- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT07740070
Cognitive Processing of Natural Sequences in Humans and Artificial Intelligence (AI) (SEQUOIA)
SEQUOIA : Cognitive Processing of Natural Sequences in Humans and Artificial Intelligence (AI)
The goal of this study is to identify electrical patterns in the cortex that enable the generation of predictions in natural auditory sequences such as speech and music.
Between 500 and 700 participants in total (250 to 350 normally hearing participants (including 60 to 120 participants from West Africa and 60 to 120 participants from Western Europe) and 250 to 350 participants with hearing loss (no restrictions on origin)).
Participants will listen to naturally recorded music and speech via headphones. They will be asked to rate these stimuli on a scale from 0 to 10 in terms of pleasure and comprehension, using a keyboard and mouse or voice input. Additionally, they will be required to sing or produce novel/improvised vocal responses using high-fidelity microphones. This entire procedure will be conducted under electroencephalography (EEG) to record neuronal responses throughout the process.
Studieoversigt
Status
Betingelser
Undersøgelsestype
Tilmelding (Anslået)
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
- Voksen
- Ældre voksen
Tager imod sunde frivillige
Prøveudtagningsmetode
Studiebefolkning
Hearing participants will be recruited from the general population in the Paris region.
We will also recruit participants with hearing impairment through ENT clinics, in hearing aid dispensing centers.
Finally, we will specifically recruit participants residing in Paris and of West African origin to examine differences related to cultural experience.
Beskrivelse
Inclusion Criteria:
For hearing participants:
- Average pure-tone thresholds ≤ 20 dB HL
For participants with hearing loss:
- Average pure-tone thresholds > 20 dB HL
For participants of West African origin:
- Average pure-tone thresholds ≤ 20 dB HL
- Declare that both parents are of West African origin, either by their own birth or by the birth of both of their parents.
Exclusion Criteria:
- No known neurological or audiological disorders
- Participants under legal guardianship (tutelle, curatelle)
- Participants deprived of legal liberty by judicial or administrative decision
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Kohorter og interventioner
Gruppe / kohorte |
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Normal hearing participants from West Africa
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Normal hearing participants from Western Europe
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Participants with hearing loss
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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Correlation between neural recordings and IA models
Tidsramme: Day 1
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To identify electrical patterns in cortex which generates predictions in natural auditory sequences (such as speak and music).
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Day 1
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Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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Compare predictions generated across different cultural contexts
Tidsramme: Day 1
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specifically, comparing West African and Western European communities in Paris
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Day 1
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Compare predictions for identical stimuli across repeated sessions to establish a link between processing and successful memorization/retention.
Tidsramme: From enrollement to visit 2 (10 days)
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From enrollement to visit 2 (10 days)
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Compare predictions generated between hearing individuals and those with hearing impairments.
Tidsramme: Day 2
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Day 2
|
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Correlate predictive measures with responses to autism symptom questionnaires across the various experiments.
Tidsramme: Day 1
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Day 1
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Samarbejdspartnere og efterforskere
Sponsor
Samarbejdspartnere
Datoer for undersøgelser
Studer store datoer
Studiestart (Anslået)
Primær færdiggørelse (Anslået)
Studieafslutning (Anslået)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Faktiske)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- 2024-102 SEQUOIA
- 2025-A00021-48 (Anden identifikator: ID-RCB)
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Studerer et amerikansk FDA-reguleret enhedsprodukt
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