Azithromycin and cough-specific health status in patients with chronic obstructive pulmonary disease and chronic cough: a randomised controlled trial

Farida F Berkhof, Nynke E Doornewaard-ten Hertog, Steven M Uil, Huib A M Kerstjens, Jan W K van den Berg, Farida F Berkhof, Nynke E Doornewaard-ten Hertog, Steven M Uil, Huib A M Kerstjens, Jan W K van den Berg

Abstract

Background: Macrolides reduce exacerbations in patients with COPD. Their effects on health status has not been assessed as primary outcome and is less clear. This study assessed the effects of prophylactic azithromycin on cough-specific health status in COPD-patients with chronic productive cough.

Methods: In this randomised controlled trial 84 patients met the eligibility criteria: age of ≥40 years, COPD GOLD stage ≥2 and chronic productive cough. The intervention-group (n = 42) received azithromycin 250 mg 3 times a week and the control-group (n = 42) received a placebo. Primary outcome was cough-specific health status at 12 weeks, measured with the Leicester Cough Questionnaire (LCQ). Secondary outcomes included generic and COPD-specific health status and exacerbations. Changes in adverse events and microbiology were monitored.

Results: Mean age of participants was 68 ± 10 years and mean FEV1 was 1.36 ± 0.47 L. The improvement in LCQ total score at 12 weeks was significantly greater with azithromycin (difference 1.3 ± 0.5, 95% CI 0.3;2.3, p = 0.01) and met the minimal clinically important difference. Similar results were found for the domain scores, and COPD-specific and generic health status questionnaires. Other secondary endpoints were non-significant. No imbalances in adverse events were found.

Conclusions: Prophylactic azithromycin improved cough-specific health status in COPD-patients with chronic productive cough to a clinically relevant degree.

Trial registration: ClinicalTrials.gov NCT01071161.

Figures

Figure 1
Figure 1
Consort flow chart. * 5 patients with lung cancer, 4 patients with idiopathic interstitial lung disease, 1 patient with bronchiectasis † 2 patients with diarrhoea and 1 with disturbance of taste. ‡ informed consent. § patient with disturbance of taste. Withdrew after 12 weeks.
Figure 2
Figure 2
Change over time in LCQ total score. Repeated measures of the Leicester Cough Questionnaire (LCQ) total scores at 0, 2, 6, 9, 12 and 18 weeks between the azithromycin (n = 38) and placebo (n = 39) group. Error bars indicate 95% confidence intervals.
Figure 3
Figure 3
Time to first exacerbation COPD. Kaplan Meier curves showing the proportion of patients with a first exacerbation against time in days for the azithromycin (n = 42) and placebo (n = 42) group.

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