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Cross-education of Skill and Strength in Healthy People Subjected to an Upper-limb Disuse Model (IMMO-CROSS)

22. Mai 2026 aktualisiert von: Iván Alejandro Cuyul Vásquez, Universidad Catolica de Temuco

Cross-education of Skill and Strength Through Contralateral Manual Dexterity Training in Healthy Young Adults Subjected to an Upper-limb Disuse Model: A Randomized Controlled Trial.

This randomized controlled trial aims to compare manual dexterity and strength between a group undergoing a contralateral manual dexterity training program and a no-intervention control group in healthy, physically inactive individuals subjected to an induced upper-limb disuse model.

Studienübersicht

Status

Noch keine Rekrutierung

Bedingungen

Intervention / Behandlung

Detaillierte Beschreibung

Cross-education of skill offers promising opportunities for the rehabilitation of upper-limb musculoskeletal injuries. An approach based on contralateral manual dexterity training could accelerate functional recovery, reduce motor skill loss during periods of immobilization, and optimize conventional rehabilitation protocols. However, controlled studies are needed to analyze the efficacy of specific unilateral training protocols designed to maximize cross-education before clinical translation. To date, no experimental studies have been published on healthy individuals subjected to upper-limb disuse models alongside contralateral skill training involving functional tasks. This cross-education effect could potentially prevent the loss of manual dexterity and strength that occurs during immobilization. For this research, a contralateral manual dexterity training protocol was developed based on the functional limitations commonly experienced by individuals with forearm and hand musculoskeletal injuries (e.g., distal radius fractures, wrist sprains, carpal tunnel syndrome, and tendinopathies). Additionally, the protocol incorporates characteristics from training programs that have demonstrated the greatest cross-education effect.

Studientyp

Interventionell

Einschreibung (Geschätzt)

34

Phase

  • Unzutreffend

Kontakte und Standorte

Dieser Abschnitt enthält die Kontaktdaten derjenigen, die die Studie durchführen, und Informationen darüber, wo diese Studie durchgeführt wird.

Studienkontakt

  • Name: Iván A. Cuyul-Vásquez, PhD(c)
  • Telefonnummer: +56452205205
  • E-Mail: icuyul@uct.cl

Studienorte

  • Chile
    • Araucania
      • Temuco, Araucania, Chile, 4813302
        • UCT, Facultad de ciencias de la Salud
        • Kontakt:
          • Iván A. Cuyul-Vásquez, PhD(c)
          • Telefonnummer: +56452205205
          • E-Mail: icuyul@uct.cl
        • Kontakt:
          • Cuyul-Vásquez Iván Cuyul-Vásquez, PhD(C)
          • Telefonnummer: +56452205205
          • E-Mail: icuyul@uct.cl

Teilnahmekriterien

Forscher suchen nach Personen, die einer bestimmten Beschreibung entsprechen, die als Auswahlkriterien bezeichnet werden. Einige Beispiele für diese Kriterien sind der allgemeine Gesundheitszustand einer Person oder frühere Behandlungen.

Zulassungskriterien

Studienberechtigtes Alter

  • Erwachsene

Akzeptiert gesunde Freiwillige

Ja

Beschreibung

Inclusion Criteria:

  • Individuals will be eligible for inclusion if they are right-handed adults aged 18 to 35 years with a body mass index (BMI) between 18.5 and 30 kg/m².
  • Individuals must be classified as physically inactive, defined as not meeting the World Health Organization criteria of at least 150 minutes of moderate-intensity physical activity or 75 minutes of vigorous-intensity physical activity per week.

Exclusion Criteria:

  • Individuals who have engaged in physical training (e.g., any form of strength or aerobic exercise) or specific manual dexterity training within the past 6 months. - Individuals who regularly participate in artistic, occupational, or sporting activities requiring high levels of manual dexterity (e.g., musicians, gamers, craftspeople).
  • Individuals with a history of orthopedic or traumatic injuries affecting either upper extremity. Individuals with pathologies or conditions that preclude safe training (e.g., uncontrolled hypertension, or visual, auditory, or cognitive impairments [for example, dyscalculia]).
  • Individuals currently using nutritional supplements or medications that interfere with the regulation of skeletal muscle mass and strength (e.g., whey protein, creatine) or the central nervous system (e.g., antidepressants, anxiolytics, hypnotics).

Studienplan

Dieser Abschnitt enthält Einzelheiten zum Studienplan, einschließlich des Studiendesigns und der Messung der Studieninhalte.

Wie ist die Studie aufgebaut?

Designdetails

  • Hauptzweck: Behandlung
  • Zuteilung: Zufällig
  • Interventionsmodell: Parallele Zuordnung
  • Maskierung: Doppelt

Waffen und Interventionen

Teilnehmergruppe / Arm
Intervention / Behandlung
Experimental: Contralateral manual dexterity training
Participants in the experimental group will perform contralateral manual dexterity training focused on moving 0.5, 1.0, or 1.5 kg cylinders using different grips and movements across various planes on a gridded board. Participants will execute various grips to place the cylinders into the quadrants indicated on a smartphone screen.
Sonstiges: Contralateral Manual Dexterity Training
The subjects in the experimental group will perform contralateral manual dexterity training focused on moving cylinders of 0.5, 1 or 1.5 kilos with grips and movements in different planes on a gridded board. Participants will have to develop different grips and place the cylinders in the quadrants indicated on a smartphone screen.
Kein Eingriff: Control group without intervention

Was misst die Studie?

Primäre Ergebnismessungen

Ergebnis Maßnahme
Maßnahmenbeschreibung
Zeitfenster
Fine Manual Dexterity
Zeitfenster: Baseline and day 7
Fine manual dexterity will be assessed using the Functional Dexterity test (FDT). Using a stopwatch, the evaluator records the total time in seconds that the participant takes to complete the task.
Baseline and day 7
Force control
Zeitfenster: Baseline and day 7
In a seated position with the elbow flexed, participants will perform isometric contractions to reach a target torque guided by real-time visual feedback. The accuracy of maintaining these contractions in the wrist flexor and extensor muscles will be assessed using a Humac Norm isokinetic dynamometer (Computer Sports Medicine, Inc., Stoughton, MA, USA). Participants will perform a continuous 60-second isometric contraction exercise. During this period, participants will adjust their force level to between 10% and 30% of their maximum voluntary contraction (MVC) at 10-second intervals. Three attempts will be performed per limb. The Root Mean Square Error (RMSE) will be recorded.
Baseline and day 7
Gross Manual Dexterity
Zeitfenster: Baseline and day 7
This gross manual dexterity will be assessed using the same task performed during the experimental group's contralateral manual dexterity training. Specifically, participants will complete 15 trials, moving cylinders of varying weights across a gridded board following a sequence displayed on a smartphone. The time required to complete these 15 trials will be recorded.
Baseline and day 7

Sekundäre Ergebnismessungen

Ergebnis Maßnahme
Maßnahmenbeschreibung
Zeitfenster
Handgrip strength
Zeitfenster: Baseline and day 7
Maximum lumbrical and cylindrical grip strength will be assessed using a Jamar Plus+ digital hand dynamometer. The highest value from three attempts will be recorded for each assessment
Baseline and day 7
Joint Position Sense Test
Zeitfenster: Baseline and day 7
Proprioception: Wrist flexion-extension joint position sense will be assessed using the Joint Position Sense Test (JPST). All measurements will be conducted with a Humac Norm isokinetic dynamometer (Computer Sports Medicine, Inc., Stoughton, MA, USA). Three attempts will be made per limb. The absolute error (difference in degrees between 30° and the angle achieved during the test) will be recorded.
Baseline and day 7
Left/right judgment
Zeitfenster: Baseline and day 7
Left/right judgment will be assessed using the Recognise™ application (Noigroup, Adelaide, Australia). Performance on the laterality judgment task was quantified using the Inverse Efficiency Score (IES), calculated as the average reaction time of correct responses divided by the proportion of correct responses (IES = RT / PC). 3 blocks of 20 images (60 images total). Maximum exposure time: 5 seconds per image.
Baseline and day 7

Andere Ergebnismessungen

Ergebnis Maßnahme
Maßnahmenbeschreibung
Zeitfenster
Physical activity level
Zeitfenster: Baseline and day 7
Weekly metabolic equivalents (MET-min/week) will be calculated using the validated Spanish version of the Global physical activity questionnaire (GPAQ).
Baseline and day 7
Psychological Distress
Zeitfenster: Baseline
Psychological Distress, including symptoms of depression, anxiety, and stress, will be assessed using the 21-item Depression, Anxiety and Stress Scale (DASS-21). This self-report instrument will be used to quantify the severity of emotional distress across these three domains. This scale has a minimum score of 0 and a maximum of 126 points (total score calculated by doubling the sum of the 21 items). Higher scores in DASS-21 indicate greater psychological distress.
Baseline
Sleep Quality:
Zeitfenster: Baseline
Sleep disturbances and overall sleep quality will be assessed using the Pittsburgh Sleep Quality Index (PSQI). This scale has a minimum score of 0 and a maximum of 21 points (higher scores indicate worse sleep quality)
Baseline
Daily steps
Zeitfenster: During 7 days of immobilization
Physical activity will be monitored using a Xiaomi Band 9 smartwatch (number of daily steps), which participants will wear throughout the seven-day mobilization period.
During 7 days of immobilization
Sleep time
Zeitfenster: During 7 days of immobilization
Sleep time will be measured using a Xiaomi Band 9 smartwatch (hours), which participants will wear throughout the seven-day immobilization period.
During 7 days of immobilization

Mitarbeiter und Ermittler

Hier finden Sie Personen und Organisationen, die an dieser Studie beteiligt sind.

Sponsor

Universidad Catolica de Temuco

Mitarbeiter

University of Valencia
Universidad de La Frontera

Studienaufzeichnungsdaten

Diese Daten verfolgen den Fortschritt der Übermittlung von Studienaufzeichnungen und zusammenfassenden Ergebnissen an ClinicalTrials.gov. Studienaufzeichnungen und gemeldete Ergebnisse werden von der National Library of Medicine (NLM) überprüft, um sicherzustellen, dass sie bestimmten Qualitätskontrollstandards entsprechen, bevor sie auf der öffentlichen Website veröffentlicht werden.

Haupttermine studieren

Studienbeginn (Geschätzt)

25. Mai 2026

Primärer Abschluss (Geschätzt)

1. Oktober 2026

Studienabschluss (Geschätzt)

30. Januar 2027

Studienanmeldedaten

Zuerst eingereicht

14. Mai 2026

Zuerst eingereicht, das die QC-Kriterien erfüllt hat

22. Mai 2026

Zuerst gepostet (Tatsächlich)

29. Mai 2026

Studienaufzeichnungsaktualisierungen

Letztes Update gepostet (Tatsächlich)

29. Mai 2026

Letztes eingereichtes Update, das die QC-Kriterien erfüllt

22. Mai 2026

Zuletzt verifiziert

1. Mai 2026

Mehr Informationen

Begriffe im Zusammenhang mit dieser Studie

Schlüsselwörter

Zusätzliche relevante MeSH-Bedingungen

Andere Studien-ID-Nummern

  • INMO-CROSS-2026

Plan für individuelle Teilnehmerdaten (IPD)

Planen Sie, individuelle Teilnehmerdaten (IPD) zu teilen?

NEIN

Arzneimittel- und Geräteinformationen, Studienunterlagen

Studiert ein von der US-amerikanischen FDA reguliertes Arzneimittelprodukt

Nein

Studiert ein von der US-amerikanischen FDA reguliertes Geräteprodukt

Nein

Diese Informationen wurden ohne Änderungen direkt von der Website clinicaltrials.gov abgerufen. Wenn Sie Ihre Studiendaten ändern, entfernen oder aktualisieren möchten, wenden Sie sich bitte an register@clinicaltrials.gov. Sobald eine Änderung auf clinicaltrials.gov implementiert wird, wird diese automatisch auch auf unserer Website aktualisiert .

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