Early administration of low-dose aspirin for the prevention of preterm and term preeclampsia: a systematic review and meta-analysis
Stéphanie Roberge, Pia Villa, Kypros Nicolaides, Yves Giguère, Merja Vainio, Abdelouahab Bakthi, Alaa Ebrashy, Emmanuel Bujold, Stéphanie Roberge, Pia Villa, Kypros Nicolaides, Yves Giguère, Merja Vainio, Abdelouahab Bakthi, Alaa Ebrashy, Emmanuel Bujold
Abstract
Objective: To compare the effect of early administration of aspirin on the risk of preterm and term preeclampsia.
Method: A systematic review and meta-analysis of randomized controlled trials were performed. Women who were randomized to low-dose aspirin or placebo/no treatment at or before 16 weeks of gestation were included. The outcomes of interest were preterm preeclampsia (delivery <37 weeks) and term preeclampsia. Pooled relative risks (RR) with their 95% confidence intervals (CI) were computed.
Results: The search identified 7,941 citations but only five trials on a combined total of 556 women fulfilled the inclusion criteria. When compared to controls, aspirin initiated ≤16 weeks of gestation was associated with a major reduction of the risk of preterm preeclampsia (RR 0.11, 95% CI 0.04-0.33) but had no significant effect on term preeclampsia (RR 0.98, 95% CI 0.42-2.33).
Conclusion: Low-dose aspirin administrated at or before 16 weeks of gestation reduces the risk of preterm but not term preeclampsia.
Copyright © 2012 S. Karger AG, Basel.
Source: PubMed