Subjective Assessment of Spatial Orientation Abilities in Alzheimer's Disease (ESCAPE-AD)

Inclusion Criteria:

For all subjects :

• Native French speakers
• Independent mobility: (minimum mobility range of 3 (i.e., neighborhood) on the LSA-F assessment of the mobility zone scale)
• Person affiliated with a social security system or beneficiary of such a system

Patients (Subgroup A1) and healthy control subjects (Group C):

• Individuals who have received complete information about the clinical research organization and have signed their written informed consent
• Patients (Subgroups A2 and A3) and Companions (Group B) Individuals who have received complete information about the clinical research and have agreed to participate

Patients (group A):

• Aged 55 to 85
• Diagnosis of probable Alzheimer's disease (NINCDR-ADRDA diagnostic criteria)
• Score of 4 or less on the Hachinski Ischemic Scale
• Score of 20 or higher on the Folstein MMSE (Mini Mental State Examination)
• In the case of specific treatment for Alzheimer's disease (anticholinesterase and memantine treatments), treatment stability for > 15 days
• Able to walk independently, i.e., without assistance, whether human or technical, except for a simple cane

Caregivers (group B):

• Caregivers of a person with dementia included in group A, with regular contact (at least 10 hours per week, spread over a minimum of 3 times per week)
• Healthy control subjects (group C):
• Aged 55 to 85
• Able to walk independently, i.e., without assistance, whether human or technical, except for a single cane
• Normal performance on the Folstein Mini-Mental State Examination (MMSE), according to GRECO (Cognitive Assessment Task Force) standards

Exclusion Criteria:

For all subjects:

• Adults subject to legal protection measures (guardianship, curatorship, judicial protection)
• Adults unable to give their consent
• Persons deprived of their liberty by judicial or administrative decision, persons receiving psychiatric care pursuant to Articles L. 3212-1 and L. 3213-1.
• Persons capable of giving consent but unable to read French
• Persons capable of giving consent but unable to write
• One of the members of the patient/caregiver dyad refusing to participate in the study.

Patients (subgroup A1) and healthy control subjects (group C):

• Sensory or phasic deficit interfering with the task.
• History of moderate or severe head trauma (with loss of consciousness).
• Change in psychotropic treatment less than 48 hours before the tests
• Chronic alcoholism
• Severe depression (score greater than or equal to 10 on the GDS-15 Geriatric Depression Scale)
• Presence of other clinically significant psychiatric or neurological conditions (except Alzheimer disease for case subjects)