Investigation of neutrophil lymphocyte ratio and blood glucose regulation in patients with type 2 diabetes mellitus
Fatih Sefil, Kemal Turker Ulutas, Recep Dokuyucu, Ahmet Taner Sumbul, Erhan Yengil, Abdullah Erman Yagiz, Erkan Yula, Ihsan Ustun, Cumali Gokce, Fatih Sefil, Kemal Turker Ulutas, Recep Dokuyucu, Ahmet Taner Sumbul, Erhan Yengil, Abdullah Erman Yagiz, Erkan Yula, Ihsan Ustun, Cumali Gokce
Abstract
Objective: Leukocytosis is thought to be directly associated with the pathogenesis of atherosclerosis and metabolic syndrome. Increased white blood cell (WBC) count is related to cardiovascular disease in patients with type 2 diabetes mellitus; raised neutrophil lymphocyte ratio (NLR) is associated with metabolic syndrome. There is little information, however, concerning a correlation between glycosylated haemoglobin (HbA1c) and NLR. The aim of the present study was to investigate the relationship between NLR and blood glucose regulation.
Methods: This retrospective study was conducted in patients with type 2 diabetes mellitus, divided into two groups according to HbA1c levels: group 1, HbA1c levels ≤ 7%; group 2, HbA1c levels > 7%. Venous WBC, neutrophil and lymphocyte counts were determined.
Results: Of 71 patients included, fasting serum glucose, neutrophil and WBC counts were significantly higher in group 2 compared with group 1. NLR had a positive correlation with HbA1c.
Conclusion: There may be a significant relationship between NLR and blood glucose regulation. The authors propose that increased NLR may be associated with elevated HbA1c in patients with type 2 diabetes mellitus.
Keywords: Glycosylated haemoglobin (HbA1c); diabetes mellitus; neutrophil lymphocyte ratio.
Source: PubMed