Functional neuroimaging of emotional processing in women with polycystic ovary syndrome: a case-control pilot study
Courtney A Marsh, Alison Berent-Spillson, Tiffany Love, Carol C Persad, Rodica Pop-Busui, Jon-Kar Zubieta, Yolanda R Smith, Courtney A Marsh, Alison Berent-Spillson, Tiffany Love, Carol C Persad, Rodica Pop-Busui, Jon-Kar Zubieta, Yolanda R Smith
Abstract
Objective: To evaluate emotional processing in women with insulin-resistant polycystic ovary syndrome (IR-PCOS) and its relationship to glucose regulation and the mu-opioid system.
Design: Case-control pilot.
Setting: Tertiary referring medical center.
Patient(s): Seven women with IR-PCOS and five non-insulin-resistant controls, aged 21-40 years, recruited from the general population.
Intervention(s): Sixteen weeks of metformin (1,500 mg/day) in women with IR-PCOS.
Main outcome measure(s): Assessment of mood, metabolic function, and neuronal activation during an emotional task using functional magnetic resonance imaging (fMRI), and mu-opioid receptor availability using positive emission tomography (PET).
Result(s): We found that insulin-resistant PCOS patients [1] had greater limbic activation during an emotion task than controls (n = 5); [2] trended toward decreased positive affect and increased trait anxiety; [3] after metformin treatment, had limbic activation that no longer differed from controls; and [4] had positive correlations between fMRI limbic activation during emotional processing and mu-opioid binding potential.
Conclusion(s): Patients with IR-PCOS had greater regional activation during an emotion task than the controls, although this resolved with metformin therapy. Alterations in mu-opioid neurotransmission may underlie limbic system activity and mood disorders in IR-PCOS.
Trial registration: ClinicalTrials.gov NCT00670800.
Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3900232/bin/nihms454368f1.jpg)
![Figure 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/3900232/bin/nihms454368f2.jpg)
Source: PubMed