North Carolina, Forenede Stater, 28262
        • Carolinas Medical Center/Levine Cancer Institute-University
      • Concord, North Carolina, Forenede Stater, 28025
        • Carolinas HealthCare System NorthEast
      • Durham, North Carolina, Forenede Stater, 27710
        • Duke University Medical Center
      • Gastonia, North Carolina, Forenede Stater, 28054
        • CaroMont Regional Medical Center
      • Greensboro, North Carolina, Forenede Stater, 27403
        • Cone Health Cancer Center
      • Greenville, North Carolina, Forenede Stater, 27858
        • East Carolina University
      • Matthews, North Carolina, Forenede Stater, 28105
        • Matthews Radiation Oncology Center
      • Monroe, North Carolina, Forenede Stater, 28112
        • Carolinas HealthCare System Union
      • Supply, North Carolina, Forenede Stater, 28462
        • South Atlantic Radiation Oncology
      • Wilmington, North Carolina, Forenede Stater, 28401
        • Coastal Carolina Radiation Oncology
    • North Dakota
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Sanford Bismarck Medical Center
    • Ohio
      • Akron, Ohio, Forenede Stater, 44304
        • Summa Akron City Hospital/Cooper Cancer Center
      • Akron, Ohio, Forenede Stater, 44307
        • Akron General Medical Center
      • Barberton, Ohio, Forenede Stater, 44203
        • Summa Barberton Hospital
      • Beachwood, Ohio, Forenede Stater, 44122
        • UHHS-Chagrin Highlands Medical Center
      • Canton, Ohio, Forenede Stater, 44710
        • Aultman Health Foundation
      • Chardon, Ohio, Forenede Stater, 44024
        • Geaugra Hospital
      • Cincinnati, Ohio, Forenede Stater, 45220
        • Good Samaritan Hospital - Cincinnati
      • Cincinnati, Ohio, Forenede Stater, 45242
        • Bethesda North Hospital
      • Cincinnati, Ohio, Forenede Stater, 45219
        • University of Cincinnati/Barrett Cancer Center
      • Cleveland, Ohio, Forenede Stater, 44106
        • Case Western Reserve University
      • Cleveland, Ohio, Forenede Stater, 44195
        • Cleveland Clinic Foundation
      • Cleveland, Ohio, Forenede Stater, 44111
        • Cleveland Clinic Cancer Center/Fairview Hospital
      • Columbus, Ohio, Forenede Stater, 43210
        • Ohio State University Comprehensive Cancer Center
      • Columbus, Ohio, Forenede Stater, 43219
        • The Mark H Zangmeister Center
      • Columbus, Ohio, Forenede Stater, 43222
        • Mount Carmel Health Center West
      • Delaware, Ohio, Forenede Stater, 43015
        • Delaware Radiation Oncology
      • Independence, Ohio, Forenede Stater, 44131
        • Cleveland Clinic Cancer Center Independence
      • Mayfield Heights, Ohio, Forenede Stater, 44124
        • Hillcrest Hospital Cancer Center
      • Medina, Ohio, Forenede Stater, 44256
        • Summa Health Center at Lake Medina
      • Mentor, Ohio, Forenede Stater, 44060
        • Lake University Ireland Cancer Center
      • Middleburg Heights, Ohio, Forenede Stater, 44130
        • Southwest General Health Center Ireland Cancer Center
      • Parma, Ohio, Forenede Stater, 44129
        • University Hospitals Parma Medical Center
      • Sandusky, Ohio, Forenede Stater, 44870
        • North Coast Cancer Care
      • Strongsville, Ohio, Forenede Stater, 44136
        • Cleveland Clinic Cancer Center Strongsville
      • West Chester, Ohio, Forenede Stater, 45069
        • University Pointe
      • Westlake, Ohio, Forenede Stater, 44145
        • UHHS-Westlake Medical Center
      • Wooster, Ohio, Forenede Stater, 44691
        • Cleveland Clinic Wooster Family Health and Surgery Center
    • Oklahoma
      • Lawton, Oklahoma, Forenede Stater, 73505
        • Cancer Centers of Southwest Oklahoma Research
      • Oklahoma City, Oklahoma, Forenede Stater, 73104
        • University of Oklahoma Health Sciences Center
      • Oklahoma City, Oklahoma, Forenede Stater, 73120
        • Mercy Hospital Oklahoma City
    • Oregon
      • Eugene, Oregon, Forenede Stater, 97401
        • Willamette Valley Cancer Center
      • Portland, Oregon, Forenede Stater, 97227
        • Kaiser Permanente Northwest
      • Portland, Oregon, Forenede Stater, 97227
        • Compass Oncology Rose Quarter
      • The Dalles, Oregon, Forenede Stater, 97058
        • Mid-Columbia Medical Center/Celilo Cancer Center
    • Pennsylvania
      • Allentown, Pennsylvania, Forenede Stater, 18103
        • Lehigh Valley Hospital-Cedar Crest
      • Beaver, Pennsylvania, Forenede Stater, 15009
        • UPMC-Heritage Valley Health System Beaver
      • Bethlehem, Pennsylvania, Forenede Stater, 18015
        • Saint Luke's University Hospital-Bethlehem Campus
      • Dunmore, Pennsylvania, Forenede Stater, 18512
        • Northeast Radiation Oncology Center
      • Ephrata, Pennsylvania, Forenede Stater, 17522
        • Ephrata Cancer Center
      • Erie, Pennsylvania, Forenede Stater, 16505
        • The Regional Cancer Center
      • Furlong, Pennsylvania, Forenede Stater, 18925
        • Fox Chase Cancer Center Buckingham
      • Gettysburg, Pennsylvania, Forenede Stater, 17325
        • Adams Cancer Center
      • Greensburg, Pennsylvania, Forenede Stater, 15601
        • UPMC Cancer Centers - Arnold Palmer Pavilion
      • Harrisburg, Pennsylvania, Forenede Stater, 17109
        • PinnacleHealth Cancer Center-Community Campus
      • Hershey, Pennsylvania, Forenede Stater, 17033-0850
        • Penn State Milton S Hershey Medical Center
      • Lancaster, Pennsylvania, Forenede Stater, 17604
        • Lancaster General Hospital
      • Meadowbrook, Pennsylvania, Forenede Stater, 19046
        • Holy Redeemer Hospital And Medical Center
      • Monroeville, Pennsylvania, Forenede Stater, 15146
        • Intercommunity Cancer Center
      • Moon, Pennsylvania, Forenede Stater, 15108
        • UPMC-Coraopolis/Heritage Valley Radiation Oncology
      • Natrona Heights, Pennsylvania, Forenede Stater, 15065
        • Allegheny Valley Hospital
      • Philadelphia, Pennsylvania, Forenede Stater, 19111
        • Fox Chase Cancer Center
      • Philadelphia, Pennsylvania, Forenede Stater, 19107
        • Thomas Jefferson University Hospital
      • Philadelphia, Pennsylvania, Forenede Stater, 19104
        • University of Pennsylvania/Abramson Cancer Center
      • Philadelphia, Pennsylvania, Forenede Stater, 19140
        • Temple University Hospital
      • Philadelphia, Pennsylvania, Forenede Stater, 19107
        • Pennsylvania Hospital
      • Pittsburgh, Pennsylvania, Forenede Stater, 15212
        • Allegheny General Hospital
      • Pittsburgh, Pennsylvania, Forenede Stater, 15213
        • UPMC-Magee Womens Hospital
      • Pittsburgh, Pennsylvania, Forenede Stater, 15232
        • UPMC-Shadyside Hospital
      • Pittsburgh, Pennsylvania, Forenede Stater, 15215
        • UPMC-Saint Margaret
      • West Reading, Pennsylvania, Forenede Stater, 19611
        • Reading Hospital
      • Wexford, Pennsylvania, Forenede Stater, 15090
        • Wexford Health and Wellness Pavilion
      • York, Pennsylvania, Forenede Stater, 17403
        • WellSpan Health-York Hospital
    • Rhode Island
      • Providence, Rhode Island, Forenede Stater, 02903
        • Rhode Island Hospital
      • Providence, Rhode Island, Forenede Stater, 02905
        • Women and Infants Hospital
      • Providence, Rhode Island, Forenede Stater, 02904
        • Radiation Oncology Associates Incorporated
      • Warwick, Rhode Island, Forenede Stater, 02886
        • Kent County Hospital
    • South Carolina
      • Charleston, South Carolina, Forenede Stater, 29425
        • Medical University of South Carolina
      • Charleston, South Carolina, Forenede Stater, 29401
        • Roper Hospital
      • Charleston, South Carolina, Forenede Stater, 29414
        • Bon Secours Saint Francis Hospital
      • Georgetown, South Carolina, Forenede Stater, 29440
        • Georgetown Hospital System
      • Greenville, South Carolina, Forenede Stater, 29607
        • Saint Francis Cancer Center
      • Greenville, South Carolina, Forenede Stater, 29605
        • Greenville Health System Cancer Institute-Andrews
      • Greenville, South Carolina, Forenede Stater, 29605
        • Greenville Health System Cancer Institute-Faris
      • Greenville, South Carolina, Forenede Stater, 29615
        • Greenville Health System Cancer Institute-Eastside
      • Greer, South Carolina, Forenede Stater, 29651
        • Gibbs Cancer Center-Pelham
      • Greer, South Carolina, Forenede Stater, 29650
        • Greenville Health System Cancer Institute-Greer
      • Hilton Head Island, South Carolina, Forenede Stater, 29926
        • The Radiation Oncology Center-Hilton Head/Bluffton
      • Seneca, South Carolina, Forenede Stater, 29672
        • Greenville Health System Cancer Institute-Seneca
      • Spartanburg, South Carolina, Forenede Stater, 29303
        • Spartanburg Medical Center
      • Spartanburg, South Carolina, Forenede Stater, 29307
        • Greenville Health System Cancer Institute-Spartanburg
      • West Columbia, South Carolina, Forenede Stater, 29169
        • Lexington Medical Center
    • South Dakota
      • Sioux Falls, South Dakota, Forenede Stater, 57105
        • Avera Cancer Institute
      • Sioux Falls, South Dakota, Forenede Stater, 57117-5134
        • Sanford USD Medical Center - Sioux Falls
    • Tennessee
      • Germantown, Tennessee, Forenede Stater, 38138
        • The West Clinic - Wolf River
      • Knoxville, Tennessee, Forenede Stater, 37916
        • Thompson Cancer Survival Center
      • Memphis, Tennessee, Forenede Stater, 38120
        • Baptist Memorial Hospital and Cancer Center-Memphis
      • Nashville, Tennessee, Forenede Stater, 37232
        • Vanderbilt University/Ingram Cancer Center
    • Texas
      • Abilene, Texas, Forenede Stater, 79606
        • Texas Cancer Center
      • Amarillo, Texas, Forenede Stater, 79106
        • The Don and Sybil Harrington Cancer Center
      • Arlington, Texas, Forenede Stater, 76014
        • Texas Oncology-Arlington South
      • Austin, Texas, Forenede Stater, 78705
        • Texas Oncology-Austin Midtown
      • Austin, Texas, Forenede Stater, 78731
        • Texas Oncology - Central Austin Cancer Center
      • Austin, Texas, Forenede Stater, 78745
        • Texas Oncology - South Austin Cancer Center
      • Bedford, Texas, Forenede Stater, 76022
        • Texas Oncology Bedford
      • Dallas, Texas, Forenede Stater, 75235
        • Parkland Memorial Hospital
      • Dallas, Texas, Forenede Stater, 75390
        • UT Southwestern/Simmons Cancer Center-Dallas
      • Flower Mound, Texas, Forenede Stater, 75028
        • Texas Oncology-Flower Mound
      • Fort Worth, Texas, Forenede Stater, 76104
        • The Klabzuba Cancer Center
      • Houston, Texas, Forenede Stater, 77030
        • M D Anderson Cancer Center
      • Houston, Texas, Forenede Stater, 77030
        • The Methodist Hospital System
      • Houston, Texas, Forenede Stater, 77094
        • MD Anderson Regional Care Center-Katy
      • Houston, Texas, Forenede Stater, 77024
        • Memorial Hermann Memorial City Medical Center
      • Laredo, Texas, Forenede Stater, 78041
        • Doctor's Hospital of Laredo
      • Lubbock, Texas, Forenede Stater, 79415
        • University Medical Center
      • Lubbock, Texas, Forenede Stater, 79410
        • Covenant Medical Center-Lakeside
      • Lubbock, Texas, Forenede Stater, 79430
        • Texas Tech University Health Sciences Center-Lubbock
      • Nassau Bay, Texas, Forenede Stater, 77058
        • MD Anderson Regional Care Center-Bay Area
      • Plano, Texas, Forenede Stater, 75093
        • Texas Oncology-Plano West
      • Round Rock, Texas, Forenede Stater, 78681
        • Texas Oncology - Round Rock Cancer Center
      • Round Rock, Texas, Forenede Stater, 78665
        • Scott and White Healthcare Round Rock
      • San Antonio, Texas, Forenede Stater, 78229
        • University of Texas Health Science Center at San Antonio
      • Sherman, Texas, Forenede Stater, 75090
        • Texas Cancer Center-Sherman
      • Sugar Land, Texas, Forenede Stater, 77478
        • MD Anderson Regional Care Center-Sugar Land
      • Sugar Land, Texas, Forenede Stater, 77479
        • Texas Oncology Cancer Center Sugar Land
      • Temple, Texas, Forenede Stater, 76508
        • Scott and White Memorial Hospital
      • The Woodlands, Texas, Forenede Stater, 77384
        • MD Anderson Regional Care Center-The Woodlands
      • Webster, Texas, Forenede Stater, 77598
        • Deke Slayton Cancer Center
    • Utah
      • Murray, Utah, Forenede Stater, 84107
        • Intermountain Medical Center
      • Provo, Utah, Forenede Stater, 84604
        • Utah Valley Regional Medical Center
      • Salt Lake City, Utah, Forenede Stater, 84112
        • Huntsman Cancer Institute/University of Utah
      • South Jordan, Utah, Forenede Stater, 84009
        • South Jordan Health Center
    • Vermont
      • Saint Johnsbury, Vermont, Forenede Stater, 05819
        • Norris Cotton Cancer Center-North
    • Virginia
      • Alexandria, Virginia, Forenede Stater, 22304
        • Inova Alexandria Hospital
      • Charlottesville, Virginia, Forenede Stater, 22908
        • University of Virginia Cancer Center
      • Falls Church, Virginia, Forenede Stater, 22042
        • INOVA Fairfax Hospital
      • Fishersville, Virginia, Forenede Stater, 22939
        • Augusta Health Cancer Center
      • Fredericksburg, Virginia, Forenede Stater, 22401
        • Mary Washington Hospital
      • Hampton, Virginia, Forenede Stater, 23666
        • Sentara Cancer Institute at Sentara CarePlex Hospital
      • Norfolk, Virginia, Forenede Stater, 23507
        • Sentara Norfolk General Hospital
      • Portsmouth, Virginia, Forenede Stater, 23708-2197
        • Naval Medical Center - Portsmouth
      • Richmond, Virginia, Forenede Stater, 23298
        • Virginia Commonwealth University/Massey Cancer Center
      • Roanoke, Virginia, Forenede Stater, 24014
        • Oncology and Hematology Associates of Southwest Virginia
      • Virginia Beach, Virginia, Forenede Stater, 23454
        • Sentara Virginia Beach General Hospital
    • Washington
      • Auburn, Washington, Forenede Stater, 98001
        • MultiCare Auburn Medical Center
      • Bellevue, Washington, Forenede Stater, 98004
        • Overlake Hospital Medical Center
      • Bremerton, Washington, Forenede Stater, 98310
        • Harrison Medical Center
      • Federal Way, Washington, Forenede Stater, 98002
        • Virginia Mason Federal Way Medical Center
      • Gig Harbor, Washington, Forenede Stater, 98332
        • Tacoma/Valley Radiation Oncology Centers-Gig Harbor
      • Gig Harbor, Washington, Forenede Stater, 98335
        • MultiCare Gig Harbor Medical Park
      • Kennewick, Washington, Forenede Stater, 99336
        • Tri-Cities Cancer Center
      • Mount Vernon, Washington, Forenede Stater, 98273
        • Skagit Valley Hospital Regional Cancer Care Center
      • Puyallup, Washington, Forenede Stater, 98372
        • MultiCare Good Samaritan Hospital
      • Puyallup, Washington, Forenede Stater, 98372
        • Tacoma/Valley Radiation Oncology Centers-Puyallup
      • Seattle, Washington, Forenede Stater, 98109
        • Fred Hutchinson Cancer Research Center
      • Seattle, Washington, Forenede Stater, 98109
        • Seattle Cancer Care Alliance
      • Seattle, Washington, Forenede Stater, 98195
        • University of Washington Medical Center
      • Seattle, Washington, Forenede Stater, 98101
        • Virginia Mason Medical Center
      • Spokane, Washington, Forenede Stater, 99202
        • Cancer Care Northwest - Spokane South
      • Spokane, Washington, Forenede Stater, 99208
        • Spokane Valley Cancer Center-Mayfair
      • Tacoma, Washington, Forenede Stater, 98405
        • Northwest Medical Specialties PLLC
      • Tacoma, Washington, Forenede Stater, 98405
        • MultiCare Tacoma General Hospital
      • Tacoma, Washington, Forenede Stater, 98405
        • Tacoma/Valley Radiation Oncology Centers-Saint Joe's
      • Tacoma, Washington, Forenede Stater, 98405
        • Saint Joseph Medical Center
      • Vancouver, Washington, Forenede Stater, 98684
        • Compass Oncology Vancouver
    • West Virginia
      • Morgantown, West Virginia, Forenede Stater, 26506
        • West Virginia University Healthcare
    • Wisconsin
      • Antigo, Wisconsin, Forenede Stater, 54409
        • Langlade Hospital and Cancer Center
      • Appleton, Wisconsin, Forenede Stater, 54911
        • ThedaCare Regional Cancer Center
      • Appleton, Wisconsin, Forenede Stater, 54911
        • Fox Valley Surgical Associates Limited
      • Appleton, Wisconsin, Forenede Stater, 54911
        • Radiology Associates of Appleton/ThedaCare Regional Medical Center
      • Eau Claire, Wisconsin, Forenede Stater, 54701
        • Sacred Heart Hospital
      • Grafton, Wisconsin, Forenede Stater, 53024
        • Aurora Cancer Care-Grafton
      • Green Bay, Wisconsin, Forenede Stater, 54311
        • Aurora BayCare Medical Center
      • Green Bay, Wisconsin, Forenede Stater, 54301
        • Saint Vincent Hospital Cancer Center Green Bay
      • Green Bay, Wisconsin, Forenede Stater, 54303
        • Saint Vincent Hospital Cancer Center at Saint Mary's
      • Johnson Creek, Wisconsin, Forenede Stater, 53038
        • UW Cancer Center Johnson Creek
      • Kenosha, Wisconsin, Forenede Stater, 53142
        • Aurora Cancer Care-Kenosha South
      • La Crosse, Wisconsin, Forenede Stater, 54601
        • Gundersen Lutheran Medical Center
      • La Crosse, Wisconsin, Forenede Stater, 54601
        • Mayo Clinic Health System-Franciscan Healthcare
      • Madison, Wisconsin, Forenede Stater, 53792
        • University of Wisconsin Hospital and Clinics
      • Marshfield, Wisconsin, Forenede Stater, 54449
        • Marshfield Clinic
      • Marshfield, Wisconsin, Forenede Stater, 54449
        • Saint Joseph's Hospital
      • Menomonee Falls, Wisconsin, Forenede Stater, 53051
        • Community Memorial Hospital
      • Milwaukee, Wisconsin, Forenede Stater, 53226
        • Froedtert and The Medical College of Wisconsin
      • Milwaukee, Wisconsin, Forenede Stater, 53215
        • Aurora Saint Luke's Medical Center
      • Milwaukee, Wisconsin, Forenede Stater, 53233
        • Aurora Sinai Medical Center
      • Minocqua, Wisconsin, Forenede Stater, 54548
        • Marshfield Clinic-Minocqua Center
      • Neenah, Wisconsin, Forenede Stater, 54956
        • Surgical Associates of Neenah SC
      • Oconomowoc, Wisconsin, Forenede Stater, 53066
        • ProHealth Oconomowoc Memorial Hospital
      • Oshkosh, Wisconsin, Forenede Stater, 54904
        • Vince Lombardi Cancer Clinic - Oshkosh
      • Racine, Wisconsin, Forenede Stater, 53405
        • Wheaton Franciscan Cancer Care - All Saints
      • Rice Lake, Wisconsin, Forenede Stater, 54868
        • Marshfield Clinic-Rice Lake Center
      • Stevens Point, Wisconsin, Forenede Stater, 54482
        • Marshfield Clinic Stevens Point Center
      • Stevens Point, Wisconsin, Forenede Stater, 54481
        • Saint Michael's Hospital
      • Summit, Wisconsin, Forenede Stater, 53066
        • Aurora Medical Center in Summit
      • Two Rivers, Wisconsin, Forenede Stater, 54241
        • Vince Lombardi Cancer Clinic-Two Rivers
      • Waukesha, Wisconsin, Forenede Stater, 53188
        • UW Cancer Center at ProHealth Care
      • Waukesha, Wisconsin, Forenede Stater, 53188
        • ProHealth Waukesha Memorial Hospital
      • Wausau, Wisconsin, Forenede Stater, 54401
        • Aspirus Regional Cancer Center
      • Wauwatosa, Wisconsin, Forenede Stater, 53226
        • Aurora Cancer Care-Milwaukee West
      • West Allis, Wisconsin, Forenede Stater, 53227
        • Aurora West Allis Medical Center
      • West Bend, Wisconsin, Forenede Stater, 53095
        • The Alyce and Elmore Kraemer Cancer Care Center
      • Weston, Wisconsin, Forenede Stater, 54476
        • Diagnostic and Treatment Center
  • Irland
    • Co Dublin
      • Dublin, Co Dublin, Irland, 6
        • Saint Lukes Hospital
    • Co Galway
      • Galway, Co Galway, Irland
        • University College Hospital Galway
  • Israel
      • Tel Hashomer, Israel, 52621
        • Chaim Sheba Medical Center
  • Japan
      • Matsuyama, Japan, 791-0280
        • Shikoku Cancer Center
      • Saitama, Japan, 350-1298
        • Saitama Medical University International Medical Center
    • Aoba-ku
      • Sendai, Aoba-ku, Japan, 980-8574
        • Tohoku University School of Medicine
    • Hokkaido
      • Sapporo, Hokkaido, Japan, 060-8648
        • Hokkaido University Hospital
    • Hyogo
      • Akashi-city, Hyogo, Japan, 673-8558
        • Hyogo Cancer Center
    • Iwate
      • Morioka, Iwate, Japan, 020-8505
        • Iwate Medical University School of Medicine
    • Maebashi
      • Gunma, Maebashi, Japan, 371-8511
        • Gunma University Hospital
    • Niigata
      • Niigata City, Niigata, Japan, 951-8520
        • Niigata University Medical and Dental Hospital
  • Korea, Republikken
      • Seoul, Korea, Republikken, 120-752
        • Yonsei University Health System-Severance Hospital
  • Puerto Rico
      • San Juan, Puerto Rico, 00936
        • San Juan City Hospital

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

  • Patienten skal have underskrevet og dateret en Institutional Review Board (IRB)-godkendt samtykkeformular, der er i overensstemmelse med føderale og institutionelle retningslinjer
  • Patienten skal have en Eastern Cooperative Oncology Group (ECOG) præstationsstatus på 0 eller 1
  • Patienten skal have klinisk T1-3, N1 brystkræft på diagnosetidspunktet (før neoadjuverende behandling); Klinisk aksillær nodal involvering kan vurderes ved palpation, ultralyd, CT-scanning, magnetisk resonansbilleddannelse (MRI), positronemissionstomografi (PET)-scanning eller PET/CT-scanning
  • Patienten skal have haft patologisk bekræftelse af aksillær nodal involvering ved præsentationen (før neoadjuverende terapi) baseret på enten en positiv finnålsaspirat (FNA) (demonstrerer maligne celler) eller positiv kernenålebiopsi (demonstrerer invasivt adenokarcinom); FNA- eller kernenål-biopsien kan udføres enten ved palpation eller ved billedvejledning; dokumentation af aksillær nodal positivitet ved sentinel node biopsi (før neoadjuverende terapi) er ikke tilladt
  • Patienterne skal have fået udført østrogenreceptoranalyse (ER) på den primære brysttumor før neoadjuverende terapi i henhold til gældende retningslinjer fra American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) for hormonreceptortestning; hvis negativ for ER, skal vurdering af progesteronreceptor (PgR) også udføres i henhold til gældende ASCO/CAP-retningslinjer for hormonreceptortestning (http://www.asco.org)
  • Patienterne skal have fået foretaget HER2-testning på den primære brysttumor før neoadjuverende kemoterapi i henhold til de nuværende ASCO/CAP-retningslinjer for testning af human epidermal vækstfaktor receptor 2 i brystkræft (http://www.asco.org); patienter, der har en primær tumor, der enten er HER2-positiv eller HER2-negativ, er kvalificerede
  • Patienten skal have gennemført mindst 8 ugers standard neoadjuverende kemoterapi bestående af et antracyklin- og/eller taxan-baseret regime
  • For patienter, der får adjuverende kemoterapi efter operationen, kan der maksimalt gives 12 ugers påtænkt kemoterapi, men skal afsluttes før randomisering; (hvis behandlingsforsinkelser opstår, skal kemoterapi afsluttes inden for 14 uger); dosis og tidsplan for den adjuverende kemoterapi er efter investigators skøn; Bemærk: Det foretrækkes, at al påtænkt kemoterapi administreres i neoadjuverende omgivelser
  • Patienter med HER2-positive tumorer skal have modtaget neoadjuverende anti-HER2-behandling (enten med hele eller med en del af den neoadjuverende kemoterapikur), medmindre det er medicinsk kontraindiceret

  • På tidspunktet for den endelige operation skal alle fjernede aksillære knuder være histologisk fri for cancer; acceptable procedurer til vurdering af aksillær nodal status på operationstidspunktet omfatter:

    • Akselknudedissektion
    • Sentinel node biopsi alene eller
    • Sentinel node biopsi efterfulgt af aksillær node dissektion
    • Bemærk: Patienter er kvalificerede, uanset om der er resterende invasivt karcinom i den kirurgiske brystprøve, eller om der er tegn på patologisk fuldstændig respons; patienter, der viser sig at være patologisk node-positive på operationstidspunktet, baseret på sentinel node biopsi alene, er kandidater til A011202, en undersøgelse udviklet af Alliance in Oncology, en NCI Cooperative Group; hvis A011202 er åben på investigators institution, skal patienter kontaktes om deltagelse i A011202 undersøgelsen
  • Patienter med patologisk stadieinddeling af ypN0(i+) eller ypN0(mol+) er kvalificerede (Bemærk: Postneoadjuverende terapi er udpeget med et "yp"-præfiks.)
  • Patienter, der har gennemgået enten en total mastektomi eller en lumpektomi er berettiget
  • For patienter, der gennemgår lumpektomi, skal marginerne af den resekerede prøve eller re-excision være histologisk fri for invasiv tumor og DCIS som bestemt af den lokale patolog; yderligere operative procedurer kan udføres for at opnå klare marginer; hvis tumor stadig er til stede ved den resekerede margin efter re-excision(er), skal patienten gennemgå total mastektomi for at være berettiget; (patienter med marginer positive for lobulært karcinom in situ [LCIS] er kvalificerede uden yderligere resektion)
  • For patienter, der gennemgår mastektomi, skal marginerne være histologisk fri for resterende (mikroskopisk eller grov) tumor
  • Intervallet mellem den sidste operation for brystkræft (inklusive re-excision af marginer) og randomisering må ikke være mere end 70 dage; også, hvis der blev givet adjuverende kemoterapi, må intervallet mellem den sidste kemoterapibehandling og randomisering ikke være mere end 70 dage
  • Patienten skal være kommet sig efter operationen med snittet fuldstændigt helet og ingen tegn på infektion
  • Hvis der blev givet adjuverende kemoterapi, burde kemoterapirelateret toksicitet, der kan interferere med levering af strålebehandling, være forsvundet

Ekskluderingskriterier:

  • Endelige kliniske eller radiologiske tegn på metastatisk sygdom
  • T4-tumorer inklusive inflammatorisk brystkræft
  • Dokumentation af aksillær nodal positivitet før neoadjuverende terapi alene ved sentinel node biopsi
  • N2- eller N3-sygdom påvist klinisk eller ved billeddiagnostik
  • Patienter med histologisk positive aksillære knuder efter neoadjuverende terapi
  • Patienter med mikroskopiske positive marginer efter endelig operation
  • Synkron eller tidligere kontralateral invasiv brystkræft eller DCIS; (patienter med synkrone og/eller tidligere kontralaterale LCIS er berettigede)
  • Enhver tidligere historie, ikke inklusive indekscancer, af ipsilateral invasiv brystkræft eller ipsilateral DCIS behandlet med strålebehandling; (patienter med synkron eller tidligere ipsilateral LCIS er kvalificerede)
  • Anamnese med ikke-brystmaligniteter (bortset fra in situ kræftformer kun behandlet ved lokal excision og basalcelle- og pladecellekarcinomer i huden) inden for 5 år før randomisering
  • Enhver strålebehandling af den aktuelt diagnosticerede brystkræft forud for randomisering
  • Enhver fortsat brug af kønshormonbehandling, f.eks. p-piller, ovariehormonerstatningsterapi; patienter er berettigede, hvis disse lægemidler seponeres før randomisering
  • Forudgående bryst- eller thoraxstrålebehandling (RT) for enhver tilstand
  • Aktiv kollagen vaskulær sygdom, specifikt dermatomyositis med et kreatinin phosphokinase (CPK) niveau over det normale eller med et aktivt hududslæt, systemisk lupus erythematosus eller sklerodermi
  • Graviditet eller amning på tidspunktet for studiestart; (Bemærk: Graviditetstest skal udføres inden for 2 uger før randomisering i henhold til institutionelle standarder for kvinder i den fødedygtige alder)
  • Anden ikke-malign systemisk sygdom, der ville forhindre patienten i at modtage undersøgelsesbehandling eller ville forhindre nødvendig opfølgning
  • Psykiatriske eller vanedannende lidelser eller andre tilstande, der efter investigatorens mening vil forhindre patienten i at opfylde undersøgelseskravene

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Aktiv komparator: Gruppe 1A Lumpektomi: ingen regional nodal XRT med WBI
Lumpektomipatienter gennemgår strålebehandling af hele brystet ved hjælp af IMRT eller 3D-CRT en gang dagligt 5 dage om ugen i 5 uger efterfulgt af et strålebehandlingsboost til lumpektomihulen en gang dagligt 5 dage om ugen i 1-1/2 uge.
Stråling: WBI
Andre navne:
  • Helbrystbestråling (WBI)
Ingen indgriben: Gruppe 1B Mastektomi: Ingen regional nodal eller brystvæg XRT
Mastektomipatienter gennemgår ikke strålebehandling.
Eksperimentel: Gruppe 2A lumpektomi: Regional nodal XRT med WBI
Lumpektomipatienter gennemgår regional nodal strålebehandling med strålebehandling af hele brystet ved hjælp af IMRT eller 3D-CRT én gang dagligt 5 dage om ugen i 5 uger efterfulgt af et stråleterapi-boost til lumpektomihulen én gang dagligt 5 dage om ugen i 1-1/2 uge. .
Stråling: WBI
Andre navne:
  • Helbrystbestråling (WBI)
Stråling: regional nodal XRT
Andre navne:
  • XRT: Ekstern strålebehandling
Eksperimentel: Gruppe 2B Mastektomi: Regional nodal XRT og brystvæg XRT
Mastektomipatienter gennemgår regional nodal strålebehandling ved hjælp af IMRT eller 3D-CRT en gang dagligt 5 dage om ugen i 5 uger.
Stråling: regional nodal XRT
Andre navne:
  • XRT: Ekstern strålebehandling
Stråling: chestwall XRT
Andre navne:
  • XRT: Ekstern strålebehandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Tidsramme
IBC-RFI
Tidsramme: Tid fra randomisering til invasiv lokal, regional eller fjern recidiv eller død som følge af brystkræft, vurderet op til 10 år
Tid fra randomisering til invasiv lokal, regional eller fjern recidiv eller død som følge af brystkræft, vurderet op til 10 år

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
OS
Tidsramme: Tid fra randomisering til død uanset årsag, vurderet op til 10 år
Tid fra randomisering til død uanset årsag, vurderet op til 10 år
LRRFI
Tidsramme: Tid fra randomisering til tilbagefald af primær cancer m/i bryst eller lymfeknuder i ipsilateral aksill, infraclavicular fossa eller ipsilateral intern brystkæde uden tegn på fjern sygdom eller død på grund af brystkræft, vurderet op til 10 år
Tid fra randomisering til tilbagefald af primær cancer m/i bryst eller lymfeknuder i ipsilateral aksill, infraclavicular fossa eller ipsilateral intern brystkæde uden tegn på fjern sygdom eller død på grund af brystkræft, vurderet op til 10 år
DRFI
Tidsramme: Tid fra randomisering til udvikling af tumor i alle områder ud over lokale eller regionale grænser, eller død på grund af brystkræft, vurderet op til 10 år
Tid fra randomisering til udvikling af tumor i alle områder ud over lokale eller regionale grænser, eller død på grund af brystkræft, vurderet op til 10 år
DFS-DCIS
Tidsramme: Tid fra randomisering til lokalt recidiv efter mastektomi/ipsilateral bryst post-lumpektomi, regionalt/fjern recidiv, kontralateral sygdom, anden primær cancer eller død af en hvilken som helst årsag før recidiv eller SPC, vurderet op til 10 år
Tid fra randomisering til lokalt recidiv efter mastektomi/ipsilateral bryst post-lumpektomi, regionalt/fjern recidiv, kontralateral sygdom, anden primær cancer eller død af en hvilken som helst årsag før recidiv eller SPC, vurderet op til 10 år
Tid til SPC
Tidsramme: Tid fra randomisering til udvikling af en anden primær invasiv cancer på et hvilket som helst sted undtagen plade- og basalcellekarcinom i huden, vurderet op til 10 år
Tid fra randomisering til udvikling af en anden primær invasiv cancer på et hvilket som helst sted undtagen plade- og basalcellekarcinom i huden, vurderet op til 10 år
Effekt af strålebehandling på kosmetisk resultat hos mastektomi- og lumpektomipatienter vurderet ved livskvalitetsspørgeskema
Tidsramme: Vurderet før randomisering, 3 måneder eller ved slutningen af ​​RT, og 6, 12 og 24 måneder fra randomisering
Vurderet før randomisering, 3 måneder eller ved slutningen af ​​RT, og 6, 12 og 24 måneder fra randomisering
Hyppigheder af uønskede hændelser klassificeret i henhold til Common Terminology Criteria for Adverse Events (CTCAE) version 4.0
Tidsramme: Op til 30 dage efter afsluttet undersøgelsesbehandling
Op til 30 dage efter afsluttet undersøgelsesbehandling
Molekylære forudsigere for tilbagefald
Tidsramme: Vævsprøver indsamlet inden for 90 dage efter randomisering
At teste den prognostiske rolle af genekspressionsprofiler i resterende tumorvæv og at udvikle prædiktorer for graden af ​​reduktion af lokoregionalt tilbagefald.
Vævsprøver indsamlet inden for 90 dage efter randomisering

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

NSABP Foundation Inc

Samarbejdspartnere

National Cancer Institute (NCI)
Radiation Therapy Oncology Group

Efterforskere

  • Ledende efterforsker: Norman Wolmark, MD, NSABP Foundation Inc

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. august 2013

Primær færdiggørelse (Faktiske)

14. september 2023

Studieafslutning (Anslået)

1. august 2028

Datoer for studieregistrering

Først indsendt

3. juni 2013

Først indsendt, der opfyldte QC-kriterier

6. juni 2013

Først opslået (Anslået)

7. juni 2013

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Anslået)

27. december 2023

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

20. december 2023

Sidst verificeret

1. december 2023

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • NSABP-B-51
  • U10CA012027 (U.S. NIH-bevilling/kontrakt)
  • NCI-2012-03198 (Registry Identifier: CTRP (Clinical Trial Reporting Program))

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Abonner