Clinical outcomes and serologic response in solid organ transplant recipients with COVID-19: A case series from the United States

Monica Fung, Charles Y Chiu, Catherine DeVoe, Sarah B Doernberg, Brian S Schwartz, Charles Langelier, Timothy J Henrich, Deborah Yokoe, John Davis, Steven R Hays, Sindhu Chandran, Jasleen Kukreja, Dianna Ng, John Prostko, Russell Taylor, Kevin Reyes, Emma Bainbridge, Allison Bond, Peter Chin-Hong, Jennifer M Babik, Monica Fung, Charles Y Chiu, Catherine DeVoe, Sarah B Doernberg, Brian S Schwartz, Charles Langelier, Timothy J Henrich, Deborah Yokoe, John Davis, Steven R Hays, Sindhu Chandran, Jasleen Kukreja, Dianna Ng, John Prostko, Russell Taylor, Kevin Reyes, Emma Bainbridge, Allison Bond, Peter Chin-Hong, Jennifer M Babik

Abstract

The coronavirus disease 2019 (COVID-19) pandemic caused by SARS coronavirus 2 (SARS-CoV-2) has caused significant morbidity and mortality for patients and stressed healthcare systems worldwide. The clinical features, disease course, and serologic response of COVID-19 among immunosuppressed patients such as solid organ transplant (SOT) recipients, who are at presumed risk for more severe disease, are not well characterized. We describe our institutional experience with COVID-19 among 10 SOT patients, including the clinical presentation, treatment modalities, and outcomes of 7 renal transplant recipients, 1 liver transplant recipient, 1 heart transplant recipient, and 1 lung transplant recipient. In addition, we report the serologic response in SOT recipients, documenting a positive IgG response in all 7 hospitalized patients. We also review the existing literature on COVID-19 in SOT recipients to consolidate the current knowledge on COVID-19 in the SOT population for the transplant community.

Keywords: antibody biology; clinical research/practice; infection and infectious agents - viral; infectious disease.

© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.

Figures

FIGURE 1
FIGURE 1
SARS-COV-2 IgG serology and PCR results for all 7 solid organ transplant recipients requiring hospitalization. IgG serology was conducted using Abbott chemiluminescent microparticle immunoassay detecting IgG antibodies to the SARS-CoV-2 nucleocapsid protein with index value of 1.4 (dotted line) set as positive threshold. PCR was conducted on nasopharyngeal and pooled nasopharyngeal/oropharyngeal swab samples

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Source: PubMed

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