Paravalvular leak after transcatheter aortic valve replacement: the new Achilles' heel? A comprehensive review of the literature
Philippe Généreux, Stuart J Head, Rebecca Hahn, Benoit Daneault, Susheel Kodali, Mathew R Williams, Nicolas M van Mieghem, Maria C Alu, Patrick W Serruys, A Pieter Kappetein, Martin B Leon, Philippe Généreux, Stuart J Head, Rebecca Hahn, Benoit Daneault, Susheel Kodali, Mathew R Williams, Nicolas M van Mieghem, Maria C Alu, Patrick W Serruys, A Pieter Kappetein, Martin B Leon
Abstract
Paravalvular leak (PVL) is a frequent complication of transcatheter aortic valve replacement (TAVR) and is seen at a much higher rate after TAVR than after conventional surgical aortic valve replacement. Recent reports indicating that PVL may be correlated with increased late mortality have raised concerns. However, the heterogeneity of methods for assessing and quantifying PVL, and lack of consistency in the timing of such assessments, is a hindrance to understanding its true prevalence, severity, and effect. This literature review is an effort to consolidate current knowledge in this area to better understand the prevalence, progression, and impact of post-TAVR PVL and to help direct future efforts regarding the assessment, prevention, and treatment of this troublesome complication.
Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Source: PubMed