Characterization of a metabolomic profile associated with responsiveness to therapy in the acute phase of septic shock
Alice Cambiaghi, Bernardo Bollen Pinto, Laura Brunelli, Francesca Falcetta, Federico Aletti, Karim Bendjelid, Roberta Pastorelli, Manuela Ferrario, Alice Cambiaghi, Bernardo Bollen Pinto, Laura Brunelli, Francesca Falcetta, Federico Aletti, Karim Bendjelid, Roberta Pastorelli, Manuela Ferrario
Abstract
The early metabolic signatures associated with the progression of septic shock and with responsiveness to therapy can be useful for developing target therapy. The Sequential Organ Failure Assessment (SOFA) score is used for stratifying risk and predicting mortality. This study aimed to verify whether different responses to therapy, assessed as changes in SOFA score at admission (T1, acute phase) and 48 h later (T2, post-resuscitation), are associated with different metabolite patterns. We examined the plasma metabolome of 21 septic shock patients (pts) enrolled in the Shockomics clinical trial (NCT02141607). Patients for which SOFAT2 was >8 and Δ = SOFAT1 - SOFAT2 < 5, were classified as not responsive to therapy (NR, 7 pts), the remaining 14 as responsive (R). We combined untargeted and targeted mass spectrometry-based metabolomics strategies to cover the plasma metabolites repertoire as far as possible. Metabolite concentration changes from T1 to T2 (Δ = T2 - T1) were used to build classification models. Our results support the emerging evidence that lipidome alterations play an important role in individual patients' responses to infection. Furthermore, alanine indicates a possible alteration in the glucose-alanine cycle in the liver, providing a different picture of liver functionality from bilirubin. Understanding these metabolic disturbances is important for developing any effective tailored therapy for these patients.
Conflict of interest statement
The authors declare that they have no competing interests.
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5575075/bin/41598_2017_9619_Fig1_HTML.jpg)
Figure 2
Untargeted metabolomics. Metabolites whose change…
Figure 2
Untargeted metabolomics. Metabolites whose change in peak intensity from T1 to T2 in…
Figure 3
Targeted metabolomics. Metabolites whose concentration…
Figure 3
Targeted metabolomics. Metabolites whose concentration (μM) is significantly different between responsive (R) and…
Figure 4
Targeted metabolomics. Metabolites whose concentration…
Figure 4
Targeted metabolomics. Metabolites whose concentration (μM) from T1 to T2 in the two…
Figure 5
Coefficients values of the logistic…
Figure 5
Coefficients values of the logistic regression models for targeted metabolomics (panel A) and…
Figure 6
Three-dimensional PLS-DA score plots on…
Figure 6
Three-dimensional PLS-DA score plots on 20 features for targeted metabolomics model (panel A)…
Figure 7
Plasma sPLA2-IIA levels (μg/L) in…
Figure 7
Plasma sPLA2-IIA levels (μg/L) in responsive (R) and non-responsive (NR) patients at T1…
- An Innovative Approach for The Integration of Proteomics and Metabolomics Data In Severe Septic Shock Patients Stratified for Mortality.Cambiaghi A, Díaz R, Martinez JB, Odena A, Brunelli L, Caironi P, Masson S, Baselli G, Ristagno G, Gattinoni L, de Oliveira E, Pastorelli R, Ferrario M. Cambiaghi A, et al. Sci Rep. 2018 Apr 27;8(1):6681. doi: 10.1038/s41598-018-25035-1. Sci Rep. 2018. PMID: 29703925 Free PMC article.
- Mortality prediction in patients with severe septic shock: a pilot study using a target metabolomics approach.Ferrario M, Cambiaghi A, Brunelli L, Giordano S, Caironi P, Guatteri L, Raimondi F, Gattinoni L, Latini R, Masson S, Ristagno G, Pastorelli R. Ferrario M, et al. Sci Rep. 2016 Feb 5;6:20391. doi: 10.1038/srep20391. Sci Rep. 2016. PMID: 26847922 Free PMC article. Clinical Trial.
- Identification of a transcriptome profile associated with improvement of organ function in septic shock patients after early supportive therapy.Barcella M, Bollen Pinto B, Braga D, D'Avila F, Tagliaferri F, Cazalis MA, Monneret G, Herpain A, Bendjelid K, Barlassina C. Barcella M, et al. Crit Care. 2018 Nov 21;22(1):312. doi: 10.1186/s13054-018-2242-3. Crit Care. 2018. PMID: 30463588 Free PMC article.
- Translational Metabolomics of Head Injury: Exploring Dysfunctional Cerebral Metabolism with Ex Vivo NMR Spectroscopy-Based Metabolite Quantification.Wolahan SM, Hirt D, Glenn TC. Wolahan SM, et al. In: Kobeissy FH, editor. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Chapter 25. In: Kobeissy FH, editor. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Chapter 25. PMID: 26269925 Free Books & Documents. Review.
- Fluid therapy for septic shock resuscitation: which fluid should be used?Corrêa TD, Rocha LL, Pessoa CM, Silva E, de Assuncao MS. Corrêa TD, et al. Einstein (Sao Paulo). 2015 Jul-Sep;13(3):462-8. doi: 10.1590/S1679-45082015RW3273. Epub 2015 Aug 21. Einstein (Sao Paulo). 2015. PMID: 26313437 Free PMC article. Review.
- Plasma enzymatic activity, proteomics and peptidomics in COVID-19-induced sepsis: A novel approach for the analysis of hemostasis.Dos Santos F, Li JB, Juocys N, Mazor R, Beretta L, Coufal NG, Lam MTY, Odish MF, Irigoyen MC, O'Donoghue AJ, Aletti F, Kistler EB. Dos Santos F, et al. Front Mol Biosci. 2023 Jan 11;9:1051471. doi: 10.3389/fmolb.2022.1051471. eCollection 2022. Front Mol Biosci. 2023. PMID: 36710882 Free PMC article.
- EASY-FIA: A Readably Usable Standalone Tool for High-Resolution Mass Spectrometry Metabolomics Data Pre-Processing.Morabito A, De Simone G, Ferrario M, Falcetta F, Pastorelli R, Brunelli L. Morabito A, et al. Metabolites. 2022 Dec 21;13(1):13. doi: 10.3390/metabo13010013. Metabolites. 2022. PMID: 36676938 Free PMC article.
- Metabolic fingerprint of patients showing responsiveness to treatment of septic shock in intensive care unit.Pandey S, Siddiqui MA, Azim A, Sinha N. Pandey S, et al. MAGMA. 2022 Nov 30. doi: 10.1007/s10334-022-01049-9. Online ahead of print. MAGMA. 2022. PMID: 36449125
- Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism.Yeudall S, Upchurch CM, Seegren PV, Pavelec CM, Greulich J, Lemke MC, Harris TE, Desai BN, Hoehn KL, Leitinger N. Yeudall S, et al. Sci Adv. 2022 Nov 25;8(47):eabq1984. doi: 10.1126/sciadv.abq1984. Epub 2022 Nov 23. Sci Adv. 2022. PMID: 36417534 Free PMC article.
- Systems Anesthesiology: Integrating Insights From Diverse Disciplines to Improve Perioperative Care.Ruscic KJ, Hanidziar D, Shaw KM, Wiener-Kronish J, Shelton KT. Ruscic KJ, et al. Anesth Analg. 2022 Oct 1;135(4):673-677. doi: 10.1213/ANE.0000000000006166. Epub 2022 Sep 15. Anesth Analg. 2022. PMID: 36108178 No abstract available.
-
- Angus DC, et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit. Care Med. 2001;29:1301–1310. - PubMed
- Research Support, Non-U.S. Gov't
- Aged
- Aged, 80 and over
- Critical Care / methods*
- Female
- Humans
- Male
- Mass Spectrometry
- Metabolome*
- Metabolomics
- Middle Aged
- Plasma / chemistry*
- Resuscitation / methods*
- Shock, Septic / pathology*
- Shock, Septic / therapy*
- Survival Analysis
- Time Factors
- Treatment Outcome
- Full Text Sources
- Other Literature Sources
- Medical
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The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
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![Figure 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5575075/bin/41598_2017_9619_Fig2_HTML.jpg)
Figure 3
Targeted metabolomics. Metabolites whose concentration…
Figure 3
Targeted metabolomics. Metabolites whose concentration (μM) is significantly different between responsive (R) and…
Figure 4
Targeted metabolomics. Metabolites whose concentration…
Figure 4
Targeted metabolomics. Metabolites whose concentration (μM) from T1 to T2 in the two…
Figure 5
Coefficients values of the logistic…
Figure 5
Coefficients values of the logistic regression models for targeted metabolomics (panel A) and…
Figure 6
Three-dimensional PLS-DA score plots on…
Figure 6
Three-dimensional PLS-DA score plots on 20 features for targeted metabolomics model (panel A)…
Figure 7
Plasma sPLA2-IIA levels (μg/L) in…
Figure 7
Plasma sPLA2-IIA levels (μg/L) in responsive (R) and non-responsive (NR) patients at T1…
- An Innovative Approach for The Integration of Proteomics and Metabolomics Data In Severe Septic Shock Patients Stratified for Mortality.Cambiaghi A, Díaz R, Martinez JB, Odena A, Brunelli L, Caironi P, Masson S, Baselli G, Ristagno G, Gattinoni L, de Oliveira E, Pastorelli R, Ferrario M. Cambiaghi A, et al. Sci Rep. 2018 Apr 27;8(1):6681. doi: 10.1038/s41598-018-25035-1. Sci Rep. 2018. PMID: 29703925 Free PMC article.
- Mortality prediction in patients with severe septic shock: a pilot study using a target metabolomics approach.Ferrario M, Cambiaghi A, Brunelli L, Giordano S, Caironi P, Guatteri L, Raimondi F, Gattinoni L, Latini R, Masson S, Ristagno G, Pastorelli R. Ferrario M, et al. Sci Rep. 2016 Feb 5;6:20391. doi: 10.1038/srep20391. Sci Rep. 2016. PMID: 26847922 Free PMC article. Clinical Trial.
- Identification of a transcriptome profile associated with improvement of organ function in septic shock patients after early supportive therapy.Barcella M, Bollen Pinto B, Braga D, D'Avila F, Tagliaferri F, Cazalis MA, Monneret G, Herpain A, Bendjelid K, Barlassina C. Barcella M, et al. Crit Care. 2018 Nov 21;22(1):312. doi: 10.1186/s13054-018-2242-3. Crit Care. 2018. PMID: 30463588 Free PMC article.
- Translational Metabolomics of Head Injury: Exploring Dysfunctional Cerebral Metabolism with Ex Vivo NMR Spectroscopy-Based Metabolite Quantification.Wolahan SM, Hirt D, Glenn TC. Wolahan SM, et al. In: Kobeissy FH, editor. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Chapter 25. In: Kobeissy FH, editor. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Chapter 25. PMID: 26269925 Free Books & Documents. Review.
- Fluid therapy for septic shock resuscitation: which fluid should be used?Corrêa TD, Rocha LL, Pessoa CM, Silva E, de Assuncao MS. Corrêa TD, et al. Einstein (Sao Paulo). 2015 Jul-Sep;13(3):462-8. doi: 10.1590/S1679-45082015RW3273. Epub 2015 Aug 21. Einstein (Sao Paulo). 2015. PMID: 26313437 Free PMC article. Review.
- Plasma enzymatic activity, proteomics and peptidomics in COVID-19-induced sepsis: A novel approach for the analysis of hemostasis.Dos Santos F, Li JB, Juocys N, Mazor R, Beretta L, Coufal NG, Lam MTY, Odish MF, Irigoyen MC, O'Donoghue AJ, Aletti F, Kistler EB. Dos Santos F, et al. Front Mol Biosci. 2023 Jan 11;9:1051471. doi: 10.3389/fmolb.2022.1051471. eCollection 2022. Front Mol Biosci. 2023. PMID: 36710882 Free PMC article.
- EASY-FIA: A Readably Usable Standalone Tool for High-Resolution Mass Spectrometry Metabolomics Data Pre-Processing.Morabito A, De Simone G, Ferrario M, Falcetta F, Pastorelli R, Brunelli L. Morabito A, et al. Metabolites. 2022 Dec 21;13(1):13. doi: 10.3390/metabo13010013. Metabolites. 2022. PMID: 36676938 Free PMC article.
- Metabolic fingerprint of patients showing responsiveness to treatment of septic shock in intensive care unit.Pandey S, Siddiqui MA, Azim A, Sinha N. Pandey S, et al. MAGMA. 2022 Nov 30. doi: 10.1007/s10334-022-01049-9. Online ahead of print. MAGMA. 2022. PMID: 36449125
- Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism.Yeudall S, Upchurch CM, Seegren PV, Pavelec CM, Greulich J, Lemke MC, Harris TE, Desai BN, Hoehn KL, Leitinger N. Yeudall S, et al. Sci Adv. 2022 Nov 25;8(47):eabq1984. doi: 10.1126/sciadv.abq1984. Epub 2022 Nov 23. Sci Adv. 2022. PMID: 36417534 Free PMC article.
- Systems Anesthesiology: Integrating Insights From Diverse Disciplines to Improve Perioperative Care.Ruscic KJ, Hanidziar D, Shaw KM, Wiener-Kronish J, Shelton KT. Ruscic KJ, et al. Anesth Analg. 2022 Oct 1;135(4):673-677. doi: 10.1213/ANE.0000000000006166. Epub 2022 Sep 15. Anesth Analg. 2022. PMID: 36108178 No abstract available.
-
- Angus DC, et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit. Care Med. 2001;29:1301–1310. - PubMed
- Research Support, Non-U.S. Gov't
- Aged
- Aged, 80 and over
- Critical Care / methods*
- Female
- Humans
- Male
- Mass Spectrometry
- Metabolome*
- Metabolomics
- Middle Aged
- Plasma / chemistry*
- Resuscitation / methods*
- Shock, Septic / pathology*
- Shock, Septic / therapy*
- Survival Analysis
- Time Factors
- Treatment Outcome
- Full Text Sources
- Other Literature Sources
- Medical
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
![Figure 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5575075/bin/41598_2017_9619_Fig3_HTML.jpg)
Figure 4
Targeted metabolomics. Metabolites whose concentration…
Figure 4
Targeted metabolomics. Metabolites whose concentration (μM) from T1 to T2 in the two…
Figure 5
Coefficients values of the logistic…
Figure 5
Coefficients values of the logistic regression models for targeted metabolomics (panel A) and…
Figure 6
Three-dimensional PLS-DA score plots on…
Figure 6
Three-dimensional PLS-DA score plots on 20 features for targeted metabolomics model (panel A)…
Figure 7
Plasma sPLA2-IIA levels (μg/L) in…
Figure 7
Plasma sPLA2-IIA levels (μg/L) in responsive (R) and non-responsive (NR) patients at T1…
- An Innovative Approach for The Integration of Proteomics and Metabolomics Data In Severe Septic Shock Patients Stratified for Mortality.Cambiaghi A, Díaz R, Martinez JB, Odena A, Brunelli L, Caironi P, Masson S, Baselli G, Ristagno G, Gattinoni L, de Oliveira E, Pastorelli R, Ferrario M. Cambiaghi A, et al. Sci Rep. 2018 Apr 27;8(1):6681. doi: 10.1038/s41598-018-25035-1. Sci Rep. 2018. PMID: 29703925 Free PMC article.
- Mortality prediction in patients with severe septic shock: a pilot study using a target metabolomics approach.Ferrario M, Cambiaghi A, Brunelli L, Giordano S, Caironi P, Guatteri L, Raimondi F, Gattinoni L, Latini R, Masson S, Ristagno G, Pastorelli R. Ferrario M, et al. Sci Rep. 2016 Feb 5;6:20391. doi: 10.1038/srep20391. Sci Rep. 2016. PMID: 26847922 Free PMC article. Clinical Trial.
- Identification of a transcriptome profile associated with improvement of organ function in septic shock patients after early supportive therapy.Barcella M, Bollen Pinto B, Braga D, D'Avila F, Tagliaferri F, Cazalis MA, Monneret G, Herpain A, Bendjelid K, Barlassina C. Barcella M, et al. Crit Care. 2018 Nov 21;22(1):312. doi: 10.1186/s13054-018-2242-3. Crit Care. 2018. PMID: 30463588 Free PMC article.
- Translational Metabolomics of Head Injury: Exploring Dysfunctional Cerebral Metabolism with Ex Vivo NMR Spectroscopy-Based Metabolite Quantification.Wolahan SM, Hirt D, Glenn TC. Wolahan SM, et al. In: Kobeissy FH, editor. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Chapter 25. In: Kobeissy FH, editor. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Chapter 25. PMID: 26269925 Free Books & Documents. Review.
- Fluid therapy for septic shock resuscitation: which fluid should be used?Corrêa TD, Rocha LL, Pessoa CM, Silva E, de Assuncao MS. Corrêa TD, et al. Einstein (Sao Paulo). 2015 Jul-Sep;13(3):462-8. doi: 10.1590/S1679-45082015RW3273. Epub 2015 Aug 21. Einstein (Sao Paulo). 2015. PMID: 26313437 Free PMC article. Review.
- Plasma enzymatic activity, proteomics and peptidomics in COVID-19-induced sepsis: A novel approach for the analysis of hemostasis.Dos Santos F, Li JB, Juocys N, Mazor R, Beretta L, Coufal NG, Lam MTY, Odish MF, Irigoyen MC, O'Donoghue AJ, Aletti F, Kistler EB. Dos Santos F, et al. Front Mol Biosci. 2023 Jan 11;9:1051471. doi: 10.3389/fmolb.2022.1051471. eCollection 2022. Front Mol Biosci. 2023. PMID: 36710882 Free PMC article.
- EASY-FIA: A Readably Usable Standalone Tool for High-Resolution Mass Spectrometry Metabolomics Data Pre-Processing.Morabito A, De Simone G, Ferrario M, Falcetta F, Pastorelli R, Brunelli L. Morabito A, et al. Metabolites. 2022 Dec 21;13(1):13. doi: 10.3390/metabo13010013. Metabolites. 2022. PMID: 36676938 Free PMC article.
- Metabolic fingerprint of patients showing responsiveness to treatment of septic shock in intensive care unit.Pandey S, Siddiqui MA, Azim A, Sinha N. Pandey S, et al. MAGMA. 2022 Nov 30. doi: 10.1007/s10334-022-01049-9. Online ahead of print. MAGMA. 2022. PMID: 36449125
- Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism.Yeudall S, Upchurch CM, Seegren PV, Pavelec CM, Greulich J, Lemke MC, Harris TE, Desai BN, Hoehn KL, Leitinger N. Yeudall S, et al. Sci Adv. 2022 Nov 25;8(47):eabq1984. doi: 10.1126/sciadv.abq1984. Epub 2022 Nov 23. Sci Adv. 2022. PMID: 36417534 Free PMC article.
- Systems Anesthesiology: Integrating Insights From Diverse Disciplines to Improve Perioperative Care.Ruscic KJ, Hanidziar D, Shaw KM, Wiener-Kronish J, Shelton KT. Ruscic KJ, et al. Anesth Analg. 2022 Oct 1;135(4):673-677. doi: 10.1213/ANE.0000000000006166. Epub 2022 Sep 15. Anesth Analg. 2022. PMID: 36108178 No abstract available.
-
- Angus DC, et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit. Care Med. 2001;29:1301–1310. - PubMed
- Research Support, Non-U.S. Gov't
- Aged
- Aged, 80 and over
- Critical Care / methods*
- Female
- Humans
- Male
- Mass Spectrometry
- Metabolome*
- Metabolomics
- Middle Aged
- Plasma / chemistry*
- Resuscitation / methods*
- Shock, Septic / pathology*
- Shock, Septic / therapy*
- Survival Analysis
- Time Factors
- Treatment Outcome
- Full Text Sources
- Other Literature Sources
- Medical
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
![Figure 4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5575075/bin/41598_2017_9619_Fig4_HTML.jpg)
Figure 5
Coefficients values of the logistic…
Figure 5
Coefficients values of the logistic regression models for targeted metabolomics (panel A) and…
Figure 6
Three-dimensional PLS-DA score plots on…
Figure 6
Three-dimensional PLS-DA score plots on 20 features for targeted metabolomics model (panel A)…
Figure 7
Plasma sPLA2-IIA levels (μg/L) in…
Figure 7
Plasma sPLA2-IIA levels (μg/L) in responsive (R) and non-responsive (NR) patients at T1…
- An Innovative Approach for The Integration of Proteomics and Metabolomics Data In Severe Septic Shock Patients Stratified for Mortality.Cambiaghi A, Díaz R, Martinez JB, Odena A, Brunelli L, Caironi P, Masson S, Baselli G, Ristagno G, Gattinoni L, de Oliveira E, Pastorelli R, Ferrario M. Cambiaghi A, et al. Sci Rep. 2018 Apr 27;8(1):6681. doi: 10.1038/s41598-018-25035-1. Sci Rep. 2018. PMID: 29703925 Free PMC article.
- Mortality prediction in patients with severe septic shock: a pilot study using a target metabolomics approach.Ferrario M, Cambiaghi A, Brunelli L, Giordano S, Caironi P, Guatteri L, Raimondi F, Gattinoni L, Latini R, Masson S, Ristagno G, Pastorelli R. Ferrario M, et al. Sci Rep. 2016 Feb 5;6:20391. doi: 10.1038/srep20391. Sci Rep. 2016. PMID: 26847922 Free PMC article. Clinical Trial.
- Identification of a transcriptome profile associated with improvement of organ function in septic shock patients after early supportive therapy.Barcella M, Bollen Pinto B, Braga D, D'Avila F, Tagliaferri F, Cazalis MA, Monneret G, Herpain A, Bendjelid K, Barlassina C. Barcella M, et al. Crit Care. 2018 Nov 21;22(1):312. doi: 10.1186/s13054-018-2242-3. Crit Care. 2018. PMID: 30463588 Free PMC article.
- Translational Metabolomics of Head Injury: Exploring Dysfunctional Cerebral Metabolism with Ex Vivo NMR Spectroscopy-Based Metabolite Quantification.Wolahan SM, Hirt D, Glenn TC. Wolahan SM, et al. In: Kobeissy FH, editor. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Chapter 25. In: Kobeissy FH, editor. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Chapter 25. PMID: 26269925 Free Books & Documents. Review.
- Fluid therapy for septic shock resuscitation: which fluid should be used?Corrêa TD, Rocha LL, Pessoa CM, Silva E, de Assuncao MS. Corrêa TD, et al. Einstein (Sao Paulo). 2015 Jul-Sep;13(3):462-8. doi: 10.1590/S1679-45082015RW3273. Epub 2015 Aug 21. Einstein (Sao Paulo). 2015. PMID: 26313437 Free PMC article. Review.
- Plasma enzymatic activity, proteomics and peptidomics in COVID-19-induced sepsis: A novel approach for the analysis of hemostasis.Dos Santos F, Li JB, Juocys N, Mazor R, Beretta L, Coufal NG, Lam MTY, Odish MF, Irigoyen MC, O'Donoghue AJ, Aletti F, Kistler EB. Dos Santos F, et al. Front Mol Biosci. 2023 Jan 11;9:1051471. doi: 10.3389/fmolb.2022.1051471. eCollection 2022. Front Mol Biosci. 2023. PMID: 36710882 Free PMC article.
- EASY-FIA: A Readably Usable Standalone Tool for High-Resolution Mass Spectrometry Metabolomics Data Pre-Processing.Morabito A, De Simone G, Ferrario M, Falcetta F, Pastorelli R, Brunelli L. Morabito A, et al. Metabolites. 2022 Dec 21;13(1):13. doi: 10.3390/metabo13010013. Metabolites. 2022. PMID: 36676938 Free PMC article.
- Metabolic fingerprint of patients showing responsiveness to treatment of septic shock in intensive care unit.Pandey S, Siddiqui MA, Azim A, Sinha N. Pandey S, et al. MAGMA. 2022 Nov 30. doi: 10.1007/s10334-022-01049-9. Online ahead of print. MAGMA. 2022. PMID: 36449125
- Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism.Yeudall S, Upchurch CM, Seegren PV, Pavelec CM, Greulich J, Lemke MC, Harris TE, Desai BN, Hoehn KL, Leitinger N. Yeudall S, et al. Sci Adv. 2022 Nov 25;8(47):eabq1984. doi: 10.1126/sciadv.abq1984. Epub 2022 Nov 23. Sci Adv. 2022. PMID: 36417534 Free PMC article.
- Systems Anesthesiology: Integrating Insights From Diverse Disciplines to Improve Perioperative Care.Ruscic KJ, Hanidziar D, Shaw KM, Wiener-Kronish J, Shelton KT. Ruscic KJ, et al. Anesth Analg. 2022 Oct 1;135(4):673-677. doi: 10.1213/ANE.0000000000006166. Epub 2022 Sep 15. Anesth Analg. 2022. PMID: 36108178 No abstract available.
-
- Angus DC, et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit. Care Med. 2001;29:1301–1310. - PubMed
- Research Support, Non-U.S. Gov't
- Aged
- Aged, 80 and over
- Critical Care / methods*
- Female
- Humans
- Male
- Mass Spectrometry
- Metabolome*
- Metabolomics
- Middle Aged
- Plasma / chemistry*
- Resuscitation / methods*
- Shock, Septic / pathology*
- Shock, Septic / therapy*
- Survival Analysis
- Time Factors
- Treatment Outcome
- Full Text Sources
- Other Literature Sources
- Medical
![Figure 5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5575075/bin/41598_2017_9619_Fig5_HTML.jpg)
![Figure 6](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5575075/bin/41598_2017_9619_Fig6_HTML.jpg)
![Figure 7](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5575075/bin/41598_2017_9619_Fig7_HTML.jpg)
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Source: PubMed