Antiplaque and antigingivitis effects of a gel containing Punica granatum Linn extract: a double-blind clinical study in humans

Alexandre Daher Yunes Salgado, Juliana Lemos Maia, Sérgio Luís da Silva Pereira, Telma Leda Gomes de Lemos, Olívia Morais de Lima Mota, Alexandre Daher Yunes Salgado, Juliana Lemos Maia, Sérgio Luís da Silva Pereira, Telma Leda Gomes de Lemos, Olívia Morais de Lima Mota

Abstract

Objectives: The antiplaque and antigingivitis effects of a gel containing 10% Punica granatum Linn extract were evaluated using a 21-day partial-mouth experimental model of gingivitis.

Methods: 23 volunteers participated in this cross-over, double-blind study, carried out in 2 phases of 21 days each. For each period of the experiment, an acrylic toothshield was made for each volunteer to carry the test or placebo gel as well as to avoid brushing of the 4 experimental teeth (posterior teeth in the lower left quadrant). The subjects were randomly assigned to use either the placebo gel (control group) or the test gel (experimental group) and were instructed to brush the remaining teeth normally 3 times a day. On days 0 and 21, the visible plaque index (VPI) and gingival bleeding index (GBI) were recorded.

Results: The results did not show statistically significant difference between control and experimental groups for either of the indices (VPI and GBI).

Conclusion: The gel containing 10% Punica granatum Linn extract was not efficient in preventing supragingival dental plaque formation and gingivitis.

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