Denne side blev automatisk oversat, og nøjagtigheden af ​​oversættelsen er ikke garanteret. Der henvises til engelsk version for en kildetekst.

Burn Mortality Prediction Scores (BURN-PRED)

1. juli 2026 opdateret af: Gaziantep City Hospital

Comparative Performance of ABSI, Revised Baux Score, and Modified Ryan Score for In-Hospital Mortality Prediction in Hospitalized Burn Admissions: A Retrospective Cohort Study

This retrospective observational cohort study evaluates hospitalized burn admissions treated at the Burn Center of Gaziantep City Hospital between October 2023 and February 2026. The study aims to compare the ability of three burn severity scoring systems, the Abbreviated Burn Severity Index (ABSI), Revised Baux score, and modified Ryan score, to predict in-hospital mortality.

Electronic medical records were reviewed for demographic characteristics, burn-related variables, inhalation injury, burn depth, intensive care admission, mechanical ventilation, sepsis, surgical procedures, length of hospital stay, and survival status at hospital discharge. The primary outcome is in-hospital mortality. The predictive performance of the scoring systems will be evaluated using receiver operating characteristic analysis and logistic regression.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Burn injuries are associated with substantial morbidity, mortality, intensive care use, prolonged hospitalization, and surgical burden. Early identification of patients at high risk of death may support clinical triage, intensive care planning, resource allocation, and communication with patients' families.

This study is a single-center, retrospective, observational cohort study conducted at the Burn Center of Gaziantep City Hospital, a tertiary referral burn center serving southern Türkiye and cross-border regions. The study includes hospitalized burn admissions treated between October 2023 and February 2026.

A total of 1315 burn admission records were screened. Admissions transferred to another facility before final clinical outcome assessment and admissions in which treatment was refused were excluded. After applying eligibility criteria, 1082 hospitalized burn admissions were included in the primary analysis cohort.

The study evaluates the prognostic performance of the Abbreviated Burn Severity Index (ABSI), Revised Baux score, and modified Ryan score for predicting in-hospital mortality. ABSI is calculated using age, sex, total body surface area burned, inhalation injury, and full-thickness burn status. Revised Baux score is calculated using age, total body surface area burned, and the presence of inhalation injury. The modified Ryan score is calculated using age category, total body surface area burned category, inhalation injury, and third-degree burn status.

The primary outcome is in-hospital mortality, defined as death occurring during the index hospitalization. Secondary evaluations include associations between mortality and selected clinical variables, including inhalation injury, sepsis, intensive care admission, mechanical ventilation, number of surgical procedures, and length of hospital stay.

The discriminative performance of prognostic scores will be assessed using receiver operating characteristic analysis. Area under the curve, confidence intervals, optimal cut-off values, sensitivity, and specificity will be reported. Associations between score increments and mortality will be examined using univariable logistic regression.

Undersøgelsestype

Observationel

Tilmelding (Faktiske)

1082

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Tyrkiet (Türkiye)
    • Gaziantep
      • Gaziantep, Gaziantep, Tyrkiet (Türkiye), 27470
        • Gaziantep City Hospital Burn Center

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Barn
  • Voksen
  • Ældre voksen

Tager imod sunde frivillige

Ingen

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

The study population consists of hospitalized burn admissions treated at the Burn Center of Gaziantep City Hospital, a tertiary referral burn center, between October 2023 and February 2026. The cohort includes burn admissions with documented in-hospital outcomes and sufficient electronic medical record data for calculation of ABSI, Revised Baux score, and modified Ryan score.

Beskrivelse

Inclusion Criteria: Hospitalized burn admissions treated at the Burn Center of Gaziantep City Hospital between October 2023 and February 2026.

Admissions with a documented in-hospital outcome of discharge alive or death. Admissions with available electronic medical records for age, sex, total body surface area burned, burn depth, inhalation injury, and core clinical variables.

Exclusion Criteria: Admissions transferred to another facility before final clinical outcome assessment.

Admissions in which treatment was refused. Admissions without sufficient electronic medical record data for calculation of the prognostic scores or assessment of the primary outcome.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Kohorter og interventioner

Gruppe / kohorte
Intervention / Behandling
Hospitalized Burn Admissions
Hospitalized burn admissions treated at the Burn Center of Gaziantep City Hospital between October 2023 and February 2026 and included in the retrospective primary analysis cohort. Prognostic scores, including ABSI, Revised Baux score, and modified Ryan score, were calculated from routinely recorded electronic medical data. No intervention was assigned by the study protocol.
Andet: Retrospective Prognostic Score Assessment
ABSI, Revised Baux score, and modified Ryan score were retrospectively calculated using routinely collected electronic medical record data from hospitalized burn admissions. These scores were evaluated for their ability to predict in-hospital mortality. No drug, device, procedure, or treatment intervention was assigned by the study protocol.
Andre navne:
  • ABSI
  • Revised Baux score
  • Modified Ryan score

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
In-Hospital Mortality
Tidsramme: From hospital admission to hospital discharge or in-hospital death, assessed up to 240 days.
In-hospital mortality was defined as death occurring during the index hospitalization for burn injury. Mortality status was determined from electronic hospital records and was used as the primary outcome for evaluating the prognostic performance of burn severity scoring systems.
From hospital admission to hospital discharge or in-hospital death, assessed up to 240 days.

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Area Under the Receiver Operating Characteristic Curve for the Abbreviated Burn Severity Index
Tidsramme: Score variables were obtained from admission and early hospitalization records; in-hospital mortality was assessed from hospital admission to discharge or in-hospital death, up to 240 days.
The Abbreviated Burn Severity Index was calculated using age, sex, total body surface area burned, inhalation injury, and full-thickness burn status recorded in electronic hospital records. Higher scores indicate greater burn severity and higher predicted mortality risk. Predictive discrimination for in-hospital mortality was evaluated using the area under the receiver operating characteristic curve. The area under the curve ranges from 0.0 to 1.0, with higher values indicating better discriminative performance.
Score variables were obtained from admission and early hospitalization records; in-hospital mortality was assessed from hospital admission to discharge or in-hospital death, up to 240 days.
Area Under the Receiver Operating Characteristic Curve for the Revised Baux Score
Tidsramme: Score variables were obtained from admission and early hospitalization records; in-hospital mortality was assessed from hospital admission to discharge or in-hospital death, up to 240 days.
The Revised Baux score was calculated using age, total body surface area burned, and the presence of inhalation injury. Higher scores indicate greater burn severity and higher predicted mortality risk. Predictive discrimination for in-hospital mortality was evaluated using the area under the receiver operating characteristic curve. The area under the curve ranges from 0.0 to 1.0, with higher values indicating better discriminative performance.
Score variables were obtained from admission and early hospitalization records; in-hospital mortality was assessed from hospital admission to discharge or in-hospital death, up to 240 days.
Predictive Performance of the Modified Ryan Score
Tidsramme: Score variables were obtained from admission and early hospitalization records; in-hospital mortality was assessed from hospital admission to discharge or in-hospital death, up to 240 days.
The predictive performance of the modified Ryan score for in-hospital mortality was evaluated using receiver operating characteristic analysis. Area under the curve, 95% confidence interval, optimal cut-off value, sensitivity, and specificity were calculated.
Score variables were obtained from admission and early hospitalization records; in-hospital mortality was assessed from hospital admission to discharge or in-hospital death, up to 240 days.
Association of Selected Clinical Factors With In-Hospital Mortality
Tidsramme: Clinical factors and mortality status were assessed from hospital admission to hospital discharge or in-hospital death, up to 240 days.
The association of selected clinical factors, including inhalation injury, sepsis, intensive care admission, mechanical ventilation, number of surgical procedures, and length of hospital stay, with in-hospital mortality was evaluated using appropriate statistical analyses.
Clinical factors and mortality status were assessed from hospital admission to hospital discharge or in-hospital death, up to 240 days.

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Gaziantep City Hospital

Efterforskere

  • Ledende efterforsker: Bekir Suat Kurkcuoglu, Gaziantep City Hospital

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

7. oktober 2023

Primær færdiggørelse (Faktiske)

28. februar 2026

Studieafslutning (Faktiske)

28. februar 2026

Datoer for studieregistrering

Først indsendt

22. juni 2026

Først indsendt, der opfyldte QC-kriterier

1. juli 2026

Først opslået (Faktiske)

8. juli 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

8. juli 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

1. juli 2026

Sidst verificeret

1. juni 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • GCH-BURN-SCORES-2026

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

INGEN

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ingen

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Forbrændingsskade

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Taiwan

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer

3
Abonner