Preserved speech abilities and compensation following prefrontal damage

R L Buckner, M Corbetta, J Schatz, M E Raichle, S E Petersen, R L Buckner, M Corbetta, J Schatz, M E Raichle, S E Petersen

Abstract

Lesions to left frontal cortex in humans produce speech production impairments (nonfluent aphasia). These impairments vary from subject to subject and performance on certain speech production tasks can be relatively preserved in some patients. A possible explanation for preservation of function under these circumstances is that areas outside left prefrontal cortex are used to compensate for the injured brain area. We report here a direct demonstration of preserved language function in a stroke patient (LF1) apparently due to the activation of a compensatory brain pathway. We used functional brain imaging with positron emission tomography (PET) as a basis for this study.

References

    1. Arch Neurol. 1971 Oct;25(4):302-6
    1. J Neurophysiol. 1995 Nov;74(5):2163-73
    1. Brain. 1979 Dec;102(4):805-15
    1. Am Psychol. 1983 May;38(5):525-37
    1. J Nucl Med. 1983 Sep;24(9):782-9
    1. J Nucl Med. 1983 Sep;24(9):790-8
    1. Brain. 1984 Jun;107 ( Pt 2):463-85
    1. J Comput Assist Tomogr. 1985 Jan-Feb;9(1):141-53
    1. Nature. 1988 Feb 18;331(6157):585-9
    1. J Cereb Blood Flow Metab. 1989 Feb;9(1):96-103
    1. J Nucl Med. 1989 Feb;30(2):141-9
    1. Brain. 1991 Aug;114 ( Pt 4):1803-17
    1. Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1837-41
    1. Brain. 1992 Dec;115 ( Pt 6):1769-82
    1. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):4952-6
    1. Cereb Cortex. 1994 Jan-Feb;4(1):8-26
    1. J Neurosci. 1995 Jan;15(1 Pt 1):12-29
    1. Ann Neurol. 1995 Jun;37(6):723-32
    1. Neuropsychologia. 1977;15(4-5):653-74

Source: PubMed

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

3
Abonner