Cross-education of Skill and Strength in Healthy People Subjected to an Upper-limb Disuse Model (IMMO-CROSS)
22. maj 2026 opdateret af: Iván Alejandro Cuyul Vásquez, Universidad Catolica de Temuco
Cross-education of Skill and Strength Through Contralateral Manual Dexterity Training in Healthy Young Adults Subjected to an Upper-limb Disuse Model: A Randomized Controlled Trial.
This randomized controlled trial aims to compare manual dexterity and strength between a group undergoing a contralateral manual dexterity training program and a no-intervention control group in healthy, physically inactive individuals subjected to an induced upper-limb disuse model.
Studieoversigt
Status
Ikke rekrutterer endnu
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
Cross-education of skill offers promising opportunities for the rehabilitation of upper-limb musculoskeletal injuries.
An approach based on contralateral manual dexterity training could accelerate functional recovery, reduce motor skill loss during periods of immobilization, and optimize conventional rehabilitation protocols.
However, controlled studies are needed to analyze the efficacy of specific unilateral training protocols designed to maximize cross-education before clinical translation.
To date, no experimental studies have been published on healthy individuals subjected to upper-limb disuse models alongside contralateral skill training involving functional tasks.
This cross-education effect could potentially prevent the loss of manual dexterity and strength that occurs during immobilization.
For this research, a contralateral manual dexterity training protocol was developed based on the functional limitations commonly experienced by individuals with forearm and hand musculoskeletal injuries (e.g., distal radius fractures, wrist sprains, carpal tunnel syndrome, and tendinopathies).
Additionally, the protocol incorporates characteristics from training programs that have demonstrated the greatest cross-education effect.
Undersøgelsestype
Interventionel
Tilmelding (Anslået)
34
Fase
- Ikke anvendelig
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiekontakt
- Navn: Iván A. Cuyul-Vásquez, PhD(c)
- Telefonnummer: +56452205205
- E-mail: icuyul@uct.cl
Studiesteder
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Araucania
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Temuco, Araucania, Chile, 4813302
- UCT, Facultad de ciencias de la Salud
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Kontakt:
- Iván A. Cuyul-Vásquez, PhD(c)
- Telefonnummer: +56452205205
- E-mail: icuyul@uct.cl
-
Kontakt:
- Cuyul-Vásquez Iván Cuyul-Vásquez, PhD(C)
- Telefonnummer: +56452205205
- E-mail: icuyul@uct.cl
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Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
- Voksen
Tager imod sunde frivillige
Ja
Beskrivelse
Inclusion Criteria:
- Individuals will be eligible for inclusion if they are right-handed adults aged 18 to 35 years with a body mass index (BMI) between 18.5 and 30 kg/m².
- Individuals must be classified as physically inactive, defined as not meeting the World Health Organization criteria of at least 150 minutes of moderate-intensity physical activity or 75 minutes of vigorous-intensity physical activity per week.
Exclusion Criteria:
- Individuals who have engaged in physical training (e.g., any form of strength or aerobic exercise) or specific manual dexterity training within the past 6 months. - Individuals who regularly participate in artistic, occupational, or sporting activities requiring high levels of manual dexterity (e.g., musicians, gamers, craftspeople).
- Individuals with a history of orthopedic or traumatic injuries affecting either upper extremity. Individuals with pathologies or conditions that preclude safe training (e.g., uncontrolled hypertension, or visual, auditory, or cognitive impairments [for example, dyscalculia]).
- Individuals currently using nutritional supplements or medications that interfere with the regulation of skeletal muscle mass and strength (e.g., whey protein, creatine) or the central nervous system (e.g., antidepressants, anxiolytics, hypnotics).
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Dobbelt
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
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Eksperimentel: Contralateral manual dexterity training
Participants in the experimental group will perform contralateral manual dexterity training focused on moving 0.5, 1.0, or 1.5 kg cylinders using different grips and movements across various planes on a gridded board.
Participants will execute various grips to place the cylinders into the quadrants indicated on a smartphone screen.
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The subjects in the experimental group will perform contralateral manual dexterity training focused on moving cylinders of 0.5, 1 or 1.5 kilos with grips and movements in different planes on a gridded board.
Participants will have to develop different grips and place the cylinders in the quadrants indicated on a smartphone screen.
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Ingen indgriben: Control group without intervention
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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Fine Manual Dexterity
Tidsramme: Baseline and day 7
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Fine manual dexterity will be assessed using the Functional Dexterity test (FDT).
Using a stopwatch, the evaluator records the total time in seconds that the participant takes to complete the task.
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Baseline and day 7
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Force control
Tidsramme: Baseline and day 7
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In a seated position with the elbow flexed, participants will perform isometric contractions to reach a target torque guided by real-time visual feedback.
The accuracy of maintaining these contractions in the wrist flexor and extensor muscles will be assessed using a Humac Norm isokinetic dynamometer (Computer Sports Medicine, Inc., Stoughton, MA, USA).
Participants will perform a continuous 60-second isometric contraction exercise.
During this period, participants will adjust their force level to between 10% and 30% of their maximum voluntary contraction (MVC) at 10-second intervals.
Three attempts will be performed per limb.
The Root Mean Square Error (RMSE) will be recorded.
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Baseline and day 7
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Gross Manual Dexterity
Tidsramme: Baseline and day 7
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This gross manual dexterity will be assessed using the same task performed during the experimental group's contralateral manual dexterity training.
Specifically, participants will complete 15 trials, moving cylinders of varying weights across a gridded board following a sequence displayed on a smartphone.
The time required to complete these 15 trials will be recorded.
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Baseline and day 7
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Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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Handgrip strength
Tidsramme: Baseline and day 7
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Maximum lumbrical and cylindrical grip strength will be assessed using a Jamar Plus+ digital hand dynamometer.
The highest value from three attempts will be recorded for each assessment
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Baseline and day 7
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Joint Position Sense Test
Tidsramme: Baseline and day 7
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Proprioception: Wrist flexion-extension joint position sense will be assessed using the Joint Position Sense Test (JPST).
All measurements will be conducted with a Humac Norm isokinetic dynamometer (Computer Sports Medicine, Inc., Stoughton, MA, USA).
Three attempts will be made per limb.
The absolute error (difference in degrees between 30° and the angle achieved during the test) will be recorded.
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Baseline and day 7
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Left/right judgment
Tidsramme: Baseline and day 7
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Left/right judgment will be assessed using the Recognise™ application (Noigroup, Adelaide, Australia).
Performance on the laterality judgment task was quantified using the Inverse Efficiency Score (IES), calculated as the average reaction time of correct responses divided by the proportion of correct responses (IES = RT / PC). 3 blocks of 20 images (60 images total).
Maximum exposure time: 5 seconds per image.
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Baseline and day 7
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Andre resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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Physical activity level
Tidsramme: Baseline and day 7
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Weekly metabolic equivalents (MET-min/week) will be calculated using the validated Spanish version of the Global physical activity questionnaire (GPAQ).
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Baseline and day 7
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Psychological Distress
Tidsramme: Baseline
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Psychological Distress, including symptoms of depression, anxiety, and stress, will be assessed using the 21-item Depression, Anxiety and Stress Scale (DASS-21).
This self-report instrument will be used to quantify the severity of emotional distress across these three domains.
This scale has a minimum score of 0 and a maximum of 126 points (total score calculated by doubling the sum of the 21 items).
Higher scores in DASS-21 indicate greater psychological distress.
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Baseline
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Sleep Quality:
Tidsramme: Baseline
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Sleep disturbances and overall sleep quality will be assessed using the Pittsburgh Sleep Quality Index (PSQI).
This scale has a minimum score of 0 and a maximum of 21 points (higher scores indicate worse sleep quality)
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Baseline
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Daily steps
Tidsramme: During 7 days of immobilization
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Physical activity will be monitored using a Xiaomi Band 9 smartwatch (number of daily steps), which participants will wear throughout the seven-day mobilization period.
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During 7 days of immobilization
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Sleep time
Tidsramme: During 7 days of immobilization
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Sleep time will be measured using a Xiaomi Band 9 smartwatch (hours), which participants will wear throughout the seven-day immobilization period.
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During 7 days of immobilization
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Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Anslået)
25. maj 2026
Primær færdiggørelse (Anslået)
1. oktober 2026
Studieafslutning (Anslået)
30. januar 2027
Datoer for studieregistrering
Først indsendt
14. maj 2026
Først indsendt, der opfyldte QC-kriterier
22. maj 2026
Først opslået (Faktiske)
29. maj 2026
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
29. maj 2026
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
22. maj 2026
Sidst verificeret
1. maj 2026
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- INMO-CROSS-2026
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