Dual Time Point PET in Lymphoma
This study aims to investigate the value of dual time point PET/CT in lymphoma. Since FDG uptake is linked to glucose metabolism, PET imaging is also used to detect suspected sites for infectious and inflammatory disorders. In a clinical setting, it is a challenge to distinguish between FDG uptake in benign and malignant lesions and this gives rise to a considerable quantity of false positive results and decreased positive predictive values. Performing FDG-PET imaging sixty minutes after injection is common practice in the staging and surveillance of lymphoma but this procedure may not be optimal, especially not in settings where benign inflammatory lesions are of clinical concern.
In an attempt to find an alternative method for this discrimination, dual time point FDG-PET was introduced. This technique has shown itself to be a potentially promising method in FDG-PET imaging for distinguishing between malignant and benign lesions using SUV values. The reason for the different FDG uptake patterns between inflammatory and malignant lesions is unclear. Several factors may contribute to this phenomenon on a cellular basis. It has been shown that cancer cells exhibit increased numbers of glucose transporter and low level of glucose-6-phosphatase. Varying levels between different cancer cell types may explain the different FDG uptake curves. Because various cell types exhibit varying rates of FDG uptake we believe that kinetic investigation may prove to be of value in understanding different types of lymphoma and identifying how to perform precise imaging for staging and surveillance.
Studieoversigt
Status
Betingelser
Undersøgelsestype
Tilmelding (Forventet)
Kontakter og lokationer
Studiesteder
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Odense, Danmark, 5000
- Rekruttering
- Odense University Hospital, Department of hematology
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Kontakt:
- Karen Mylam, MD
- Telefonnummer: 0045 6441 3186
- E-mail: karen.mylam@rsyd.dk
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Ledende efterforsker:
- Karen Juul Mylam, MD
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Roskilde, Danmark, 4000
- Ikke rekrutterer endnu
- Roskilde Hospital
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Kontakt:
- Lars Møller Pedersen, MD
- E-mail: lmpn@regionsjaelland.dk
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Underforsker:
- Lars Møller Pedersen, MD
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Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Prøveudtagningsmetode
Studiebefolkning
Beskrivelse
Inclusion Criteria:
- Age>18 years
- Planned for curative treatment
Exclusion Criteria:
- Previously treatment with chemotherapy or irradiation
- Primary CNS lymphoma
- Recurrent lymphoma
- Transformation from indolent lymphoma
- Presence of diabetes mellitus, HIV, chronic inflammatory disease or infections
- Pregnancy or lactation
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Kohorter og interventioner
Gruppe / kohorte |
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Patients with suspected lymphoma.
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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Progression Free Survival
Tidsramme: 2 years
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To evaluate the predictive value of PET after 60min compared to PET after 180min in terms of outcome.
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2 years
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Progression free survival
Tidsramme: 3 years
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To evaluate the predictive value of PET after 60min compared to PET after 180min in terms of outcome.
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3 years
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Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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Overall survival
Tidsramme: 2 years, 3 years
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To evaluate the predictive value of PET after 60min compared to PET after 180min in terms of outcome.
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2 years, 3 years
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Andre resultatmål
Resultatmål |
Tidsramme |
|---|---|
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To compare SUVmax with the expression of GLUT1, hexokinase, G6Pase in lymphoma cells
Tidsramme: 1 day (After diagnostic biopsy)
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1 day (After diagnostic biopsy)
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Samarbejdspartnere og efterforskere
Sponsor
Datoer for undersøgelser
Studer store datoer
Studiestart
Primær færdiggørelse (Forventet)
Studieafslutning (Forventet)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Skøn)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- 10.06b
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