Contrast-enhanced whole-heart coronary magnetic resonance angiography at 3.0-T: a comparative study with X-ray angiography in a single center
Qi Yang, Kuncheng Li, Xin Liu, Xiaoming Bi, Zhi Liu, Jing An, Al Zhang, Renate Jerecic, Debiao Li, Qi Yang, Kuncheng Li, Xin Liu, Xiaoming Bi, Zhi Liu, Jing An, Al Zhang, Renate Jerecic, Debiao Li
Abstract
Objectives: The purpose of this study was to prospectively evaluate the diagnostic performance of 3.0-T contrast-enhanced whole-heart coronary magnetic resonance angiography (CMRA) in patients with suspected coronary artery disease (CAD).
Background: A slow-infusion, contrast-enhanced whole-heart CMRA approach has recently been developed at 3.0-T. The accuracy of this technique has not yet been determined among patients with suspected CAD.
Methods: The 3.0-T contrast-enhanced whole-heart CMRA was performed in 69 consecutive patients. An electrocardiography-triggered, navigator-gated, inversion-recovery prepared, segmented gradient-echo sequence was used to acquire isotropic whole-heart CMRA with slow infusion of 0.2 mmol/kg gadobenate dimeglumine. The diagnostic accuracy of whole-heart CMRA in detecting significant stenoses (> or =50%) was evaluated using X-ray angiography as the reference.
Results: The CMRA examinations were successfully completed in 62 patients. Acquisition time of whole-heart CMRA procedure was 9.0 +/- 1.9 min. The 3.0-T whole-heart CMRA correctly identified significant CAD in 32 patients and correctly ruled out CAD in 23 patients. The sensitivity, specificity, and accuracy of whole-heart CMRA for detecting significant stenoses were 91.6% (87 of 95), 83.1% (570 of 686), and 84.1% (657 of 781), respectively, on a per-segment basis. These values were 94.1% (32 of 34), 82.1% (23 of 28), and 88.7% (55 of 62), respectively, on a per-patient basis.
Conclusions: Contrast-enhanced whole-heart CMRA with 3.0-T allows for the accurate detection of coronary artery stenosis with high sensitivity and moderate specificity.
Figures
![Figure 1. Flow chart of patient inclusion](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2758632/bin/nihms128277f1.jpg)
![Figure 2. 3T contrast-enhanced whole-heart CMRA images…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2758632/bin/nihms128277f2a.jpg)
![Figure 2. 3T contrast-enhanced whole-heart CMRA images…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2758632/bin/nihms128277f2b.jpg)
![Figure 3. 3T contrast-enhanced whole-heart CMRA images…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2758632/bin/nihms128277f3a.jpg)
![Figure 3. 3T contrast-enhanced whole-heart CMRA images…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2758632/bin/nihms128277f3b.jpg)
![Figure 4. 3T contrast-enhanced whole-heart CMRA images…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2758632/bin/nihms128277f4a.jpg)
![Figure 4. 3T contrast-enhanced whole-heart CMRA images…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2758632/bin/nihms128277f4b.jpg)
![Figure 4. 3T contrast-enhanced whole-heart CMRA images…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2758632/bin/nihms128277f4c.jpg)
![Figure 4. 3T contrast-enhanced whole-heart CMRA images…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2758632/bin/nihms128277f4d.jpg)
![Figure 4. 3T contrast-enhanced whole-heart CMRA images…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2758632/bin/nihms128277f4e.jpg)
![Figure 4. 3T contrast-enhanced whole-heart CMRA images…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2758632/bin/nihms128277f4f.jpg)
Source: PubMed