Concurrent validity of kidney transplant questionnaire in US renal transplant recipients

Marie A Chisholm-Burns, Steven R Erickson, Christina A Spivey, Rainer Wg Gruessner, Bruce Kaplan, Marie A Chisholm-Burns, Steven R Erickson, Christina A Spivey, Rainer Wg Gruessner, Bruce Kaplan

Abstract

Background: Valid instrumentation in the assessment of health-related quality of life (HQoL) in renal transplant recipients is critical to identifying particular nuances and determinants of HQoL in this population. Therefore, the validity of disease-specific instruments to measure HQoL in renal transplant recipients, such as the Kidney Transplant Questionnaire (KTQ), needs further investigation. The objective of this study was to assess the concurrent validity of the KTQ in adult US renal transplant recipients using the well established SF-12 Health Survey version 2 (SF-12v2) as the comparison instrument.

Methods: One hundred and fourteen renal transplant recipients met the following inclusion criteria for this study, ie, were at least 21 years of age, more than two years post-transplant, and receiving immunosuppressant therapy. Subjects were asked to complete a series of HQoL instruments, ie, the KTQ and the SF-12v2 (physical component summary [PCS-12] and mental component summary [MCS-12]). Descriptive statistics were calculated, and correlational analyses were conducted to examine the concurrent validity of the HQoL instruments.

Results: Among 100 participants (87.7% response rate), the majority of participants were male (52%), had deceased donor transplants (63%), and received Medicare benefits (84%). PCS-12 was positively correlated with three of five KTQ subscales (P < 0.05), ie, KTQ-physical (r = 0.43), KTQ-fatigue (r = 0.42), and KTQ-uncertainty/fear (r = 0.2). MCS-12 was positively correlated with all KTQ subscales (P < 0.01), ie, KTQ-physical (r = 0.26), KTQ-fatigue (r = 0.48), KTQ-uncertainty/fear (r = 0.33), KTQ-emotional (r = 0.47), and KTQ-appearance (r = 0.28).

Conclusion: The findings support the concurrent validity of the KTQ in US renal transplant recipients. Future studies should continue exploring the validity of the KTQ, as well as its practical and research utility in HQoL measurement in the renal transplant population.

Keywords: SF-12 Health Survey; concurrent validity; kidney transplant questionnaire; quality of life; renal transplant recipients.

References

    1. The WHOQOL Group. The World Health Organization quality of life assessment (WHOQOL): position paper from the World Health Organization. Soc Sci Med. 1995;41:1403–1409.
    1. Rebollo P, Ortega F, Ortega T, Valdés C, García-Mendoza M, Gómez E. Spanish validation of the “Kidney Transplant Questionnaire”: a useful instrument for assessing health related quality of life in kidney transplant patients. Health Qual Life Outcomes. 2003;1:56.
    1. Fiebiger W, Mitterbauer C, Oberbauer R. Health-related quality of life outcomes after kidney transplantation. Health Qual Life Outcomes. 2004;2:2.
    1. Bohlke M, Marini SS, Rocha M, et al. Factors associated with health-related quality of life after successful kidney transplantation: a population-based study. Qual Life Res. 2009;18:1185–1193.
    1. Laupacis A, Keown P, Pus N, et al. A study of the quality of life and cost-utility of renal transplantation. Kidney Int. 1996;50:235–242.
    1. Laupacis A, Pus N, Muirhead N, Wong C, Ferguson B, Keown P. Disease-specific questionnaire for patients with a renal transplant. Nephron. 1993;64:226–231.
    1. Rostami Z, Tavallaii S-A, Jahani Y, Einollahi B. Assessment of quality of life in a single-center transplantation population using the Kidney Transplant Questionnaire-25 Questionnaire. Transplant Proc. 2011;43:590–591.
    1. Eysenck MW. Psychology: An International Perspective. New York, NY: Psychology Press; 2004.
    1. Monette DR, Sullivan TJ, DeJong CR. Applied Social Research: A Tool for the Human Services. Belmont, CA: Brooks/Cole; 2011.
    1. Streiner DL, Norman GR. Health Measurement Scales: A Practical Guide to Their Development and Use. 4th ed. New York, NY: Oxford University Press; 2008.
    1. Ware J, Kosinski M, Turner-Bowker D, Gandek B. User’s Manual for the SF-12v2®Health Survey (with a supplement documenting SF-12® health survey) Lincoln, RI: QualityMetric Incorporated; 2009.
    1. Liem YS, Bosch JL, Arends LR, Heijenbrok-Kal MH, Hunink MG. Quality of life assessed with the Medical Outcomes Study Short Form 36-Item Health Survey of patients on renal replacement therapy: a systematic review and meta-analysis. Value Health. 2007;10:390–397.
    1. Stavem K, Ganss R. Reliability and validity of the ESRD Symptom Checklist-Transplantation Module in Norwegian kidney transplant recipients. BMC Nephrol. 2006;7:17.
    1. Barotfi S, Molnar MZ, Almasi C, et al. Validation of the Kidney Disease Quality of Life-Short Form questionnaire in kidney transplant patients. J Psychosom Research. 2006;60:495–504.
    1. McHorney CA, Tarlov AR. Individual-patient monitoring in clinical practice: are available health status surveys adequate. Qual Life Res. 1995;4:293–307.
    1. George D, Mallery P. SPSS for Windows Step by Step: A Simple Guide and Reference. 11.0 Update. 4th ed. Boston, MA: Allyn and Bacon; 2003.
    1. Sakthong P, Charoenvisuthiwongs R, Shabunthom R. A comparison of EQ-5D index scores using the UK, US, and Japan preference weights in a Thai sample with type 2 diabetes. Health Qual Life Outcomes. 2008;6:71.
    1. Sprangers MAG, Schwartz CE. Integrating response shift into health-related quality of life research: a theoretical model. Soc Sci Med. 1999;48:1507–1515.
    1. Organ Procurement Transplantation Network. National data. [Accessed January 31, 2011]. Available at: .

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