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Anxiety Levels in Living Liver Donors

7. september 2026 opdateret af: Zekine Begec, Inonu University

Evaluation of Preoperative and Postoperative Anxiety in Living Liver Donors

Anxiety is a state of worry and apprehension caused by internal and external threats. High preoperative anxiety levels have been associated with increased anesthetic requirements, higher morbidity, and mortality rates. In adult patients undergoing various surgical procedures, preoperative anxiety rates have been reported to range from 11% to 80%. Most studies show that postoperative anxiety levels are related to preoperative anxiety levels. In patients undergoing general anesthesia, anxiety levels increase a few days after surgery as issues related to recovery and pain become apparent. Patients with high postoperative anxiety levels have also been reported to have a higher rate of medical complications.

Studieoversigt

Status

Rekruttering

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Liver transplantation is the only treatment for end-stage liver disease. The shortage of organ donations is leading clinicians to increasingly perform transplants from living donors. The biggest concern in living-donor liver transplantation is donor safety.

Liver donors undergo a major surgical operation that offers no medical benefit to them. The procedure can involve not only a physical but also a psychological burden. Given this situation, protecting both the physical and psychological health of liver donors is essential.

Anxiety studies primarily focus on organ transplant recipients However, the quality of life of donors and psychological conditions such as anxiety and depression are attracting increasing attention in the field of organ transplantation today. Neuropsychiatric Disease and Treatment 2018:14 1999-2005 A literature review revealed that there are limited studies investigating how donors are affected during the transplantation process in living-donor liver transplantation.

The aim of our study is to determine the preoperative and postoperative anxiety levels of donors in living donor liver transplantation and to identify possible conditions that may be associated with anxiety.

Undersøgelsestype

Observationel

Tilmelding (Anslået)

100

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiekontakt

Undersøgelse Kontakt Backup

Studiesteder

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Voksen
  • Ældre voksen

Tager imod sunde frivillige

Ja

Prøveudtagningsmetode

Sandsynlighedsprøve

Studiebefolkning

Living liver donors

Beskrivelse

Inclusion Criteria:

  • ASA 1-2 group patients aged 18-65 years who are liver transplant donors

Exclusion Criteria:

  • Patients with communication problems, those who are illiterate,
  • Patients do not have sufficient time for the tests,
  • Patients using sedatives, antidepressants, or antiepileptic drugs,
  • Patients with cerebrovascular or psychiatric diseases,
  • Patients with alcohol or substance addiction,
  • Patients who do not want or cannot undergo the second test

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Kohorter og interventioner

Gruppe / kohorte
Intervention / Behandling
Living liver donors
Liver transplant donors who will undergo surgery between May and July 2026
Adfærdsmæssigt: Anxiety scores
Anxiety scores will evaluated STAI test. The STAI test consists of two sections of 20 questions each. The first section of the test includes questions about how the person feels at that moment. Answers are given on a scale of 4 points. For example: I am calm right now: not at all=1, a little=2, a lot=3, completely=4. The second section of the test includes questions about how the person feels in general and is also answered on a scale of 4 points.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Anxiety Scores
Tidsramme: From 24 hours prior to the operation to postoperative 3. day and 7. day
The STAI test is a questionnaire comprising two, 20-item scales used to measure state and trait anxiety. The anxiety levels of LLDs will be evaluated by using the STAI. The STAI-State (STAI-S) form will be use to measure the current anxiety level. The test includes questions about how the person feels at that moment. Answers are given on a scale of 4 points. For example: I am calm right now: not at all=1, a little=2, a lot=3, completely=4. The STAI-Trait (STAI-T) form will be use to measure the underlying (ongoing/personality) anxiety level of the patient. The test includes questions about how the person feels in general and is also answered on a scale of 4 points. Each patient will complete these forms preoperatively and postoperatively. The mean (total) score on the STAI has a minimum of 20 and a maximum of 80. The STAI scores are generally classified as no anxiety or low anxiety (score of 20-37), moderate anxiety (score of 38-44), and high anxiety (score of 45-80).
From 24 hours prior to the operation to postoperative 3. day and 7. day

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Presence of an alternative donor
Tidsramme: Prior to the operation
The relationship between the presence or absence of an alternative donor and donors anxiety scores will be evaluated. This will be defined as "alternative donor available" or "alternative donor not available."
Prior to the operation
Recipient Prognosis
Tidsramme: at the postoperative 3. day and 7. day
The relationship between the recipients prognosis and donors anxiety scores will be evaluated. This will be defined as the recipient living or not living
at the postoperative 3. day and 7. day

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Inonu University

Efterforskere

  • Ledende efterforsker: Zekine Begeç, professor, Inonu University Department of Anesthesia

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

4. maj 2026

Primær færdiggørelse (Faktiske)

15. august 2026

Studieafslutning (Anslået)

15. september 2026

Datoer for studieregistrering

Først indsendt

29. april 2026

Først indsendt, der opfyldte QC-kriterier

4. maj 2026

Først opslået (Faktiske)

8. maj 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

9. september 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

7. september 2026

Sidst verificeret

1. september 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • Anxiety

Plan for individuelle deltagerdata (IPD)

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