Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study

Abstract

The aim of this study was to identify factors associated with the death of patients with COVID-19 pneumonia caused by the novel coronavirus SARS-CoV-2.All clinical and laboratory parameters were collected prospectively from a cohort of patients with COVID-19 pneumonia who were hospitalised to Wuhan Pulmonary Hospital (Wuhan City, Hubei Province, China) between 25 December 2019 and 7 February 2020. Univariate and multivariate logistic regression analysis revealed that age ≥65 years (OR 3.765, 95% CI 1.146–17.394; p=0.023), pre-existing concurrent cardiovascular or cerebrovascular diseases (OR 2.464, 95% CI 0.755–8.044; p=0.007), CD3+CD8+ T-cells ≤75 cells·μL−1 (OR 3.982, 95% CI 1.132–14.006; p<0.001) and cardiac troponin I ≥0.05 ng·mL−1 (OR 4.077, 95% CI 1.166–14.253; p<0.001) were associated with an increase in risk of mortality from COVID-19 pneumonia.” has been corrected to: “Univariate and multivariate logistic regression analysis revealed that age ≥65 years (OR 3.765, 95% CI 1.201−11.803; p=0.023), pre-existing concurrent cardiovascular or cerebrovascular diseases (OR 2.464, 95% CI 1.279−4.747; p=0.007), CD3+CD8+ T-cells ≤75 cells·μL−1 (OR 3.982, 95% CI 1.761–9.004; p<0.001) and cardiac troponin I ≥0.05 ng·mL−1 (OR 4.077, 95% CI 1.778–9.349; p<0.001) were associated with an increase in risk of mortality from COVID-19 pneumonia. In a sex-, age- and comorbid illness-matched case-control study, CD3+CD8+ T-cells ≤75 cells·μL-1 and cardiac troponin I ≥0.05 ng·mL-1 remained as predictors for high mortality from COVID-19 pneumonia.We identified four risk factors: age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75 cells·μL-1 and cardiac troponin I ≥0.05 ng·mL-1 The latter two factors, especially, were predictors for mortality of COVID-19 pneumonia patients.

Conflict of interest statement

Conflict of interest: Rong-Hui Du has nothing to disclose. Conflict of interest: Li-Rong Liang has nothing to disclose. Conflict of interest: Cheng-Qing Yang has nothing to disclose. Conflict of interest: Wen Wang has nothing to disclose. Conflict of interest: Tan-Ze Cao has nothing to disclose. Conflict of interest: Ming Li has nothing to disclose. Conflict of interest: Guang-Yun Guo has nothing to disclose. Conflict of interest: Juan Du has nothing to disclose. Conflict of interest: Chun-Lan Zheng has nothing to disclose. Conflict of interest: Qi Zhu has nothing to disclose. Conflict of interest: Ming Hu has nothing to disclose. Conflict of interest: Xu-Yan Li has nothing to disclose. Conflict of interest: Peng Peng has nothing to disclose. Conflict of interest: Huan-Zhong Shi has nothing to disclose.

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