Chronic Obstructive Pulmonary Disease Patients' Acceptance in E-Health Clinical Trials

Saeed M Alghamdi, Ahmed M Al Rajah, Yousef S Aldabayan, Abdulelah M Aldhahir, Jaber S Alqahtani, Abdulaziz A Alzahrani, Saeed M Alghamdi, Ahmed M Al Rajah, Yousef S Aldabayan, Abdulelah M Aldhahir, Jaber S Alqahtani, Abdulaziz A Alzahrani

Abstract

Introduction: Telehealth (TH) interventions with Chronic Obstructive Pulmonary Disease (COPD) management were introduced in the literature more than 20 years ago with different labeling, but there was no summary for the overall acceptance and dropout rates as well as associated variables.

Objective: This review aims to summarize the acceptance and dropout rates used in TH interventions and identify to what extent clinical settings, sociodemographic factors, and intervention factors might impact the overall acceptance and completion rates of TH interventions.

Methods: We conducted a systematic search up to April 2021 on CINAHL, PubMed, MEDLINE (Ovid), Cochrane, Web of Sciences, and Embase to retrieve randomized and non-randomized control trials that provide TH interventions alone or accompanied with other interventions to individuals with COPD.

Results: Twenty-seven studies met the inclusion criteria. Overall, the unweighted average of acceptance and dropout rates for all included studies were 80% and 19%, respectively. A meta-analysis on the pooled difference between the acceptance rates and dropout rates (weighted by the sample size) revealed a significant difference in acceptance and dropout rates among all TH interventions 51% (95% CI 49% to 52; p < 0.001) and 63% (95% CI 60% to 67; p < 0.001), respectively. Analysis revealed that acceptance and dropout rates can be impacted by trial-related, sociodemographic, and intervention-related variables. The most common reasons for dropouts were technical difficulties (33%), followed by complicated system (31%).

Conclusions: Current TH COPD interventions have a pooled acceptance rate of 51%, but this is accompanied by a high dropout rate of 63%. Acceptance and dropout levels in TH clinical trials can be affected by sociodemographic and intervention-related factors. This knowledge enlightens designs for well-accepted future TH clinical trials. PROSPERO registration number CRD4201707854.

Keywords: COPD; chronic obstructive pulmonary disease; meta-analysis; systematic review; telehealth.

Conflict of interest statement

The authors of this paper declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow diagram showing studies related to the TH (telehealth) interventions in COPD (with Chronic Obstructive Pulmonary Disease).

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