Role of Total Thyroidectomy in Relieving Local Symptoms in Hashimoto's Thyroiditis
The Role of Total Thyroidectomy in Relieving Chronic Local Symptoms Associated With Hashimoto's Thyroiditis: Prospective Cohort Study
This study aims to evaluate the role and effectiveness of total thyroidectomy in relieving compressive and local symptoms (such as dysphagia, dyspnea, and anterior neck pain/discomfort) in patients with Hashimoto's thyroiditis who fail to improve with conservative medical management.
Studieoversigt
Status
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
Hashimoto's thyroiditis is a chronic autoimmune disease often presenting with goiter and local pressure symptoms. While levothyroxine replacement is standard for hypothyroidism, persistent compressive symptoms, cosmetic concerns, or suspicion of malignancy may necessitate surgical intervention.
This study investigates patients diagnosed with Hashimoto's thyroiditis presenting with significant local symptoms. Eligible patients undergoing total thyroidectomy will be evaluated preoperatively and postoperatively to assess symptom resolution, postoperative complication rates (such as hypocalcemia and recurrent laryngeal nerve injury), and overall patient satisfaction following surgery.
Undersøgelsestype
Tilmelding (Anslået)
Kontakter og lokationer
Studiekontakt
- Navn: Ahmed Atef Muslim, Bachelor of Medicine and Surge
- Telefonnummer: +201099626447
- E-mail: ahmed.atef.465.aa@gmail.com
Studiesteder
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Asyut Governorate
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Asyut, Asyut Governorate, Egypten, 71515
- Assiut University Hospitals
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Kontakt:
- Ahmed Atef Muslim, Bachelor of Medicine and Surge
- Telefonnummer: +201099626447
- E-mail: ahmed.atef.465.aa@gmail.com
-
-
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Prøveudtagningsmetode
Studiebefolkning
Patients diagnosed with Hashimoto's thyroiditis who suffer from persistent local compressive symptoms and undergo total thyroidectomy at the Department of Surgery, Assiut University Hospitals.
Beskrivelse
Inclusion Criteria:
- Adults patients with confirmed Hashimoto's thyroiditis (elevated serum anti-thyroid peroxidase \anti-thyroglobulin antibodies, characteristic ultrasound findings and/or positive fine needle aspiration cytology)
- Biochemically euthyroid with normal thyroid function test.
- Presence of persistent local symptoms (neck pain, throat discomfort,neck tightness,chocking) for more than 6 months
- Patient fit and motivated to surgery.
Exclusion Criteria:
- Confirmed or high-suspicion thyroid malignancy (Bethesda V or IV on FNAC
- Previous thyroid or neck surgery
- Patient refusal to participate in the study
- Severe comorbidities precluding general anesthesia
- Active psychiatric illness
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Observationsmodeller: COHORT
- Tidsperspektiver: PROSPECTIVE
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Improvement or Relief of Local Compressive Symptoms
Tidsramme: 6 months postoperatively
|
Assessment of changes in patient-reported compressive symptoms (such as dysphagia, dyspnea, and local neck discomfort or pressure) following total thyroidectomy compared to baseline status. |
6 months postoperatively
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Incidence of Postoperative Complications
Tidsramme: Up to 30 days postoperatively
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Rate of surgical complications including transient or permanent hypocalcemia, recurrent laryngeal nerve injury, and wound complications. |
Up to 30 days postoperatively
|
Samarbejdspartnere og efterforskere
Sponsor
Efterforskere
- Studieleder: Ahmed Gamal Hamdan, Lecturer
Datoer for undersøgelser
Studer store datoer
Studiestart (Anslået)
Primær færdiggørelse (Anslået)
Studieafslutning (Anslået)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Faktiske)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- Hashimoto's Thyroiditis
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
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