Ultrasound and multi-biomarker disease activity score for assessing and predicting clinical response to tofacitinib treatment in patients with rheumatoid arthritis

Amir A Razmjou, Jenny Brook, David Elashoff, Gurjit Kaeley, Soo Choi, Tanaz Kermani, Veena K Ranganath, Amir A Razmjou, Jenny Brook, David Elashoff, Gurjit Kaeley, Soo Choi, Tanaz Kermani, Veena K Ranganath

Abstract

Background: Musculoskeletal ultrasound (MSUS) and the multi-biomarker disease activity (MBDA) score are outcome measures that may aid in the management of rheumatoid arthritis (RA) patients. This study evaluated tofacitinib response by MSUS/MBDA scores and assessed whether baseline MSUS/MBDA scores or their early changes predict later clinical response.

Methods: Twenty-five RA patients treated with tofacitinib were assessed at baseline, 2, 6 and 12-weeks. Power doppler (PDUS) and gray scale (GSUS) ultrasound scores, MBDA score, clinical disease activity index (CDAI), and disease activity score (DAS28) were obtained. Pearson correlations and multiple linear regression models were used to evaluate associations and identify predictors of response to therapy.

Results: MSUS, MBDA scores, CDAI, and DAS28 improved significantly over 12 weeks (p < 0.0001). Baseline MSUS and MBDA score correlated with each other, and with 12-week changes in CDAI/DAS28 (r = 0.45-0.62, p < 0.05), except for GSUS with DAS28. Two-week change in MSUS correlated significantly with 12-week changes in CDAI/DAS28 (r = 0.42-0.57, p < 0.05), except for early change in PDUS with 12-week change in CDAI. Regression analysis demonstrated significant independent associations between baseline PDUS/MBDA score and 6-week change in CDAI/DAS28, with adjustment for baseline CDAI/DAS28 (all p < 0.05); and between baseline MBDA scores and 12-week change in DAS28 (p = 0.03).

Conclusions: RA patients treated with tofacitinib for 12 weeks demonstrated improvement by clinical, imaging, and biomarker end-points. Baseline PDUS and MBDA score were predictive of CDAI and DAS28 responses. This is the first study to evaluate early measurements of MSUS and MBDA score as predictors of clinical response in RA patients treated with tofacitinib.

Trial registration: ClinicalTrials.gov NCT02321930 (registered 12/22/2014).

Keywords: Multi-biomarker disease activity score; Outcome measures; Rheumatoid arthritis; Ultrasound.

Conflict of interest statement

Competing interestsVK Ranganath, MD, MS- consultant BMS, DSMB Amgen, grants- Pfizer, BMS, Mallinckrodt, Genentech. All other authors have no competing interests to declare.

© The Author(s) 2020.

Figures

Fig. 1
Fig. 1
Baseline and 12-Week MSUS images after treatment with tofacitinib (GSUS and PDUS). Panels a and b show images of PIP3 and MCP1 in both B-mode and power Doppler before and after treatment with tofacitinib

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