The prevalence of the metabolically healthy obese phenotype in an aging population and its association with subclinical cardiovascular disease: The Brazilian study on healthy aging

Lara Roberson, Sameer Shaharyar, Ehimen Aneni, Wladimir Freitas, Michael Blaha, Arthur Agatston, Roger Blumenthal, Raul D Santos, Hamid Feiz, Khurram Nasir, Andrei Sposito, Lara Roberson, Sameer Shaharyar, Ehimen Aneni, Wladimir Freitas, Michael Blaha, Arthur Agatston, Roger Blumenthal, Raul D Santos, Hamid Feiz, Khurram Nasir, Andrei Sposito

Abstract

Background: Current literature has elucidated a new phenotype, metabolically healthy obese (MHO), with risks of cardiovascular disease similar to that of normal weight individuals. Few studies have examined the MHO phenotype in an aging population, especially in association with subclinical CVD.

Research design and methods: This cross sectional study population consisted of 208 octogenarians and older. Anthropometrics, biochemical, and radiological parameters were measured to assess obesity, metabolic health (assessed by the National Cholesterol Education Program -Adult Treatment Panel (NCEP-ATP III) criteria), and subclinical measures of CVD.

Results: The prevalence of MHO was 13.5% (N = 28). No significant association with MHO was noted for age, coronary artery calcium score, cIMT, or hs-CRP > 3 mg/dl (p = NS).

Conclusions: Our results suggest that the MHO phenotype exists in the elderly; however, subclinical CVD measures were not different in sub-group analysis suggesting traditional metabolic risk factor algorithms may not be accurate in the very elderly.

Keywords: Aging; Metabolic Syndrome; Obesity; Subclinical CVD.

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