The effect of a streptococci containing probiotic in periodontal therapy: a randomized controlled trial
Isabelle Laleman, Eftal Yilmaz, Onur Ozcelik, Cenk Haytac, Martine Pauwels, Esteban R Herrero, Vera Slomka, Marc Quirynen, Bahar Alkaya, Wim Teughels, Isabelle Laleman, Eftal Yilmaz, Onur Ozcelik, Cenk Haytac, Martine Pauwels, Esteban R Herrero, Vera Slomka, Marc Quirynen, Bahar Alkaya, Wim Teughels
Abstract
Aim: To evaluate the adjunctive effects of a Streptococcus oralis KJ3, Streptococcus uberis KJ2 and Streptococcus rattus JH145 containing probiotic tablet after scaling and root planing (SRP).
Materials and methods: Forty-eight periodontitis patients were included in this double-blind, placebo-controlled clinical trial. After root planing, patients used either a placebo or a probiotic tablet twice a day for 12 weeks. The pocket probing depth (primary outcome measure), bleeding on probing and relative attachment levels were measured at baseline, 12 and 24 weeks. At baseline, 4, 8, 12 and 24 weeks, microbiological sampling was performed and plaque and gingival indices were recorded.
Results: The primary and secondary outcome measures were significantly (p < 0.05) improved at the 12- and the 24-week evaluation in both groups. However, no significant inter-group differences could be detected at any time point, except from the % of sites with plaque that were significantly lower in the probiotic group than in the control group at the 24-week evaluation. In addition, at the 12-week time point, the salivary Prevotella intermedia counts were significantly lower in the probiotic group.
Conclusions: No differences were detected when comparing the adjunctive use of a placebo or the investigated streptococci containing probiotic tablet after SRP. ClinicalTrials.gov Identifier: NCT02403960.
Keywords: periodontitis; probiotic tablet; probiotics; scaling and root planing; streptococci; treatment.
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Source: PubMed