Differential neural responses to food images in women with bulimia versus anorexia nervosa

Samantha J Brooks, Owen G O'Daly, Rudolf Uher, Hans-Christoph Friederich, Vincent Giampietro, Michael Brammer, Steven C R Williams, Helgi B Schiöth, Janet Treasure, Iain C Campbell, Samantha J Brooks, Owen G O'Daly, Rudolf Uher, Hans-Christoph Friederich, Vincent Giampietro, Michael Brammer, Steven C R Williams, Helgi B Schiöth, Janet Treasure, Iain C Campbell

Abstract

Background: Previous fMRI studies show that women with eating disorders (ED) have differential neural activation to viewing food images. However, despite clinical differences in their responses to food, differential neural activation to thinking about eating food, between women with anorexia nervosa (AN) and bulimia nervosa (BN) is not known.

Methods: We compare 50 women (8 with BN, 18 with AN and 24 age-matched healthy controls [HC]) while they view food images during functional Magnetic Resonance Imaging (fMRI).

Results: In response to food (vs non-food) images, women with BN showed greater neural activation in the visual cortex, right dorsolateral prefrontal cortex, right insular cortex and precentral gyrus, women with AN showed greater activation in the right dorsolateral prefrontal cortex, cerebellum and right precuneus. HC women activated the cerebellum, right insular cortex, right medial temporal lobe and left caudate. Direct comparisons revealed that compared to HC, the BN group showed relative deactivation in the bilateral superior temporal gyrus/insula, and visual cortex, and compared to AN had relative deactivation in the parietal lobe and dorsal posterior cingulate cortex, but greater activation in the caudate, superior temporal gyrus, right insula and supplementary motor area.

Conclusions: Women with AN and BN activate top-down cognitive control in response to food images, yet women with BN have increased activation in reward and somatosensory regions, which might impinge on cognitive control over food consumption and binge eating.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1. Between-group map activation showing food…
Figure 1. Between-group map activation showing food > non-food activation in women with bulimia nervosa versus anorexia nervosa.
T-value bar illustrates t-value scores represented by cluster on the brain map.

References

    1. (APA) APA. Washingtion: 2000. Diagnostic and statistical manual version 4 revised.
    1. Marsh R, Steinglass JE, Gerber AJ, Graziano O'Leary K, Wang Z, et al. Deficient activity in the neural systems that mediate self-regulatory control in bulimia nervosa. Arch Gen Psychiatry. 2009;66:51–63.
    1. Uher R, Murphy T, Brammer MJ, Dalgleish T, Phillips ML, et al. Medial prefrontal cortex activity associated with symptom provocation in eating disorders. Am J Psychiatry. 2004;161:1238–1246.
    1. Geliebter A, Ladell T, Logan M, Schneider T, Sharafi M, et al. Responsivity to food stimuli in obese and lean binge eaters using functional MRI. Appetite. 2006;46:31–35.
    1. Marsh R, Maia TV, Peterson BS. Functional disturbances within frontostriatal circuits across multiple childhood psychopathologies. Am J Psychiatry. 2009;166:664–674.
    1. Bohon C, Stice E. Reward abnormalities among women with full and subthreshold bulimia nervosa: A functional magnetic resonance imaging study. Int J Eat Disord. 2010 Epub ahead of print PMID:21058348.
    1. Schienle A, Schafer A, Hermann A, Vaitl D. Binge-eating disorder: reward sensitivity and brain activation to images of food. Biol Psychiatry. 2009;65:654–661.
    1. Frank GK, Wagner A, Achenbach S, McConaha C, Skovira K, et al. Altered brain activity in women recovered from bulimic-type eating disorders after a glucose challenge: a pilot study. Int J Eat Disord. 2006;39:76–79.
    1. Wagner A, Aizenstein H, Venkatraman VK, Bischoff-Grethe A, Fudge J, et al. Altered striatal response to reward in bulimia nervosa after recovery. Int J Eat Disord. 2010;43:289–294.
    1. First M GM, Spitzer R, Williams J. New York: Biometrics Research; 2001. User's guide for the Structured Clinical Interview for Diagnosis for DSM-IVTR axis I disorders: Research version.
    1. Fairburn CG BS. Assessment of eating disorders: interview or self-report questionnaire? Int J Eat Disord. 1996;16:363–370.
    1. Zigmond AS, Snaith RP. The Hospital Anxiety and Depression Scale. Acta Psychiatrica Scandinavica. 1983;67:361–370.
    1. First M GM, Spitzer R, Williams J. Biometrics Research; 2001. User's guide for the Structured Clinical Interview for the Diagnosis for DSM-IV-R axis I disorders: Research version.
    1. Brammer MJ. Multidimensional wavelet analysis of functional magnetic resonance images. Hum Brain Mapp. 1998;6:378–382.
    1. Brammer M. Statistical analysis of functional magnetic resonance imaging data: current state and recent developments. Stat Methods Med Res. 2003;12:373–374.
    1. Bullmore E, Fadili J, Breakspear M, Salvador R, Suckling J, et al. Wavelets and statistical analysis of functional magnetic resonance images of the human brain. Stat Methods Med Res. 2003;12:375–399.
    1. Thirion B, Pinel P, Tucholka A, Roche A, Ciuciu P, et al. Structural analysis of fMRI data revisited: improving the sensitivity and reliability of fMRI group studies. IEEE Trans Med Imaging. 2007;26:1256–1269.
    1. Desmond JE, Glover GH. Estimating sample size in functional MRI (fMRI) neuroimaging studies: statistical power analyses. J Neurosci Methods. 2002;118:115–128.
    1. Linden DE. How psychotherapy changes the brain--the contribution of functional neuroimaging. Mol Psychiatry. 2006;11:528–538.
    1. Coletta M, Platek S, Mohamed FB, van Steenburgh JJ, Green D, et al. Brain activation in restrained and unrestrained eaters: an fMRI study. J Abnorm Psychol. 2009;118:598–609.
    1. Schur EA, Kleinhans NM, Goldberg J, Buchwald D, Schwartz MW, et al. Activation in brain energy regulation and reward centers by food cues varies with choice of visual stimulus. Int J Obes (Lond) 2009;33:653–661.
    1. Goldstone AP, de Hernandez CG, Beaver JD, Muhammed K, Croese C, et al. Fasting biases brain reward systems towards high-calorie foods. Eur J Neurosci. 2009;30:1625–1635.
    1. Siep N, Roefs A, Roebroeck A, Havermans R, Bonte ML, et al. Hunger is the best spice: an fMRI study of the effects of attention, hunger and calorie content on food reward processing in the amygdala and orbitofrontal cortex. Behav Brain Res. 2009;198:149–158.
    1. Beaver JD, Lawrence AD, van Ditzhuijzen J, Davis MH, Woods A, et al. Individual differences in reward drive predict neural responses to images of food. J Neurosci. 2006;26:5160–5166.
    1. Berridge KC. 'Liking' and 'wanting' food rewards: brain substrates and roles in eating disorders. Physiol Behav. 2009;97:537–550.
    1. Everitt BJ, Robbins TW. Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci. 2005;8:1481–1489.
    1. Cole MW, Schneider W. The cognitive control network: Integrated cortical regions with dissociable functions. Neuroimage. 2007;37:343–360.
    1. Asahi S, Okamoto Y, Okada G, Yamawaki S, Yokota N. Negative correlation between right prefrontal activity during response inhibition and impulsiveness: a fMRI study. Eur Arch Psychiatry Clin Neurosci. 2004;254:245–251.
    1. Schlosser RG, Wagner G, Schachtzabel C, Peikert G, Koch K, et al. Fronto-cingulate effective connectivity in obsessive compulsive disorder: A study with fMRI and dynamic causal modeling. Hum Brain Mapp. 2010;31:1834–1850.
    1. Lock J, Garrett A, Beenhakker J, Reiss AL. Aberrant brain activation during a response inhibition task in adolescent eating disorder subtypes. Am J Psychiatry. 2011;168:55–64.
    1. Marsh R, Horga G, Wang Z, Wang P, Klahr KW, et al. An fMRI Study of Self-Regulatory Control and Conflict Resolution in Adolescents With Bulimia Nervosa. Am J Psychiatry. 2011 Epub ahead of print PMID:21676991.
    1. Craig AD. The sentient self. Brain Struct Funct. 2010;214:563–577.
    1. Nunn K, Frampton I, Gordon I, Lask B. The fault is not in her parents but in her insula--a neurobiological hypothesis of anorexia nervosa. Eur Eat Disord Rev. 2008;16:355–360.
    1. Kaye WH, Fudge JL, Paulus M. New insights into symptoms and neurocircuit function of anorexia nervosa. Nat Rev Neurosci. 2009;10:573–584.
    1. Brooks S, Prince A, Stahl D, Campbell IC, Treasure J. A systematic review and meta-analysis of cognitive bias to food stimuli in people with disordered eating behaviour. Clin Psychol Rev. 2011;31:37–51.
    1. Herman CP, Polivy J. Anxiety, restraint, and eating behavior. J Abnorm Psychol. 1975;84:66–72.
    1. Pretorius N, Waller G, Gowers S, Schmidt U. Validity of the Eating Disorders Examination-Questionnaire when used with adolescents with bulimia nervosa and atypical bulimia nervosa. Eat Weight Disord. 2009;14:e243–248.
    1. Frank S, Laharnar N, Kullmann S, Veit R, Canova C, et al. Processing of food pictures: influence of hunger, gender and calorie content. Brain Res. 2010;1350:159–166.

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