Retinal nerve fiber layer changes in migraine: A protocol for systematic review and meta-analysis

XiaoGuang Lin, ZhongQuan Yi, XueLing Zhang, QinQin Liu, RuYuan Cai, ChaoChun Chen, HongJie Zhang, PanWen Zhao, PingLei Pan, XiaoGuang Lin, ZhongQuan Yi, XueLing Zhang, QinQin Liu, RuYuan Cai, ChaoChun Chen, HongJie Zhang, PanWen Zhao, PingLei Pan

Abstract

Background: Migraine is a common neurological disease, which seriously affects the quality of life and daily activities of patients. Although migraine is a transient phenomenon of cerebral vasoconstriction, it is well documented that recurrent attacks of migraine may lead to abnormalities in retinal structure. Optical coherence tomography (OCT) is a sensitive method to detect subtle damage in retinal nerve fiber layer (RNFL). There have been many studies investigating the difference in RNFL thickness with optical coherence tomography (OCT) between migraine patients and healthy controls. However, the results were not consistent. Our purpose is to perform a meta-analysis to investigate RNFL alterations in migraine.

Methods: We will search PubMed, Embase, Web of science for studies assessing the differences in RNFL measured by OCT between patients with migraine and healthy controls. Case-control studies published in English will be included. Two reviewers will independently screen eligible articles, extract data, and assess quality. This meta-analysis will synthesize selected research data and compare the difference in RNFL thickness between patients with migraine and healthy controls. We will use Stata 15 in this meta-analysis. I statistics will be used to assess heterogeneity. If I ≤ 50%, the data are synthesized will use a fixed effect model. Otherwise, a random effect model will be performed. Publication bias will be determined by the Egger test. The methodological quality of all included studies will be evaluated by the Newcastle-Ottawa Scale (NOS). We will perform subgroup analysis, sensitivity analysis, and meta-regression analysis to test the robustness of the results.

Results: We will obtain quantitative results regarding the difference in RNFL thickness between migraine patients and healthy controls. The results will be published in a peer-reviewed journal.

Conclusions: The results of this study provide a high-quality synthesis of existing evidence and provide a basis for assessing the effect of migraine on the thickness of RNFL.

Registration number: INPLASY 202060033.

Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
The PRISMA flow diagram of study selection process.

References

    1. Barnett R. Migraine. Lancet 2019;394:1897.
    1. Buse DC, Silberstein SD, Manack AN, et al. Psychiatric comorbidities of episodic and chronic migraine. J Neurol 2013;260:1960–9.
    1. Wang SJ, Chen PK, Fuh JL. Comorbidities of migraine. Front Neurol 2010;1:16.
    1. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 2017;390:1211–59.
    1. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016;388:1545–602.
    1. Woldeamanuel YW, Cowan RP. Migraine affects 1 in 10 people worldwide featuring recent rise: A systematic review and meta-analysis of community-based studies involving 6 million participants. J Neurol Sci 2017;372:307–15.
    1. Giffin NJ, Ruggiero L, Lipton RB, et al. Premonitory symptoms in migraine: an electronic diary study. Neurology 2003;60:935–40.
    1. Vecchia D, Pietrobon D. Migraine: a disorder of brain excitatory-inhibitory balance? Trends Neurosci 2012;35:507–20.
    1. Cephalalgia, Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders. 3rd edn.2018;38.
    1. Burstein R, Noseda R, Borsook D. Migraine: multiple processes, complex pathophysiology. J Neurosci 2015;35:6619–29.
    1. Goadsby PJ, Charbit AR, Andreou AP, et al. Neurobiology of migraine. Neuroscience 2009;161:327–41.
    1. Cutrer FM. Pathophysiology of migraine. Semin Neurol 2010;30:120–30.
    1. Ayata C. Cortical spreading depression triggers migraine attack: pro. Headache 2010;50:725–30.
    1. Gipponi S, Scaroni N, Venturelli E, et al. Reduction in retinal nerve fiber layer thickness in migraine patients. Neurol Sci 2013;34:841–5.
    1. Zengin MO, Elmas Z, Cinar E, et al. Choroidal thickness changes in patients with migraine. Acta Neurol Belg 2015;115:33–7.
    1. Martinez A, Proupim N, Sanchez M. Retinal nerve fibre layer thickness measurements using optical coherence tomography in migraine patients. Br J Ophthalmol 2008;92:1069–75.
    1. Martinez A, Proupim N, Sanchez M. Scanning laser polarimetry with variable corneal compensation in migraine patients. Acta Ophthalmolog 2009;87:746–53.
    1. McCabe JM, Croce KJ. Optical coherence tomography. Circulation 2012;126:2140–3.
    1. Mwanza J-C, Oakley JD, Budenz DL, et al. Macular ganglion cell-inner plexiform layer: automated detection and thickness reproducibility with spectral domain-optical coherence tomography in glaucoma. Invest Ophthalmol Vis Sci 2011;52:8323–9.
    1. Kim KE, Yoo BW, Jeoung JW, et al. Long-term reproducibility of macular ganglion cell analysis in clinically stable glaucoma patients. Invest Ophthalmol Vis Sci 2015;56:4857–64.
    1. Chen JJ. Optical coherence tomography and neuro-ophthalmology. J Neuroophthalmol 2018;38:e5–8.
    1. Trick GL, Calotti FY, Skarf B. Advances in imaging of the optic disc and retinal nerve fiber layer. J Neuroophthalmol 2006;26:284–95.
    1. Fujimoto J, Swanson E. The development, commercialization, and impact of optical coherence tomography. Invest Ophthalmol Vis Sci 2016;57:OCT1–3.
    1. Sergott RC, Balcer LJ. The latest on optical coherence tomography. J Neuroophthalmol 2014;34Suppl:S1–2.
    1. Savino PJ. Evaluation of the retinal nerve fiber layer: descriptive or predictive? J Neuroophthalmol 2009;29:245–9.
    1. Costello FE. Optical coherence tomography technologies: which machine do you want to own? J Neuroophthalmol 2014;34Suppl:S3–9.
    1. Abdellatif MK, Fouad MM. Effect of duration and severity of migraine on retinal nerve fiber layer, ganglion cell layer, and choroidal thickness. Eur J Ophthalmol 2018;28:714–21.
    1. Ao R, Wang R, Yang M, et al. Altered retinal nerve fiber layer thickness and choroid thickness in patients with migraine. Eur Neurol 2018;80:130–7.
    1. Yener AÜ, Korucu O. Quantitative analysis of the retinal nerve fiber layer, ganglion cell layer and optic disc parameters by the swept source optical coherence tomography in patients with migraine and patients with tension-type headache. Acta Neurol Belg 2019;119:541–8.
    1. Simsek IB, Aygun D, Yildiz S. Retinal nerve fibre layer thickness in migraine patients with or without aura. Neuroophthalmology 2015;39:17–21.
    1. Feng Y-F, Guo H, Huang J-H, et al. Retinal nerve fiber layer thickness changes in migraine: a meta-analysis of case-control studies. Curr Eye Res 2016;41:814–22.
    1. Yu JG, Feng YF, Xiang Y, et al. Retinal nerve fiber layer thickness changes in Parkinson disease: a meta-analysis. PloS One 2014;9:e85718.
    1. Moher D, Liberati A, Tetzlaff J, Altman DG. PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 2009;339:b2535.
    1. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 2010;25:603–5.
    1. Jacobs B, Dussor G. Neurovascular contributions to migraine: moving beyond vasodilation. Neuroscience 2016;338:130–44.
    1. Tatham AJ, Medeiros FA. Detecting structural progression in glaucoma with optical coherence tomography. Ophthalmology 2017;124:S57–65.
    1. Kara SA, Erdemoğlu AK, Karadeniz MY, et al. Color Doppler sonography of orbital and vertebral arteries in migraineurs without aura. J Clin Ultrasound 2003;31:308–14.
    1. Schrems WA, Schrems-Hoesl LM, Bendschneider D, et al. Predicted and measured retinal nerve fiber layer thickness from time-domain optical coherence tomography compared with spectral-domain optical coherence tomography. JAMA Ophthalmol 2015;133:1135–43.

Source: PubMed

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