Growth Outcomes of Preterm Infants Exposed to Different Oxygen Saturation Target Ranges from Birth
Cristina T Navarrete, Lisa A Wrage, Waldemar A Carlo, Michele C Walsh, Wade Rich, Marie G Gantz, Abhik Das, Kurt Schibler, Nancy S Newman, Anthony J Piazza, Brenda B Poindexter, Seetha Shankaran, Pablo J Sánchez, Brenda H Morris, Ivan D Frantz 3rd, Krisa P Van Meurs, C Michael Cotten, Richard A Ehrenkranz, Edward F Bell, Kristi L Watterberg, Rosemary D Higgins, Shahnaz Duara, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Abhik Das, Marie Gantz, Alan H Jobe, Michael S Caplan, Avroy A Fanaroff, Deanne E Wilson-Costello, Bonnie S Siner, Arlene Zadell, Julie DiFiore, Monika Bhola, Harriet G Friedman, Gulgun Yalcinkaya, Edward F Donovan, Vivek Narendran, Kimberly Yolton, Kate Bridges, Barbara Alexander, Cathy Grisby, Marcia Worley Mersmann, Holly L Mincey, Jody Hessling, Teresa L Gratton, Ronald N Goldberg, Ricki F Goldstein, Patricia Ashley, Kathy J Auten, Kimberley A Fisher, Katherine A Foy, Sharon F Freedman, Kathryn E Gustafson, Melody B Lohmeyer, William F Malcolm, David K Wallace, Barbara J Stoll, Ira Adams-Chapman, Susie Buchter, David P Carlton, Sheena Carter, Sobha Fritz, Ellen C Hale, Amy K Hutchinson, Maureen Mulligan LaRossa, Gloria V Smikle, Stephanie Wilson Archer, Anna M Dusick, James A Lemons, Gary J Myers, Leslie D Wilson, Faithe Hamer, Ann B Cook, Dianne E Herron, Carolyn Lytle, Heike M Minnich, Mary Anne Berberich, Carol J Blaisdell, Dorothy B Gail, James P Kiley, W Kenneth Poole, Jamie E Newman, Betty K Hastings, Jeanette O'Donnell Auman, Carolyn Petrie Huitema, James W Pickett 2nd, Dennis Wallace, Kristin M Zaterka-Baxter, David K Stevenson, Susan R Hintz, M Bethany Ball, Barbara Bentley, Elizabeth F Bruno, Alexis S Davis, Maria Elena DeAnda, Anne M DeBattista, Lynne C Huffman, Jean G Kohn, Melinda S Proud, Renee P Pyle, Nicholas H St John, Hali E Weiss, John M Fiascone, Elisabeth C McGowan, Anne Furey, Brenda L MacKinnon, Ellen Nylen, Ana Brussa, Cecelia Sibley, Namasivayam Ambalavanan, Myriam Peralta-Carcelen, Monica V Collins, Shirley S Cosby, Vivien A Phillips, Kirstin J Bailey, Fred J Biasini, Maria Hopkins, Kristen C Johnston, Sara Krzywanski, Kathleen G Nelson, Cryshelle S Patterson, Richard V Rector, Leslie Rodriguez, Amanda Soong, Sally Whitley, Sheree York, John A Widness, Michael J Acarregui, Jonathan M Klein, Tarah T Colaizy, Karen J Johnson, Diane L Eastman, Charles R Bauer, Ruth Everett-Thomas, Maria Calejo, Alexis N Diaz, Silvia M Frade Eguaras, Andrea Garcia, Kasey Hamlin-Smith, Michelle Harwood Berkowits, Sylvia Hiriart-Fajardo, Helina Pierre, Arielle Rigaud, Alexandra Stroerger, Robin K Ohls, Janell Fuller, Julie Rohr, Conra Backstrom Lacy, Jean Lowe, Rebecca Montman, Luc Brion, Charles R Rosenfeld, Walid A Salhab, Roy J Heyne, Sally S Adams, James Allen, Lijun Chen, Laura Grau, Alicia Guzman, Gaynelle Hensley, Elizabeth T Heyne, Jackie Hickman, Melissa H Lepps, Linda A Madden, Nancy A Miller, Janet S Morgan, Araceli Solis, Lizette E Torres, Catherine Twell Boatman, Diana M Vasil, Kathleen A Kennedy, Jon E Tyson, Esther G Akpa, Nora I Alaniz, Susan Dieterich, Patricia W Evans, Charles Green, Beverly Foley Harris, Margarita Jiminez, Anna E Lis, Karen Martin, Sarah Martin, Georgia E McDavid, Brenda H Morris, M Layne Poundstone, Stacey Reddoch, Saba Siddiki, Maegan C Simmons, Patti L Pierce Tate, Sharon L Wright, Beena G Sood, Athina Pappas, Rebecca Bara, Elizabeth Billian, Laura A Goldston, Mary Johnson, Vineet Bhandari, Harris C Jacobs, Pat Cervone, Patricia Gettner, Monica Konstantino, JoAnn Poulsen, Janet Taft, Christine G Butler, Nancy Close, Walter Gilliam, Sheila Greisman, Elaine Romano, Joanne Williams, Cristina T Navarrete, Lisa A Wrage, Waldemar A Carlo, Michele C Walsh, Wade Rich, Marie G Gantz, Abhik Das, Kurt Schibler, Nancy S Newman, Anthony J Piazza, Brenda B Poindexter, Seetha Shankaran, Pablo J Sánchez, Brenda H Morris, Ivan D Frantz 3rd, Krisa P Van Meurs, C Michael Cotten, Richard A Ehrenkranz, Edward F Bell, Kristi L Watterberg, Rosemary D Higgins, Shahnaz Duara, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Abhik Das, Marie Gantz, Alan H Jobe, Michael S Caplan, Avroy A Fanaroff, Deanne E Wilson-Costello, Bonnie S Siner, Arlene Zadell, Julie DiFiore, Monika Bhola, Harriet G Friedman, Gulgun Yalcinkaya, Edward F Donovan, Vivek Narendran, Kimberly Yolton, Kate Bridges, Barbara Alexander, Cathy Grisby, Marcia Worley Mersmann, Holly L Mincey, Jody Hessling, Teresa L Gratton, Ronald N Goldberg, Ricki F Goldstein, Patricia Ashley, Kathy J Auten, Kimberley A Fisher, Katherine A Foy, Sharon F Freedman, Kathryn E Gustafson, Melody B Lohmeyer, William F Malcolm, David K Wallace, Barbara J Stoll, Ira Adams-Chapman, Susie Buchter, David P Carlton, Sheena Carter, Sobha Fritz, Ellen C Hale, Amy K Hutchinson, Maureen Mulligan LaRossa, Gloria V Smikle, Stephanie Wilson Archer, Anna M Dusick, James A Lemons, Gary J Myers, Leslie D Wilson, Faithe Hamer, Ann B Cook, Dianne E Herron, Carolyn Lytle, Heike M Minnich, Mary Anne Berberich, Carol J Blaisdell, Dorothy B Gail, James P Kiley, W Kenneth Poole, Jamie E Newman, Betty K Hastings, Jeanette O'Donnell Auman, Carolyn Petrie Huitema, James W Pickett 2nd, Dennis Wallace, Kristin M Zaterka-Baxter, David K Stevenson, Susan R Hintz, M Bethany Ball, Barbara Bentley, Elizabeth F Bruno, Alexis S Davis, Maria Elena DeAnda, Anne M DeBattista, Lynne C Huffman, Jean G Kohn, Melinda S Proud, Renee P Pyle, Nicholas H St John, Hali E Weiss, John M Fiascone, Elisabeth C McGowan, Anne Furey, Brenda L MacKinnon, Ellen Nylen, Ana Brussa, Cecelia Sibley, Namasivayam Ambalavanan, Myriam Peralta-Carcelen, Monica V Collins, Shirley S Cosby, Vivien A Phillips, Kirstin J Bailey, Fred J Biasini, Maria Hopkins, Kristen C Johnston, Sara Krzywanski, Kathleen G Nelson, Cryshelle S Patterson, Richard V Rector, Leslie Rodriguez, Amanda Soong, Sally Whitley, Sheree York, John A Widness, Michael J Acarregui, Jonathan M Klein, Tarah T Colaizy, Karen J Johnson, Diane L Eastman, Charles R Bauer, Ruth Everett-Thomas, Maria Calejo, Alexis N Diaz, Silvia M Frade Eguaras, Andrea Garcia, Kasey Hamlin-Smith, Michelle Harwood Berkowits, Sylvia Hiriart-Fajardo, Helina Pierre, Arielle Rigaud, Alexandra Stroerger, Robin K Ohls, Janell Fuller, Julie Rohr, Conra Backstrom Lacy, Jean Lowe, Rebecca Montman, Luc Brion, Charles R Rosenfeld, Walid A Salhab, Roy J Heyne, Sally S Adams, James Allen, Lijun Chen, Laura Grau, Alicia Guzman, Gaynelle Hensley, Elizabeth T Heyne, Jackie Hickman, Melissa H Lepps, Linda A Madden, Nancy A Miller, Janet S Morgan, Araceli Solis, Lizette E Torres, Catherine Twell Boatman, Diana M Vasil, Kathleen A Kennedy, Jon E Tyson, Esther G Akpa, Nora I Alaniz, Susan Dieterich, Patricia W Evans, Charles Green, Beverly Foley Harris, Margarita Jiminez, Anna E Lis, Karen Martin, Sarah Martin, Georgia E McDavid, Brenda H Morris, M Layne Poundstone, Stacey Reddoch, Saba Siddiki, Maegan C Simmons, Patti L Pierce Tate, Sharon L Wright, Beena G Sood, Athina Pappas, Rebecca Bara, Elizabeth Billian, Laura A Goldston, Mary Johnson, Vineet Bhandari, Harris C Jacobs, Pat Cervone, Patricia Gettner, Monica Konstantino, JoAnn Poulsen, Janet Taft, Christine G Butler, Nancy Close, Walter Gilliam, Sheila Greisman, Elaine Romano, Joanne Williams
Abstract
Objective: To test whether infants randomized to a lower oxygen saturation (peripheral capillary oxygen saturation [SpO2]) target range while on supplemental oxygen from birth will have better growth velocity from birth to 36 weeks postmenstrual age (PMA) and less growth failure at 36 weeks PMA and 18-22 months corrected age.
Study design: We evaluated a subgroup of 810 preterm infants from the Surfactant, Positive Pressure, and Oxygenation Randomized Trial, randomized at birth to lower (85%-89%, n = 402, PMA 26 ± 1 weeks, birth weight 839 ± 186 g) or higher (91%-95%, n = 408, PMA 26 ± 1 weeks, birth weight 840 ± 191 g) SpO2 target ranges. Anthropometric measures were obtained at birth, postnatal days 7, 14, 21, and 28; then at 32 and 36 weeks PMA; and 18-22 months corrected age. Growth velocities were estimated with the exponential method and analyzed with linear mixed models. Poor growth outcome, defined as weight <10th percentile at 36 weeks PMA and 18-22 months corrected age, was compared across the 2 treatment groups by the use of robust Poisson regression.
Results: Growth outcomes including growth at 36 weeks PMA and 18-22 months corrected age, as well as growth velocity were similar in the lower and higher SpO2 target groups.
Conclusion: Targeting different oxygen saturation ranges between 85% and 95% from birth did not impact growth velocity or reduce growth failure in preterm infants.
Keywords: ELBW growth; oxygen saturation target.
Conflict of interest statement
The authors declare no conflicts of interest.
Copyright © 2016 Elsevier Inc. All rights reserved.
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Source: PubMed