Topical Liposomal Ozonated Oil in Complicated Corneal Disease: A Report on Three Clinical Cases

Abstract

Infectious and traumatic corneal diseases require adequate therapy against infection and promote re-epithelialization. The appearance of multidrug-resistant bacterial strains, induced by excessive use of antibiotics in the treatment of infectious diseases, has urged researchers to study new antimicrobial formulations. Ozonated oils have demonstrated antiseptic (antibacterial, antifungal and antiviral) and reparative properties and can be proposed for the prevention and treatment of acute and chronic local infections, as an alternative to conventional topical antimicrobials. In ocular treatment, ozonated oil can exert tissue repair and anti-inflammatory and bactericidal activity. Moreover, its specific formulation makes it well tolerated and biocompatible with the ocular surface. Herein, we report on three cases of corneal inflammation (dendritic epithelial keratitis, corneal injuries caused by olive leaves, and neurotrophic corneal ulcer), treated with liposomal ozonated oil (Ozodrop®, FB VISION S.p.a. San Benedetto del Tronto, Italy), successfully resolved using topical liposomal ozonated oil.

Keywords: corneal trauma; corneal ulcers; corneal wound healing; infectious keratitis; ozonated oil.

Conflict of interest statement

The authors report no conflicts of interest in this work.

© 2021 Passidomo et al.

Figures

Figure 1

Right eye of a 56-year-old patient with dendritic epithelial keratitis during the follow-up period ((A): baseline; (B): after 3 days; (C): after 4 days; (D): after 7 days).

Figure 2

A 65-year-old man immediately after a corneal trauma caused by an olive leaf ((A): Large inferior trauma between 2 and 6 o’clock; (B): after 2 days; (C): after 3 days of treatment).

Figure 3

Corneal abscess in a 63-year-old woman ((A): slit lamp; (B): corneal OCT; (C): after 3 days; (D): after 5 days; (E): corneal confocal microscopy after 5 days; (F): corneal abscess nearly solved after 7 days; (G): after 10 days; (H): after 12 days; (I–K): the OCT examination shows a gradual and progressive normalisation of corneal anatomy, with resolution of the abscess area and the ulcer).