Cytokine-guided Robotic Cystectomy (CY-ROC)
Diagnostic Accuracy of Increased Serum Cytokine Levels as a Marker of Paralytic Ileus Following Robotic Radical Cystectomy
There is a recognised complication of surgery known as a 'Paralytic Ileus', where bowel function is reduced after an operation, causing an obstruction and resulting in nausea and vomiting. This complication is more common in patients that have robotic surgery due to the positioning required and the gas pressures required for keyhole/robotic surgery. While some of the factors involved in a paralytic ileus are known, the full mechanism and the chemicals involved are not yet fully understood.
This study is looking at the level of specific chemicals called 'cytokines', and the changes in the level of these cytokines in the blood before and after robotic surgery, specifically during bladder removal (cystectomy). Cytokine levels will be compared against post-operative recovery and whether a paralytic ileus is developed.
Studieoversigt
Status
Betingelser
Detaljeret beskrivelse
Cytokines are signalling proteins that are release by immune cells in response to stress on the body. In this study the aim is to evaluate the concordance between cytokine rise (specifically monitoring the following cytokines: Interferon (IFN)-gamma, tumour necrosis factor (TNF)-alpha, Interleukin (IL) -1beta, IL-2, IL-4, IL-6, IL-12 and IL-17) and postoperative ileus (a condition where bowel function slows causing build up of faecal matter) following robotic radical cystectomy and the pneumoperitoneum (gas insufflation of the abdomen) pressures that were required intra-operatively.
This study includes patients undergoing radical cystectomy. The study will measure pre-anaesthetic, post-anaesthetic, immediately post-operatively and two further post-operative serum cytokines levels and compare them with the pneumoperitoneal pressures required intra-operatively and the outcome of whether a clinical diagnosis of paralytic ileus was made.
Serum cytokine levels will be taken on five occasions:
- st Sample (Baseline)-Before induction of anaesthetic
- nd Sample-Immediately after induction of anaesthetic
- rd Sample-Immediately post-operative
- th Sample - 2 hours post-operative
- th Sample - 1 day post-operative
No alterations will be made to the care of the patient, this is purely an observational study.
Undersøgelsestype
Tilmelding (Forventet)
Kontakter og lokationer
Studiesteder
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Hertfordshire
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Stevenage, Hertfordshire, Det Forenede Kongerige, SG14AB
- Rekruttering
- East and North Hertfordshire NHS Trust
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Kontakt:
- Nikhil Vasdev, ChM (Urol), FRCS (Urol)
- Telefonnummer: 01438 28 4042
- E-mail: nikhil.vasdev@nhs.net
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Kontakt:
- Alexander Hampson, MBBS
- Telefonnummer: 01438 28 4042
- E-mail: alexander.hampson@nhs.net
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Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Prøveudtagningsmetode
Studiebefolkning
Beskrivelse
Inclusion Criteria:
- Patients aged between 40 and 75 years of age
- Patients undergoing a Robotic radical cystectomy
- Patient consenting to enter the study
- Patients consenting for blood samples for cytokine analysis
Exclusion Criteria:
- Patients <40 years of age and patients >75 years of age
- Patients unwilling or unable to consent
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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Correlation between cytokine rise (intra-and post-operatively) and postoperative ileus following robotic radical cystectomy
Tidsramme: 24 hours post-surgery
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Serum cytokine levels
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24 hours post-surgery
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Samarbejdspartnere og efterforskere
Samarbejdspartnere
Datoer for undersøgelser
Studer store datoer
Studiestart (Faktiske)
Primær færdiggørelse (Forventet)
Studieafslutning (Forventet)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Faktiske)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Andre undersøgelses-id-numre
- RD2018-65
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
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