Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia
H Dean Hosgood 3rd, Wen-Chang Wang, Yun-Chul Hong, Jiu-Cun Wang, Kexin Chen, I-Shou Chang, Chien-Jen Chen, Daru Lu, Zhihua Yin, Chen Wu, Wei Zheng, Biyun Qian, Jae Yong Park, Yeul Hong Kim, Nilanjan Chatterjee, Ying Chen, Gee-Chen Chang, Chin-Fu Hsiao, Meredith Yeager, Ying-Huang Tsai, Hu Wei, Young Tae Kim, Wei Wu, Zhenhong Zhao, Wong-Ho Chow, Xiaoling Zhu, Yen-Li Lo, Sook Whan Sung, Kuan-Yu Chen, Jeff Yuenger, Joo Hyun Kim, Liming Huang, Ying-Hsiang Chen, Yu-Tang Gao, Jin Hee Kim, Ming-Shyan Huang, Tae Hoon Jung, Neil Caporaso, Xueying Zhao, Zhang Huan, Dianke Yu, Chang Ho Kim, Wu-Chou Su, Xiao-Ou Shu, In-San Kim, Bryan Bassig, Yuh-Min Chen, Sung Ick Cha, Wen Tan, Hongyan Chen, Tsung-Ying Yang, Jae Sook Sung, Chih-Liang Wang, Xuelian Li, Kyong Hwa Park, Chong-Jen Yu, Jeong-Seon Ryu, Yongbing Xiang, Amy Hutchinson, Jun Suk Kim, Qiuyin Cai, Maria Teresa Landi, Kyoung-Mu Lee, Jen-Yu Hung, Ju-Yeon Park, Margaret Tucker, Chien-Chung Lin, Yangwu Ren, Reury-Perng Perng, Chih-Yi Chen, Li Jin, Kun-Chieh Chen, Yao-Jen Li, Yu-Fang Chiu, Fang-Yu Tsai, Pan-Chyr Yang, Joseph F Fraumeni Jr, Adeline Seow, Dongxin Lin, Baosen Zhou, Stephen Chanock, Chao Agnes Hsiung, Nathaniel Rothman, Qing Lan, H Dean Hosgood 3rd, Wen-Chang Wang, Yun-Chul Hong, Jiu-Cun Wang, Kexin Chen, I-Shou Chang, Chien-Jen Chen, Daru Lu, Zhihua Yin, Chen Wu, Wei Zheng, Biyun Qian, Jae Yong Park, Yeul Hong Kim, Nilanjan Chatterjee, Ying Chen, Gee-Chen Chang, Chin-Fu Hsiao, Meredith Yeager, Ying-Huang Tsai, Hu Wei, Young Tae Kim, Wei Wu, Zhenhong Zhao, Wong-Ho Chow, Xiaoling Zhu, Yen-Li Lo, Sook Whan Sung, Kuan-Yu Chen, Jeff Yuenger, Joo Hyun Kim, Liming Huang, Ying-Hsiang Chen, Yu-Tang Gao, Jin Hee Kim, Ming-Shyan Huang, Tae Hoon Jung, Neil Caporaso, Xueying Zhao, Zhang Huan, Dianke Yu, Chang Ho Kim, Wu-Chou Su, Xiao-Ou Shu, In-San Kim, Bryan Bassig, Yuh-Min Chen, Sung Ick Cha, Wen Tan, Hongyan Chen, Tsung-Ying Yang, Jae Sook Sung, Chih-Liang Wang, Xuelian Li, Kyong Hwa Park, Chong-Jen Yu, Jeong-Seon Ryu, Yongbing Xiang, Amy Hutchinson, Jun Suk Kim, Qiuyin Cai, Maria Teresa Landi, Kyoung-Mu Lee, Jen-Yu Hung, Ju-Yeon Park, Margaret Tucker, Chien-Chung Lin, Yangwu Ren, Reury-Perng Perng, Chih-Yi Chen, Li Jin, Kun-Chieh Chen, Yao-Jen Li, Yu-Fang Chiu, Fang-Yu Tsai, Pan-Chyr Yang, Joseph F Fraumeni Jr, Adeline Seow, Dongxin Lin, Baosen Zhou, Stephen Chanock, Chao Agnes Hsiung, Nathaniel Rothman, Qing Lan
Abstract
A recent genome-wide association study (GWAS) of subjects from Japan and South Korea reported a novel association between the TP63 locus on chromosome 3q28 and risk of lung adenocarcinoma (p = 7.3 × 10(-12)); however, this association did not achieve genome-wide significance (p ≤ 10(-7)) among never-smoking males or females. To determine if this association with lung cancer risk is independent of tobacco use, we genotyped the TP63 SNPs reported by the previous GWAS (rs10937405 and rs4488809) in 3,467 never-smoking female lung cancer cases and 3,787 never-smoking female controls from 10 studies conducted in Taiwan, Mainland China, South Korea, and Singapore. Genetic variation in rs10937405 was associated with risk of lung adenocarcinoma [n = 2,529 cases; p = 7.1 × 10(-8); allelic risk = 0.80, 95% confidence interval (CI) = 0.74-0.87]. There was also evidence of association with squamous cell carcinoma of the lung (n = 302 cases; p = 0.037; allelic risk = 0.82, 95% CI = 0.67-0.99). Our findings provide strong evidence that genetic variation in TP63 is associated with the risk of lung adenocarcinoma among Asian females in the absence of tobacco smoking.
Conflict of interest statement
Conflicts of interest The authors have no conflicts of interest to report.
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Source: PubMed