Effect of intraoperative goal-directed fluid therapy on the postoperative brain edema in patients undergoing high-grade glioma resections: a study protocol of randomized control trial

Xiaoyuan Liu, Xingyue Zhang, Yifang Fan, Shu Li, Yuming Peng, Xiaoyuan Liu, Xingyue Zhang, Yifang Fan, Shu Li, Yuming Peng

Abstract

Introduction: Brain edema is the most frequent postoperative complication after brain tumor resection, especially in patients with high-grade glioma. However, the effect of SVV-based goal-directed fluid therapy (GDFT) on postoperative brain edema and the prognosis remain unclear.

Methods and analysis: This is a prospective, randomized, double-blinded, parallel-controlled trial aiming to observe whether stroke volume variation (SVV)-based GDFT could improve the postoperative brain edema in patients undergoing supratentorial high-grade gliomas compared with traditional fluid therapy. The patient will be given 3 ml/kg hydroxyethyl starch solution when the SVV is greater than 15% continuously for more than 5 min intraoperatively. The primary outcome will be postoperative cerebral edema volume on brain CT within 24 h.

Ethics and dissemination: This trial has been registered at ClinicalTrials.gov (NCT03323580) and approved by the Ethics Committee of Beijing Tiantan Hospital, Capital Medical University (reference number: KY2017-067-02). The findings will be disseminated in peer-reviewed journals and presented at national or international conferences relevant to the subject fields.

Trial registration: ClinicalTrials.gov NCT03323580 (First posted: October 27, 2017; Last update posted: February 11, 2022).

Conflict of interest statement

The authors declare that they have no competing interests.

© 2022. The Author(s).

Figures

Fig. 1
Fig. 1
Flow chart of the study. GDFT goal-directed fluid therapy
Fig. 2
Fig. 2
GDFT protocol. SVV stroke volume variation, MAP mean arterial pressure, HR heart rate, Hb hemoglobin, GDFT goal-directed fluid therapy
Fig. 3
Fig. 3
Data collection at each time point. Pre-op preoperative, Op operative, GDFT goal-directed fluid therapy, SDT standard treatment, MRI magnetic resonance imaging, CT computerized tomography, NRS Numeric Rating Scale

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