- ICH GCP
- US Clinical Trials Registry
- Klinisk utprøving NCT07740070
Cognitive Processing of Natural Sequences in Humans and Artificial Intelligence (AI) (SEQUOIA)
SEQUOIA : Cognitive Processing of Natural Sequences in Humans and Artificial Intelligence (AI)
The goal of this study is to identify electrical patterns in the cortex that enable the generation of predictions in natural auditory sequences such as speech and music.
Between 500 and 700 participants in total (250 to 350 normally hearing participants (including 60 to 120 participants from West Africa and 60 to 120 participants from Western Europe) and 250 to 350 participants with hearing loss (no restrictions on origin)).
Participants will listen to naturally recorded music and speech via headphones. They will be asked to rate these stimuli on a scale from 0 to 10 in terms of pleasure and comprehension, using a keyboard and mouse or voice input. Additionally, they will be required to sing or produce novel/improvised vocal responses using high-fidelity microphones. This entire procedure will be conducted under electroencephalography (EEG) to record neuronal responses throughout the process.
Studieoversikt
Status
Forhold
Studietype
Registrering (Antatt)
Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
- Voksen
- Eldre voksen
Tar imot friske frivillige
Prøvetakingsmetode
Studiepopulasjon
Hearing participants will be recruited from the general population in the Paris region.
We will also recruit participants with hearing impairment through ENT clinics, in hearing aid dispensing centers.
Finally, we will specifically recruit participants residing in Paris and of West African origin to examine differences related to cultural experience.
Beskrivelse
Inclusion Criteria:
For hearing participants:
- Average pure-tone thresholds ≤ 20 dB HL
For participants with hearing loss:
- Average pure-tone thresholds > 20 dB HL
For participants of West African origin:
- Average pure-tone thresholds ≤ 20 dB HL
- Declare that both parents are of West African origin, either by their own birth or by the birth of both of their parents.
Exclusion Criteria:
- No known neurological or audiological disorders
- Participants under legal guardianship (tutelle, curatelle)
- Participants deprived of legal liberty by judicial or administrative decision
Studieplan
Hvordan er studiet utformet?
Designdetaljer
Kohorter og intervensjoner
Gruppe / Kohort |
|---|
|
Normal hearing participants from West Africa
|
|
Normal hearing participants from Western Europe
|
|
Participants with hearing loss
|
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Correlation between neural recordings and IA models
Tidsramme: Day 1
|
To identify electrical patterns in cortex which generates predictions in natural auditory sequences (such as speak and music).
|
Day 1
|
Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Compare predictions generated across different cultural contexts
Tidsramme: Day 1
|
specifically, comparing West African and Western European communities in Paris
|
Day 1
|
|
Compare predictions for identical stimuli across repeated sessions to establish a link between processing and successful memorization/retention.
Tidsramme: From enrollement to visit 2 (10 days)
|
From enrollement to visit 2 (10 days)
|
|
|
Compare predictions generated between hearing individuals and those with hearing impairments.
Tidsramme: Day 2
|
Day 2
|
|
|
Correlate predictive measures with responses to autism symptom questionnaires across the various experiments.
Tidsramme: Day 1
|
Day 1
|
Samarbeidspartnere og etterforskere
Sponsor
Samarbeidspartnere
Studierekorddatoer
Studer hoveddatoer
Studiestart (Antatt)
Primær fullføring (Antatt)
Studiet fullført (Antatt)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Faktiske)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- 2024-102 SEQUOIA
- 2025-A00021-48 (Annen identifikator: ID-RCB)
Legemiddel- og utstyrsinformasjon, studiedokumenter
Studerer et amerikansk FDA-regulert medikamentprodukt
Studerer et amerikansk FDA-regulert enhetsprodukt
Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .