Modification of the antinociceptive effect of morphine by centrally administered diazepam and midazolam

P Mantegazza, M Parenti, R Tammiso, P Vita, F Zambotti, N Zonta, P Mantegazza, M Parenti, R Tammiso, P Vita, F Zambotti, N Zonta

Abstract

1 Intracerebroventricular administration of diazepam or midazolam decreased the antinociceptive effect of morphine in rats as measured by the "tail flick" method. 2 Midazolam, injected into the periaqueductal grey matter (PAG) antagonized the analgesic effect of morphine. The action of midazolam was partially reversed by bicuculline. 3 These findings support the view that the effect of benzodiazephines on morphine antinociception may be mediated through gamma-aminobutyric acid receptors.

References

    1. Curr Ther Res Clin Exp. 1965 Nov;7(11):721-40
    1. Experientia. 1969 Apr 15;25(4):381
    1. Arch Int Pharmacodyn Ther. 1970 May;185(1):135-48
    1. Arch Int Pharmacodyn Ther. 1973 Jul;204(1):77-85
    1. Adv Biochem Psychopharmacol. 1973;8(0):245-61
    1. Physiol Behav. 1970 Jan;5(1):119-21
    1. Life Sci. 1976 May 15;18(10):1111-23
    1. J Pharmacol Exp Ther. 1976 Nov;199(2):389-99
    1. Biochem Pharmacol. 1976 Dec 1;25(23):2669-70
    1. Neuropharmacology. 1977 Feb;16(2):149-50
    1. Eur J Pharmacol. 1977 Feb 21;41(4):399-408
    1. Eur J Pharmacol. 1978 Oct 15;51(4):417-22
    1. Annu Rev Pharmacol Toxicol. 1979;19:531-45
    1. Brain Res. 1979 Jul 13;170(2):279-97
    1. Br J Pharmacol. 1979 Sep;67(1):103-7
    1. Nature. 1980 Sep 4;287(5777):65-7
    1. Naunyn Schmiedebergs Arch Pharmacol. 1981 Jun;316(3):231-4
    1. Indian J Physiol Pharmacol. 1964 Jan;8:27-32

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