Type 2 diabetes mellitus and colorectal neoplasia risk in Hispanics: a case-control study
Yaritza Díaz-Algorri, María Eugenia Lozada, Sofía M López, Carlos E Bertrán-Rodríguez, Cinthia M González-Hernández, Dilka González, Cynthia M Pérez-Cardona, Jessica Hernández, Carmen Pedrosa, Doris H Toro, María González-Pons, Marcia Cruz-Correa, Yaritza Díaz-Algorri, María Eugenia Lozada, Sofía M López, Carlos E Bertrán-Rodríguez, Cinthia M González-Hernández, Dilka González, Cynthia M Pérez-Cardona, Jessica Hernández, Carmen Pedrosa, Doris H Toro, María González-Pons, Marcia Cruz-Correa
Abstract
Aims: There is inconclusive evidence regarding the potential link between diabetes mellitus (DM) and colorectal cancer (CRC). Associations between type 2 DM and colorectal neoplasia (CRN; colorectal cancer and/or adenomas) have not been well studied in Hispanics, an ethnic minority at high risk for type 2 DM. This study aims to assess the association between type 2 DM and CRN in Hispanics.
Methods: Hispanics with incident CRN and colonoscopy-negative controls from 2005 to 2009 were evaluated. Diagnosis of type 2 DM was established by previous medical diagnosis and/or use of DM treatments. Unconditional logistic regression was performed to estimate odds ratios for the association between type 2 DM and CRN.
Results: A total of 451 participants (mean age 61.1±11.9years, 59.6 % men) were evaluated (218 with incident CRC, 77 with colorectal adenomas, and 156 colonoscopy-negative controls). The prevalence of type 2 DM in this study was 25.1%. After adjusting for potential confounding variables, women with type 2 DM were 2.74 (95% CI: 0.94-7.99) times more likely to have CRN and 4.83 times more likely to present with proximal colonic CRN (95% CI: 1.25-18.58) than women without type 2 DM. No statistically significant associations were found between type 2 DM and CRN among men.
Conclusions: An increased odds for CRN and proximal location of CRN was observed among Hispanic women with type 2 DM. Since DM is a highly prevalent disease in this population, adherence to routine CRC screening is of outmost importance.
Keywords: Colorectal adenomas; Colorectal cancer; Colorectal neoplasia; Hispanics; Type 2 DM; Type 2 diabetes.
Copyright © 2015 Elsevier Inc. All rights reserved.
Source: PubMed