Salivary Antioxidant Capacity Before and After Complete Dental Rehabilitation
Salivary Antioxidant Capacity of Children With Severe Early Childhood Caries (S-ECC) Before and After Complete Dental Rehabilitation
Studieoversigt
Status
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
Background: The association of total salivary antioxidant capacity (TAC) to severe early childhood caries (S-ECC) has been studied in the past. It is not clear if TAC is an indicator of the inflammatory response to the lesion or a marker of the disease.
Aim: This study aimed to measure the salivary TAC levels in children with early childhood caries before and after dental treatment and compare the results to caries free children.
Methodology: Salivary samples were obtained from 20 children in their fifth year of life diagnosed S-ECC and 20 age and gendersex matched controls. Complete dental rehabilitation under general anesthesia was performed for the 20 children with S-ECC, and follow up salivary samples were obtained one week and three months post operatively. The TAC was measured using a commercially available Oxygen Radical Absorbance Antioxidant Assay measurement kit (Zen-Bio ORAC™, AMS Biotechnology, Abington UK).
Undersøgelsestype
Tilmelding (Faktiske)
Kontakter og lokationer
Studiesteder
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Riyadh, Saudi Arabien
- Riyadh Colleges of Dentistry and Pharmacy
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Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Prøveudtagningsmetode
Studiebefolkning
- Children who are on long term medications,
- Children with chronic diseases
- Children who have had an infection less than three weeks prior to collection of saliva
Beskrivelse
Inclusion Criteria:
- Medically fit children
- Age below 71 months
- Test group - to be diagnosed with severe ECC
- Control group - to be caries free
Exclusion Criteria:
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Kohorter og interventioner
Gruppe / kohorte |
Intervention / Behandling |
|---|---|
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S-ECC
Children in their fifth year of life with severe early childhood caries Children selected will require complete dental rehabilitation under general anesthesia All enrolled children will receive treatment of all dental carious lesions under general anesthesia
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Dental treatment of all teeth affected by dental caries in a single visit under general anesthesia
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|
Control
Children age and sex matched with the S-ECC group who are free of dental caries
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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Change in TAC after one week
Tidsramme: One week
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Change in Total Salivary Antioxidant Capacity of children from baseline to one week after treatment
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One week
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Change in TAC after Three months
Tidsramme: Three months
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Change in Total Salivary Antioxidant Capacity of children from baseline to three months after treatment
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Three months
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Samarbejdspartnere og efterforskere
Efterforskere
- Ledende efterforsker: Sharat C Pani, MDS, Riyadh Colleges of Dentistry and Pharmacy
Datoer for undersøgelser
Studer store datoer
Studiestart (Faktiske)
Primær færdiggørelse (Faktiske)
Studieafslutning (Faktiske)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Faktiske)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- FPGRP/ /43435005/126
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
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